Progress of Acupuncture and Moxibustion Research on the Signal Transduction Pathways Involved in Cell Apoptosis in Myocardial Ischemia Reperfusion Injury

XIAO Yan; DING Liang; GU Yi-huang

doi:10.13702/j.1000-0607.2017.05.017

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Progress of Acupuncture and Moxibustion Research on the Signal Transduction Pathways Involved in Cell Apoptosis in Myocardial Ischemia Reperfusion Injury

更新时间：2023-08-11

- Progress of Acupuncture and Moxibustion Research on the Signal Transduction Pathways Involved in Cell Apoptosis in Myocardial Ischemia Reperfusion Injury
- Acupuncture Research Vol. 42, Issue 5, Pages: 463-466(2017)
- 作者机构：
  
  1. 南京中医药大学第二临床医学院
  2. 苏州市中西医结合医院脾胃病科
- 作者简介：
- 基金信息：
- DOI：10.13702/j.1000-0607.2017.05.017
  CLC：
- Published：2017
- 稿件说明：
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XIAO Yan, DING Liang, GU Yi-huang. Progress of Acupuncture and Moxibustion Research on the Signal Transduction Pathways Involved in Cell Apoptosis in Myocardial Ischemia Reperfusion Injury[J]. Acupuncture research, 2017, 42(5): 463-466.
DOI：

XIAO Yan, DING Liang, GU Yi-huang. Progress of Acupuncture and Moxibustion Research on the Signal Transduction Pathways Involved in Cell Apoptosis in Myocardial Ischemia Reperfusion Injury[J]. Acupuncture research, 2017, 42(5): 463-466. DOI： 10.13702/j.1000-0607.2017.05.017.

摘要

心肌缺血再灌注损伤(MIRI)引起的细胞凋亡现象在临床上非常常见

减轻MIRI细胞凋亡是心肌病学应用基础研究中的一个热点。MIRI中存在着不同程度的心肌细胞凋亡现象

但引发心肌细胞凋亡的有关信号转导机制尚不十分明确。目前研究已证实

针灸可通过死亡受体通路、线粒体通路及内质网通路3大途径有效地干预MIRI细胞凋亡。本文就针灸干预MIRI细胞凋亡的机制特点进行归纳总结

以期为进一步探讨针灸抗MIRI细胞凋亡的信号转导通路及临床应用针灸防治MIRI细胞凋亡提供新思路。

Abstract

Myocardial cell apoptosis is very common in the clinic

and is caused by myocardial ischemia reperfusion injury(MIRI).There are different degrees of cell apoptosis in MIRI.However

initiation of the signal transduction mechanism of myocardial cell apoptosis is unclear.The present research confirmed that acupuncture and moxibustion are effective interventions for cell apoptosis in MIRI through three approaches:the death receptor pathway

mitochondrial pathway and endoplasmic reticulum pathway.In this paper

the authors summarize the mechanism characteristics of acupuncture and moxibustion in MIRI cell apoptosis

and discuss the signal transduction pathways involved in the effects of acupuncture and moxibustion in MIRI cell apoptosis

in order to provide new ideas and evidence for the clinical application of acupuncture and moxibustion to prevent cell apoptosis in MIRI.

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Related Institution

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Clinical Medicine School of Guangdong Pharmaceutical University

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