最新刊期
卷 36 ， 期 1 ， 2011
- 摘要：Objective To observe the effect of electroacupuncture(EA) on the efficacy of estrogen-induced regulation of reproductive endocrine in ovariectomized(OVX) rats.Methods Thirty SD rats were randomly divided into control,model(OVX),EA-Guanyuan(CV 4),Estrogen(E) and EA+E groups(n=6 in each group).OVX model was duplicated by removing the bilateral ovaries.EA(5 Hz/20 Hz,1-2 mA) was applied to "Guanyuan"(CV 4) for 30 min,once every other day and for 3 sessions.Estrogen at doses of 0.5 mg/kg and 0.25 mg/kg was intraperitonealy given to rats in the E group and EA+E group,respectively.Serum estrogen and cortisol contents were assayed by enzyme linked immunosorbent assay and the expression of hypothalamic gonadotrophin releasing hormone(GnRH)mRNA,G protein-coupled receptor 54(GPR 54)mRNA,kisspeptin-1(Kiss-1) mRNA and corticotropin releasing hormone(CRH) mRNA were detected by using real time polymerase chain reaction(RT-PCR).Results Compared with the control group,the expression levels of GnRH mRNA,GPR 54 mRNA and Kiss-1 mRNA in hypothalamus in the model group were increased significantly(P<0.05),while the expression of hypothalamic CRH mRNA was down-regu-lated obviously(P<0.05),and serum cortisol and estrogen levels were reduced significantly(P<0.05).In comparison with the model group,the expression levels of hypothalamic GnRH mRNA in the EA,E and EA+E groups,and those of hypothalamic GPR 54 mRNA and Kiss-1 mRNA in the E and EA+E groups were down-regulated considerably(P<0.05);whereas hypothalamic CRH mRNA expression levels in the E and EA+E groups were up-regulated obviously(P<0.05),and serum cortisol and estrogen contents in the E and EA+E groups were increased remarkably(P<0.05).Comparison among the EA and EA+E groups showed that the effects of EA+E group were significantly superior to those of EA group in down-regulating hypothalalmic GnRH mRNA and GPR 54 mRNA expression,and in up-regulating hypothalamic CRH mRNA expression and serum cortisol and estrogen contents(P<0.05).No significant differences were found between E and EA+E groups in down-regulating hypothalamic GnRH mRNA,GPR 54 mRNA and Kiss-1 mRNA expression,and in up-regulating hypothalamic CRH mRNA expression and serum cortisol and estrogen levels(P>0.05).Conclusion EA-CV 4 is able to potentiate the effects of low-dose of estrogen in down-regulating hypothalamic GnRH mRNA,GPR 54 mRNA and Kiss-1 mRNA expression,and up-regulating hypothalamic CRH mRNA expression and raising serum cortisol and estrogen contents in OVX rats,showing a favorable modulation effect on reproductive endocrine activity.关键词：Ovariectomy;Electroacupuncture;Hypothalamus;GnRH mRNA;GPR 54 mRNA;Kiss-1 mRNA;CRH mRNA;Estrogen;Cortisol1122|451|1更新时间：2023-08-11
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Effect of "Xiusanzhen" on Expression of Hippocampal Bcl-2 and Bax Proteins in Alzheimer Disease Rats
摘要：Objective To observe the effect of electroacupuncture(EA) of "Xiusanzhen"[3 acupoints,i.e.,bilateral "Yingxiang"(LI 20) and "Yintang"(EX-HN 3)] on expression of B-cell lymphoma/leukemia-2(Bcl-2,an antiapoptosis protein) and Bax(a protein for promoting apoptosis) in the hippocampus in Alzheimer disease(AD)rats,so as to explore its clinical mecha-nisms underlying relieving AD.Methods A total of 40 Sprague Dawley rats were randomly divided into normal control,AD mo-del,EA and olfactory nerve transaction(ONT)+EA groups,with 10 rats in each.AD model was established by injection of β-amyloid(Aβ)1-40(2 μL containing 10 μg) into the hippocampus(Bregma: 3.5 mm,L: 2.0 mm,H:-2.8 mm below dura),and the ON was sectioned by using a fine needle.EA(80-100 Hz,1-3 mA) was applied to bilateral LI 20 and EX-HN 3 for 10 min,once daily(except Saturdays and Sundays) for 6 weeks.The expression of Bcl-2 and Bax of hippocampus was measured by immunohistochemistory.Results Compared with the normal control group,the expression of Bcl-2 of hippocampus was significantly lower in the AD model group(P<0.05),and that of Bax in AD model group was much higher(P<0.01).In comparison with the model group,the expression of hippocampal Bcl-2 was up-regulated significantly(P<0.01),and that of hippocampal Bax protein down-regulated considerably in the EA group(P<0.01).No significant differences were found between AD model and ONT+EA groups in the expression of hippocampal Bcl-2 and Bax proteins(P>0.05),suggesting a necessary premise condition for EA in regulating hippocampal Bcl-2 and Bax expression.Conclusion "Xiusanzhen" can regulate the expression of hippocampal Bcl-2 and Bax proteins in AD rats,which may contribute to its clinical effect in relieving AD,and the therapeutic effect depends on the integrity of the olfactory nerve pathway.关键词：Alzheimer Disease;Electroacupuncture;Xiusanzhen;Hippocampus;Olfactory nerve pathway;Bcl-2;Bax1352|521|10更新时间：2023-08-11 - 摘要：Objective To observe the effect of electroacupuncture(EA) on uterine microcirculation in dysmenorrhea rats so as to investigate its mechanism underlying relieving primary dysmenorrheal(PD).Methods Female SD rats undergoing diestrus were randomly divided into saline control,model,Sanyinjiao(SP 6),Xuanzhong(GB 39) and non-acupoint groups,with 6 rats in each.PD model was established by subcutaneous injection of estradiol benzoate for 10 days and intra-peritoneal injection of oxytocin(2 U) 1 h after the last estradiol injection.EA(2 Hz/100 Hz,1-1.5 mA) was applied to the above-mentioned acupoints and non-acupoint area for 20 minutes.Numbers and diameters of the uterine microvessels(11-100 μm) and capillaries(≤10 μm),and the state of the uterine microcirculation were observed by using a Cold Light Microcirculation Detector.ResultsIn comparison with the saline control group,the numbers and diameters of uterine microvessels and capillaries at the correspon-ding time-points 5 min,10 min and 20 min were decreased significantly in the model group(P<0.05,P<0.01).While compared with the model group,the numbers and diameters of uterine microvessels and capillaries at 20 min after EA in the SP 6 group were increased significantly(P<0.05).The diameter of uterus capillaries of SP 6 group was significantly bigger than that of the non-acupoint group at the time-point 20 min(P<0.05).No significant differences were found among the SP 6,GB 39 and non-acupoint groups in the diameter of uterine microvessels(P>0.05).Conclusion EA of SP 6 can effectively increase the number of ute-rine microvessels and capillaries and the diameter of the uterine microvessels and capillaries in PD rats,which may contribute to its effect in relieving dysmenorrhea by improving uterine microcirculation.关键词：Dysmenorrhea;Uterine microcirculation;Electroacupuncture;SP 6;GB 391148|608|14更新时间：2023-08-11
- 摘要：Objective To observe the effect of repeated electroacupuncture(EA) on the expression of cannabinoid receptor-1(CB 1) mRNA and dopamine 1 receptor(D 1) mRNA in Nucleus Accumbens(NAC)-Caudate Nucleus(CN) region in inflammatory-pain rats,so as to study its underlying mechanism in analgesia.Methods A total of 30 SD rats were randomized into normal control,model,EA,EA+AM 251 and WIN 55212-2 groups,with 6 cases in each group.EA(2 Hz/100 Hz,1-3 mA) was applied to "Zusanli"(ST 36) and "Kunlun"(BL 60) for 30 min,once every other day,and 4 sessions all together.Arthritis model was established by injection of Freund's complete adjuvant 0.05 mL in the rat's left ankle.Thermal pain threshold(paw withdrawal latency,PWL) was detected before and after modeling and after repeated EA and/or intraperitoneal injection of AM 251(an inverse antagonist at the CB 1 cannabinoid receptor,0.1 mg/100 g) and WIN 55212-2(a potent cannabinoid receptor agonist,0.2 mg/100 g).The expression of CB 1 receptor mRNA and D 1 receptor mRNA in the NAC-CN region was measured by real time fluorescence quantitative-polymerase chain reaction.Results Compared with the control group,the pain threshold values of the model group was decreased significantly(P<0.01).In comparison with the model group,the pain threshold values of the EA group and WIN 55212-2 group were increased considerably on day 10(P<0.01).No significant differences were found between the EA+AM 251 and model groups and between the EA and WIN 55212-2 groups in PWL after the treatment(P>0.05).Compared with the control group,both CB 1 R mRNA and D 1 R mRNA expression levels in the model group were increased slightly,while in comparison with the model group and EA+AM 251 group,CB 1 R mRNA and D 1 R mRNA expression levels in the EA group and WIN 55212-2 group were upregulated obviously.No significant differences were found between the EA+AM 251 and model groups and between the EA and WIN 55212-2 groups in CB 1 R mRNA and D 1 R mRNA expression levels.关键词：Electroacupuncture;Adjuvant arthritis;Cannabinoid receptor-1;Dopamine D1 receptor;Nucleus Accumbens-Caudate Nucleus1188|306|7更新时间：2023-08-11
- 摘要：Objective To explore the morphological basis of electroacupuncture(EA) in relieving addiction of keta-mine.Methods Forty Sprague-Dawley rats were randomized into normal control,normal saline(10 mL/kg),model and keta-mine+EA groups.Ketamine-addiction model was established by intraperitoneal administration of ketamine(100 mg/kg),once a day for 7 days.EA(2 Hz) was applied to "Zusanli"(ST 36) and "Sanyinjiao"(SP 6) for 30 min,once a day for 7 days.The expression of tyrosine hydroxylase(TH) and c-fos in the hippocampal CA 1 region was detected by immunohistochemistry.Results In comparison with the normal control group and normal saline group,the numbers of both TH immuno-reaction(IR)-positive and c-fos IR-positive neurons in the hippocampal region in the model group were increased significantly(P<0.05,P<0.01).Correspondingly,the expression of both TH IR-positive and c-fos IR-positive products in the hippocampal CA1 region in the model group was upregulated evidently(P<0.05,P<0.01).After EA of "Zusanli"(ST 36)-"Sanyinjiao"(SP 6),compared with the model group,the expression of both TH IR-positive and c-fos IR-positive products was downregulated considerably(P<0.01).Conclusion EA of "Zusanli"(ST 36)-"Sanyinjiao"(SP 6) can downregulate ketamine-addiction induced increase of expression of tyrosine hydroxylase and c-fos in the hippocampal CA1 region in ketamine-addiction rats,which may contribute to its effect in relieving ketamine addiction symptoms in clinic.关键词：Ketamine-addiction;Tyrosine hydroxylase expression;c-fos expression;Electroacupuncture;Hippo-campal CA1 region1332|246|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of warm-needle moxibustion on the gastric mucosal injury caused by anti-rheumatic dose of Aspirin.Methods Forty SD rats were equally randomized into blank group,model group,warm needling group and Omeprazole(for relieving peptic ulcer) group,with 10 rats in each.The rats were forced to undergo 12 hours' fasting and 4 hours' water-deprivation before the experiments.Normal saline(10 mL/kg) was given to the rats in the blank group.Gastric mucosa lesion model was established by intragastric infusion of aspirin(420 mg/kg).Warm needling was applied to "Zhongwan"(CV 12),"Xiawan"(CV 10),"Zusanli"(ST 36) and "Neiguan"(PC 6) for 30 min,once a day for 7 days.The rats of the Omeprazole group were fed with Omeprazole(10 mg/100 g body weight) once a day for 7 days.According to Guth's method,the ulcer index(UI) of the gastric mucosa was calculated following killing the rats.The activity of superoxide dismutase(SOD) and the levels of malondialdehyde(MDA) in the serum and gastric mucosa were detected with hydroxylamine method and thiobarbituric acid method,respectively.Results Compared with the blank group,the gastric UI,MDA levels of both serum and gastric mucosa in the model group were increased obviously(P<0.01),while serum and gastric mucosal SOD activity in the model group were decreased considerably(P<0.01).In comparison with the model group,the gastric UI,and both serum and gastric mucosal MDA contents in the warm needling group and Omeprazole group were down-regulated significantly(P<0.01),whereas both serum and mucosal SOD activity in the warm needling group and serum SOD activity in the Omeprazole group were up-regulated significantly(P<0.01).Comparison between the warm needling group and Omeprazole group showed that the UI,both serum and gastric mucosal SOD activity,and serum MDA level of the former group were evidently higher than those of the Omeprazole group(P<0.05),but gastric mucosal MDA level of the warm needling group was apparently lower than that of the Omeprazole group(P<0.05).Conclusion Warm-needle moxibustion can reduce the gastric lesion(ulcer) caused by aspirin in the rat,which may be closed associated with its effects in up-regulating both serum and gastric mucosal SOD activity and down-regulating both serum and gastric mucosal MDA levels.关键词：Warm-needle moxibustion therapy;Gastric mucosal lesion;Gastric ulcer index;SOD;MDA1308|444|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of moxibustion of "Zusanli"(ST 36) on hepatic glycogen level and ultrastructure changes in exercise-induced fatigue rats.Methods Thirty-three SD rats were randomly and equally divided into control,model and moxibustion groups.The fatigue model was established by forcing the rat to have a loaded exhaustion swim,once daily for 21 days.Moxibustion was applied to bilateral "Zusanli" for about 30 min,once every other day for 11 times.The hepatic glycogen content was detected by chromatometry and the hepatic ultrastructure was observed by using transmission electron microscope.Results The hepatic glycogen content in the fatigue model group decreased significantly compared with the control group(P<0.01),and that in the moxibustion group was increased significantly compared with the model group(P<0.05).Under transmission electron microscope,it was found that the glycogen in the hypatocytes of the model was decreased and the ultrastructure of mitochondria and rough endoplasmic reticulum was unclear in outline.In moxibustion group,more glycogen granules were found in hepatocytes,and the structure of mitochondria and rough endoplasmic reticulum was basically clear.Conclusion Moxi-bustion may increase hepatic glycogen content and improve ultrastructure of hypatocytes in fatigue rats,which may be part of its mechanism underlying relieving exercise-induced fatigue.关键词：Fatigue;Exhaustive exercise;Moxibustion;Hepatic glycogen;Ultrastructure of hypatocytes1289|727|6更新时间：2023-08-11
- 摘要：Objective To observe the effect of different strength of acupuncture stimulation on blood pressure and plasma endothelin(E)-1 in spontaneous hypertension rats(SHR),so as to seek a better acupuncture parameter for clinical treatment of hypertension.Methods Twenty-eight 9-week-old SHRs were randomized into mild-stimulation group,moderate-stimulation group,strong-stimulation group and model group(n=7 in each group).Seven normotensive SD rats served as a normal control group.Acupuncture stimulation with mild,moderate and strong stimulation was applied to bilateral "Taichong"(LR3) for 5 min,once daily for 7 days.Blood pressure(BP) was determined by using a non-invasive BP-6 detection system.Plasma ET-1 was assayed by radioimmunoassay.Results Compared with the model group,the systolic pressure of the moderate-stimulation group on the 6th and 7th day was decreased significantly after acupuncture of "Taichong"(LR 3)(P<0.01),being significantly lower than that of the mild-and strong-stimulation groups(P<0.01).In comparison with the normal control group,plasma ET-1 level in the model group was increased significantly(P<0.01),while compared with the model group,only that in the moderate-stimulation group was down-regulated considerably(P<0.01).No significant differences were found between the mild-stimulation and model groups,between the strong-stimulation and model groups,and between the mild-stimulation and strong-stimulation groups in plasma ET-1 level(P>0.05).Conclusion Moderate-stimulation of "Taichong"(LR3) can lower blood pressure and plasma EA-1 level in spontaneous hypertension rats.The reduced level of plasma ET-1 may be one of its mechanisms underlying improving hypertension.关键词：Spontaneous hypertension;Acupuncture stimulation strength;Taichong(LR3);Plasma endothelin-11307|860|9更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupoint-catgut-implantation on blood pressure and cardiac function in chronic heart failure(CHF) rats.Methods A total of 60 SD female rats were randomly divided into sham-operation group(sham),CHF model group,catgut-implantation group,Captopril group.CHF model was established by suprarenal abdominal artery constriction.Surgical catgut(No.3-0,2-3 mm length piece) was implanted into bilateral "Neiguan"(PC 6),"Xinshu"(BL 15) and "Zusanli"(ST 36) twice for 7 weeks.Rats of the Captopril group were treated with intragastric infusion of Captopril from the 50th day on after the operation,once daily for 7 weeks.Blood pressure(BP) including the systolic blood pressure(SBP),dia-stolic blood pressure(DBP) and mean blood pressure(MBP),heart rate(HR) and the left ventricular ejection fraction(LVEF) were detected respectively by cardiac sonography.Results On the 14th week after modeling,in comparison with the sham group,the SBP,DBP,MBP and HR in rats of the model group were increased significantly(P<0.01,P<0.05),while LVEF of the model group was decreased considerably(P<0.01).Compared with the model group,the SBP,DBP,MBP and HR after 7 weeks' treatment in rats of the catgut-implantation and Captopril groups were decreased considerably(P<0.01),while the LVEF of the catgut-implantation group was increased evidently(P<0.05).No significant differences were found between the catgut-implantation and Captopril groups in the SBP,DBP,MBP and HR levels,and between the model and Captopril groups in LVEF values(P>0.05).Conclusion Acupoint-catgut-implantation can down-regulate BP and HR,and increase LVEF in chronic congestive heart failure rats,which may contribute to its effect in ameliorating the cardiac function.关键词：Chronic heart failure;Acupoint-catgut-implantation;Cardiac function;Blood pressure;Left ventricular ejection fraction1140|259|0更新时间：2023-08-11
- 摘要：Objective To observe the characteristics of needling sensation of "Deqi"(feelings of soreness,numbness,distending and heaviness,SNDH) by using positron emission tomography(PET) based on changes of glucose metabolism in diffe-rent functional brain areas.Methods Eighteen normal volunteers [9 men and 9 women,mean age(23.23±3.32) years] were randomly divided into control,Waiguan(SJ 5) and non-acupoint groups(n=6 in each group).SJ 5 and non-acupoint(the midpoint between SJ 5 and the running course of the Small Intestine Meridian on the right forearm) were punctured by using a sterilized filiform needle.PET scan of the brain began 40 min after intravenous 18F-fluorodeoxyglucose(FDG) injection(0.11 mCi/kg body weight,left opisthenar vein).Needling sensations including "Deqi"(n=5),tingling(n=5) and no-apparently-specific-feeling(NASF) were acquired by acupuncture stimulation and grouped.The needling sensations were evaluated by using Visual Analog Scale(VAS).The acquired image data of different needling-sensation groups were analyzed using SPM 2.0 software in the Matlab Platform.Results After receiving acupuncture stimulation of SJ 5,5 volunteers in the Waiguan(SJ 5) group experienced fee-lings of SNDH,with the mean VAS score being 4.23±1.50,and 5 volunteers of the non-acupoint group had a tingling feeling,with the mean VAS score being 5.73±2.40.The VAS score of the tingling group was significantly higher than that of SNDH group(P<0.05).Compared with the NASF control group,the activated cerebral areas were Brodmann area(BA) 7,13,20,22,39,42 and BA 45 in the SNDH group,mainly involving the left temporal lobe,superior temporal gyrus,etc.and being obviously different to those of the control group(P<0.001,k>10 voxels).The activated cerebral areas in the tingling group were BA 18,19,22,24,25,32,36,40 and BA 45,predominantly involving the left limbic lobe,hippocampal gyrus,etc.and being appa-rently different to those of the control group(P<0.001,k>10 voxels).Conclusion Acupuncture of Waiguan(SJ 5) mainly produces feelings of soreness,numbness,distending and heaviness,and the activated cerebral areas mainly involve the left temporal lobe,superior temporal gyrus,etc.;while acupuncture of its neighboring non-acupoint chiefly induces a feeling of tingling in the healthy subjects,and the activated regions predominately involve the left limbic lobe,hippocampal gyrus,etc.1072|863|10更新时间：2023-08-11
- 摘要：Objective To evaluate the clinical therapeutic effect of acupoint-catgut-embedment therapy in the treatment of mammary gland hyperplasia(MGH).Methods Eighty MGH patients were equally randomized into acupoint-catgut-embedment(ACE) group and medication(Rupixiao,a herbal patent drug for relieving MGH) group according to odd-numbered days or even-numbered days of visiting.Subcutaneous catgut-embedment was performed in Wuyi(ST 15),Rugen(ST 18),Tanzhong(CV 17),Xuehai(SP 10),Zusanli(ST 36) and Yanglingquan(GB 34),once every 15 days for 3 months.Patients of the medication group were treated by oral administration of Rupixiao(3 tablets,3 times per day,3 months altogether).The degree of breast pain and the size of the hyperplastic lump were observed before and after the treatment.Serum estrodiol,progesterone and prolactin contents on day 1 to day 3 of menstruation were detected by using an automation chemiluminescence immune analysator.Results After the treatment,of the two 40 MGH patients in the ACE and medication groups,16(40.0%) and 5(12.5%) were cured basically,8(20.0%) and 8 were improved markedly in their symptoms and signs,16(40.0%) and 22(55.0%) were effective,and 0 and 5(12.5%) failed in the treatment,with the effective rates being 100% and 87.5%,respectively.The therapeutic effect of the ACE group was significantly better than that of the medication group(P<0.05).In comparison with the pre-treatment,the pain grades and the size of the hyperplastic lump in both ACE and medication groups decreased significantly after immediate termination of the treatment and 6 months after the treatment(P<0.01),and the therapeutic effects of the ACE group were significantly superior to those of the medication group in reducing pain grade and hyperplastic lump size(P<0.01).After the treatment,serum estrodiol and progesterone contents were decreased evidently in both ACE and medication groups(P<0.01,P<0.05).Type-B ultrasonic examination showed that of the two 40 MGH patients in the ACE and medication groups,16 and 5 cases turned to normal in their mammary glands,and the cure rate of the ACE group was evidently higher than that of the medication group(P<0.01).Conclusion Acupoint-catgut-embedment is effective in relieving MGH,and its therapeutic effect is apparently superior to that of medication(oral administration of Rupixiao).1390|536|0更新时间：2023-08-11
- 摘要：Objective To observe the clinical efficacy of pricking bleeding of 3 points of the thumb tip,and 3 points of the auricular helix for treatment of vocal cord submucosal bleeding(VCSB),so as to provide a better therapy for it.Methods Sixty VCSB patients were equally randomized into pricking bleeding group and ultrasonic atomizing inhalation(UAI) group.Pric-king bleeding was applied to Shaoshang(LU 11,0.1 cun to the nail on the radial side),Zhongshang(the center of the thumb back,0.1 cun to the nail),Laoshang(0.1 cun to the nail on the ulnar side),Lun 1,3 and 5(MA-H) of the helix,once daily for 7 days.Ultrasonic atomizing inhalation treatment was given to patients of the UAI group for 15 min every time,once daily for 7 days.The scores of symptoms and signs and their difference values were calculated before and after the treatment.The acoustical parameters maximum phonation time(MPT),frequency perturbation quotient(FPQ),amplitude perturbation quotient(APQ),ratio of harmonic to noise(H/N) were detected by using a USSA Computer Language Phonetic Spectrum Analysis System.ResultsOf the two 30 cases of VCSB patients in the pricking bleeding and UAI groups,20(66.67%) and 12(40.00%)were cured,7(23.33%) and 6(20.00%) were improved remarkably,3(10.00%) and 8(26.67%) improved,and 0 and 4(13.33%) failed,with the cure plus markedly effective rates being 90% and 60%,respectively.The cure plus markedly effective rate of the pricking bleeding group was significantly superior to that of the UAI group(P<0.01).The difference values between pre-treatment and post-treatment in hoarseness,laryngalgia,throat dryness,throat burning sensation,throat clearing,vocal bleeding,glottis dysraphism,and total score were significantly higher in the pricking bleeding group than those in the UAI group(P<0.05).In comparison with the pre-treatment,MPT and H/N values were increased obviously(P<0.05),and FPQ and APQ decreased clearly in the two groups after the treatment(P<0.05),suggesting an improvement of the acoustical parameters after the treatment.But,no significant differences were found between the two groups(P>0.05).Conclusion Pricking bleeding therapy is effective in relieving submucosal bleeding of the vocal cord and can improve its clinical symptoms and signs.关键词：Vocal cord submucosal bleeding;Pricking bleeding therapy;Acoustical parameters767|148|0更新时间：2023-08-11
- 摘要：Objective To observe the therapeutic effect of acu-moxibustion for ordinary psoriasis,so as to find a better curative method for it.Methods A total of 60 cases of psoriasis were equally randomized into medication group[(8.67±6.53) months in duration of disease,(39.25±10.21) years in age] and acu-moxibustion group [(9.16±7.37) months in duration of disease,and(37.38±11.36) years in age] according to a random number table.For patients of acu-moxibustion group,main acupoints used were Feishu(BL13),Geshu(BL17),Ganshu(BL18),Pishu(BL 20) and Shenshu(BL 23),combined with other acupoints [Hegu(LI 4),Weizhong(BL 40),etc.] according to the affected part of the body.Moxibustion was applied to Shenshu(BL 23) and the injured skin area for about 3 min every time.Acu-moxibustion treatment was given once every other day conti-nuously for 12 weeks.Patients of the medication group were treated with oral administration of Acitretin capsules(20 mg/d,for 12 weeks).The therapeutic effect was evaluated by using psoriasis area and severity index(PASI) scoring method.Results After the treatment,the integrative scores of PASI in both medication and acu-moxibustion groups decreased significantly(P<0.01),and that of the acu-moxibustion group was significantly lower than that of the medication group(P<0.05).Of the both 30 psoriasis patients in the medication and acu-moxibustion groups,1(3.33%) and 4(13.33%) were cured basically,15(50.00%) and 17(56.67%) were improved significantly,12(40.00%) and 6(20.00%) were effective,and 2(6.67%) and 3(10.00%) invalid,with the effective rates being 93.33% and 90.00%,respectively.The cured plus markedly effective rate of the acu-moxibustion group was significantly higher than that of the medication group(P<0.05).Conclusion Acu-moxibustion therapy is effective in the treatment of psoriasis and is remarkably superior to that of medication.关键词：Ordinary psoriasis;Acu-moxibustion;Acitretin capsule1002|1011|2更新时间：2023-08-11
- 摘要：Objective To compare the difference of bone proportional cun of acupuncture between the description in book Lingshu·Gudu(Miraculous Pivot: Proportional Bone Measurement) and the current National Standard for Locating the Acupoint("National Standard" in short),so as to determine the proportional relationship of the distance between two positions of the human body in terms of bone proportional cun.Methods A total of 100 volunteers [age: 18-25 years,body weight:(64.0±8.2)kg,and height:(169.3±5.7)cm] were enlisted in the present study.The distances of the bilateral isonym acupoints [Touwei(ST 8),Yunmen(LU 2),etc.,] or two sites on the body surface such as the bilateral nipples,Tiantu(CV 22)-umbilicus,etc.,were detected by using a soft ruler or a detector in accordance with the Methods of Anthropometry for Locating Acupuncture Points(GB/T 23237-2009,"National Standard").Results 1) The distances between the bilateral Touwei(ST 8) and bilateral Wangu(GB 12) were(134.54±14.72) mm and(161.73±25.05) mm respectively,both being different to the conventional equal lengths used nowadays.2) The ratios of a) the distance between the bilateral Yunmen(LU 2) and that between the bilateral nipples,and b) the distance between Tiantu(CV 22) and the umbilicus center and that between the umbilicus center and the superior margin of the pubic symphysis were 233.28∶194.46,and 398.09∶153.45,respectively,being identical to the descriptions of book Lingshu·Gudu,but being different to those of the current "National Standard".3) The distances between the anterior axillary fold and the cubital transverse crease,between the posterior axillary fold and the cubital transverse crease,and between Jianyu(LI 15) and the cubital transverse crease were(203.89±32.39) mm,(194.31±64.06) mm,and(286.45±21.16) mm respectively.In terms of proportional bone-length,the distance between the anterior axillary fold and the cubital transverse crease was converted to be 12 cun,being bigger than 9 cun recorded in the "National Standard".4) The distances between the superior border of the pubic symphysis and the superior border of patella,and between the superior border of patella and the patella apex were(439.96±801.51) mm,and(48.41±9.40) mm,separately.When converted to the proportional bone-length,they are identical to the 18.0 cun and 2.0 cun recorded in the current "National Standard".Conclusion The real distances between bilateral Touwei(ST 8) and between two nipples are not equal,the ratio of the distance between Tiantu(CV 22) and the umbilicus center and that between the umbilicus and the superior margin of the pubic symphysis,and the converted proportional bone-length of the distance between the anterior axillary fold and the cubital crease are not identical to the descriptions in current "National Standard" on acupoints location.关键词：Acupuncture;Bone proportional cun;Proportional bone measurement;Anthropometry993|351|3更新时间：2023-08-11
- 摘要：Along with the development of evidence-based medicine,more and more systematic review/Meta-analysis papers on acupuncture therapy have been published in China.Most researches have played an important part in guiding clinical study and practice on acupuncture.However,low quality researches may mislead the users.In the present paper,we analyze shortcomings of the published papers in China about systemic review/Meta-analysis on acupuncture therapy from the methodological quality according to the assessment tool: Oxman-Guyatt Overview Quality Assessment Questionnaire(OQAQ).Moreover,we also analyze some possible factors affecting the quality of systemic review/Meta-analysis and put forward a few of measures for improving the quality of systemic review.关键词：Acupuncture;Evidence based medicine;Methodology quality;Systematic review;Meta-analysis1762|1187|11更新时间：2023-08-11
- 摘要：The method for needling and moxibustion is an indispensable component of acupuncturology.In clinical practice of acupuncture and moxibustion,efficacy specificity of different needling and moxibustion methods for different clinical conditions or different phases of a disease exists objectively,which is in a close relation with the results of clinical interventions.Starting with the correlation between the efficacy specificity of different needling and moxibustion methods and different clinical conditions or syndromes,the authors of the present paper put forward to collect abundant literature on needling and moxibustion methods,extract and analyze standard formats of information,establish literature database on needling and moxibustion methods and then design literature data application platform.On the basis of those mentioned above,a data mining model of needling and moxibustion methods will be established for revealing the potential knowledge and regularities about application of needling and moxibustion met-hods from the related abundant fuzzy and incomplete literature data according to data analysis and designed research program on efficacy specificity.关键词：Acupuncture and moxibustion;Needling and moxibustion method;Efficacy specificity;Research thoughts and methodology;Data mining;Database1934|952|24更新时间：2023-08-11
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