最新刊期
卷 36 ， 期 3 ， 2011
- 摘要：Objective To observe the effect of plasma derived from healthy volunteers undergoing moxibustion(moxibustion plasma) on alchol-injured human gastric epithelial GES-1 cells in vitro,and expression of heat shock protein 70(HSP 70,cell apoptosis inhibitory protein),apoptosis inducing factor(AIF),Smac(a mitochondrial protein),and Caspase 3 and Caspase 9(the latter 3 proteins are also involved in cell apoptosis) in order to study its mechanisms underlying protecting gastric mucous membrane.Methods Twenty-four healthy volunteer subjects(half men and half women) were randomized into acupoint-moximustion(A-M) [Zhongwan(CV 12),Guanyuan(CV 4) and Zusanli(ST 36)] group and non-acupoint-moxibustion(NA-M,3 cun right to CV 12 and CV 4,1 cun medial to ST 36) group(n=12/group).Moxibustion was applied to the above-mentioned 3 acupoints and non-acupoints for 30 min,once daily for 10 days.Venous blood of the subjects was collected before and after moxibustion.The cultured GES-1 cells were divided into: control group,ethanol-injury group(model),A-M plasma group(A-M-P,plasma got from volunteers undergoing A-M),and NA-M plasma group(NA-M-P,plasma got from volunteers accepting NA-M).The GES-1 cells of the latter 3 groups were treated with 8% ethanol for duplicating cell injury model.Apoptosis was detected by flowcytometry.Expression of HSP 70,second mitochondria-derived activator of Caspase(Smac) and AIF proteins of GES-1 cells were assayed by western blotting,and the immunoactivity of cysteinyl aspirate-specific proteinase-3 and 9(Caspase-3,9)was detected by immunocytochemistry.Results In comparison with the control group,the apoptosis rate,the expression of HSP 70,Smac and AIF proteins,and the immunoactivity of Caspase-3 and Caspase-9 of the model group were increased significantly(P<0.01).Compared with the model group,the apoptosis rate of GES-1 cells,the expression of Smac and AIF proteins,and the immunoactivity of Caspase-3 and Caspase-9 in the A-M-P group,the apoptosis rate,the expression of Smac and the immunoactivity of Caspase-3 and Caspase-9 in the NA-M-P group were all down-regulated considerably(P<0.05,P<0.01).In comparison with the model group,HSP 70 expression of the A-M-P group was up-regulated significantly(P<0.01).The apoptosis rate of GES-1 cells,the expression levels of Smac,AIF,Caspase-3 and Caspase-9 were significantly lower in the A-M-P group than in the NA-M-P group(P<0.05,P<0.01),while the expression of HSP 70 was apparently higher in the A-M-P group than in the NA-M-P group(P<0.01).Conclusion Plasma derived from the subjects undergoing moxibustion of Zusanli(ST 36),Zhongwan(CV 12) and Guanyuan(CV 4) can inhibit apoptosis of GES-1 cells in vitro,which is closely related to its effects in up-regulating intracellular HSP 70 expression and down-regulating mitochondrial apoptosis protein expression of AIF,Smac,Caspase-3 and Caspase-9.关键词：Moxibustion plasma;Human gastric epithelial GSE-1 cell;Apoptosis;HSP 70;Smac;AIF;Caspase-3,-91187|457|2更新时间：2023-08-11
- 摘要：Objective To observe the effect of combined administration of intragastric perfusion of extract of Hypericum Perforatum L(HP-L) and electroacupuncture(EA) of "Baihui"(GV 20) and "Yamen"(GV 15) on behavior and brain microcirculation in depression rats.Methods Female SD rats were randomized into control,model,lower-dose of HP-L(lower-dose in short,10 mg/kg),lower-dose+EA,higher-dose(20 mg/kg) and higher-dose+EA groups(n=10/group).Depression model was established by lonely raising and chronic unpredictable mild stress(tail cramping,water-deprivation,fasting,electrical shock stimulation,etc.) for 21 days.EA(2 Hz,1 mA) was applied to "Baihui"(GV 20) and "Yamen"(GV 15) for 20 min,once daily for 14 days.Changes of ethology including glucose-consumption during 1 h,crossing and rearing scores of open-field test during 3 min(for assessing the rats' locomoto)and laser Doppler flowmetry values of cortical regional cerebral bloodflow(r CBF) were detected,and Morris water maze test(for assessing the rats' learning-memory ability) was conducted.Results In comparison with the control group,the sucrose consumption,crossing and rearing scores of open-field test,the average swimming velocity(ASV),the ratios of path length and swimming duration near the hidden-platform and the path length and swimming duration far from the platform of Morris water maze test during 70 seconds,and the cortical r CBF value in the model group were decreased significantly(P<0.01),while the total swimming distance and escape latency in the model group increased apparently(P<0.01).Compared to the model group,the average sucrose consumption,crossing and rearing scores of open-field test,the ASV,and the ratios of path length and swimming duration near the platform and those far from the platform in the lower-dose,lower-dose+EA,higher-dose and higher-dose+EA groups,and the cortical r CBF in the lower-dose+EA and higher-dose+EA groups were increased considerably(P<0.05,P<0.01).The total swimming distances and escape latencies of lower-dose,lower-dose+EA,higher-dose and higher-dose+EA groups were significantly shortened in comparison with the model group(P<0.05,P<0.01).The sucrose consumption and crossing score were significantly higher in the higher-dose+EA group than in the lower-dose group(P<0.05).The escape latency was significantly shorter in the higher-dose+EA group than in the lower-dose group(P<0.05).No significant differences were found among the lower-dose,lower-dose+EA and higher-dose groups in the sucrose consumption,crossing score and escape latency;among the lower-dose,lower-dose+EA,higher-dose and higher-dose+EA groups in the rearing score and ASV;among the lower-dose,higher-dose and model groups in the cortical r CBF(P>0.05).Conclusion EA can enhance the effect of extract of HP-L in increasing sucrose consumption,crossing score and cerebral blood flow,and in shortening escape latency in depression rats,which may contribute to their effect in improving depression.But HP-L itself has no effect on cortical microcirculation.关键词：Electroacupuncture;Depression;Hypericum Perforatum L;Behavior;Cortical microcirculation1257|377|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) of "Tianshu"(ST 25) on colonic smooth muscle structure and interstitial cells of Cajal(ICC) in slow transit constipation(STC) rats,so as to investigate its mechanism underlying improving STC.Methods Wistar rats(n=56) were randomly allocated to control(n=20),model and EA groups(n=18/group).STC model was established by feeding the rats with forage containing compound Diphenoxylate.EA(0.8-1.3 mA,2 Hz/15 Hz) was applied to bilateral "Tianshu"(ST 25) for 15 min,once daily for 14 days.The treatment was given beginning from the next day on after the rat's first black stool excretion was found.The colonic smooth muscle structure was observed under microscope after sectioning and HE staining.The immunoactivity(average optical density,OD) of intestinal immuno-reaction(IR) po-sitive ICC product was detected by immunohistochemistry.Results ①Microscopic observation displayed that after mode-ling,the rat's intestinal mucosa gland showed atrophy with reduction in the acinar number,being sparse in distribution;and the smooth muscle thickness was obviously thinner compared with the normal control group(P<0.05).Whereas this situation of the colonic smooth muscle in the EA group was close to that of the normal control group.Compared with the model group,the thickness of the intestinal smooth muscle in the EA group was significantly bigger(P<0.05).②Immunohistochemical results showed that the average OD values and number of IR-positive colonic ICC in the model group were obviously decreased in comparison with the normal control group(P<0.05).Compared with the model group,the average OD values and the number of IR-positive colonic ICC in the EA group were upregulated considerably(P<0.05).Conclusion EA of bilateral "Tianshu"(ST 25) is able to improve STC-induced structural changes of the colonic smooth muscle,and upregulate expression of colonic ICC in STC rats,which may be responsible for its efficacy in improving STC.关键词：Electroacupuncture;Tianshu(ST 25);Slow transit constipation;Colonic smooth muscle structure;Interstitial cells of Cajal1765|1342|15更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupuncture on colonic stem cell factor(SCF)-receptor tyrosine kinase(Kit,a transmembrane protein c-kit) system in colocolic anastomosis rats so as to explore its underlying mechanism in regulating intestinal motility after enteroenterostomy.Methods Thirty SD rats were randomized into control,model(colocolic anastomosis) and acupuncture groups(n=10/group).Acupuncture was applied to bilateral "Zusanli"(ST 36),"Sanyinjiao"(SP 6) and "Taichong"(LR 3),once a day for 3 days.The fecal-excretion time and the propulsive rate of the small intestine were measured.The immunoactivity of c-kit immunoreaction positive products in the colon tissue 2 cm below the caecum was detected using immunohistochemistry and the expression of SCF mRNA detected using real time-polymerase chain reaction(RT-PCR) method.Results Following colocolic anastomosis,the intestinal propulsive rate in the model group was decreased considerably in comparison with the control group(P<0.01).Compared with the model group,the first fecal-excretion time and the intestinal propulsive rate were improved significantly in the acupuncture group(P<0.05).In comparison with the control group,the immunoacti-vity of c-kit and the expression of SCF mRNA in colon tissue were down-regulated obviously in the model group(P<0.05,P<0.01),while in comparison with the model group,the expression levels of c-kit and SCF mRNA were increased in the acupuncture group significantly(P<0.05).Conclusion Acupuncture can suppress enteroenterostomy-induced down-regulation of the expression of c-kit protein and SCF mRNA in colocolic anastomosis rats,which may contribute to its effect in regulating the intestinal motility after enteroenterostomy.关键词：Colocolic anastomosis;Acupuncture;Intestinal propulsive rate;c-kit protein;SCF mRNA1027|162|3更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupuncture of "Zusanli"(ST 36) on immune function in progressively exhausted swimming rats so as to reveal its mechanism underlying improvement of strenuous exercise.Methods Thirty-two SD rats were randomly allocated into control group,strenuous exercise(model) group,acupuncture-Xuehai(SP 10) group,Acupuncture-Zusanli(ST 36) group(n=8/group).The rats were forced to have a swimming in a water tank for 15-90 min in the first 8 days(once daily),then,a progressively exhausted load swimming 1-3 times everyday from day 9 to 13.Bilateral SP 10 and ST 36 were punctured with filiform needles and stimulated with uniform reinforcing and reducing manipulation,once daily,after termination of the swimming and for 13 days.Serum interferon-gamma(IFN-γ) and interleukin-4(IL-4) contents were assayed by using enzyme linked immunosorbent assay.The rat's body weight and the spleen weight were weighted by using an electronic balance for calculating the spleen index(spleen weight /body weight ×100%) after killing the rat under deep anesthesia.Results Compared with the model group,the time of swimming-induced exhaustion appearing at the first time from day 9 to day 13 in the SP 10 and ST 36 groups was apparently lengthened(P<0.01).No significant difference was found between SP 10 and ST 36 groups in the time of swimming-induced exhaustion appearing at the first time of the forced swimming.Compared with the control group,the spleen index,serum IFN-γ contents and IFN-γ/IL-4 in the model group were decreased significantly(P<0.01,P<0.05).In comparison with the model group,the serum IL-4 contents in the SP 10 and ST 36 groups were decreased markedly(P<0.05,P<0.01),and serum IFN-γ content and IFN-γ/IL-4 in the ST 36 group were increased significantly(P<0.05,P<0.01).The IFN-γ level was significantly higher in the ST 36 group than in the SP 10 group(P<0.05).No significant diffe-rences were found between SP 10 and ST 36 groups in the spleen index,IL-4 and IFN-γ/IL-4(P>0.05).Conclusion Acupuncture at "Zusanli"(ST 36) can lengthen the time of forced swimming-induced exhaustion,and upregulate serum IFN-γ content and IFN-γ/IL-4 in exhausted swimming rats,which may contribute to its effect in correcting Th 1/Th 2 imbalance after strenuous exercise.The effect of acupuncture of ST 36 is superior to that of acupuncture of SP 10.关键词：Acupuncture;Strenuous exercise;Serum IFN-γ;IL-4;IFN-γ/IL-41168|262|2更新时间：2023-08-11
- 摘要：Objective To evaluate the effect of electroacupuncture(EA) of the auricular concha(EA-AC) on serum cytokines contents and pulmonary transcription factor nuclear factor-κB(NF-κB) expression in lipopolysaccharide(LPS) induced endotoxaemia rats so as to study its mechanism underlying cholinergic anti-inflammatory efficacy.Methods Male SD rats were randomized into normal control,model(LPS),simple EA-AC,EA-AC+LPS,vagal nerve stimulation(VNS)+LPS,and EA-Zusanli(ST 36)+LPS groups(n=12/group).Endotoxaemia model was duplicated by intravenous(tail vein) injection of LPS(0.5 mL/kg).Two intradermal needles were inserted into the central sites of the cavity of concha and cymba of auricular concha respectively on each side and stimulated electrically by using an electrical stimulator(i.e.,EA-AC).VNS was applied to the left cervical vagal nerve,and EA(1 mA,10 Hz,pulse-width 1 ms) was also applied to bilateral "Zusanli"(ST 36).Serum cytokines(TNF-α,IL-6) contents 2 h after modeling were determined by using enzyme linked immunosorbent assay(ELISA),and pulmonary NF-κB p 65 expression 2 h after modeling was detected by using western blotting.Results Compared with the normal control group,serum TNF-α and IL-6 contents,and pulmonary NF-κB p 65 expression level in the model group were increased significantly(P<0.01).In comparison with the model group,serum TNF-α contents in the simple EA-AC,EA-AC+LPS,VNS+LPS and ST 36+LPS groups,and serum IL-6 contents and pulmonary NF-κB p 65 expression levels in the simple EA-AC,EA-AC+LPS and VNS+LPS groups were down-regulated considerably(P<0.05,P<0.01).Compared with the VNS+LPS group,serum TNF-α and IL-6 contents,and pulmonary NF-κB p 65 expression level in the ST 36+LPS group were increased significantly(P<0.05,P<0.01).In comparison with the EA-AC+LPS group,pulmonary NF-κB p 65 expression level in the ST 36+LPS group was increased remarkably(P<0.05).Conclusion Both EA of auricular concha and vagus nerve stimulation can significantly lower serum TNF-α and IL-6 contents,and down-regulate pulmonary NF-κB p 65 expression level in endotoxaemia rats,suggesting a similar cholinergic anti-inflammatory mechanism between them.关键词：EA of auricular concha;Vagus nerve stimulation;Endotoxaemia;Inflammatory cytokines;Pulmonary NF-κB p 65 expression1615|483|12更新时间：2023-08-11
- 摘要：Objective To observe the effect of scalp-acupuncture on the expression of matrix metalloproteinase 9(MMP-9) in the endothelium of the microvessels in the hippocampal CA 3 area in local cerebral ischemia(CI) rats,so as to study its underlying mechanism in improving CI. Methods Eighty male Wistar rats were randomized into normal control(n=8),sham-operation(n=8),CI model(n=32),and scalp-acupuncture(n=32) groups.The later two groups were further equally and respectively divided into 1,3,5 and 10 d subgroups.CI model was established by occlusion of the middle cerebral artery(MCAO)."Baihui"(GV 20) and "Qubin"(GB 7) were punctured with filiform needles and stimulated by twirling the needle at a frequency of about 200 revolutions/min for 1 min.The needles were retained for 30 min and re-manipulated once again every 10 min.The treatment was given once daily,continuously for 1,3,5 and 10 days respectively in different subgroups.MMP-9 immunoactivity of hippocampal CA 3 area was assayed by immunohistochemistry(SABC). Results Following CI,the CI rats' neural deficit scores in the model and scalp-acupuncture(treatment) groups had no apparent difference(P>0.05).After acupuncture,the neural deficit score in the treatment group decreased gradually,and was significantly lower than that in the 10 d subgroup of model group(P<0.05).Compared with the 1,3,5 and 10 d subgroups of control group,the total area and integral optical density(IOD) values of MMP-9 immunoactivity of hippocampal CA 3 area were all increased significantly in the corresponding 4 subgroups of model group(P<0.01).Compared with the 3,5 and 10 d subgroups of the model group,the total area and IOD values of MMP-9 immunoreaction positive products in the corresponding 3 subgroups of scalp-acupuncture group were decreased significantly(P<0.05,P<0.01).Conclusion Scalp-acupuncture can effectively down-regulate MMP-9 expression in the hippocampal CA 3 area in focal cerebral ischemia rats,which may contribute to its effect in improving the neural deficit.关键词：Cerebral ischemia;Scalp acupuncture therapy;Matrix metalloproteinase-9;Neural deficit score1411|316|3更新时间：2023-08-11
- 摘要：Objective To study the morphologic structure,afferent projections of "Neiguan"(PC 6),"Hegu"(LI 4) and "Futu"(LI 18) acupoint regions so as to understand their underlying mechanisms in acupuncture anesthesia for thyroid surgery.Methods A total of 66 Wistar rats were used in the present study.① Horseradish peroxidase(HRP,10%,10 μL) was injected into PC 6,LI 4 and LI 18 acupoints and the thyroid area on the right side,respectively(n=6).② Propidium iodide(PI,10%,10 μL) or Bisbenzimide(Bb,5%,10 μL) was injected into above-mentioned 3 acupoints and the thyroid region on the right side,respectively(n=6).The numbers and percentages of the labeled neurons in the dorsal root ganglia(DRGs,C 1-C 8 and T 1) were observed under microscope.③ Cutaneous connexin(Cx) 43 immunoactivity of LI 18,PC 6,LI 4 and "Zusanli"(ST 36) regions and their individual non-acupoint regions(about 0.5 cm lateral to LI 18,PC 6,LI 4,and ST 36,n=12) was determined by immunohistochemistry.Results 1)HRP-labeled neurons after injection of HRP into LI 18 were found in DRGs of C 1-C 5,predominantly C 2-C 4,those from LI 4 found in DRGs of C 3-C 8,mainly C 5-C 7,those from PC 6 found in DRGs of C 3-T 1,chiefly C 5-C 8,and those from the thyroid region found in C 1-C 6,predominantly C 2-C 5,suggesting an overlap or convergence of afferent projections from the 3 acupoints and the thyroid regions being in C 3-C 5.2) After injection of PI into LI 18,LI 4 and PC 6,and Bb into the thyroid region,the percentages of PI-and Bb-labeled neurons in DRGs of C 1-C 8 and T 1 were from 46.4% to 50.0% and the percentages of the double labeled neurons were 3.8% in the LI 18-thyroid group,3.1% in the LI 4-thyroid group and 3.6% in the PC 6-thyroid group,respectively,suggesting a bifurcate innervation of DRG neurons between these acupoints and the thyroid region.3) In comparison with the individual non-acupuncture and non-acupoint subgroups,the immunoactivity of cutaneous Cx 43 in the LI 18,LI 4,PC 6,and ST 36 subgroups was upregulated considerably after acupuncture stimulation(P<0.05).Conclusion Neurons of DRGs of C 1-C 8 and T 1 innervating "Futu"(LI 18),"Hegu"(LI 4) and "Neiguan"(PC 6) and the thyroid gland have an overlap or convergence in DRGs of C 3-C 5 and a bifurcate innervation.Acupuncture stimulation may upregulate cutaneous Cx 43 expression in the acupoint regions.关键词：Acupoints;Convergence between acupoint and thyroid gland;Cutaneous connexin 43;Futu(LI 18);Neiguan(PC 6);Hegu(LI 4)1318|417|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) of "Shenmen"(HT 7),"Neiguan"(PC 6),etc.on monoamine neurotransmitter contents of hypothalamic paraventricular nucleus(PVN) region in myocardial ischemia(MI) rats,so as to analyze the substantial basis of efficacy specificity of acupoints in improving MI.Methods SD rats were rando-mized into normal control,model,EA-Shenmen(HT 7),EA-Neiguan(PC 6) and EA-Taiyuan(LU 9) groups(n=10/group).MI model was duplicated by occlusion of the anterior descending branch of the left coronary artery.EA(2 Hz,1.1 mA) was applied to left "Shenmen"(HT 7),"Neiguan"(PC 6) and "Taiyuan"(LU 9) for 10 min,once daily for 3 days.The hypothalamic PVN region tissue was collected for assaying the contents of norepinephrine(NE),dopamine(DA) and serotonin(5-HT) by using enzyme linked immunosorbent assay.Results In comparison with the normal control group,the contents of NE,DA and 5-HT in hypothalamic PVN in the model group were decreased significantly(P<0.01).Compared with the model group,the contents of NE,DA and 5-HT in hypothalamic PVN in the EA-Neiguan(PC 6) and EA-Shenmen(HT 7) groups,and that of NE in the EA-Taiyuan(LU 9) group were increased significantly(P<0.01,P<0.05).The effects of EA-Neiguan(PC 6) and EA-Shenmen(HT 7) were significantly superior to that of EA-Taiyuan(LU 9)in increasing the contents of hypothalamic NE,DA and 5-HT(P<0.05,P<0.01).Conclusion Electroacupuncture of PC 6 and HT 7 can suppress MI-induced decrease of NE,DA and 5-HT contents in the hypothalamic PVN region in rats,which may contribute to its effect in resisting myocardial ischemia.The effects of EA-PC 6 and EA-HT 7 are superior to those of EA-LU 9.关键词：Electroacupuncture;Hypothalamic PVN;Monoamine neurotransmitters;Relative specificity of acupoint1385|475|9更新时间：2023-08-11
- 摘要：Objective To assess the therapeutic effect of Jin's "Sanzhen" therapy combined with rehabilitation training on limb-motor function of stroke patients by using Fugl-Meyer scale.Methods A total of 254 hemiplegic stroke outpatients and inpatients from 7 hospitals were randomly divided into Jin's "Sanzhen"(JSZ) group(n=83),rehabilitation group(n=84) and combination group(n=87).Acupuncture was applied to acupoints of Jin's "Sanzhen" including Quchi(LI 11),Waiguan(SJ 5) and Hegu(LI 4);Futu(ST 32),Zusanli(ST 36) and Sanyinjiao(SP 6);etc.The acupuncture needles were retained for 30 min after "Deqi".Rehabilitation training included passive joint movement,standing-sitting training,tapping-pressing stimulation,walking training,etc.The treatment was conducted once daily,5 sessions a week and for 4 weeks.Fugl-Meyer scale composed of 100-point motor domain of the upper-and lower-extremity sections was used to assess the patients' motor function.Results On day 28 after the treatment,of the 83,84 and 87 hemiplegic stroke patients in the JSZ,rehabilitation and combination groups,48(57.8%),31(36.9%) and 50(57.5%) experienced marked improvement in their clinical symptoms and signs,26(31.3%),44(52.4%) and 31(35.6%) had an improvement,and 9(10.8%),9(10.7%) and 6(6.9%) failed in the treatment,with the total effective rates being 89.2%,89.3% and 93.1%,respectively.The neurological deficit score(NDS) of the combination group was significantly lower than that of the rehabilitation group(P<0.05).The Fugl-Meyer assessment score(FMAS) for extremity motor function of the combination group was apparently higher than those of the JSZ and rehabilitation groups(P<0.05).No significant differences were found between the JSZ and rehabilitation groups in both NDS and FMAS(P>0.05).Conclusion Jin's "Sanzhen" therapy combined with rehabilitation training can significantly improve the limb motor function of hemiplegic stroke patients,and has a good synergistic effect.关键词：Apoplectic hemiplegia;Jin's "Sanzhen" therapy;Rehabilitation training;Combined treatment1259|570|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupuncture of the body surface projection region of the pyramidal decussationes on spastic cerebral palsy(CP) so as to explore an effective therapy for it.Methods A total of 120 CP infant patients were randomized into control group(treated with modern rehabilitation training,n=60)and acupuncture group(treated with acupuncture combined with modern rehabilitation training,n=60).Four acupuncture needles were penetrated subcutaneously through the region between Yuzhen(BL 9)and Tianzhu(BL 10)equidistantly(the superficial projection region of the pyramidal decussationes),once daily for 3 months.The modified Ashworth rating,gross motor function measure(GMFM)-88 scores and synthetic function scale were adopted to assess the therapeutic effect after the treatment.Results After the treatment,of the 59 and 58 CP children in the control and acupuncture groups,17(28.81%) and 26(44.83%) experienced marked improvement in their symptoms,33(55.84%) and 27(46.55%) had an improvement,9(15.25%) and 5(8.62%) failed in the treatment,with the total effective rates being 84.75% and 91.38%,respectively.The effective rate of the acupuncture group was significantly superior to that of the control group(P<0.05).The scores of modified Ashworth rating and GMFM-88 of the control group were significantly lower than those of the acupuncture group after the treatment(P<0.05).Conclusion Acupuncture combined with modern rehabilitation training is effective in the treatment of CP children patients.关键词：Spastic cerebral palsy;Acupuncture;Projection region of the pyramidal decussationes;Randomized controlled clinical trials;Limb motor function1007|496|6更新时间：2023-08-11
- 摘要：Objective To Investigate the clinical efficacy of electroacupuncture(EA) at different frequencies for patients with impaired glucose tolerance(IGT).Methods A total of 120 IGT outpatients were randomly divided into control,EA-5 Hz,EA-50 Hz,and EA-100 Hz groups(n=30/group).EA(1 mA) was applied to bilateral Pishu(BL 20),Shenshu(BL 23),Zusanli(ST 36) and Sanyinjiao(SP 6) for 20 min,once daily for 60 sessions.Body mass index(BMI),fasting blood glucose(FBG) and 2-hour post-prandial blood glucose(2 h PBG) contents were detected by using BAYER Blood Sugar Analyzer and glycosylated haemoglobin(HbA1c) content was detected by enzymatic assay.Results Following the treatment,both HbA1c and 2 h PBG levels in the EA-5 Hz group were significantly lower than those of the control group and those of pre-treatment in the same one group(P<0.05,P<0.01).No significant differences were found between the EA-5 Hz and control groups,between pre-treatment and post-treatment in the EA-5 Hz group in BMI and FBG levels;between the EA-50 Hz and control groups,between the EA-100 Hz and control groups,and between pre-treatment and post-treatment in the EA-50 Hz and EA-100 Hz groups in BMI,FBG,2 h PBG and HbA1c levels(P>0.05).Conclusion Lower frequency EA of BL 20,BL 23,ST 36 and SP 9 can reduce HbA1c and 2 h PBG levels in IGT patients,suggesting a helpful effect of EA in controlling the development of diabetes.关键词：Impaired glucose tolerance;Electroacupuncture;Low frequency EA;Blood sugar;Glycosylated haemoglobin971|329|2更新时间：2023-08-11
- 摘要：Digitalis glycosides,a group of cardiotonic agents for heart failure,have been used for a long time,but may often trigger arrhythmias as a result of digitalis intoxication.It is of great significance in finding a method to reduce their toxicity and improve clinical curative effects simultaneously in the application of digitalis glycosides.It has been well documented that acupuncture has good therapeutic effects in improving cardiac function and inhibiting arrhythmia induced by myocardial ischemia.Acupuncture combined with chemotherapeutics can reduce the adverse effects of chemotherapeutics.Accordingly,acupuncture combined with digitalis is likely to reduce the side effects of digitalis by regulating intracellular Ca2+,improving the function of Ca2+-ATPase in the sarcoplasmic reticulum,increasing calcium sensitivity of cardiac troponin,etc.These considerations may provide a novel clue for treatment of heart failure by joint administration of acupuncture and drugs.关键词：Acupuncture combined with drugs;Digitalis;Heart failure;Efficacy-enhancement and toxicity-attenuation1342|635|2更新时间：2023-08-11
- 摘要：Objective To evaluate the clinical effect of acupuncture therapy for fibromyalgia syndrome(FMS) by analyzing the available studies so as to provide clinical decision-making reference.Methods The published papers on clinical trails for acupuncture treatment of FMS were widely retrieved from Chinese Biomedical Databases(1979-2010),www.cnki.net(1979-2010),VIP China Scientific Journal Database(1989-2010),Digital Periodicals on Wanfang Data(1998-2010),PubMed(1966-2010),etc.and by using关键词：Acupuncture;Fibromyalgia syndrome;Clinical evidence;Evidence-based medicine1505|849|3更新时间：2023-08-11
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