最新刊期
卷 35 ， 期 6 ， 2010
- 摘要：Objective To observe the effect of electroacupuncture(EA) on the expression of ionotropic glutamate receptor(iGluR) subunits and their mRNAs in the lumbar segments of spinal cord in rats with neuropathic pain,so as to explore its underlying mechanism in relieving spinal hyperalgesia.Methods Thirty SD rats were randomly divided into control,model,and EA groups,with 10 rats in each.The spared nerve injury(SNI) model was established by ligature of the sural nerve after cutting off the common peroneal nerve and anterior tibial nerve.EA(2Hz,1mA) was applied to "Huantiao"(GB30) and "Weizhong"(BL40) for 30min,once daily for 7 days.Mechanical pain threshold was detected before and after modeling and before and after EA treatment.The expression levels of N-methyl-d-aspartic acid(NMDA) receptor subunits NR1 and NR2B,and AMPA receptor subunit GluR1 of iGluR and their genes were assayed by Western blot and reverse transcription polymerase chain reaction(RT-PCR) separately.Results In comparison with control group,the mechanical pain thresholds were decreased significantly on day 2,7 and day 14 following modeling in the model group(P<0.05,P<0.01).While compared with the model group,the pain threshold was increased considerably on day 14 in the EA group(P<0.01).Compared with the control group,the expression levels of lumbar spinal cord NR2B and NR2B mRNA in the model group were increased significantly(P<0.05),and those of lumbar spinal cord NR1 and NR1 mRNA,GluR1 and GluR1 mRNA in the model group increased slightly(P>0.05).In comparison with the model group,the expression levels of lumbar spinal cord NR2B and NR2B mRNA in the EA group were down-regulated remarkably(P<0.05),and those of lumbar spinal cord NR1 and NR1 mRNA,GluR1 and GluR1 mRNA in the EA group down-regulated slightly(P>0.05).Conclusion EA can significantly suppress pain reaction in rats with neuropathic pain proba-bly through down-regulating the expression of lumbar spinal cord NR2B protein and NR2B mRNA.关键词：Neuropathic pain;Electroacupuncture;Spinal cord;iGluR subunits1239|396|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupoint-embedement of medicated-thread and acupoint-injection of Chuanxiongzine on the expression of urokinase-type plasminogen activator(uPA) and plasminogen activator inhibitor-1(PAI-1) in the cerebral cortex in rats with cerebral ischemia-reperfusion injury(CI/RI),so as to explore its underlying mechanism in protecting the ischemic cerebral tissue.Methods Seventy-eight SD rats were randomly divided into normal control group(n=6),sham operation(sham) group(n=18),model group(n=18),acupoint injection(AI) group(n=18),and acupoint-thread-embedment(ATE) group(n=18).Rats of the latter 4 groups were randomized into 1d,3d and 5d subgroups,with 6 rats in each.CI/RI model was established by occlusion of the right middle cerebral artery(MCAO) for 30 min and reperfusion.For rats of the AI group,Chuanxiongzine(0.1mL/200g) was injected into "Baihui"(GV20) and "Dazhui"(GV14),and for those of ATE group,a piece of medicated thread containing collagen protein(extracted from the rat's tail tissue) and Chuanxiongzine + retarder was embedded into GV20 and GV14,respectively.The expression of uPA and PAI-1 in the cerebral cortex on the ischemia side was detected by immunohistochemistry.Results In comparison with the normal control group,the expression of uPA of the ischemia cerebral cortex on day 1,3 and day 5 in the model group was increased significantly(P<0.01),while the PAI-1 expression decreased remarkably in the model group(P<0.01).Compared with the 3 time-points of the model group,cortical uPA expression levels at the 3 time-points in the AI group and those of day 3 and day 5 in the ATE group were down-regulated significantly(P<0.01),whereas cortical PAI-1 expression levels at the 3 time-points in both AI and ATE groups up-regulated considerably(P<0.05,P<0.01).Comparison between AI and ATE groups showed that the expression levels of cortical uPA in the latter group on day 3 and day 5 were significantly lower than those of the former group(P<0.05),whereas the cortical PAI-1 expression levels in the latter group on day 3 and day 5 were evidently higher than those of the former group(P<0.05).But,cortical PAI-1 expression of the ATE group on day 1 was significantly lower than that of the AI group(P<0.05).No significant differences were found between the AI and ATE groups in the expression level of cortical uPA on day 1 and between normal and sham groups in both uPA and PAI-1 expression levels at the 3 time-points(P>0.05).Conclusion Both AI and ATE can down-regulate cortical uPA expression and up-regulate cortical PAI-1 expression in rats with CI/RI,which may contribute to their protective effect in reducing cerebral ischemic injury.关键词：Acupoint-thread-embedment;Acupoint injection;Cerebral ischemia-reperfusion;Cerebral uPA and PAI-1 expression;Immunohistochemistry1192|199|0更新时间：2023-08-11
- 摘要：Objective To observe the influence of electroacupuncture(EA) of "Fengfu"(GV16) and "Taichong"(LR3) on morphological changes and apoptotic percentage of substantia nigra cells so as to explore its underlying mechanism in relieving Parkinson's disease.Methods Forty Wistar rats were randomly divided into normal control,sham-operation(sham),model and EA groups,with 10 rats in each.The Parkinson's disease model was established by micro-injection of 6-hydroxyl-dopamine(6-OHDA) into the right striatum.EA(2Hz,1mA) was applied to "Fengfu"(GV16) and "Taichong"(LR3) for 30 min,once daily for 2 weeks.HE staining,Nissl staining and immunohistochemical staining were conducted for observing the morphological changes of substantia nigra pars compacta(SNc) and striatum,and the tyrosine hydroxylase(TH) immuno-reaction(IR) positive neurons and nerve fibers.The apoptosis was detected by flow cytometry.Results Compared to the normal control and sham groups,the total number of TH-IR positive neurons and Nissl-stained cells,and OD value of TH-IR positive nerve fibers in the SNc on the 6-OHDA-lesioned side were significantly lower in the model group(P<0.01).Compared with the model group,the aforementioned 3 indexes of the EA group were increased obviously(P<0.01).The percentage of apoptosis of SNc on the 6-OHDA-lesioned side was obviously lower in the EA group than in the model group(P<0.01),but still obviously higher than in the normal group and sham group(P<0.01).Conclusion Electroacupuncture therapy can significantly increase the number of neurons of substantia nigra and the density of striatum nerve fibers,and reduce the apoptotic percentage of substantia nigra cells in the Parkinsonian rats,which may contribute to its effect in relieving Parkinson's disease.关键词：Parkinson's disease;Electroacupuncture;Apoptosis;Substantia nigra;Striatum1407|514|7更新时间：2023-08-11
- 摘要：Objective To explore the relationship between the effect of electroacupuncture(EA) and EA of different layer tissues of the acupoint area and different acupoints in upregulating mean arterial pressure(MAP) and heart rate(HR) in hypotension plus bradycardia rats.Methods A total of 200 SD rats were used in the present study.Bradycardia plus hypotension model was established by intravenous injection of 0.4% propranolol(0.4mg/100g,maintaining dosage 0.025mg/100g per minute).EA(2Hz /15Hz,5mA) was applied to 1) right "Daling"(PC7) and "Jiexi"(ST41),"Ximen"(PC4) and "Housanli"(ST36),"Quze"(PC3) and "Dubi"(ST35) which have a similar tissue structure,and are located in the upper and lower limbs and different meridians,and non-acupoint [3 mm left-superior to the "Tianshu"(ST25)],2) skin,muscle layer and periosteum part of "Ximen"(PC4),3) skin,muscle layer and periosteum of "Housanli"(ST36) for 15min.The HR and MAP were recorded by using a multi-channel physiological signal sampling-processing system.Results 1)In comparison with the model group,the percentages of the increased HR and MAP in the "Ximen"(PC4),"Quze"(PC3),"Housanli"(ST36) and "Jiexi"(ST41) groups,PC4-skin,PC4-muscle,PC4-periosteum,ST36-skin,ST36-muscle and ST36 periosteum groups,and the increased HR in the "Dubi"(ST35) group were upregulated significantly(P<0.05,P<0.01).The percentages of the increased HR and MAP were significantly higher in the "Quze"(PC3) and "Ximen"(PC4) groups than in the "Daling"(PC7) group(P<0.01),and the increased HR evidently higher in the "Housanli"(ST36) and "Jiexi"(ST41) groups than in the "Dubi"(ST35) group(P<0.01),suggesting different effects of EA stimulation of different acupoints in the same one meridian.No significant differences were found among the "Ximen"(PC4),"Quze"(PC3),"Housanli"(ST36) and "Jiexi"(ST41) groups,and between the "Daling"(PC7) and model groups,and between the non-acupoint and model groups in the rising rates of both HR and MAP(P>0.05).2) Regarding the effects of EA of different tissue layers in "Ximen"(PC4) and "Housanli"(ST36) areas,the rising rates of HR were markedly higher in the PC4-skin group than in the "Ximen"(PC4),PC4-muscle and PC4-periosteum groups(P<0.01),and considerably higher in the "Housanli"(ST36),ST36-skin,and ST36-muscle groups than in ST36-periosteum group(P<0.05).The rising rates of MAP were significantly higher in the PC4-skin and PC 4-muscle groups than in the "Ximen"(PC4) and PC 4-periosteum groups(P<0.01),and considerably higher in the ST36-skin group than in the "Housanli"(ST36),ST36-muscle and ST36-periosteum groups(P<0.01),suggesting different effects of EA stimulation of different tissue layers in the same one acupoint.No significant differences were found between the "Ximen"(PC4) and PC 4-muscle groups,among the "Housanli"(ST36),ST36-skin and ST36-muscle groups in the rising rates of HR,between the "Ximen"(PC4) and PC4-perio-steum groups,and among the "Housanli"(ST36),ST36-muscle and ST36-periosteum groups in the rising rates of MAP(P>0.05).3) The effect of the PC4-skin group was significantly superior to that of the ST36-skin group in increasing HR(P<0.01),and the effect of the PC4-muscle group was obviously stronger than that of the ST 36-muscle group in raising MAP(P<0.01),suggesting different therapeutic effects of EA stimulation of the similar tissue in different meridian-acupoints.The effects of the "Ximen"(PC4) and "Housanli"(ST36) groups in raising both HR and MAP,and that of the PC4-muscle and ST36-muscle groups in upregulaing HR,and that of the PC4-periosteum and ST36-periosteum groups in raising MAP were comparable(P>0.05).Conclusion EA of different acupoints of the same one meridian,the similar structure of different meridian acupoints and different tissue layers of the same one acupoint have their own relatively specific effects in upregulating HR and MAP in hypotension plus bradycardia rats.关键词：Acupoint;Specifity of efficacy;Structure of acupoint;Location of acupoint1289|1022|2更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) on serum tumor necrosis factor-α(TNF-α),IL-1 and IL-4 levels in rats with chronic inflammatory pain,so as to investigate its underlying mechanism in relieving pain.Methods Forty-eight SD rats were randomized into control,model,EA-unilateral ST36,and EA-bilateral ST36 groups,with 12 rats in each.Chronic inflammatory pain model was established by intradermal injection of Freund's complete adjuvant(0.1mL) into the right paw.EA(2Hz/100Hz,1-2-3mA) was applied to the unilateral "Zusanli"(ST36) and bilateral "Zusanli"(ST36) for 30 min,once every 3 days and continuously for 4 weeks.Serum TNF-α,IL-1 and IL-4 contents were detected by enzyme linked immunosorbent assay.Results Compared with the control group,serum TNF-α,IL-1 and IL-4 contents of the model group increased significantly(P<0.01),while in comparison with the model group,the levels of the 3 indexes were decreased considerably in both unilateral and bilateral ST36 groups(P<0.01).No significant differences were found between the unilateral ST36 and bilateral ST36 groups in serum TNF-α,IL-1 and IL-4 contents(P>0.05).Conclusion EA can effectively lower serum TNF-α,IL-1 and IL-4 levels in inflammatory pain rats,which may contribute to its effect in relieving inflammatory pain.关键词：Inflammatory pain;Electroacupuncture;Serum TNF-α;IL-1;IL-41182|390|3更新时间：2023-08-11
- 摘要：Objective To investigate neuroanatomical characteristics of the primary sensory afferent and the motor neurons coming from and innervating acupoint "Chengshan"(BL 57) area in the rat by using cholera toxin subunit B conjugated with Alexa Fluor 488(CTB-Alexa488),a new generation of fluorescent neural tracing reagent.Methods Four male SD rats were used in the present study.Under anesthesia,0.05% CTB-Alexa488(5μL) was injected into the central part of the rear of the hind leg,a corresponding site of "Chengshan"(BL 57) in the human body.After 4048 surviving hours,the rat's brain,spinal cord and dorsal root ganglia(DRGs) of the lumbar segments(L1-L6) were dissected following perfusion with 4% paraformaldehyde,cut into sections and observed under fluorescent microscope equipped with a digital camera.The neurons labeled by CTB-Alexa488 were counted.Results All CTB-Alexa488 labeled neurons appeared in green under fluorescent filters of 45048 surviving hours,the rat's brain,spinal cord and dorsal root ganglia(DRGs) of the lumbar segments(L1-L6) were dissected following perfusion with 4% paraformaldehyde,cut into sections and observed under fluorescent microscope equipped with a digital camera.The neurons labeled by CTB-Alexa488 were counted.Results All CTB-Alexa488 labeled neurons appeared in green under fluorescent filters of 450490 and were located ipsilaterally on the injection side.The labeled primary sensory neurons were found in the DRGs at L4(11 neurons) and L5(35 neurons).Among them,29 neurons(63.04%) were bigger,with their cell body diameters being 35490 and were located ipsilaterally on the injection side.The labeled primary sensory neurons were found in the DRGs at L4(11 neurons) and L5(35 neurons).Among them,29 neurons(63.04%) were bigger,with their cell body diameters being 3550μm and 17(36.96%) smaller,with their body diameters being lower than 35μm.The labeled motor neurons were found to distri-bute in the mediolateral portion of lamina Ⅸ,forming a longitudinal column from L4 to L5.Of the observed 316 motor neurons,259(81.96%) belong to α type with their body diameters being 2550μm and 17(36.96%) smaller,with their body diameters being lower than 35μm.The labeled motor neurons were found to distri-bute in the mediolateral portion of lamina Ⅸ,forming a longitudinal column from L4 to L5.Of the observed 316 motor neurons,259(81.96%) belong to α type with their body diameters being 2540μm and 57(18.04%) to γ type with their body diameters bei-ng lower than 25μm.Conclusion The CTB-Alexa488-labeled primary sensory and motor neurons innervating acupoint "Chengshan"(BL57) distribute in the DRGs of L4-L5.The present fluorescent tracing technique may be quite useful for investigating the neural characteristics of acupoints.关键词：Chengshan(BL57);Innervation;Cholera toxin subunit B conjugated with Alexa Fluor 488(CTB-Alexa488);Dorsal root ganglia;Spinal cord1473|461|7更新时间：2023-08-11
- 摘要：Objective To observe the peripheral and central neural connection of acupoint "Hegu"(LI4),"Neiguan"(PC6),"Futu"(LI18) and the thyroid gland(TG) region with fluorescence double-labelling method.Methods Thirty male Wistar rats were divided into LI4-LI18 group,PC6-LI18 group,TG-LI18 group,LI4-TG group,and PC6-TG group,with 6 rats in each.Fluorescence dyes Propidium Iodide(PI,10μL) and Bisbenzimide(Bb,10μL) were,separately,injected into those acupoints mentioned above and the TG region.Sixty hours after PI-injection and 12 hours after Bb-injection,the rats under deep anesthesia were transcardiacally perfused with PBS containing 4% polyoxymethylene,followed by taking the spinal cord and dorsal root ganglia(DRGs) of the cervical segments(C1-C8) and thoracic 1(T1) segment.Fluorescent single-and dual-labeled cells of the sliced DRGs and cervical spinal cord were observed by fluorescence microscope.Results 1) All PI-and Bb-labeled cells were found to distribute in DRGs from C1-T1 segments.PI single-labeled cells from LI4 and PC6 mainly distributed in DRGs from C4 to C8.Bb single-labeled cells from LI18 and TG region distributed in DRGs from C1-C6.2) Dual-labeled cells in the LI4-LI18 group,PC6-LI18 group,LI4-TG group,and PC6-TG group distributed in DRGs from C3 to C7,suggesting bifurcate peripheral processes of the cervical DRG neurons to innervate LI18,LI4,PC6 and the TG region.And the dual-labeled cells of the TG-LI18 group distributed mainly in DRGs from C1 to C4.3) A small number of single-labeled neurons(about 8% of total labeled cells in DRGs)and only several dual-labeled neurons were found in the anterior horn of the cervical spinal cord.Conclusion LI18,LI4 and PC6 and the thyroid gland have the same peripheral cells in DRGs of C3-C7 segments,suggesting that the bifurcate peripheral innervation may provide an anatomic evidence for the analgesic effect of acupuncture of LI18,LI4 and PC6 on thyroidectomy.关键词：Fluorescent dual-labelling;Thyroid gland;Hegu(LI4);Neiguan(PC6);Futu(LI18);Cervical DRG1342|287|7更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupuncture on the nerve conduction function in patients with diabetic peripheral neuropathy.Methods Eighty diabetic patients were equally randomized into acupuncture group and medication group.Uniform reinforcing and reducing manipulation of acupuncture for regulating both spleen and stomach was applied to bilateral Quchi(LI11),Hegu(LI4),Xuehai(SP10),Diji(SP8),Zhongwan(CV12),Zusanli(ST36),Yinlingquan(SP9),etc.,for 30min,once daily for 4 weeks.Patients of the medication group were treated with intramuscular injection of Mecobalamine(500μg),once daily for 4 weeks.The sensory conduction velocity(SCV),motor conduction velocity(MCV),the amplitude and latency of the evoked potential of the tibial nerve were detected before and after the treatment by using an Electromyograph and Evoked Potential Equipment.Results After the treatment,of the two 40 cases in the medication and acupuncture groups,12(30.0%) and 24(60.0%) were cured basically,12(30.0%) and 10(25.0%) experienced marked improvement in their symptoms,9(22.5%) and 4(10.0%) were effective,and 7(17.5%) and 2(5.0%) failed in the treatment,with the total effective rates being 82.5% and 95.0% respectively.The therapeutic effect of the acupuncture group was significantly superior to that of the medication group(P<0.05).In comparison with the pre-treatment,the SCV,MCV,amplitude and latency of the evoked potential of the tibial nerve in the acupuncture group were improved significantly after the treatment(P<0.05,P<0.01).Compared with the medication group,the SCV,the amplitude and the latency of the tibial nerve in the acupuncture group were also improved significantly after the treatment(P<0.05,P<0.01).Conclusion Manipulation of acupuncture for regulating spleen-stomach function has a better effect on the conduction function of the tibial nerve than Mecobalamine in the treatment of diabetic patients with peripheral neuropathy.关键词：Diabetic peripheral neuropathy;Acupuncture therapy;Spleen-stomach regulation needling1041|740|6更新时间：2023-08-11
- 摘要：Objective To observe the effect of otopoint-needle embedment on migraine and to explore its underlying mechanism.Methods Ninety-two migraine outpatients were equally randomized into acupuncture group and medication group.For patients of the acupuncture group,one sterilized intradermal needle was inserted into E(MA-AT)-point and advanced toward Nie(Temple-point,MA-AT),then another inserted into Nie(Temple-point,MA-AT) and advanced toward Zhen(Occipus-point,MA-AT),followed by fixing the needles with a piece of adhesive-tape respectively,combined with Wei(Stomach-point,MA-IC),Jiaogan(Sympathesis-point,MA-AH 7) for migraine patients with nausea and vomiting,and with Yan(Eye-point,MA-L 1) for those with phengophobia.Plasma serotonin(5-HT) contents before and after the treatment were detected by fluorescence spectrophotometry.Results In comparison with the pre-treatment,the synthetic scores of two groups one month and 6 months after the treatment were decreased significantly(P<0.01).The integrative sores of the acupuncture group one month and 6 months after the treatment were significantly lower than those of the medication group(P<0.01).The total effective rates of recent efficacy and long-term efficacy of the acupuncture group were 82.61%(38/46) and 83.72%(36/43) respectively,being significantly higher than those [67.39%(31/46) and 57.14%(24/42)] of the medication group.After the treatment,plasma 5-HT content of the acupuncture group was remarkablely higher than that of the medication group(P<0.05).Conclusion Otopoint-needle implant can effectively relieve headache in migraine patients and upregulate plasma 5-HT level.关键词：Migraine;Otopoint-needle embedment;Plasma 5-HT1401|748|3更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupuncture combined with dietary adjustments and aerobic exercise on the body weight,body mass index(BMI) and serum leptin content of patients with simple obesity,so as to evaluate the efficacy of the present therapy in the treatment of simple obesity.Methods A total of 61 cases of out-patients were randomly divided into control(n=30) and treatment(n=31) groups.Patients in the control group were treated with dietary adjustments and aerobic exercise everyday(30min/d),continuously for 51 days,and those of the treatment group were treated with acupuncture [Zhongwan(CV 12),Tianshu(ST 25),Guanyuan(CV 4),etc.] plus dietary adjustment and aerobic exercise everyday,with 15 days being a course of treatment,3 days' interval between every two courses,and 3 courses altogether.Serum leptin content was detected by using radioimmunoassay.Results Compared with pre-treatment,the body weight and BMI and serum leptin levels in the control and treatment groups were all decreased significantly(P<0.01).Comparison between the two groups showed that the body weight at the end of the 1st and 3rd course of treatment,the BMI at the end of the 1st,2nd and 3rd course of treatment,and serum leptin level after the treatment in the treatment group were all significantly lower than those in the control group(P<0.05,P<0.01).The difference values of body weight and BMI between pre-treatment and post-treatment of the treatment group were obviously higher than those of the control group(P<0.01),suggesting a better therapeutic effect of acupuncture combined with dietary adjustments and aerobic exercise in the treatment of simple obesity.Conclusion Acupuncture combined with dietary adjustments and aerobic exercise can reduce the body weight,BMI and serum leptin level,which is better than dietary adjustments plus aerobic exercise.关键词：Simple obesity;Acupuncture;Diet adjustments;Aerobic exercise;Body weight;BMI;Serum leptin1343|328|2更新时间：2023-08-11
- 摘要：Objective To evaluate the efficacy of routine plus mental-regulating acupoints on the head for post-operative gastroparesis syndrome.Methods Twenty patients were randomized into treatment group and control group,with 10 cases in each.For patients in the control group,transcutaneous nerve electrical stimulation(TENS) of Pishu(BL20),Weishu(BL21) and Sanjiaoshu(BL22) was given for 20min,followed by acupuncture of Neiguan(PC6),Zhongwan(CV12),Qihai(CV6),Tianshu(ST25),etc.,plus abdominal TDP irradiation and pellet-pressure of otopoints: Wei(MA-IC),Jiaogan(MA-AH7),Neifenmi(MA-IC3),Sanjiao(MA-IC4),Pizhixia(MA-AT1),etc.For patients of the treatment group,in addition to the treatment mentioned above,acupoints Baihui(GV20),Yintang(EX-HN3) and scalp-point Weiqu(Stomach Area) for adjusting the mental activity were punctured.The treatment was conducted once daily,5 times a week and continuously for 4 weeks.Changes of the psychological status including Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale(HAMA) scores,and gastric drainage volume/d were recorded.Results In comparison with pre-treatment,the HAMD and HAMA scores of both the treatment group and the control group after the treatment were decreased significantly(P<0.01),and the therapeutic effects of the treatment group in reducing HAMD and HAMA scores were evidently superior to those of the control group(both P<0.05).The gastric drainage volume/d in the two groups both decreased after the treatment.Of the two 10 cases in the treatment and control groups,10 and 8 were cured,0 and 2 were improved.No significant difference was found between the two groups in the therapeutic effect(P>0.05),but the treatment sessions of the treatment and control groups were 7.3±1.3 and 10.4±2.1,respectively(P<0.01).Conclusion Mental activity-adjusting acupoints plus routine acupuncture(TENS,TDP irradiation and o-topoint-pellet pressure) can effectively improve post-surgical gastroparesis patients' psychological status and raise clinical therapeutic effect.关键词：Gastroparesis;Acupuncture;Mental activity-adjusting acupoints;Otopoint-pellet pressure802|383|5更新时间：2023-08-11
- 摘要：Objective To observe the clinical efficacy of acupuncture in the treatment of hypertension patients.Me-thods A total of 80 out-patients and in-patients with primary hypertension were randomly and equally divided into acupuncture group and medication group.Patients of the acupuncture group were treated with acupuncture stimulation of Fengchi(GB20),Quchi(LI11),Taichong(LR3),etc.for 30min,combined with Xingjian(LR2),Xiaxi(GB43) for hyperactivity of the liver-yang,with Ganshu(BL18) and Fuliu(KI7) for severe phlegm-damp,and with Guanyuan(CV4) and Shenshu(BL23) for deficiency of both yin and yang,once per day,continuously for one month except weekends.In addition,patients of the medication group were ordered to take Diovan(80 mg) once daily,continuously for 30 days.Both casual blood pressure(CBP) and ambulatory blood pressure(ABP) were detected by using an auscult-type baumanometer and a dynamic blood monitor,respectively.Results Of the two 40 cases in the medication and acupuncture groups,18(45.0%) and 27(67.5%) experienced marked improvement in the reduction of blood pressure,14(35.0%) and 11(27.5%) were improved,8(20.0%) and 2(5.0%) failed,with the effective rates being 80.0% and 95.0%,respectively.The therapeutic effect of the acupuncture group was significantly superior to that of medication group in improving hypertension(P<0.05).Conclusion Acupuncture is superior to Diovan in relieving hypertension.关键词：Hypertension;Acupuncture;Clinical trial895|1221|2更新时间：2023-08-11
- 摘要：Objective To evaluate the therapeutic effect of acupuncture for the aphasia.Methods The publications of acupuncture for the treatment of aphasia are comprehensively searched from relevant domestic medical literature databases,China National Knowledge Infrastructure and Chinese BioMedical Literature Database.Meta analysis was conducted by using the publications.Results Twenty six trials of 338 matched the selection criteria and their data were suitable for Meta analysis.The total aphasia patients were 1749.The total odds ratio(OR) of the improvement with acupuncture plus language training and drugs compared with language training plus drug intervention was 3.66(95% confidence interval,2.81,4.76),and the funnel plot was approximately symmetry.It is indicated that the curative effect of the acupuncture group is better than that of the control group(Z=9.60,P<0.001).Conclusion The effect of acupuncture with language training plus drugs for the treatment of aphasia is better than that of language training plus drugs only.关键词：Acupuncture;Aphasia;Meta analysis1136|637|3更新时间：2023-08-11
- 摘要：In the treatment of various clinical conditions,acu-moxibustion implements are absolutely necessary.In the present paper,the authors make a systemic investigation on the developmental course of acu-moxibustion implements from 1) acupuncture needles,2) moxibustion materials and tools,and 3) modern therapeutic apparatuses for acu-moxibustion.Regarding the acupuncture needle,the authors reviewed its histological evolution from the Bian-needle(stone needle),bone needle,metal needle,nine types of needles,etc.,to the disposable sterile acupuncture needle.The authors also comprehensively recount the improvement of materials and auxiliary appliances for moxibustion in different periods,and the process of development and application traits of modern electroacupuncture and moxibustion instruments.In this way,this article outlines the whole development of acu-moxibustion implements from the antiquity to the present in China.关键词：Acu-moxibustion;Acu-moxibustion implement;Development1085|1375|8更新时间：2023-08-11
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