最新刊期
卷 36 ， 期 5 ， 2011
- 摘要：Objective To observe the effect of regional thermal(moxibustion-like) stimulation on discharges of neurons in the medullary subnucleus reticularis dorsalis(SRD) and to study the best thermal stimulation parameters in the rat.Methods Experiments were performed on 15 male Sprague-Dawley rats under anesthesia(10% urethane,1.0-1.5 g/kg).Unit discharges of single neurons in the medullary SRD were recorded extracellularly with glass micropipettes.Thermal stimulation(warm water filled in a glass bottle) with different temperature(40 ℃,42 ℃,44 ℃,46 ℃,48 ℃,50 ℃,52 ℃) and covering different area(diameter: 1.0 cm,1.5 cm,2.0 cm,2.5 cm,3.0 cm,3.5 cm,4.0 cm) was applied to "Zhongwan"(CV 12) region for 30 s.Firing rates of SRD neurons were analyzed by using Power-Lab Chart 5.0.Results When thermal stimulation with temperature of 40 ℃ and 42 ℃ and the stimulated area of 1.0-4.0 cm in diameter was applied to CV 12 region,discharges of the medullary SRD neurons had no obvious changes.When the temperature was increased to 44 ℃and 46 ℃,the electrical activities of SRD neurons were increased linearly along with the increase of the stimulated area of 1.0-4.0 cm in diameter.When the temperature was increased further from 48 ℃ to 52 ℃,the increased electrical activities of SRD neurons peaked at the stimulated area of 3.5 cm in diameter.In addition,thermal stimulation at a temperature of 50 ℃ and an area of 4.0 cm in diameter induced a larger increase of discharges of SRD neurons in comparison with that of 46 ℃ plus an area of 3.5 cm/4.0 cm in diameter(P<0.05).No significant differences were found between 50 ℃ and 52 ℃ at any stimulated areas mentioned above(P>0.05).Conclusion Noxious thermal(44-52 ℃) stimulation of CV 12 region can activate SRD neuron,which reaches a plateau when the stimulated area is increased to a certain range.关键词：Moxibustion-like thermal stimulation;Extracellular discharge;Subnucleus reticularis dorsalis;Thermal stimulating temperature;Thermal stimulating area;Zhongwan(CV 12)1301|643|17更新时间：2023-08-11
- 摘要：Objective To observe the effects of mild-warm moxibustion on dynamic blood flow,microvessel count(MVC)and vascular endothelial growth factor(VEGF) expression in the wound tissue of the chronic skin ulcer in rats,so as to reveal its underlying mechanism in promoting wound recovery.Methods A total of 104 male SD rats with skin injury were randomly divided into control group(n=8),model group(n=32),TDP(far-infrared heating device) group(n=32) and moxibustion group(n=32).Chronic refractory raw surface wound model was established by muscular injection of Hydrocortisone Sodium Succinate.For rats of the TDP and moxibustion groups,TDP irridiation and mild-warm moxibustion were applied to the raw surface,bilateral "Shenshu"(BL 23) and "Zusanli"(ST 36) for 15 min,once daily for 3,7 and 14 days respectively.The healing rate and the healing time of raw surface of the wound were observed.The blood flow of the raw surface of the wound tissue was measured by laser Doppler flowmeter and the MVC in granulation tissue of chronic skin ulcer was counted under light microscope.VEGF expression was detected by immunohistochemistry.Results In comparison with the control group,the healing rate of the wound raw surface was significantly lower and the healing time was prolonged in the model group(P<0.01).Compared with the model group,the healing rates on day 3,7,10 and 14 were significantly higher and the healing time was strikingly faster in both TDP and moxibustion groups(P<0.01,P<0.05),and the effects of the moxibustion group in increasing the healing rate and shortening the healing time were significantly better than those of TDP group(P<0.01).In comparison with the model group,the blood flow volume,MVC and VEGF expression levels on day 3 and 7 were upregulated significantly in both TDP and moxibustion groups(P<0.01,P<0.05);while the blood flow volume,MVC and VEGF expression level in the moxibustion group and the blood flow volume and VEGF expression level in the TDP group downregulated considerably on day 14(P<0.01).No significant difference was found between the TDP and moxibustion groups in the MVC on day 14 after the treatment(P>0.05).ConclusionMild-warm moxibustion can promote wound healing,which is closely with its effects in increasing blood flow and MVC,and upre-gulating VEGF expression in the wound granulation tissue of the chronic skin ulcer.关键词：Mild warm moxibustion;Chronic skin ulcer;Healing time;Wound healing rate;Microcirculation;MVC;VEGF1453|477|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) on the differentiation and proliferation of nerve stem cells in the hippocampal dentate gyrus(DG) in splenic asthenia pedo-rats so as to study its central mechanism.Methods A total of 72 SD male rats were randomly assigned to normal control group(n=24),model group(n=24) and EA group(n=24) which were further divided into 7 d,14 d,28 d and 49 d time-points(n=6).Splenic asthenia model was established by intrape-ritoneal injection of reserpine and gavage of Dahuang(Radix et Rhizoma Rhei) fluid.EA was applied to bilateral "Zusanli"(ST 36) and "Sanyinjiao"(SP 6) for 20 min,once daily for 7,14,28 and 49 days respectively.Brdu,Nestin,glial fibrillary acidic protein(GFAP),and neuron-specific enolase(NSE) expression in the DG of hippocampus were detected by immunohistochemistry double staining.Results Compared with the normal control group,the numbers of Brdu,Brdu/GFAP,Brdu/NSE immunorea-ctive(IR) positive cells in the DG of hippocampus on day 7 and 14,and that of Brdu/Nestin IR-positive cells on day 7 were decreased considerably in the model group(P<0.05).Compared to the model group,the numbers of hippocampal Brdu IR-positive cells at the 4 time-points,Brdu/Nestin and Brdu/GFAP on day 7,14 and 49,and Brdu/NSE on day 7,14 and 28 were increased significantly in the EA group(P<0.05).No significant differences were found between the model and control groups in the numbers of hippocampal Brdu and Brdu/NSE IR-positive cells on day 28 and 49,in the number of Brdu/Nestin IR-positive cells on day 14 and 49,in the number of Brdu/GFAP IR-positive cells on day 28;and between the EA and model groups in the numbers of Brdu/Nestin and Brdu/GFAP IR-positive cells on day 28,and in the number of Brdu/NSE IR-positive cells on day 49(P>0.05).Conclusion EA of ST 36 and SP 6 can effectively suppress splenic asthenia syndrome-induced decrease of the numbers of Brdu,Brdu/GFAP,Brdu/Nestin and Brdu/NSE IR-positive cells in the DG of hippocampus at the early stage in the splenic asthenia rats,which may contribute to its effect in improving splenic asthenia symptoms in clinic by promoting the proliferation and differentiation of some nerve stem cells in the hippocampus.关键词：Electroacupuncture;Splenic asthenia syndrome;Hippocampus;Nerve stem cell;Proliferation;Differentiation1332|212|1更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) combined with gavage of borneol on the permeability and ultrastructure of the blood-brain barrier(BBB) in mice,so as to reveal its mechanism underlying improving permeability of BBB.Methods For assaying Evans blue(EB) content in the brain,60 Kunming mice were evenly divided into control,EA,borneol(0.2 g/kg,borneol-0.2),borneol(0.4 g/kg,borneol-0.4),borneol(0.2 g/kg,borneol-0.2)+EA and borneol(0.4 g/kg,borneol-0.4)+EA groups.For determination of P-glycoprotein [P-gp,a member of the superfamily of ATP-binding cassette(ABC) transporters which transport various molecules across extra-and intra-cellular membranes] function and the ultrastructure of BBB,other 84 mice were randomized into control,borneol-0.2,borneol-0.4,borneol-0.2+EA,borneol-0.4+EA and verapamil groups(n=10 for P-gp function analysis,and n=2 for electron microscopic observation).EA(2 Hz,1 mA) was applied to "Baihui"(GV 20) and "Yamen"(GV 15) for 20 min,once daily for 14 days.EB(2.5%,0.2 mL/kg) and rhodamine(Rh)123(0.2 mg/kg) were injected intravenously first through the tail vein,and their contents in the brain and Rh 123 in the plasma were detected after EA by using an ultraviolet fluorescence microplate reader.At the same time,the permeation index(Kp) was calculated by the ratio of Rh 123brain/Rh 123blood.Results Compared with the control group,the cerebral EB and Rh 123 contents and Kp of BBB in the EA,borneol-0.2,borneol-0.4,borneol-0.2+EA,borneol-0.4+EA and verapamil groups were increased significantly(P<0.05,P<0.01).The cerebral EB content was significantly higher in the borneol-0.2+EA group than in the borneol-0.2 group(P<0.05),suggesting a synergistic effect of EA and borneol.No significant differences were found among the EA,borneol-0.2 and borneol-0.4 groups in cerebral EB levels,among the control,EA,borneol-0.2,borneol-0.4,borneol-0.2+EA,borneol-0.4+EA and verapamil groups in plasma Rh 123 contents,and among the EA,borneol-0.2,borneol-0.4,borneol-0.2+EA,borneol-0.4+EA and verapamil groups in cerebral Rh 123 contents and Kp of BBB(P>0.05).Results of the electron transmission microscope showed that the compact degree of the tight junction of BBB was decreased in the borneol-0.2,borneol-0.4,borneol-0.2+EA,borneol-0.4+EA groups but not in the EA group.Conclusion EA and gavage of borneol treatments may enhance the permeability of BBB for EB and Rh 123 and have a certain synergistic effect in mice.The effect of borneol may be closely with the inhibition of P-glycoprotein and the decrease of tight junction of BBB while the effect of EA treatment is probably related to the inhibition of P-glycoprotein only.关键词：EA;Borneol;BBB;P-glycoprotein;Ultrastructure1342|449|9更新时间：2023-08-11
- 摘要：Objective To explore the mechanism of acupuncture in preventing and treating stress-induced gastric mucosal injury from the view of brain-gut axis.Methods Forty male Wistar rats were randomly divided into normal control,model 1,treatment,model 2 and prevention groups(n=8).Gastric mucosa injury model was established by intragastric perfusion of dehydrated alcohol(1.0 mL/rat).Rats of the treatment group were treated with acupuncture after modeling,while those of the prevention group treated first,followed by modeling.The time of modeling in model 1 group and model 2 group was simultaneous with that of the treatment group and prevention group respectively.Acupuncture was applied to "Zusanli"(ST 36),"Zhongwan"(CV 12) and "Neiguan"(PC 6) for 20 min,once daily for 5 days.Before sampling the tissues,10% charcoal suspension was intragastric perfused 1 h for analyzing the rate of gastrointestinal propulsion(distance from the upper end of the charcoal powder to the cardia / total length of the cardia to the anus×100%).Gastric mucosal ulcer index was measured by using Guth's method.The contents of β-endorphin(β-EP)in plasma and hypothalamus were determined by enzyme-linked immunosorbent assay.Results Compared with the normal control group,the gastrointestinal propulsion rates were decreased considerably in the two model groups(P<0.05),while the gastric mucosal ulcer indexes and the contents of β-EP in both plasma and hypothalamus were increased significantly in the model groups(P<0.05,P<0.01).Compared with the corresponding model groups,the gastrointestinal propulsion rate was increased remarkably in the prevention group(P<0.05),and the gastric mucosal ulcer indexes and the contents of plasma β-EP level were decreased obviously in both treatment and prevention groups(P<0.05,P<0.01).The contents of hypothalamic β-EP were increased further in the later two groups(P<0.01).Conclusion Acupuncture of ST 36,CV 12 and PC 6 can promote the repair of gastric mucosal injury and improve gastrointestinal function,which may be related to its effects in reducing plasma β-EP and upregulating hypothalamic β-EP level.Acupuncture also has a better effect in preventing gastric mucosal injury.关键词：Stress-induced gastric mucosal injury;Acupuncture;Gastrointestinal propulsion rate;Gastric mucosal ulcer index;Plasma and hypothalamus β-endorphin1542|497|11更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) on plasma thromboxane B2(TXB2) and 6-keto-prostaglandin F1α(6-keto-PGF1α) levels in dysmenorrhea rats in order to investigate its mechanism underlying relief of primary dysmenorrhea and specificity of acupoint efficacy.Methods Female SD rats with diestrus were randomly divided into saline control(control),model,EA Sanyinjiao(SP 6),EA Xuehai(SP 10),EA Xuanzhong(GB 39) and EA non-acupoint(NAP) groups,with 10 rats in each.Dysmenorrhea model was established by subcutaneous injection of Estradiol Benzoate(0.5 mg/rat on the 1st and 10th day,and 0.2 mg/rat from the 2nd to the 9th day) and intraperitoneal injection of Oxytocin(0.2 mL/rat,1 h after last injection of Estradiol Benzoate on the 10th day).EA was applied to bilateral SP 6,SP 10,GB 39,and non-acupoint(the mid-point between the Gallbladder and Stomach meridian at the GB 39 level) for 20 min.The latency and score of writhing were recorded for 20 min.Plasma TXB2 and 6-keto-PGF1α contents were detected by radioimmunoassay.Results Compared with the control group,the latency of writhing in the model group was shortened considerably(P<0.01),and the writhing score was increased significantly(P<0.01).In comparison with the model group,the writhing latency was increased significantly only in the EA-SP 6 group(P<0.05),and the writhing scores in the EA-SP 6,EA-SP 10,EA-GB 39 and EA-NAP groups were reduced remarkably(P<0.01).Plasma TXB2 content and the ratio of TXB2/6-keto-PGF1α were significantly higher in the model group than in the control group(P<0.01).Compared to the model group,plasma TXB2 levels and the ratios of TXB2/6-keto-PGF1α in the EA-SP 6,EA-SP 10,EA-GB 39 and EA-NAP groups were downregulated markedly(P<0.05,P<0.01),while plasma 6-keto-PGF1α was upregulated strikingly only in the EA-SP 6 group(P<0.05).No significant differences were found among the EA-SP 6,EA-SP 10,EA-GB 39 and EA-NAP groups in the writhing latency and writhing score,plasma TXB2 and 6-keto-PGF1α levels(P>0.05).Conclusion EA can relieve pain reaction in dysmenorrhea rats,which may be closely associated with its effects in downregulating plasma TXB2,upregulating plasma 6-keto-PGF1α content,and balancing plasma TXB2 /6-keto-PGF1α.The effect of EA of SP 6 is relatively better.关键词：Electroacupuncture;Dysmenorrhea;Writhing reaction;Plasma TXB2;6-keto-PGF1α;Specificity of acupoint efficacy1544|485|5更新时间：2023-08-11
- 摘要：Objective To observe the changes of amino acid neurotransmitter contents in the lumbar spinal cord after electroacupuncture(EA) in rats with neuropathic pain so as to study its spinal mechanism underlying pain relief.Methods Forty SD rats were randomly divided into control,sham surgery,model and EA groups(n=10).Chronic constrictive injury(CCI)(neuropathic pain) model was duplicated by ligature of the right sciatic nerve with a piece of catgut.EA(1-3 mA,2 Hz) was applied to "Huantiao"(GB 30) and "Weizhong"(BL 40) on the injured side for 30 minutes,once a day for 7 days.The mechanical and thermal pain thresholds were measured before and after CCI,and after EA intervention.Concentrations of glutamate(Glu),aspartate(Asp),glutamine(Gln),γ-aminobutyric acid(GABA),Glycine(Gly) and taurine(Tau) in the lumbar spinal cord(L4-6) were detected by O-phthaladehyde derivatization + high performance liquid chromatography(HPLC).Results Compared with the control group,both the mechanical and thermal pain thresholds of the model group were decreased significantly on day 10 and day 16 after CCI(P<0.01).Compared with the model group,the mechanical and thermal pain thresholds in the EA group on day 16 after CCI were upregulated strikingly(P<0.01).In comparison with the control group,Glu,Asp,Gln and GABA levels in the lumbar spinal cord were significantly higher in the model group(P<0.05,P<0.01),while Gly and Tau levels in the lumbar spinal cord were markedly lower in the model group(P<0.05).In comparison with the model group,spinal Glu,Asp,and Gln contents were downregulated significantly in the EA group(P<0.01),while Gly,GABA and Tau levels were upregulated obviously(P<0.01,P<0.05).No significant differences were found between the control and sham surgery groups in the mechanical and thermal pain thresholds,and in the spinal Glu,Asp,Gln,GABA,Gly and Tau levels(P>0.05).Conclusion EA of GB 30 and BL 40 may alleviate neuropathic pain in CCI rats,which is closely with its effects in reducing the release of excitatory amino acids and promoting the release of inhibitory amino acid neurotransmitters.关键词：Electroacupuncture;Neuropathic pain;Lumbar spinal cord;Excitory amino acid neurotransmitter;Inhibitory amino acid neurotransmitter1300|379|11更新时间：2023-08-11
- 摘要：Objective To observe the effect of balance acupuncture on the thermal pain threshold and plasma β-endorphin(β-EP) and adrenocorticotrophic hormone(ACTH) levels in lumbar disc herniation rats so as to research its mechanisms underlying improvement of lumbar disc protrusion.Methods A total of 120 male rats were randomly divided into blank control(control) group,model group,sham-operation(sham)group,and acupuncture group(n=30) which were further divided into 7-days(d) and 14-d subgroups.Rats in the acupuncture group were treated with balance acupuncture of "Back Pain" point(the midpoint between two eyes) and "Hip Pain"point(the midpoint between the acromial process and the axillary furrow).Thermal pain threshold was detected by using radiant heat detector.Plasma β-EP and ACTH levels were determined by radioimmunoassay.Results Compared with the control group and pre-operation and sham group,the thermal pain reaction was increased significantly in the model group(P<0.05).In comparison with the model group,the thermal pain reaction was decreased obviously from day 10 after acupuncture treatment in the acupuncture group(P<0.05).Compared to the control group,plasma β-EP contents on day 7 and 14 and ACTH level on day 14 in the model group were increased significantly(P<0.05),while in comparison with the model group,plasma β-EP contents on day 7 and 14 and ACTH level on day 14 in the acupuncture group were down-regulated markedly(P<0.05).No significant difference were found between the control and sham groups in plasma β-EP contents and ACTH levels on day 7 and 14(P>0.05).Conclusion Balance acupuncture treatment can lower plasma ACTH level in lumbar disc herniation rats,which may contribute to its effect in easing lumbar disc herniation pain in clinic practice.关键词：Balance acupuncture;Lumbar disc herniation;Acupuncture analgesia;Plasma β-EP;Plasma ACTH1457|375|3更新时间：2023-08-11
- 摘要：Objective To observe the anti-stress effect of acupuncture-assisted anesthesia in patients undergoing pulmonary lobectomy.Methods A randomized,controlled,single-blind clinical trial was conducted in the present study.A total of 48 patients undergoing pulmonary lobectomy were randomized into regular general anesthesia(RGA),general anesthesia combined with 2 Hz electroacupuncture(EA)(GA+2 Hz-EA),general anesthesia combined with 2 Hz/100 Hz EA(GA+2 Hz/100 Hz-EA),and GA+100 Hz-EA groups(n=12).EA(1-3 mA) was applied to bilateral Houxi(SI 3),Zhigou(SJ 6),Neiguan(PC 6) and Hegu(LI 4) for 30 min,followed by general anesthesia with midazolam(0.05 mg/kg),fentanyl(5 μg/kg),propofol(2 mg/kg),and vecuronium(0.1 mg/kg).The dosages of the anesthetics,heart rate(HR),systolic blood pressure(SBP),and bispectral index(BIS)of electroencephalogram during general anesthesia were recorded.Plasma adrenaline and cortisol concentrations were assayed by radioimmunoassay.Results In comparison with the RGA group,the dosages of supplementary propofol and fentanyl in both GA+2 Hz-EA and GA+100 Hz-EA groups,and that of propofol in the GA+2 Hz/100 Hz-EA group were decreased significantly(P<0.05,P<0.01).Compared to the RGA group,both HR and SBP values during trachea extubation in the GA+2 Hz/100 Hz-EA and GA+100 Hz-EA groups were significantly lower(P<0.01,P<0.05).No significant differences were found between the GA+2 Hz/100 Hz-EA and RGA groups in the supplementary dose of fentanyl,between the GA+2 Hz-EA and RGA groups in HR and SBP values during trachea extubation,among the 4 groups in HR and SBP values before trachea extubation and in plasma adrenaline and cortisol levels(P>0.05).Conclusion Acupuncture-assisted anesthesia can decrease the dosage of general anesthetics,and effectively restrain cardiovascular stress reaction during trachea extubation in pulmonary lobectomy patients.关键词：Acupuncture-assisted anesthesia;Pulmonary lobectomy;Stress reaction;Regular general anesthesia1265|471|14更新时间：2023-08-11
- 摘要：Objective To observe the specific brain effects of electroacupuncture(EA) stimulation of Guanyuan(CV 4) and Zhongwan(CV 12).Methods Twenty-one healthy volunteers were recruited in the present study.Two silver filiform needles were separately inserted into Guanyuan(CV 4) or Zhongwan(CV 12),and manipulated with uniform reducing-reinforcing method to induce "Deqi".fMRI scan was performed before needling,during needle retention,EA stimulation,and post-EA.Data of fMRI was analyzed by using software SPM 2.The volunteer subjective needling sensations were recorded.The activation,deactivation,short-distance and long-distance functional connectivity maps of different cerebral regions were analyzed by using whole brain correlation analysis.Results Comparison between the two acupoints showed that fullness feeling was stronger in CV 4 than in CV 12.EA at CV 4 and CV 12 induced a similar stronger and prevalent deactivation in the ventral medial prefrontal cortex and the anterior cingulated cortex(ACC).The deactivation of the ACC was stronger in the CV 4 group than in the CV 12 group.The default BOLD mode of the brain at rest was modified by needle retention and EA,respectively.The short-distance functional connection brain network was significantly changed after EA.Interestingly,the ventral medial prefrontal cortex and anteroinferior portion of the anterior cingulate cortex in the limbic-paralimbic-neocortical network(LPNN) were involved in the instant post-effects of EA.Relatively smaller differences in the brain functional activity and short-distance functional connectivity were found between these two acupoints.Conclusion EA of CV 4 and CV 12 can modulate short-distance functional connectivity of the LPNN,and have fewer differences in inducing needling sensation and deactivation of ACC,etc.关键词：Electroacupuncture;fMRI;Brain functional connectivity;Acupoint specificity;Guanyuan(CV 4);Zhongwan(CV 12)1461|926|9更新时间：2023-08-11
- 摘要：Objective To observe the synergism of warm acupuncture combined with intra-articular injection of sodium hya-luronate on knee osteoarthritis(KOA).Methods A total of 179 KOA outpatients were randomized into warm acupuncture group(n=90) and control group(n=89) according to a randomized numeral table.Warm acupuncture(needle warmed by moxibustion) was applied to Zusanli(ST 36),Xuehai(SP 10),Yinlingquan(SP 9),Nèixīyǎn(EX-LE 4),etc.from the second day on after intra-articular injection of sodium hyaluronate(2 mL,once a week for 5 weeks).Sodium hyaluronate intra-articular injection was given to the patients alone in the control group.Knee joint motor function was scaled before,2 weeks(W) and 5 W after the therapy.The patients' quality of life was determined by using "Arthritis Impact Measurement Scale" before and 5 W after the the-rapy.Results In comparison with pre-therapy,the knee-joint motor function scores of both control group and acupuncture group were increased progressively and significantly 2 W and 5 W after the therapy.Both the knee-joint motor function score and the therapeutic effective rate of the acupuncture group were significantly higher than those of the control group(P<0.001,P<0.05).After the therapy,the scores of the Arthritis Impact Measurement Scale were significantly improved in both groups(P<0.01),and that of the acupuncture group was obviously lower than that of the control group(P<0.01).Conclusion Warm acupuncture combined with intra-articular injection of sodium hyaluronate is an effective therapy for knee osteoarthritis.关键词：Knee osteoarthritis;Warm acupuncture;Sodium hyaluronate;Intra-articular injection1296|273|4更新时间：2023-08-11
- 摘要："Treatment of hemorrhoids by acupuncture of Kongzui(LU 6)" has been being considered to be an example of new discovery in current clinical acupuncture practice and has produced a significant influence on domestic and foreign textbooks of acupuncturology and the health care of the people.After comprehensively analyzing this known saying,it was found that the so-called "new discovery" which has been inherited for decades of years is in fact derived from incorrect dissemination,being lack of evidence of both literature and clinical practice.关键词：Hemorrhoids;Kongzui(LU 6);Acupuncture1021|694|0更新时间：2023-08-11
- 摘要：Some scholars believe that the ancient Chinese physicians found meridian phenomena on the basis of pulse-feeling diagnosis.But the authors of the present paper don't think so,and that the relationship between the discovery of meridian phenomena and pulse-feeling diagnosis is not so simple.In the present paper,the authors analyze their correlation from the follo-wing 6 points.1) In ancient China,the difference between the pulse-feeling locations on the human body and the number of clinical disorders is huge,which is very difficult to make them to be corresponding.2) Shenmen(HT 7),one acupoint of the Heart Meri-dian of Hand-Shaoyin and one of the positions for pulse-feeling diagnosis,is not identical to the running course of meridians described in the early historic stage of China.3) Taking the corresponding correlation between the upper-lower parts of the Meridian of Hand-Yangming to make a deduction on other meridians is definitely jug-handled.4) It is logically unreasonable to demonstrate the relationship between the meridian and pulse-feeling diagnosis by taking the Luomai(collaterals of meridian) as the example.5) The running pathways of the Eight Extra-meridians which also belong to the meridian system are not identical to the regularities of "Biao" "Ben" pulses.6) In the ethnic traditional medicine,there exists an upper-lower corresponding pulse diagnosis,but,no similar text descriptions have been found in the medical works on meridians.Therefore,the meridian system is not found by means of pulse-feeling diagnosis,and rather,the meridian theory promotes the development of pulse-feeling diagnosis in clinical practice.关键词：Meridians;Pulse-feeling diagnosis760|373|1更新时间：2023-08-11
- 摘要：Chronic stress often results in neurochemical changes in the central nervous system and may lead to the onset of depression.These neurochemical changes refer to alterations of activities of neurotransmitters,neuromediators,hormones and neuronal plasticity,etc.The underlying mechanism of acupuncture in the antidepressant effect is related to its regulatory effect on the neurochemical imbalance.In the present review,the authors summarize the progress of experimental researches on acupuncture treatment of depression from 1) monoamines neurotransmitters and their receptors,2) gamma-aminobutyric acid and glutamate,3) neuropeptide Y,4) hypothalamus-pituitary-adrenal axis and hypothalamus-pituitary-throid axis activities,and 5) brain-derived neurotrophic factor.In addition,the authors also make an evaluation on the insufficiency of current studies and put forwards some suggestions on the future study.关键词：Acupuncture;Depression;Neurochemical mechanism2516|2361|8更新时间：2023-08-11
- 摘要：It has been well documented in Chinese acupuncture medicine that "Hegu(LI 4) is indicated for orofacial problems".In the present paper,the authors analyze their correlation from the learning of modern medicine and results of recent experimental studies instead of traditional meridian theory of acupuncturology.The afferent nerve fibers from the LI 4 region and the orofacial part ascend to the spinal cord,nucleus of solitary tract,reticular formation,thalamus and the cerebral cortex,respectively,and overlap in the thalamus,cerebral cortex,etc.Under the circumstances,the interaction and functional integration of the afferent signals from LI 4 acupoint and the orofacial region may occur in the central nervous system.In addition,many relevant neuroactive substances(for example,serotonin,substance P,enkephalin,γ-aminobutyric acid,glycine,calcitonin gene-related peptide,etc.) released from the sensory and motor neurons in the corresponding cerebral regions may constitute part of the substantial basis of that "Hegu(LI 4) is indicated for many orofacial disorders".关键词：Acupuncture;Orofacial problems;Hegu(LI 4);Central nervous system;Related mechanism917|963|3更新时间：2023-08-11
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