Mechanism of acupuncture of “Houxi”（SI3） and “Huantiao”（GB30） in delaying intervertebral disc degeneration by regulating PI3K/AKT/mTOR signaling pathway and autophagy of nucleus pulposus cells in rats with lumbar intervertebral disc degeneration——HU Zhi-xiang1， WU Han1， L<inline-formula><alternatives><math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mover accent="true"><mrow><mi mathvariant="normal">U</mi></mrow><mi mathvariant="normal">¨</mi></mover></math><graphic specific-use="big" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="alternativeImage/81BDA75C-4365-4f13-BF8B-1CCAFD61BDF9-M001.jpg"><?fx-imagestate width="2.53999996" height="3.04800010"?></graphic><graphic specific-use="small" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="alternativeImage/81BDA75C-4365-4f13-BF8B-1CCAFD61BDF9-M001c.jpg"><?fx-imagestate width="2.53999996" height="3.04800010"?></graphic></alternatives></inline-formula> Heng1， ZHANG Hao1， ZHAI Chun-tao1， LI Sheng-yun1，2， WANG Zheng-hao1，2， L<inline-formula><alternatives><math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mover accent="true"><mrow><mi mathvariant="normal">U</mi></mrow><mi mathvariant="normal">¨</mi></mover></math><graphic specific-use="big" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="alternativeImage/81BDA75C-4365-4f13-BF8B-1CCAFD61BDF9-M001.jpg"><?fx-imagestate width="2.53999996" height="3.04800010"?></graphic><graphic specific-use="small" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="alternativeImage/81BDA75C-4365-4f13-BF8B-1CCAFD61BDF9-M001c.jpg"><?fx-imagestate width="2.53999996" height="3.04800010"?></graphic></alternatives></inline-formula> Yu-e1，2

胡志祥; 吴涵; 吕恒; 张浩; 翟春涛; 李圣云; 王正浩; 吕玉娥

doi:10.13702/j.1000-0607.20251108

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Mechanism of acupuncture of “Houxi”（SI3） and “Huantiao”（GB30） in delaying intervertebral disc degeneration by regulating PI3K/AKT/mTOR signaling pathway and autophagy of nucleus pulposus cells in rats with lumbar intervertebral disc degeneration——HU Zhi-xiang¹， WU Han¹， L

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Heng¹， ZHANG Hao¹， ZHAI Chun-tao¹， LI Sheng-yun^1，2， WANG Zheng-hao^1，2， L

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Yu-e^1，2

更新时间：2026-05-11

- Mechanism of acupuncture of “Houxi”（SI3） and “Huantiao”（GB30） in delaying intervertebral disc degeneration by regulating PI3K/AKT/mTOR signaling pathway and autophagy of nucleus pulposus cells in rats with lumbar intervertebral disc degeneration——HU Zhi-xiang¹， WU Han¹， L $\ddot{U}$ Heng¹， ZHANG Hao¹， ZHAI Chun-tao¹， LI Sheng-yun^1，2， WANG Zheng-hao^1，2， L $\ddot{U}$ Yu-e^1，2
- Acupuncture Research Pages: 1-10(2026)
- 作者机构：
  
  1.山西中医药大学第二临床学院，山西晋中030024
  2.山西省针灸医院，太原030006
- 作者简介：
- 基金信息：
- DOI：10.13702/j.1000-0607.20251108
  CLC：
- Received：14 October 2025，
  
  Revised：2026-02-04，
  
  Online First：11 May 2026，
- 稿件说明：
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胡志祥，吴涵，吕恒，等.针刺对穴“后溪”“环跳”调节PI3K/AKT/mTOR信号通路对腰椎间盘退变模型大鼠髓核细胞自噬的影响机制［J］.针刺研究，XXXX，XX（XX）：1-10.

.Mechanism of acupuncture of “Houxi”（SI3） and “Huantiao”（GB30） in delaying intervertebral disc degeneration by regulating PI3K/AKT/mTOR signaling pathway and autophagy of nucleus pulposus cells in rats with lumbar intervertebral disc degeneration[J].Acupuncture Research,
胡志祥，吴涵，吕恒，等.针刺对穴“后溪”“环跳”调节PI3K/AKT/mTOR信号通路对腰椎间盘退变模型大鼠髓核细胞自噬的影响机制［J］.针刺研究，XXXX，XX（XX）：1-10. DOI： 10.13702/j.1000-0607.20251108.

.Mechanism of acupuncture of “Houxi”（SI3） and “Huantiao”（GB30） in delaying intervertebral disc degeneration by regulating PI3K/AKT/mTOR signaling pathway and autophagy of nucleus pulposus cells in rats with lumbar intervertebral disc degeneration[J].Acupuncture Research, DOI：10.13702/j.1000⁃0607.20251108.

\ddot{U}

Heng¹， ZHANG Hao¹， ZHAI Chun-tao¹， LI Sheng-yun^1，2， WANG Zheng-hao^1，2， L

\ddot{U}

Yu-e^1，2

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DOI：10.13702/j.1000-0607.20251108