“A literature review in the past 15 years has shown that acupuncture plays an important role in regulating the mechanism of calcium overload after cerebral ischemia-reperfusion injury. By inhibiting the opening of the Cx43 half channel, regulating intracellular free calcium concentration, suppressing calmodulin expression, and blocking L-type voltage-gated calcium channel function, acupuncture can counteract neuronal damage and protect neurological function after cerebral ischemia-reperfusion. This discovery provides new ideas and methods for the treatment of ischemic stroke.”