“It has made an important breakthrough in the treatment of neurogenic urinary retention. A new study reveals the molecular mechanism of electroacupuncture in treating neurogenic urinary retention in rats, providing a new perspective for solving this problem. The research team took the 3-phosphoinositol dependent protein kinase 1 (PDK1)/protein kinase B (Akt)/hyperpolarization activated cyclic nucleotide gated ion channel 4 (HCN4) pathway as the entry point, and through carefully designed experiments, deeply explored the effect of electroacupuncture on neurogenic urinary retention in rats. The experimental results showed that electroacupuncture stimulation of "Zhongliao" and "Zhongji" can effectively improve urinary dysfunction in rats, which is closely related to the inhibition of PDK1/Akt pathway activation, promotion of HCN4 mediated detrusor muscle excitatory contraction, and activation of urinary electrical signals. This study not only provides a new idea for the treatment of neurogenic urinary retention, but also provides strong support for the application and development of traditional medical methods such as acupuncture and moxibustion in the field of modern medicine. In the future, with in-depth research on this mechanism, we are expected to bring good news to more patients.”