“New progress has been made in the mechanism of fire needle therapy for oxaliplatin induced neuropathic pain in rats. Through the construction of an NP rat model, it was found that fire needle therapy can significantly increase the mechanical pain threshold of rats, reduce serum inflammatory factor levels, and alleviate tissue pathological damage. This effect may be related to the inhibition of mast cell activation and the downregulation of local TPS, TRPV1, and PAR2 protein expression in the acupoint area. This study not only provides experimental evidence for the treatment of neuropathic pain with fire needles, but also lays the foundation for further exploration of the mechanism of fire needle analgesia.”