“A new progress has been made in the study of the effect of electroacupuncture on the inflammatory signaling pathway of silencing signaling factor 1 (SIRT1)/Toll like receptor 4 (TLR4) in the small intestine of obese insulin resistant rats. This study investigated the mechanism by which electroacupuncture improves insulin resistance in obese rats by observing its effects. In the study, Wistar rats were randomly divided into a normal group, a model group, an electroacupuncture group, and an electroacupuncture combined inhibitor group, with 10 rats in each group. Establish an obese insulin resistance rat model by feeding high-fat diet for 8 weeks. The rats in the electroacupuncture group received electroacupuncture treatment at acupoints such as Zhongwan, Guanyuan, Zusanli, and Fenglong for a total of 8 weeks. At the same time, the rats in the electroacupuncture combined with inhibitor group received tail vein injection of SIRT1 inhibitor Sirtinol in addition to electroacupuncture treatment. The research results showed that compared with the normal group, the body mass of the model group rats significantly increased, the glucose infusion rate significantly decreased, the serum inflammatory factor content increased, the small intestine mucosa was severely damaged, the expression of SIRT1 protein decreased, and the expression of TLR4 protein increased. After electroacupuncture intervention, the body mass of rats in the electroacupuncture group and the electroacupuncture combined inhibitor group decreased, the glucose infusion rate increased, the serum inflammatory factor content decreased, the small intestine mucosal damage was reduced, the expression of TLR4 protein decreased, and the expression of SIRT1 protein increased. In the group treated with electroacupuncture combined with inhibitors, the improvement of these indicators was not as significant as in the group treated with electroacupuncture alone. This study suggests that electroacupuncture can improve body mass and insulin sensitivity in obese insulin resistant rats, and its mechanism may be related to the regulation of the SIRT1/TLR4 inflammatory signaling pathway in small intestine tissue. This provides new ideas and methods for the treatment of insulin resistance in obesity.”