最新刊期
卷 ， 期 3 ， 2004
- 摘要：Objective:To study the effect of oxytocin(OT)in nucleus raphe magnus (NRM) on electroacupuncture (EA) analgesia and its correlation with the endogenous 5-HT. Methods: In the first part of the study, 24 Wistar rats were randomly divided into normal saline group (n=8), OT group (n=6), normal saline (NS)+EA group (n=6) and OT+EA group (n=6) for observing the effect of injection of OT (4 ng) into NRM on EA analgesia. In the second part of the study, 18 Wistar rats were randomized into NS+EA, Cyproheptadin (C, an antagonist of 5-HT receptors) +NS+EA and C+OT+EA groups for analyzing the effect of injection of C (10 μg) into NRM on EA analgesia. The potassium iontophoresis induced tail-flick was used to measure the pain threshold. Results: Following administration of OT into NRM, EA and OT+EA,and during EA and after cease of EA, the percentages of the increased pain threshold were considerably higher than those of NS group. There were significant differences between OT and NS groups and between NS+EA and OT+EA groups (P< 0.01), showing that microinjection of OT in NRM can induce an enhancement of EA analgesia. Following administration of C in NRM, the percentages of the increased pain threshold of C+NS+EA and C+OT+EA groups were strikingly lower than those of NS+EA group, displaying that after administration of antagonist of 5-HT receptors, the effect of EA analgesia is weakened pronouncedly.Conclusion: OT in NRM is involved in EA analgesia, that is probably accomplished partially by endogenous 5-HT.933|0|0更新时间：2023-08-11
- 摘要：Objective: To observe the effect of balancing technique of acupuncture on serum TNF-α and soluble intercellular adhesion molecule-1 (sICAM-1) levels and on their correlation in cerebral ischemia rats for analyzing the underlying mechanism of acupuncture in preventing the cerebral tissues from ischemic injury. Methods: Sixty Wistar rats were randomly divided into control group, sham-operation group, model group and acupuncture group, with 15 cases in each group. Regional cerebral ischemia (CI) model was established by using photochemically initiated thrombosis vascular obstruction method. Serum TNF-α and sICAM-1 contents were detected with enzyme linked immunosorbent assay. “Piantan”-, “Jiantong”-, “Xitong”- “Tuntong”- and “Yaotong”-points on the healthy side were punctured and stimulated with reducing technique.Results: In CI rats of model group, serum TNF-α (2.54±0.58 ng/mL) and sICAM-1 (17.54±4.18 ng/mL) contents were significantly higher than those of normal control group (1.61±0.59 ng/mL, 11.36±3.49 ng/mL) and sham-operation group (1.77±0.61 ng/mL, 12.71±3.56 ng/mL); while in acupuncture group, TNF-α (2.16±0.53 ng/mL) and sICAM-1 (14.91±3.22 ng/mL) contents were significantly lower than those of model group (P<0.05), suggesting that acupuncture can significantly inhibit CI induced increase of serum TNF-α and sICAM-1, which may contribute to the effect of acupuncture in preventing cerebral tissues from ischemic injury. Statistical analysis indicated that there was a positive correlation between serum TNF-α and sICAM-1 contents (r= 0.834, P<0.05) in their changes before and after CI. Conclusion: Balancing technique of acupuncture can effectively suppress CI induced elevation of serum TNF-α and sICAM-1 and there is a positive correlation between TNF-α and sICAM-1 levels.976|1|2更新时间：2023-08-11
- 摘要：Objective: To observe the effects of acupuncture at different time-windows on hypoxic-ischemic cerebral palsy rats, and to study its underlying neurobiochemical mechanism. Methods: Eighty-five neonatal SD rats were randomized into control group (n=16), model group (n=23), acupuncture group-1 (n=23, acupuncture was given beginning 24 h after operation) and acupuncture group-2 (n=23, acupuncture was given beginning 8 days after operation). Cerebral palsy model was established by occlusion of the left common carotid artery and inhalation of 8% oxygen plus 92% nitrogen. “Baihui"(GV 20), Tempale-Point-1 (0.8 cm superior to the external auditory canal aperture), “Quchi"(LI 11), “Neiguan"(PC 6), “Zusanli"(ST 36) and “Yongquan"(KI 1) were punctured and the former two acupoints were stimulated electrically with an electroacupuncture apparatus. The death rate, forepaw-touching test (adhesive plaster tearing-off test), brain weight, neuronal number of hippocampal CA1 region were measured and the expression of nerve growth factor (NGF) in the brain was assayed with immunohistochemical method. Results: The death rates (13.0% and 21.7%) of both acupuncture group-1 and -2 were significantly lower than that (34.8%) of model group (P< 0.05). The duration values for tearing off adhesive-plaster on 7 d, 14 d and 21 d of acupuncture group-1 and on 14 d of acupuncture group-2 were markedly shorter than that of model group (P< 0.05), suggesting functional improvement of the rats' forelimbs. No significant difference was found among the 4 groups in the left brain weight (P<0.001). The number of neurons of hippocampal CA1 region on the left side was biggest in control group, bigger in acupuncture group-1, smaller in acupuncture group-2 and smallest in model group respectively. Twenty-one days after operation, the number of NGF immunoreaction (IR) strongly-positive neurons in the cerebral cortex, straiate body and hippocampus was biggest in acupuncture group-1, bigger in acupuncture group-2 and smaller in model group, and only very weakly IR-positive neurons were found in control group. Conclusion: ① Acupuncture can upregulate the long-term expression of NGF in the brain, which may contribute to the effect of acupuncture in improving cerebral palsy. ② Acupuncture therapy may be used to treat cerebral palsy at the early stage and can reduce hypoxia-ischemia induced injury of cerebral neurons.933|0|8更新时间：2023-08-11
- 摘要：Objective: To probe the effects of electroacupuncture (EA) stimulation of three different segments (wrist, elbow and shoulder portions) of the Heart Meridian on the cardiac function in rabbits with acute myocardial ischemia (AMI). Methods: A total of 50 rabbits anesthetized with urethane (1 g/kg) were randomized into control group, model group, EA-wrist-segment group, EA-elbow-segment group and EA-shoulder-segment group, with 10 cases in each group. AMI was induced by intravenous injection of posterior pituitary hormone (2 μ/kg+saline to 2 mL). Three different segments of the Heart Meridian were punctured and stimulated electrically with ZYZ-1 EA-Therapeutic Apparatus separately. Left ventricular pressure (LVP), maximum rising rate (dp/dtmax) of LVP, the area of myocardial force loop (ACFL) and the maximal shortening velocity of myocardium (Vmax) were used as the indexes. Results: After AMI, LVP, dp/dtmax,ACFL and Vmax in model group decreased significantly in comparison with those of control group(P<0.01), while compared with model group, values of the 4 indexes of EA-wrist-segment group, EA-elbow-segment group and EA-shoulder-segment group were significantly higher(P<0.05～0.01), values of the 4 indexes of EA-wrist-segment group were all significantly higher than those of both EA-elbow-segment group and EA-shoulder-segment group (P<0.05) , but no significant differences were found between EA-elbow-segment group and EA-shoulder-segment group in these 4 indexes. Conclusion: EA stimulation of different segments of the Heart Meridian can improve performance of the ischemic heart and the wrist segment of this meridian has a representative role.1037|0|10更新时间：2023-08-11
- 摘要：Objective: To explore the underlying mechanism of acupuncture of acupoints of the Foot-Yangming Meridian in preventing the gastro-mucosa from injury in the rabbit with gastric ulcer. Methods: 24 New Zealand rabbits were evenly randomized into control, model and acupuncture groups. Gastric ulcer model was established by intragastric perfusion of absolute ethyl alcohol (2.5 mL/kg). “Neiting”(ST 44), “Jiexi”(ST 41), “Zusanli”(ST 36), “Liangqiu”(ST 34), “Tianshu”(ST 25) and “Liangmen”(ST 21) were punctured once daily, 30 min/time, and continuously for 7 days. Somatostatin (SS) contents in the gastric mucosal tissue were assayed with radioimmunoassay technique. SS receptor(R) 1 mRNA expression was detected with reverse transcription (RT)-polymerase chain reaction (PCR) technique. Results: Gastro-mucosal SS contents of control, model and acupuncture groups were 1852.4±361.7 mIU/mL, 2978.6±587.6 mIU/mL and 1800.2± 488.1 mIU/mL respectively; and the optical density integral values of SSR 1/cyclophilin in the 3 groups were 1.04±0.36, 2.56±0.25 and 1.07±0.08 separately, showing that in gastric ulcer rabbits, gastro-mucosal SS level and SSR 1 mRNA expression increased significantly in comparison with those of normal control group (P<0.01) and after acupuncture, SS level was lowered and SSR 1 mRNA expression was downregulated significantly (P<0.01). Conclusion: Acupuncture of acupoints of the Foot-Yangming Meridian can significantly reduce the production of SS and suppress the expression of SSR 1 mRNA in experimental gastric ulcer rabbits.1272|0|0更新时间：2023-08-11
- 摘要：Objective: To elucidate the effect of electroacupuncture (EA) on arthritic flexion pain scores, pathological reaction and IL-1β mRNA and IL-1ra mRNA expression of the skin tissue of the pain focus in adjunvant monoarthritis rats. Methods: 39 SD rats were randomized into control group (n=13), inflammation group (n=13) and EA group (n=13). Arthritis model was established by subcutaneously injection of 50 μL complete Freund’s adjuvant (CFA) into unilateral rat’s hind-paw. EA (0.5～1.5 V, 4～16 Hz) was applied to “Huantiao”(GB 30) and “Yanglingquan” (GB 34) for 30 minfollowing injection of CFA. Arthritic flexion pain scores were given everyday and continuously for 7 days. At the end of the experiments, the focal skin tissue was taken to be stained by hematoxylin eosin (HE) method for detecting the inflammatory cell number (in 100×100 μm2 section), and the expression of interleulin (IL)-1β mRNA and IL-1 receptor antagonist (IL-1ra) mRNA was detected by RT-PCR. Results: ① After EA treatment, compared with inflammation group, the arthritic flexion pain scores of EA group reduced significantly (P<0.01); ② The inflammatory cells of the focus induced by CFA in EA group (45.71±5.92) were significantly fewer than those of inflammation group (95.66±6.53, P<0.01); ③ The IL-1β mRNA expression of EA group was significantly lower than that of inflammation group (P<0.01), while IL-1ra mRNA expression of EA group considerably higher than that of inflammation group (P<0.01), and IL-1ra/IL-1β of EA group (1.723± 0.049) was also significantly higher than that of inflammation group (0.948±0.034, P<0.01). Conclusion: EA can regulate the balance between IL-1β and IL-1ra to inhibit the activation of the immune cells in the pain focus, thus exert the effect of analgesia.1070|0|12更新时间：2023-08-11
- 摘要：Objective: To observe the prevention and therapeutic effects of electroacupuncture (EA) in the treatment of peripheral nervous lesion in experimental diabetes mellitus (DM) rats. Methods:42 Wistar rats were randomized into normal group (n=13), EA group (n=15) and model group (n=14). DM model was established by intraperitoneal injection of 2% Streptozotocin (STZ). Bilateral “Shenshu”(BL 23) and “Huantiao”(GB 30) were punctured with filiform needles and stimulated electrically for 20 min, once every other day (4 weeks altogether). The conduction velocity of the sciatic nerve was determined with electrophysiological method under anesthesia (20% urethane 5 mL/kg) and microstructural changes of the nerve fibers were observed under transmission electron microscope. Results: In model group, the conduction velocity of the bilateral sciatic nerves decreased significantly and the latency of the evoked action potential prolonged compared with those of normal group (P< 0.001). In comparison with model group, the conduction velocity of the bilateral sciatic nerve increased significantly (P<0.05) and the latency shortened markedly (P<0.05). In comparison with model group, both the demyelination ratio of the myelinated nerve fibers and the swelling state (thickness) of the endothelial cells of the micro-vessels in EA group reduced significantly (P<0.001). Conclusion: EA is of favorable effect in improving peripheral nervous lesion in MD rats.918|0|3更新时间：2023-08-11
- 摘要：Objective:To explore the effect of electroacupuncture (EA) on the nervous function of hypothalamic perifornical nucleus (PeF) in obesity rats.Methods: Thirty-six SD male rats were randomly and evenly divided into normal control group, model group and acupuncture group. Changes of body weight, Lee’s index, body fat, hypothalamic and serum leptin (LP) and insulin (INS) contents as well as spontaneous discharges of neurons in hypothalamic PeF were observed in obesity rats. EA (10 Hz, 1.5 V and continuous waves) was applied to “Zusanli”(ST 36) and “Neiting”(ST 44) for 10 min, once daily and continuously for 14 days. Hypothalamic tissue and serum LP and INS contents were assayed with radioimmunoassay. Electrical activity of PeF neurons were recorded by using micro-electrodes. Results: The body weight, Lee’s index, body fat, the levels of serum LP and INS as well as the discharge rate of PeF neurons in obesity rats were all markedly higher than those in normal rats, while the levels of hypothalamic LP and INS in obesity rats were strikingly lower than those in normal rats (P<0.05～0.01). Compared with model group, the body weight, Lee’s index, body fat, serum LP and INS as well as the discharge rate in acupuncture group all lowered significantly (P< 0.05～0.01); while hypothalamic LP and INS increased remarkably (P<0.01). There were positive interrelations between the spontaneous discharge rate of PeF neurons and the obesity index, between the discharge rate and the serum LP and INS levels (P<0.05～0.01). There were negative interrelations between the spontaneous discharge rate of PeF neurons and the levels of hypothalamic LP and INS. It indicated that acupuncture treatment could induce weight loss, lower serum LP and INS as well as the spontaneous discharges of PeF neurons, and raise hypothalamic LP and INS contents markedly. Conclusion: Acupuncture treatment induced decrease of peripheral LP and INS levels and reduction of the activity of PeF neurons and increase of central LP and INS contents may be responsible for the effect of acupuncture in antiobesity.1052|0|2更新时间：2023-08-11
- 摘要：Objective: To observe the specific effect of acupuncture of acupoints of Small Intestine Meridian on the microstructure and expression of heat-shock protein (HSP 70) in the inner ear for analyzing the correlation between the Small Intestine Meridian and the ear. Methods: 60 Guinea-pigs were evenly randomized into control, model, “Tinggong”(SI 19),“Jianzhen” (SI 9) and “Houxi” (SI 3) groups. Apart from the control group, intramuscular injection of gentamycin (80 mg/kg/day, continuously for 20 days) was given to the animals of the other four groups to establish oto-intoxication model. Meanwhile, “Tinggong”(SI 19),“Jianzhen”(SI 9) and “Houxi”(SI 3) were punctured respectively and stimulated with even method, once (30 min) daily, and continuously for 20 days. At the end of experiments, the guinea-pig’s cochlear tissue was collected, fixed in 4% paraformaldehyde, sliced and stained by succino-dehydrogenase. The number of cochlear hair cells was calculated under light microscope, HSP 70 was assayed with immunohistochemical method and the microstructure of cochlear hair cells were observed under transmission electron microscope. Results:The deficit cochlear cells in model,“Jianzhen” and“Houxi”groups were considerably more than those of control group (2339.8±622.4, 1568.8±447.2 and 1679.4±423.5 vs 200.1±73.5, P<0.05～0.01), whereas, those of “Tinggong” group (829.6±190.7) were significantly fewer than those of model group (P<0.05), showing a protection effect of acupuncture on cochlear cells. The microstructural injury (arrangement disorder, mitochondrial swelling, cellular membrane and nucleus membrane shrinkage, core vacuole, etc.) of the cochlear hair cell in “Tinggong” group was obviously lighter than that of model group, showing a protection effect of acupuncture. The grey value of cochlear hair cells of “Tinggong” group was significantly higher than those of the rest 4 groups (P<0.01), suggesting that acupuncture of “Tinggong” could distinctly upregulate the expression of HSP 70 in the inner ear tissue. No significant changes were found in the deficit cell number, HSP 70 expression and cellular microstructure in “Jianzhen” and “Houxi” groups, indicating that the effect of acupuncture of “Tinggong” possessed a specific effect on Gentamycin induced oto-intoxication in Guinea-pigs. Conclusion: Not all the acupoints of the Small Intestine Meridian have a remarkable interrelationship with the ear, and only the local acupoint near the ear has the specific effect, suggesting that “where is an acupoint, where is the indication”.1012|0|2更新时间：2023-08-11
- 摘要：Objective: To explore the effect of electroacupuncture (EA) on expression of c-fos in the spared dorsal root ganglia (DRG) of partially dorsal rhizotomized cats so as to analyze the correlation between c-fos and the effect of acupuncture in promoting plasticity of the spinal cord.Methods: Ten adult cats were randomly and evenly divided into control group and acupuncture group. All the cats underwent unilateral section of L 1～L 5 and L 7～S 2 DRG with the L 6 spared. In acupuncture group, EA (98 pulses/min, duration of 30 min) was applied to “Zusanli”(ST 36) and “Xuanzhong”(GB 39), “Futu”(ST 32) and “Sanyinjiao”(SP 6) alternatively which are innervated by L 6. After surviving for 7 days, these animals were killed. L 6 DRG of every group was taken out to be cut into 20 μm sections that were then stained with immunohistochemical technique (ABC method). The distribution and the number of c-fos positive neurons in the spared DRG (L 6) of each animal were observed and counted under light microscope. Results: After acupuncture, the number of c-fos positive neurons (medium and small size neurons) in the spared DRG increased apparently than that of control group (161±31 vs 98±27, P<0.05), suggesting that the therapeutic effect of EA may be mediated mainly by the medium size and small size neurons in DRG and c-fos possibly plays a role in the process of acupuncture in strengthening the plasticity of the spinal cord. Conclusion: EA of acupoints may generate up-regulation of expression of c-fos in the spared DRG.904|0|0更新时间：2023-08-11
- 摘要：Objective: To explore the relationship between the stimulation quantum of acupuncture and its effect on red blood cell (Rbc) count in blood-deficiency rats. Methods:Seventy Wistar rats were randomly and evenly assigned to A (control), B, C, D, E, F and G groups. Blood-deficiency model was established in all the animals by bleeding from the rat’s tail vessel (2 mL/time), once every other day, 3 times altogether. Rats of group B were just trussed up, and those of group C, D, E, F and G accepted acupuncture of “Zusanli”(ST 36). In group C, the needle was not manipulated after insertion. In group D, the needle was twirled for 0.5 min, half circle/time and 15 times/min. In group E, the needle was twirled for 1 min, 1 circle/time and 30 times/min; group F 2 min, 2 circles/time and 60 times/min; and group G 4 min, 4 circles/time and 120 times/min. Blood samples were collected from the caudal vessels for detecting Rbc count under microscope. Results: After bleeding, the number of Rbc in all the groups except group G all increased significantly in comparison with pre-bleeding (P<0.05～0.01). After bleeding, the counts of Rbc in group D, E and F were strikingly higher than that in group B (P<0.01), suggesting that small amplitude, low frequency and shorter duration of needling stimulation could promote production of Rbc. In group G, no significant change between pre- and post-bleeding, and no significant differences were found between group G and group B in the Rbc count, suggesting that bigger amplitude, higher frequency and longer duration of needling stimulation could suppress production of Rbc. It also displayed that when needling stimulation parameters were equal to or less than amplitude of 2 circles/time plus frequency of 60 times/minute and stimulating duration of 2 minutes, the red blood cell count increased considerably (P<0.01), which may be a critical point for generating favorable therapeutic effect; and if stronger acupuncture stimulation was given, the red blood cell count would not change. Conclusion: In the treatment of blood-deficiency syndrome, the needling stimulating quantum is rather important, and there is a critical point. When the quantum of stimulation is equal to or below the critical point, the acupuncture may produce a reinforcing effect, whereas, if it exceeds the critical point, the acupuncture may produce a reducing effect.1039|0|11更新时间：2023-08-11
- 摘要：Objective: To investigate the afferent pathways and the relationship between mouth-face region and “Hegu” (LI 4) Point. Methods: ① Biotin labeling: Twenty-four adult Wistar rats, divided into facial area and “Hegu” groups, were anesthetized with 1% sodium phentobarbital 40 mg/kg. Neurobiotin (Nb)(2.0%, 20 μL) was injected into the left mouth-face and “Hegu”(LI 4) point regions respectively.72 hours later, these animals under anesthesia were perfused transcardially with saline, then with fixative (1.5% glutaraldehyde and 1.0% paraformaldehyde in 0.1 M sodium phosphate buffer). ② Expression of c-fos: 24 Wistar rats were divided into facial area and “Hegu” groups. Under anesthesia, the left mouth-face and “Hegu” were punctured with acupuncture needles (with two needles being in each point) and stimulated with an electroacupuncture apparatus by setting the stimulating parameters as strength of 5 V, frequency of 100 Hz and duration of 30 min. 1.5～2 hours later, the rats were perfused with the same fixative mentioned above. Spinal cord and lower-brainstem tissues were sliced (30 μm) and then stained with immunohistochemical method. Results: ① Following injection of biotin into facial area, densely labeled fibers were found in the left nucleus of spinal tract of trigeminal nerve (NSTTN) and semilunar ganglion of the trigeminal nerve; light-densely labeled fibers observed in nucleus of the solitary tract (NTS) and reticular formation, and fewer positive fibers seen in the posterior horn of C 1～C 3 of the spinal cord.② The densely labeled fibers from “Hegu” (LI 4) area were found in the posterior horn of C 6, moderate amount of the labeled fibers were seen in C 4～C 5, and fewer seen in cuneate nucleus of the medulla oblongata. ③ After EA stimulation of the left facial area, a large number of fos positive neurons were observed in the ipsilateral NSTTN, moderate number of the labeled cells seen in semilunar ganglion of the trigeminal nerve, NTS and reticular formation of the medulla oblongata, and fewer c-fos positive cells seen in the ipsilateral posterior horn of C 1～C 3 segments. ④ Following EA stimulation of “Hegu”(LI 4), many c-fos positive neurons were observed in the posterior horn of C 4～C 6, and fewer labeling was seen in cuneate nucleus, NTS and reticular formation of the medulla oblongata. Conclusion: Facial area may have a direct connection with NTS, while “Hegu” point has no direct project to NTS, nevertheless, message of EA of “Hegu” may reach NTS by way of secondary afferent neurons, etc. In short, NTS may play an important role in the integration and convergence of information from the facial area and “Hegu” point.1727|0|17更新时间：2023-08-11
- 摘要：Objective: To observe the effect of scalp-acupuncture plus medication on serum malondialdehyde (MDA) content and neurological functions in cerebral infarction (CI) patients at the early stage. Methods:A total of 60 CI patients were randomly divided into routine medication group (n=30) and scalp-acupuncture plus routine medication (acupuncture) group (n=30). In addition, 30 healthy subjects were used as normal control group. Routine medication refers to supporting treatment (medicines for regulating blood pressure and blood sugar, maintaining balance of water, electrolytes and acid-base scale), improving cerebral circulation (low molecular dextran, red sage root injection, fleabane injection), dilating cerebral blood vessels, suppressing platelet agglutination and activating cerebral tissue metabolism. Dingnie Qianxiexian (MS 6) was used as the main point for CI patients who chiefly manifested dyscinesia; Dingnie Houxiexian (MS 7) selected for patients who chiefly manifested sensory disturbance; or both of them were used for motor disturbance combined with sensory disturbance, supplemented with Dingzhongxian (MS 5) and Dingpangxian I (MS 8). Acupuncture treatment was given once daily, with 10 times being a therapeutic course. Results: Before treatment, serum MDA contents of medication and acupuncture groups were significantly higher than that of normal control group (P<0.01). Following one course of treatment, comparison between post- and pre-treatment of each group showed that MDA levels (5.68±0.56 pg/mL vs 6.11±0.26 pg/mL; 5.08±0.27 pg/mL vs 6.05±0.24 pg/mL) and the scales of neurological deficit (11.70±3.63 vs 19.36±6.25; 9.43±3.76 vs 19.30±6.66) in both medication and acupuncture groups all decreased significantly (P<0.01). There was a positive correlation between the scales of neurological deficit and MDA contents before and after treatment (r=0.488, P<0.05).Conclusion:Scalp-acupuncture can effectively lower serum MDA and improve CI patients’ neurological functions.1001|0|1更新时间：2023-08-11
- 摘要：In the present paper, the authors make a brief explanation about the concepts of yin, yang, zangfu-organs and promoting flow of meridian-qi from classical meridian-collateral theory, neuroanatomy of modern medicine and clinical treatment of cervico-spondylopathy and lumbar vertebral disorders. ① From the relationship between yin-yang doctrine and neuroanatomy, we can clearly see that the two sets of doctrines both describe the regularities of symmetry of different parts of the human body. The so-called yin and yang of meridian-collateral system are closely associated with the bilateral innervation of the brain, convergence of the bilateral spinal afferent nerves and partially with the segmental distribution of the spinal nerves. ② The connotation of zangfu-organ in the theory of meridian-collaterals refers to the close correlation between the body trunk (including the spinal cord and the internal organs) and the four extremities, which the segmental distribution of the spinal nerves is deeply involved. ③ Promoting flow of meridian-qi mainly means promoting transmission of the acupuncture stimulation signals. ④ Acupoint selection for treatment of cervico-spondylopathy and lumbar vertebral disorders also show the symmetry regularity, when the peripheral nerves are stimulated to induce radiating needling sensation, a marked therapeutic effect would be achieved.721|0|4更新时间：2023-08-11
- 摘要：In the present paper, the author reviews advances of clinical treatment of diabetes mellitus(DM) and its complications with acupuncture and moxibustion therapies in recent 5 years from therapeutic methods and the research on mechanisms. Regarding the therapeutic methods, DM is frequently treated with ① filiform needle needling, ② combined application of acupuncture and moxibustion, ③ combined administration of acupuncture and Chinese herbal medicines, ④ acupoint-injection therapy, ⑤ acupoint application therapy, and ⑥ acupoint-embedment of catgut and acupoint-implantation of pancreatic islet tissue. Concerning researches on the underlying mechanism of acupuncture in treating DM, results indicated that acupuncture could effectively protect pancreatic islet cells from injury, lower fasting insulin level, regulate levels of some neurotransmitters as noradrenalin, dopamine of the thirst center as well as immunocytokine, balance prostaglandin I 2 /thromboxane A 2, reduce ACTH, etc., in experimental DM rats. These findings provide scientific basis for clinical application of acupuncture in the treatment of DM.923|0|0更新时间：2023-08-11
- 摘要：In this paper, the authors review recent development of acupuncture treatment of scapulohumeral periarthritis from syndrome-differentiation, acupoint selection, therapeutic methods and the therapeutic effects. Acupoints used are body acupoints, scalp-points, auricular acupoints, while the therapeutic methods include filiform needling, moxibustion, cupping, massage, electroacupuncture, acupoint-injection, wrist-ankle needling, etc.. Acupuncture has a good therapeutic effect in alleviating omalgia and shoulder-joint dysfunction, however, we still need taking cautiousness about assessing its effects due to limitations in the criteria for diagnosis and therapeutic effect evaluation, strict random control design, etc., thus, further strict researches are necessary.2056|0|4更新时间：2023-08-11
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