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Effects of electroacupuncture on mitophagy mediated by SIRT3/PINK1/Parkin pathway in Parkinson’s disease mice
更新时间:2024-05-09
    • Effects of electroacupuncture on mitophagy mediated by SIRT3/PINK1/Parkin pathway in Parkinson’s disease mice

    • New progress has been made in the mechanism research of electroacupuncture treatment for Parkinson's disease (PD). Experts found that electroacupuncture with "Fengfu", "Taichong", and "Zusanli" can significantly improve the motor ability of PD mice by comparing the motor ability and protein expression levels in the midbrain substantia nigra between the electroacupuncture group and the sham electroacupuncture group. The mechanism may be through activating the SIRT3/PINK1/Parkin pathway, enhancing mitochondrial autophagy, promoting the expression of tyrosine hydroxylase (TH) in the midbrain substantia nigra, reducing the aggregation of alpha synuclein (α - syn), and thus exerting neuroprotective effects. This discovery provides new ideas and methods for the treatment of PD.
    • Acupuncture Research   Vol. 49, Issue 3, Pages: 221-230(2024)
    • DOI:10.13702/j.1000-0607.20230654    

      CLC:
    • Received:31 July 2023

      Revised:10 September 2023

      Published:25 March 2024

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  • ZHANG Gui-jun,WANG Yao,LI Jun-ling,et al.Effects of electroacupuncture on mitophagy mediated by SIRT3/PINK1/Parkin pathway in Parkinson’s disease mice[J].Acupuncture Research,2024,49(03):221-230. DOI: 10.13702/j.1000-0607.20230654.

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Related Author

ZHANG Xiao-lei
HU Meng-ni
LI Ya-nan
WANG Yao
RONG Zhen
QI Ling
ZHOU Zhong-yu
MA Jun

Related Institution

Department of Acupuncture and Moxibustion, Hubei Provincial Hospital of Traditional Chinese Medicine
College of Acupuncture and Orthopaedics, Hubei University of Chinese Medicine/Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion
College of Acupuncture and Orthopedics, Hubei University of Traditional Chinese Medicine
Clinical College of Traditional Chinese Medicine, Hubei University of Traditional Chinese Medicine
School of Physical Education and Health, Hubei University of Chinese Medicine
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