最新刊期
卷 ， 期 1 ， 2003
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- 摘要：Objective: To investigate the effects of acupoint injection of Danggui (Radix Angelicae Sinensis)injectio and Huangqi (Radix Astragali seu Hedysari) injectio on blood flow of the gastric mucosa in chronic atrophic gastritis (CAG) rats. Methods:SD rat CAG model was made by feeding the rats with different concentrations of N methyl N' nitro N nitrosoguanidine (MNNG) continuously for 10 weeks. 60 CAG rats were randomly assigned to model group Ⅰ (40 μg/ mL MNNG, n =15) and model group Ⅱ ( 60 μg/mL MNNG, n =15),acupoint injection group Ⅰ ( 40 μg/mL MNNG, n =15 ) and acupoint injection group Ⅱ ( 60 μg/mL MNNG, n =15). In addition, other 10 normal rats were used as control group. In these 2 acupoint injection groups,the mixture solution of Huangqi and Danggui injection (0.1 mL) was injected into unilateral "Zusanli" (ST 36), once every other day, continuously for 20 weeks. Pathological changes of gastric mucosal tissues (the tissue sections were stained with HE method) were examined and gastric mucosal blood flow was then determined. Results: Along with the increase of the concentration of the administered MNNG, the degrees of gastric mucosal injury (shallow and deep erosion, ulcer)were increased significantly( P < 0.05 )and the gastric mucosal blood flow in the anterior region,the body part and the antral region of the stomach decreased remarkably in comparison with normal control group( P < 0.01), which presented a negative correlation between the mucosal injury and the blood flow( P < 0.05); pathologic changes of mucosal injury index, atrophy, intestinal metaplasia and dysplasia of the gastric mucosa increased significantly( P < 0.05). In acupoint injection groups,the degrees of the above mentioned gastric mucosal injury were remarkably improved( P < 0.01) and the gastric mucosal blood flow volume was significantly increased in comparison with the corresponding same MNNG concentration model groups( P < 0.05). Conclusion: The decrease of gastric mucosal blood flow plays a key role in pathogenesis of gastric mucosal injury, atrophic and gastric precancerous changes. Acupoint injection therapy may prevent and treat CAG by improving gastric mucosal blood flow supply and promoting repair of the injured gastric tissue.896|0|4更新时间：2023-08-11
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- 摘要：Objective: The aim of this study is to research effects of parafascicular nucleus(Pf) stimulation on visceral pain induced discharges of neurons in the posterior thalamic nuclei(PO). Methods: Experiments were performed on 1% chloralose anesthetized cats. Glass micropipettes were used for recording neuronal discharges in the right PO (AP: 4.0～5.5 mm, RL: 3.5～5.0 mm, H:1.0～3.5 mm). The stimulating electrode was inserted into the left Pf region (AP: 7.0 mm, RL: 1.3 mm, H:1.3 mm) for stimulating Pf with parameters of clusters of unidirectional rectangular waves (5 pulses/train), 0.5 mA and 0.5 ms wave duration. As an index of visceral pain, the greater splanchnic nerve (GSN) was stimulated electrically (25～30 V, 0.5 ms wideth single pulses). The effects of Pf stimulation on the unit discharges were also studied with test conditioning stimulation techniques. Results: A total of 59 PO neurons responding to electrical stimulation of GSN were observed. Following Pf stimulation (conditioning stimulation), discharges of majority of PO neurons (45/59, 76.27%) were inhibited, presenting prompt suppression (23/45), delayed suppression (7/45) and continuous suppression (15/45); 4 neurons (6.78%) were excited, 4 (6.78%) presented inhibition excitation or excitation inhibition responses and the rest 6 (10.17%) had no apparent changes. Conclusion: Pf may be involved in the regulation of visceral pain,mainly showing an inhibitory effect on visceral pain.725|0|1更新时间：2023-08-11
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