最新刊期
卷 ， 期 2 ， 2002
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- 摘要：Objective:To study the effect of electroacupuncture (EA) of "Dazhui" (GV 14) and "Baihui" (GV 20) on brain-derived neurotrophic factor (BDNF) expression in brain tissues of cerebral ischemia rats for analyzing the mechanism of acupuncture in preventing the ischemic cerebral neurons from injury. Methods: Local cerebral ischemia model was established by occlusion of the middle cerebral artery (MACo) of the rat. 24 Wistar rats were randomly and evenly divided into sham-operation group, cerebral ischemia group and EA+ischemia group. "Dazhui" (GV 14) and "Baihui" (GV 20) were punctured and stimulated electrically by setting the stimulating parameters as frequency of 5～ 10 Hz, sparse-dense waves, strength of 35 V and duration of 30 min. EA was given once again following 5-hours'cerebral ischemia. The rats' brain tissues were cut into sections (6 μm thick) that were stained with immunochistochemical method. Results: In sham-operation group, the number of positive BDNF-immunoreaction cells was smaller and the reaction density was lighter. In cerebral ischemia group, BDNF expression neurons increased remarkably in quantity in comparison with sham-operation group. In cerebral ischemia + EA group, BDNF expression cells increased considerably in quantity and in density compared with control group and cerebral ischemia group (P<0.01). That means EA has a protective action on ischemia cerebral injury. Conclusion: EA can potentiate BDNF expression in ischemic cerebral tissues, which maybe contribute to the effect of acupuncture in relieving ischemic injury of the cerebral neurons.1011|0|1更新时间：2023-08-11
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