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Electroacupuncture improves cognitive dysfunction in rats with Alzheimer’s disease by regulating microglial cells
更新时间:2024-05-08
    • Electroacupuncture improves cognitive dysfunction in rats with Alzheimer’s disease by regulating microglial cells

    • The research team conducted in-depth discussions on the treatment mechanism of Alzheimer's disease (AD). By constructing an AD rat model and observing the effects of electroacupuncture on microglia (MG) and Janus kinase-2 (JAK2), as well as signal transduction and transcription activator 3 (STAT3) in the hippocampal CA1 region, they found that electroacupuncture significantly improved the learning and memory abilities of AD rats. In the experiment, the research team found that the model group rats exhibited learning and memory impairments, hippocampal neuron damage, MG activation, and abnormal activation of the JAK2/STAT3 signaling pathway. After electroacupuncture treatment, the learning and memory abilities of rats were significantly improved, hippocampal neuron damage was reduced, MG activation was inhibited, and abnormal activation of the JAK2/STAT3 signaling pathway was effectively regulated. This study not only provides new ideas for the treatment of AD, but also lays the foundation for further exploration of the mechanism of electroacupuncture treatment for AD. In the future, the research team will continue to delve into the specific mechanisms of electroacupuncture treatment for AD, in order to bring more effective treatment methods to patients.
    • Acupuncture Research   Vol. 48, Issue 11, Pages: 1069-1078(2023)
    • DOI:10.13702/j.1000-0607.20230333    

      CLC: R245.9+7
    • Received:22 April 2023

      Revised:02 August 2023

      Published:25 November 2023

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  • LI Zhen,LI Meng-xing,QIN Yun-peng,et al.Electroacupuncture improves cognitive dysfunction in rats with Alzheimer’s disease by regulating microglial cells[J].Acupuncture Research,2023,48(11):1069-1078. DOI: 10.13702/j.1000-0607.20230333.

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