“New progress has been made in the study of the effect of moxibustion pretreatment on inflammatory factors in rats with cerebral ischemia-reperfusion injury. Experiments have shown that by activating the PI3K/AKT/mTOR signaling pathway, moxibustion pretreatment can significantly improve the neurological function of CIRI rats, inhibit serum inflammatory factors IL-1 β and TNF - α, and suppress brain tissue damage markers S-100 β protein and NSE. Among them, the effect of pre-treatment for 7 days is the most significant, better than that of 5 days and 3 days. This discovery not only provides new ideas for the treatment of cerebral ischemia-reperfusion injury, but also provides experimental support for the application of moxibustion in the field of neuroprotection.”