最新刊期
卷 36 ， 期 2 ， 2011
- 摘要：Objective To observe the effect of different intensities of electroacupuncture(EA) on adipose tissue inflammatory cytokines in rats with simple obesity so as to investigate its mechanism underlying body weight reduction.Methods Forty SD male rats were randomly divided into normal,model,strong EA and weak EA groups(n=10/group).Obesity model was established by feeding the rats with high fat diet.EA(20Hz,strong EA: 5V,weak EA: 2.5V) was applied to "Zusanli"(ST36) and "Sanyinjiao"(SP6) for 15min,once everyday and for 14 days.Body weight and Lee's index(=body weight 1/3×103 /body length) were detected.The fasting blood glucose was detected by hexokinase method,serum triglyceride(TG) was detected by glycerol-phosphoric acid oxidase peroxydase(GPO-POD)method,total cholesterol(TC) was detected by cholesterol oxidase method,high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) were measured by using one-step method,respectively.The expression of monocyte chemoattractant protein-1(MCP-1) mRNA and tumor necrosis factor(TNF)-α mRNA in the epididymis adipose tissue was detected by reverse transcription-polymerase chain reaction(RT-PCR).Results In comparison with the normal group,the body weight,Lee's index,blood lipid(TG,TC,LDL-C),fasting blood glucose levels,and expression of MCP-1 mRNA and TNF-α mRNA were significantly higher in the model group(P<0.01),and HDL-C was significantly lower(P<0.01).After EA,compared with the model group,the body weight,Lee's index,TG,TC,LDL-C,fasting blood glucose levels,and expression of MCP-1mRNA and TNF-α mRNA in both strong and weak EA groups were significantly decreased(P<0.01,P<0.05),and HDL-C was significantly increased(P<0.01,P<0.05).The effects of strong EA group were obviously superior to those of weak EA group(P<0.05,P<0.01).No statistical significance was observed between the two EA groups in fasting blood glucose levels(P>0.05).Conclusion EA of "Zusanli"(ST36) and "Sanyinjiao"(SP6) has a beneficial weight-reduction effect on rats with simple obesity,and moreover,the effect of strong EA stimulation is evidently superior to weak EA stimulation.关键词：Electroacupuncture;Obesity;Adipose tissue;Inflammatory cytokines;Blood lipids;MCP-1 mRNA;TNF-α mRNA1346|600|25更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupoint-injection on the expression of Bcl-2 and Bax in the cerebral tissue around the ischemic area in cerebral ischemia-reperfusion(CI/R) rats so as to investigate its mechanism underlying improvement of cerebral infarction.Methods Forty-eight Wistar rats were randomized into sham operation(sham),model and acupoint-injection groups(n=16/group).CI/R model was duplicated by occlusion of the middle cerebral artery for 2h and reperfusion for 24h."Baihui"(GV20) and "Dazhui"(GV14) were used for injection of Fufang Danggui Zhusheye(Compound Angelica-root Injectio,1000g/mL),immediately 6h,12h and 24h after modeling.Bcl-2 and Bax immunoactivity in the cerebral tissue around the ischemic area was assayed by immunohistochemistry.Blood viscosity including high,medium and low shearing rates,erythrocyte aggregation index(AI),rigidity index(RI) and deformity index(DI) were assayed by using a full-automatic hemorheolometer.Results In comparison with the sham group,the numbers of both Bcl-2 and Bax immunoreaction(IR) positive cells in the ischemic cerebral tissue in the model group were increased significantly(P<0.05).Compared with the model group,the number of Bcl-2 IR-positive cells was increased further apparently in the acupoint-injection group(P<0.05),while that of Bax IR-positive cells in the acupoint-injection group lowered considerably(P<0.05).The ratio of Bcl-2/Bax was decreased significantly in the model group than that in the sham group(P<0.05),and increased evidently in the acupoint-injection group than in the mo-del group(P<0.05).Regarding the parameters of hemorheology,compared to the sham group,the high,medium and low shear rates,erythrocyte AI and RI were increased significantly in the model group(P<0.05),while DI was decreased significantly(P<0.05).Compared to the model group,the high,medium and low shear rates,and erythrocyte AI and RI in the acupoint-injection group were down-regulated significantly,and DI of the acupoint-injection group was up-regulated markedly(P<0.05).Conclusion Acupoint-injection of Compound Angelica-root Injectio can function in up-regulating CI/R induced increase of cerebral Bcl-2 expression and suppressing CI/R induced increase of cerebral Bax expression,blood viscosity,and erythrocyte AI and RI,and inhibiting CI/R induced decrease of erythrocyte DI in CI/R rats,which may contribute to its effects in improving cerebral ischemia by resisting neuronal apoptosis and facilitating cerebral blood circulation.关键词：Cerebral ischemic/reperfusion;Acupoint-injection;Compound Angelica-root Injectio;Cerebral Bcl-2;Bax;Bcl-2/Bax;Hemorheology1407|265|1更新时间：2023-08-11
- 摘要：Objective To explore the effect of "Xiusanzhen" [electroacupuncture(EA) of bilateral "Yingxiang"(LI20) and "Yintang"(EX-HN3)] on activities of hipppocampal muscarinic cholinergic receptor(mAChR) and the involved neural path in Alzheimer Disease(AD)rats.Methods Forty Sprague Dawley rats were randomly divided into normal control,model,olfactory nerve severing(ONS)-EA of "Xiusanzhen"(ONS-EA) and EA of "Xiusanzhen"(EA) groups.AD model was established by intra-hippocampal injection(AP:3.5mm,L:2mm,H:-2.8mm) of Aβ1-40 starch-like peptide(10 μg/2μL) under the aid of a microsyringe installed in a brain stereotaxis instrument.For rats of the ONS-EA group,the olfactory nerve was severed by using a surgical knife after drilling a hole on the skull(5mm anterior to the bregma,L,R: 2mm).The mAChR density,and its maximum binding capacity(Bmax) and dissociation constant(Kd) of the hippocampus tissue were measured by using radio-ligand binding analysis and Lowry's microamount protein assay.Results In comparison with the normal control group,the hippocampal mAChR density and its Bmax in the model group were decreased remarkably(P<0.05),while the Kd of M-receptor in the model group was increased remarkably(P<0.05).In comparison with the model group,hippocampal mAChR density and its Bmax in the EA group were up-regulated obviously(P<0.05),while the Kd of mAChR in the EA group was down-regulated significantly(P<0.05).No significant differences were found between the model and ONS-EA groups in mAChR density and its Bmax and Kd(P>0.05).Conclusion "Xiusanzhen"-EA can effectively up-regulate hippocampal mAChR density and Bmax and down-regulate Kd of M-receptor of hippocampus in AD rats,which is dependent on the intact olfactory nerve pathway.关键词：Alzheimer Disease;Xiusanzhen;Electroacupuncture;Muscarinic cholinergic receptor;Hippocampus1044|308|2更新时间：2023-08-11
- 摘要：Objective To investigate the effect of electroacupuncture(EA) of "Baihui"(GV20) and "Yongquan"(KI1) on the expression of amyloid β protein(Aβ) and low density lipoprotein(LDL) receptor-related protein 1(LRP1) in the hippo-campal sulcus microvessels in amyloid precursor protein(APP) 695V717Ⅰ transgenic mice,so as to study its mechanism underlying relief of Alzheimer Disease(AD).Methods Twelve APP 695V717Ⅰ transgenic mice were randomly divided into model group and EA group.Six C 57 BL/6 mice were used as the control group.EA(2Hz/100Hz,3-5mA) was applied to "Baihui"(GV20) and "Yongquan"(KI1) for 15min,once every other day for three months.The learning-memory ability of mice was detected by using Lashley Ⅲ water maze system.The expression level of Aβ1-42,and LRP1 in the hippocampal sulcus microvessels were measured by immunohistochemistry.Results Water maze test showed that the swimming duration from the start to the goal box(terminal) in the Lashley Ⅲ water maze was significantly longer in the model group than in the control group(P<0.05),suggesting a markedly lower learning-memory capacity of APP 695V717Ⅰ transgenic mice.Compared with the model group,the swimming duration in the EA group was decreased considerably(P<0.05).The integrated optical density(IOD) value of hippo-campal Aβ1-42 immunoreaction(IR) positive products in the model group was significantly higher than that in the control group(P<0.01) and the IOD value of hippocampal LRP 1 IR-positive products in the model group was apparently lo-wer than that in the control group(P<0.01).In comparison with the model group,the IOD value of Aβ 1-42 IR-positive products in the EA group was obviously lower than that in the model group(P<0.05),while that of LRP1 IR-positive products in the EA group was significantly higher than that in the model group(P<0.05),suggesting down-regulation of hippocampal Aβ1-42 expression and up-regulation of LRP1 expression after EA,and reduction of deposition of Aβ in the cerebral microvessels after EA.Conclusion EA can improve the learning-memory capacity of APP transgenic mice,which is closely related to its effects in up-regulating hippocampal LRP1 expression and down-regulating hippocampal Aβ1-42 expression.关键词：Alzheimer Disease;Electroacupuncture;APP transgenic mice;Hippocampal sulcus;Aβ1-42;LRP11145|420|11更新时间：2023-08-11
- 摘要：Objective To investigate the effect of oculo-acupuncture therapy(OAT) on the alteration of colonic serotonin reuptake transporter(SERT) expression in rats with irritable bowel syndrome(IBS) so as to explore its underlying mechanism in relieving IBS.Methods Thirty male Wistar rats were randomized into control,IBS model and OAT groups(n=10/group).IBS model was established by repeated stress stimulation [water-intake inhibition(24h),warm box keeping(40℃,5min),electric shock stimulation(30V,120s),forced cool water swimming(14℃,5min),24h fasting,and tail clamping(180s)] for 18 days.Oculo-acupuncture stimulation was given to "Xiajiao"(Lower Energizer),"Dachang"(Large Intestine),"Gan"(Liver) and "Pi"(Spleen) areas for 20min by using filiform acupuncture needles(manipulated 1min once every 10 min).The treatment was conducted once every 12h for 7 days.Colonic SERT mRNA and protein expression levels were examined by RT-PCR and Western Blot.Results In comparison with the control group,the expression levels of both colonic SERT mRNA and protein in the model group were down-regulated remarkably(P<0.05).Compared with the model group,the expression levels of SERT gene and protein in the OAT group were increased remarkably(P<0.05).Conclusion OAT can increase colonic SERT protein and gene expression in IBS rats,which may play a role in relieving IBS in OAT clinic.关键词：Irritable bowel syndrome;Oculo-acupuncture therapy;Colonic serotonin reuptake transporter1052|265|4更新时间：2023-08-11
- 摘要：Objective To observe the influence of moxibustion of "Shenshu"(BL 23) and "Zusanli"(ST 36) on the microstructure of synovial cells in the knee-joint in rheumatoid arthritis(RA) rats so as to study its underlying mechanism in anti-inflammatory immune effect.Methods A total of 120 Wistar rats were randomized into normal control,model,acupuncture,moxi-bustion,CO2-laser and medication groups(n=20/group).RA model was duplicated by raising the rats in a windy(electro-fan blowing),cold [(6±2)℃]and wet(80%-90%)environment for 12h/d and 20 days,followed by injecting Freund's complete adjuvant(0.15mL) into the rat's ankle.Moxibustion or acupuncture or CO2 laser(10.6μm) irradiation was applied to "Shenshu"(BL 23) and "Zusanli"(ST 36) for 20min,once daily for 15 days.Intragastric perfusion of Leigongteng(Tripterygium Wilfordii Hook.f.) was given to medication group,8 mg/kg,once daily for 15 days.The thoracic gland index [weight of the thoracic gland(mg)/ body weight(g)×100%] and spleen index [weight of the spleen(mg)/body weight(g)×100%] were calculated after killing the rats under anesthesia.The ultrastructure of synovial cells of the knee-joint was observed by using transmission electron microscopy.Results In comparison with the normal control group,the thoracic gland index in the model group was decreased significantly(P<0.01),while the spleen index of the model group increased considerably(P<0.05).In comparison with the model group,the thoracic gland indexes in the acupuncture,moxibustion,CO2-laser and medication groups were increased significantly(P<0.05,P<0.01),whereas the spleen indexes in the four groups decreased evidently(P<0.05).No significant diffe-rences were found among the acupuncture,moxibustion,CO2-laser and medication groups in up-regulating the thoracic gland index and down-regulating the spleen index(P>0.05).After modeling,the synoviocytes of the knee-joint were impaired remarkably,exhibiting incomplete cellular membrane,some prolapsed organelles,marginalized stained granules in the cellular nucleus,vague nuclear membrane,enlarged rough endoplasmic reticulum,reduction in the number of mitochondria with vacuolization degeneration and multiple lysosomes.But,the pathological changes of the ultrastructure of most synoviocytes in the acupuncture,moxibustion,CO2-laser and medication groups were relatively milder.Conclusion Moxibustion can protect the immune organs(thoracic gland and spleen) from injury and improve pathological changes of the ultrastructure of local synoviocytes in RA rats.关键词：Moxibustion;Rheumatoid arthritis;Synovial cells;Ultrastructure;Thoracic gland index;Spleen index1617|1210|20更新时间：2023-08-11
- 摘要：Objective To observe the effect of red-hot filiform needle puncturing on the pain severity of knee ostarthritis(OA) and the inflammatory cytokine levels in the knee articular cavity(KAC)fluid in senile knee OA patients so as to find a better therapy for knee OA.Methods A total of 200 senile knee OA outpatients(who signed an informed consent) were randomized into treatment group and control group(n=100/group) according to a random number table and their visiting sequence.Futu(LI 18),Neixiyan(EX-LE 4),Yanglingquan(GB 34),Yinlingquan(SP 9),Zusanli(ST 36),etc.on the affected side of the body were punctured with red-hot filiform needles(cauterized on an alcohol burner) or routine filiform needles,with the needles retained for 30 min.The treatment was conducted once every other day,15 sessions altogether.Before and after the treatment,the patients' KAC fluid was sampled for assaying the contents of IL-1,IL-6 and tumor necrosis factor(TNF)-α with enzyme-linked immunosorbent assay(ELISA).The pain severity was tested by using visual analogue scale(VAS) and the comprehensive therapeutic effect was evaluated by using clinical symptoms and signs,functional activity and pain degrees.Results In comparison with pre-treatment,IL-1,IL-6 and TNF-α contents in KAC fluid were decreased significantly in both treatment and control groups(P<0.01).The IL-1,IL-6 and TNF-α levels were considerably lower in the treatment group than in the control group following the treatment(P<0.01),suggesting a marked relief of inflammation in the affected knee joint.Compared to pre-treatment,the severity scores of illness state of both treatment and control groups were decreased remarkably(P<0.01),and the VAS score of the treatment group was significantly lower than that of the control group after the treatment(P<0.05).Of the two 100 knee OA outpatients in the treatment and control groups,29(29%) and 21(21%) were controlled in their symptoms and signs;46(46%) and 34(34%) experienced apparent improvement;18(18%) and 29(29%) were effective;7(7%) and 16(16%) failed in the treatment.The comprehensive therapeutic effect of the treatment group was significantly superior to that of the control group(P<0.01).Conclusion Red-hot filiform needle puncturing is superior to routine filiform needle puncturing in relieving senile knee OA and in reducing inflammatory cytokine levels in knee OA patients.关键词：Senile knee ostarthritis;Red-hot filiform needle puncturing;Routine filiform needle puncturing;Articular inflammatory cytokines;Randomized controlled clinical trials1151|581|4更新时间：2023-08-11
- 摘要：Objective To observe the therapeutic effect of acupuncture of Ashi points in combination with moxibustion of heat-sensitive points for neck-back myofascial pain syndrome,so as to find a better combined therapy.Methods A total of 62 eligible patients were randomly divided into treatment group(acupuncture of Ashi-points plus moxibustion of heat-sensitive points,n=32) and control group(acupuncture of Ashi-points plus TDP irradiation,n=30) by using single-blind method.Ashi-points were the tenderpoints or subcutaneous induration spots determined by digital pressure in the focus region,and the heat-sensitive points were the acupoints around the subcutaneous induration spots in the neck-back regions determined by patients' feeling(heat from the ignited moxa transmitting toward the deep muscle layer,extending toward the surrounding region of the Ashi-points,etc.and the distal part of the body) during moxibustion.Ashi-points were punctured with filiform needles and stimulated with reducing method by lifting,thrusting and twirling the acupuncture needle repeatedly till "Deqi",followed by retaining the needle for 30 min.Moxibustion was given to the patients for 10-90 min(when the patient began to feel heat penetrating into the deeper muscle layer to the termination of the heat transmission).TDP irradiation was given to the Ashi-points for 30 min in every session of treatment.The treatment was conducted once daily,5 times a week,two weeks altogether.McGill pain questionnaire containing pain rating index(PRI),visual analogue scale(VAS) and present pain intensity(PPI) and "the criteria for assessing the therapeutic effect of back-myofascitis" recorded in "Standards for Diagnosis and Efficacy Evaluation of Clinical Conditions in Chinese Medicine"(published in 1994 in China) were used to evaluate the analgesic effect.Results Before the treatment,no significant differences were found between the treatment and control groups in PRI,VAS and PPI.After the treatment,PRI,VAS and PPI were all signi-ficantly lower in the treatment group than in the control group(P<0.01).Of the 32 and 30 myofascitis patients in the treatment and control groups,11(34.4%) and 3(10.0%) were cured,20(62.5%) and 25(83.3%) experienced improvement in their symptoms,1(3.1%) and 2(6.7%) had no apparent changes.The cure rate of the treatment group was significant bigger than that of the control group(P<0.05).Conclusion Acupuncture combined with moxibustion of Ashi-points can effectively relieve pain reaction in neck-back myofascial pain syndrome patients,which is significantly superior to that of acupuncture plus TDP irradiation therapy.关键词：Neck-back myofascial pain syndrome;Heat-sensitive moxibustion;Acupuncture;TDP irradiation;Ashi-points1317|823|4更新时间：2023-08-11
- 摘要：Objective To observe heroin cue-induced changes of cerebral functional magnetic resonance images(fMRI) and the effect of acupuncture of Zusanli(ST36) on them under craving state in heroin-addicted volunteers.Methods Fourteen male volunteer heroin addicts were recruited in the present study.Brain images were acquired before,during(2min) and after visualizing heroin(placed in a transparent glass mug) and acupuncture of Zusanli(ST36) on a 1.5-T Siemens Symphony MRI system equipped with a standard head coil.Acupuncture stimulation was applied to bilateral Zusanli(ST36) by manipulating a filiform needle at a frequency of about 60 cycles/min and an angle of about 180° for 2min.The acquired neuroimaging data were analyzed by AlphaSim,AFNI.Results During heroin-visual stimulation,the markedly activated brain areas(increase of blood oxygen level-dependent signal) of fMRI were bilateral middle frontal gyrus,left cingulate gyrus,bilateral insula,occipital cortex,left cu-neus,cerebellum,bilateral thalamus,right hippocampus and right amygdala etc.which are closely related to the human's cra-ving psychological activities.When acupuncture given,meaning processing stronger sensory task,the heroin-addicted subjects showed apparent activation of the brain areas including the right anterior cingulate gyrus,right insula,thalamus,right hippocampal gyrus etc.which activation degrees were significant lower than those of heroin related visual stimulation.Conclusion Acupuncture of Zusanli(ST36) can lessen heroin cue-induced activation degree of the brain areas involving psychological craving,suggesting that acupuncture is able to suppress the heroin addiction patients' drug abuse craving.关键词：Acupuncture therapy;Heroin addiction;Heroin cue;fMRI1222|480|4更新时间：2023-08-11
- 摘要：Objective To observe the therapeutic effect of acupuncture therapy for aura-absence migraine.Methods A total of 60 aura-absence migraine outpatients who signed an informed consent participated in the present study.They were randomized into medication group and acupuncture group(n=30/group) according to a randomized number table and their visiting sequence.Patients of acupuncture group were treated by acupuncture of Ashi-point,Baihui(GV20),Taiyang(EX-HN5),Shuaigu(GB8),Fengchi(GB20),Benshen(GB13) and Lieque(LU7).The acupuncture needles were retained for 30min after "Deqi",and the treatment was conducted once daily,6 times every week and continuously for 4 weeks.Patients of the medication group were treated with oral administration of Flunarizine(10mg/time,once every night) for 4 weeks.The SF-36 Quality-of-Life Instrument(SF-36) and integral scores of headache were measured before and after the treatment.Results In comparison with the pre-treatment,scores of physical functioning(PF),role-physical(RP),bodily pain(BP),social functioning(SF),role-emotional(RE),vitality(VT),mental-health(MH) and general health(GH) of SF-36 in both medication and acupuncture groups were increased significantly(P<0.05),and those of PF,RP and BP of the acupuncture group were significantly higher than the scores of the medication group(P<0.05).The integral scores of headache were decreased significantly in both medication group and acupuncture group(P<0.05),and those of the acupuncture group were remarkably lower than the scores of the medication group after the treatment(P<0.05).Of the two 30 migraine patients in the medication and acupuncture groups,1(3.33%) and 9(30.00%) were cured,1(3.33%) and 2(6.67%) had a marked improvement in their symptoms,9(30.00%) and 8(26.67%) were effective,19(63.33%) and 11(36.67%) were ineffective,with the total effective rates being 36.67% and 63.33%,respectively.The cure rate and the total effective rate of the acupuncture group were significantly higher than those of the medication group(P<0.05).Conclusion Acupuncture therapy can raise the migraineurs' life quality,lessen the times and severity of headache attack,and its therapeutic effect is superior to that of medication.关键词：Migraine;Acupuncture;SF-36;Integrative score of headache985|1029|6更新时间：2023-08-11
- 摘要：Objective To observe differences of cutaneous temperature of the 12 Jing-well points regions of the yin-meridians and yang-meridians,and on the upper and lower limbs so as to provide a reference for clinical diagnosis.Methods A total of 26 healthy young volunteers(15 men and 11 women,23 to 31 years in age) participated in the present study.The skin temperature of the 12 Jing-well points [Shaoshang(LU11),Sahngyang(LI1),Yinbai(SP1),Lidui(ST45),Shaochong(HT9),Shaoze(SI1),Yongquan(KI1),Zhiyin(BL67),Zhongchong(PC9),Guanchong(SJ1),Dadun(LR1) and Qiaoyin(GB44) ] at night(19:00-21:00) was detected under a room temperature of(20±2)℃ and humidity of 65%-75% by using an infrared thermometer.Results Comparison between the single Jing-well point of the yin-meridians and that of the yang-meridians showed that only the cutaneous temperature of Zhiyin(BL67) was significantly lower than that of Yongquan(KI1,P<0.05).No significant differences were found between Shaoshang(LU11) and Shangyang(LI1),Yinbai(SP1) and Lidui(ST45),Shaochong(HT9) and Shaoze(SI1),Zhongchong(PC9) and Guanchong(SJ1),and between Dadun(LR1) and Qiaoyin(GB44) in the skin temperature(P>0.05).Comparison between the 6 Jing-well points of the 6 yin-meridians group and those of the 6 yang-meridians group showed that the average skin temperature of the latter was significantly lower than that of the former(P<0.01).The average skin temperature was significantly lower at the 3 Jing-well points of the 3 yin-meridians of foot than that at the 3 Jing-well points of the 3 yin-meridians of hand(P<0.01).Such is the case at the 3 Jing-well points of the 3 yang-meri-dians of foot in comparison with the 3 yang-meridians of hand(P<0.01).The average skin temperature of the 6 Jing-well points of the right yang-meridians was significantly higher than that of the 6 Jing-well points of the left yang-meridians(P<0.01).No significant differences were found between the left yin-meridians and right yin-meridians in skin temperature(P>0.05).Conclusion The average skin temperature values of the Jing-well points are evidently higher at the 6 yin-meridians than at the 6 yang-meridians,obviously higher on the upper limbs than on the lower limbs,and apparently higher on the right meridians than on the left meridians in healthy volunteers.关键词：Twelve Jing-well points;Skin temperature;yin-and yang-meridians;Upper and lower limbs;Left and right meridians937|426|4更新时间：2023-08-11
- 摘要：Objective To assess the effect and methodological quality of clinically randomized controlled studies on abdominal acupuncture therapy for cervical spondylosis and to make out its current situation,validity and applicability.Methods Using the PubMed,CNKI(China Academic Journals Full-text Database),VIP(VIP Chinese Science and Technology Periodicals Database) and Wanfang Digital Periodicals Electronic Database covering the period of 1989-2009,we did a literature search on the original articles of abdominal acupuncture treatment of cervical spondylosis and selected those accorded with the standards of randomized controlled studies.Animal studies,surveys,and news articles,and those duplicated,being absent in diagnostic criteria and non-randomized controlled trials were excluded.The papers' quality was analyzed by using the Jadad quality assessment scoring system and the therapeutic effect evaluated by using Review Manage 4.2.7 software.Results A total of 8 papers containing 909 cervical spondylosis patients and written in Chinese were included.These 8 studies used the effective rate as the primary outcome,2 of them used the McGill Pain Questionnaire scales at the same time.Meta-analysis showed that the abdominal acupuncture group was better than the control group in visual analogue scale score(P<0.05).No significant differences were found between abdominal acupuncture and routine acupuncture [OR=3.29,95% CI(0.13,82.99)],EA [OR=2.09,95% CI(0.36,11.95)] and traction therapy [OR=6.06,95% CI(3.01,12.18)] in the total effective rate,pain rating index score [WMD=-2.24,95% CI(-5.29,0.81)]and the present pain intensity score[WMD=-0.84,95% CI(-2.13,0.44)].Conclusion At the present,there has been no sufficient evidence to ensure that in the treatment of cervical spondylosis,the abdominal acupuncture therapy is superior to routine acupuncture,EA and traction therapy.Attention should be paid to the randomized controlled study of larger samples and qualified design.关键词：Abdominal acupuncture;Cervical spondylosis;Randomized controlled clinical trials;Systematic reviews1389|929|1更新时间：2023-08-11
- 摘要：In the present paper,the authors review the progress of researches on the mechanism of acupuncture therapy underlying improvement of acute cerebral hemorrhage from experimental studies and research methods.The effects of acupuncture intervention mainly involve 1) lessening inflammatory reactions,2) reducing impairment of free radicals and excitatory amino acids on cerebral neurons,3) balancing release of vascular bioactive substances to increase regional cerebral blood flow,and 4) promoting repair and regeneration of the neural tissue,etc.In regard to the research methods,many new biological techniques such as biological molecular approaches,neuro-cellular chemical methods,reverse transcription-polymerase chain reaction(RT-PCR) or quantitative real time-PCR,situ hybridization,western blotting,electron microscope,etc.,have been extensively applied to researches on the underlying mechanism of acupuncture therapy for cerebral infarction.In addition,the authors also pointed out that in spite of achieving some bigger progresses in experimental studies,most of the results basically reflect static,isolated and regional changes rather than dynamic and whole body changes.For this reason,more vivo research techniques and noninvasive research methods are highly recommended to be used in the future research on the underlying mechanisms of acupuncture therapy for acute cerebral ischemia.关键词：Acupuncture therapy;Cerebral hemorrhage;Research mechanism;Review1241|566|2更新时间：2023-08-11
- 摘要：In order to elucidate the underlying mechanism of acupuncture in regulating different physiological functional activities at cellular level,abundant researches have been conducted on cellular signal transduction activities.The present article preliminarily analyzes acupuncture stimulation induced various cellular signaling pathways from the afferent physical signals of the regional mechanical stimulation at the acupoint,activation of receptors of the cellular membrane such as Guanine nucleotide bin-ding protein coupled receptors,etc.,intracellular second messenger molecules including cAMP,Ca2+,inositol triphosphate,diacyl glycerol,etc.,signal transduction pathways as mitogen-activated protein kinase,Janus kinase-signal transduction and transcription activator,nitrogen oxide-cyclic guanylic acid,etc.,to the extremely complicated cellular signal transduction networks.In addition,the present paper also makes a discussion on the present developing situation of acupuncture research.It is possible that the connective tissue of the body surface will become a key point in the future research on acupuncture remedy.More attention should be paid to the interrelation among various intracellular signaling pathways and the network of cellular signal transduction in the research on acupuncture therapy for regulating a variety of physiological effects.关键词：Acupuncture;Connective tissue;Cellular signal transduction;Efficacy mechanism;Cellular signaling network1133|697|5更新时间：2023-08-11
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