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1.北京中医医院顺义医院针灸科,北京 101300
2.广东省中医院针灸科,广州510120
3.首都医科大学附属北京中医医院针灸中心,北京 100010
4.北京中医药大学东方医院针灸科,北京 100078
Received:08 July 2023,
Revised:10 August 2023,
Published:25 December 2023
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沈凌宇,富小菲,曾沁等.不同频率电针治疗腹部肥胖型多囊卵巢综合征的疗效比较[J].针刺研究,2023,48(12):1266-1273.
SHEN Ling-yu,FU Xiao-fei,ZENG Qin,et al.Comparison of the efficacy of different frequency electroacupuncture in the treatment of polycystic ovary syndrome patients with abdominal obesity[J].Acupuncture Research,2023,48(12):1266-1273.
沈凌宇,富小菲,曾沁等.不同频率电针治疗腹部肥胖型多囊卵巢综合征的疗效比较[J].针刺研究,2023,48(12):1266-1273. DOI: 10.13702/j.1000-0607.20230575.
SHEN Ling-yu,FU Xiao-fei,ZENG Qin,et al.Comparison of the efficacy of different frequency electroacupuncture in the treatment of polycystic ovary syndrome patients with abdominal obesity[J].Acupuncture Research,2023,48(12):1266-1273. DOI: 10.13702/j.1000-0607.20230575.
目的
2
比较2 Hz连续波电针及2 Hz/100 Hz疏密波电针对腹部肥胖型多囊卵巢综合征(PCOS)患者的排卵频率、激素水平、体脂参数、生活质量及抑郁焦虑程度的作用效果差异。
方法
2
将腹部肥胖型PCOS患者随机分为低频组、疏密波组各29例。低频组采用通调带脉针刺法,电针采用连续波,频率2 Hz;疏密波组采用同种针刺方法,电针采用疏密波,频率2 Hz/100 Hz。两组均每次治疗30 min,每周治疗3次,连续12周。计算患者排卵频率,采用电化学发光法检测血清抗缪勒氏管激素(AMH)和性激素结合球蛋白(SHBG)含量,测量体质量(BW)和腰围(WC),计算体质量指数(BMI)和腰高比(WHtR),评定PCOS生活质量问卷(Chi-PCOSQ)、焦虑自评量表(SAS)、抑郁自评量表(SDS)评分。
结果
2
与治疗前比较,治疗后低频组和疏密波组排卵频率均升高(
P
<
0.01,
P
<
0.05),BW、BMI、WC、WHtR降低(
P
<
0.01),SDS评分降低(
P
<
0.01,
P
<
0.05);疏密波组血清AMH含量降低(
P
<
0.05),SHBG含量升高(
P
<
0.05),Chi-PCOSQ中关于痤疮、疲劳感及痛经的问题分数升高(
P
<
0.01,
P
<
0.05)。与低频组比较,疏密波组治疗后WC降低(
P
<
0.05)。
结论
2
2 Hz/100 Hz疏密波电针与2 Hz低频电针在改善PCOS患者排卵频率方面疗效相当。2 Hz/100 Hz疏密波电针在降低腹部肥胖型PCOS患者WC疗效上优于2 Hz低频电针,可使血清AMH降低、SHBG升高,并改善痤疮、疲劳感及痛经症状。
Objective
2
To compare the effects of 2 Hz continuous wave and 2 Hz/100 Hz dilatational wave setting in electroacupuncture(EA) on ovulation frequency, hormone levels, body fat parameters, quality of life and depression-anxiety level in polycystic ovary syndrome (PCOS) patients with abdominal obesity.
Methods
2
PCOS patients with abdominal obesity were randomly divided into low-frequency group (
n
=29) and dilatational wave group (
n
=29). Patients in both groups were treated with “Tongtiaodaimai” (regulating Dai Meridian) acupuncture therapy,and EA was applied to bilateral Daimai (GB26), Tianshu (ST25), Shenshu (BL23) and Ciliao (BL32). The low-frequency group received EA using a continuous wave at a frequency of 2 Hz, while the dilatational wave group received dilatational wave at a frequency of 2 Hz/100 Hz. Both groups received treatment for 30 min each time, 3 times per week for 12 consecutive weeks. Ovulation frequency was calculated according to the ovulation cycle. The contents of serum anti-Mullerian hormone (AMH) and sex hormone binding globulin (SHBG) were detected with electrochemiluminescence method. Body weight (BW) and waist circumference (WC) were measured, and body mass index (BMI) and waist-height ratio (WHtR) were calculated. PCOS questionnaire (Chi-PCOSQ), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were evaluated.
Results
2
Compared with before treatment, both the low-frequency group and the dilatational wave group showed an increase in ovulation frequency (
P
<
0.01,
P
<
0.05), and a decrease in BW, BMI, WC, WHtR, and SDS score (
P
<
0.01,
P
<
0.05); the dilatational wave group showed decreased serum AMH contents (
P
<
0.05) and increased serum SHBG contents (
P
<
0.05), the scores related to acne, fatigue, and dysmenorrhea in the Chi-PCOSQ increased (
P
<
0.01,
P
<
0.05). Compared with the low-frequency group, the dilatational wave group showed a reduction (
P
<
0.05) in WC after treatment.
Conclusion
2
2 Hz/100 Hz dilatational wave EA is equally effective as 2 Hz low-frequency EA in improving ovulation frequency. In terms of reducing WC in abdominal obesity type PCOS patients, 2 Hz/100 Hz dilatational wave EA is superior to 2 Hz low-frequency EA. 2 Hz/100 Hz dilatational wave EA can decrease serum AMH, increase serum SHBG, and improve symptoms of acne, fatigue, and dysmenorrhea.
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