最新刊期
卷 36 ， 期 6 ， 2011
- 摘要：Objective To observe the effect of electroacupuncture(EA) at bilateral "Futu"(LI18),etc.on the expression of 5-HT1A receptor(R) mRNA,5-HT2AR mRNA and protein in the spinal cord of rats with neck incision pain,so as to explore its underlying mechanism in relieving incision pain.Methods A total of 48 Wistar rats were randomly divided into control,model(incision pain),Futu(LI18),Hegu(LI4)-Neiguan(PC6,LI4-PC6),Zusanli(ST36)-Yanglingquan(GB34) cervical cord(ST36-GB34 C) and lumbar cord(ST36-GB34 L) groups.A 1.5cm longitudinal incision was made in the middle of the neck under Isoflurane inhalation anesthesia.Pain threshold(PT) was measured using radiant heat.EA(1-2mA,2Hz/15Hz) was applied to bilateral LI18,LI4-PC6,ST36-GB 34 for 30min.The expression of 5-HT1AR mRNA,5-HT2AR mRNA and protein in the cervical spinal cord(C1-C4) tissue,and 5-HT1AR mRNA and 5-HT2AR mRNA in the lumbar cord(L1-L3) were detected with Real-time PCR and Western blot analysis,respectively.Results After the operation,the thermal PT was shortened obviously in comparison with pre-operation(P<0.05).Compared with post-operation,the PT values were increased markedly in the LI18 group and LI4-PC 6 group(P<0.05),rather than in the ST36-GB 34 group(P>0.05).The expression levels of 5-HT1AR mRNA,5-HT2AR mRNA and 5-HT2AR protein in the cervical cord of the model group were increased significantly compared with those of the control group(P<0.05).In comparison with the model group,the expression level of 5-HT1AR mRNA was down-regulated considerably in the LI18 and LI4-PC 6 groups(P<0.05),and those of spinal 5-HT2AR mRNA and protein were up-regulated significantly in the LI18 and LI4-PC 6 groups(P<0.05).No significant changes were found in the expression of 5-HT1AR mRNA and 5-HT2AR mRNA in the ST36-GB 34 C group in comparison with the model group(P>0.05).The expression levels of 5-HT1AR mRNA and 5-HT2AR mRNA in the ST36-GB34 L group were significantly lower than those of the ST36-GB 34 C group(P<0.05).Conclusion EA of LI18 and LI4-PC 6 can significantly suppress pain reaction of neck incision in the rat,which is closely associated with its effects in down-regulating the expression of 5-HT1AR mRNA and in up-regulating 5-HT2AR mRNA and 5-HT2AR protein in the cervical spinal cord.关键词：Cervical incision pain;Acupuncture analgesia;Spinal cord;5-HT1AR mRNA;5-HT2AR mRNA;5-HT2AR protein1489|253|3更新时间：2023-08-11
- 摘要：Objective To observe the effect of transcutaneous electrical acupoint stimulation(TEAS) combined with general anesthesia on gastric dynamics in controlled hypotension dogs,so as to provide experimental evidence for compound acupuncture anesthesia.Methods Eighteen male beagle dogs were randomly divided into general anesthesia group(GA group,n=6),general anesthesia + controlled hypotension group(GA+CHT group,n=6) and general anesthesia combined with TEAS + controlled hypotension group(TEAS group,n=6).The latter two groups were administered with the same anesthetics [iso-fluane inhalation and intravenous sodium nitroprusside(SNP)]for inducing controlled hypotension(being the 40% of the baseline level).Beagles of the GA group were not treated with controlled hypotension(the initial concentration of SNP = 1μg/kg·min-1,and with an increase rate of 1μg/kg·min-1 until the controlled hypotension phase).In the TEAS group,TEAS [2Hz/100Hz,(4±1)mA]was applied to "Quchi"(LI11),"Zusanli"(ST 36),"Hegu"(LI4),and "Sanyinjiao"(SP 6) from the beginning of the stable physiological condition phase to the end of the controlled-low mean arterial pressure(MAP) phase.Electrogastrogram(EGG) was recorded,and serum gastrin(GAS) and motilin(MTL) contents were detected by enzyme-linked immunosorbent assay.Results Compared with the basic level,the amplitude value of EGG at 60min after controlled hypotension in the GA+CHT group was significantly lower(P<0.05);while the amplitude level of EGG of the TEAS group at the time-point of MAP recovery was significantly higher than those of the GA and GA+CHT groups(P<0.05).No significant changes were found among the 3 groups in the frequency levels of EGG.At the time-points of MAP recovery and 2h after MAP recovery,serum MTL and GAS levels in the TEAS group were close to their basic level(P>0.05),and serum GAS level at the time-point of 2h after MAP recovery in the TEAS group was considerably higher than those in the GA and GA+CHT groups(P<0.05).Twenty-four,48 and 72h after MAP recovery,serum GAS levels in the TEAS group were moderately(24h and 48h) and significantly(72h) higher than that of the basic level.No significant differences were found between the GA and GA+CHT groups in serum MTL and GAS levels at the time-points of 2,24,48 and 72h after MAP recovery(P>0.05).Conclusion TEAS combining with general anesthesia for controlled hypotension can improve the amplitude of EGG,and serum MTL and GAS contents,favoring the recovery of gastric dynamics and the functional protection of stomach.关键词：Transcutaneous electrical acupoint stimulation(TEAS);Compound acupuncture anesthesia;Controlled hypotension;Gastric dynamics;Serum gastrin and motilin1402|254|2更新时间：2023-08-11
- 摘要：Objective To observe the effects of moxibustion on contents of epidermal growth factor(EGF) and transforming growth factor-alpha(TGF-α) and epidermal growth factor receptor(EGFR) expression in the gastric mucosa tissue in rats with gastric mucosal lesion.Methods Thirty-six SD rats were randomly and equally divided into control,model and moxibustion groups.Gastric mucosal lesion model was duplicated by restraint and cool water immersion stress.Pre-moxibustion was applied to "Zusanli"(ST36) and "Zhongwan"(CV12),"Pishu"(BL20) and "Weishu"(BL21) alternately,once everyday for 8 days before modeling.The contents of EGF and TGF-α in gastric mucosa were detected by enzyme-linked immunosorbent assay(ELISA) and the expression of EGFR determined by immunohistochemistry.Results Compared with the control group,only TGF-α content in the gastric mucosa in the model group was increased significantly(P<0.05).Compared with the model group,the EGF and TGF-α contents and EGFR immunoactivity in the gastric mucosa were increased significantly in the moxibustion group(P<0.05,P<0.01).Conclusion Pre-moxibustion at ST36,CV12,BL20 and BL21 can up-regulate gastric mucosal EGF and TGF-α contents and EGFR protein expression in gastric mucosa lesion rats,which may contribute to its effect in relieving stress-induced gastric mucosal injury.关键词：Moxibustion;Preconditioning;Gastric mucosal lesions;Gastric EGF;TGF-α;EGF receptor expression1169|570|3更新时间：2023-08-11
- 摘要：Objective To investigate the effect of the eye-acupuncture therapy on cerebral intercellular adhesion molecule-1(ICAM-1) expression in rats with acute cerebral ischemia-reperfusion injury(CI/RI) so as to reveal its underlying mechanism.Methods Forty male SD rats were randomly and equally divided into normal,sham operation(sham),model and eye-acupuncture groups.Acute CI/RI model was established by occlusion of the middle cerebral artery with a modified suture-blocking method.Filiform needles were inserted into the "Gan"(Liver Area),"Shangjiao"(Upper Energizer Area),"Xiajiao"(Lower Energizer Area),etc.of the eye-acupuncture acupoints,and retained for 20min.The treatment was conducted twice daily,7 times altogether.Seventy-two hours after Acute CI/RI,the neurological behavior was assessed by ZeaLonga neurophysical impairment scale.Cerebral ICAM-1 protein and ICAM-1 mRNA expression levels were detected by Western blot(Penumbra area of the right cerebral infarction region) and real time-polymerase chain reaction(PCR) methods,respectively.Results After modeling,the neurophysical impairment score of the model group was increased from 0 to(2.63±0.92) points on the first day and(2.63±0.74) points 72h following Acute CI/RI.Correspondingly,cerebral ICAM-1 protein and mRNA expression was up-regulated considerably in the model group than in the normal control group(P<0.01).In comparison with the model group,the neurologic impairment score,and cerebral ICAM-1 protein and mRNA expression levels of the eye-acupuncture group were down-regulated obviously(P<0.01,P<0.05).No significant differences were found between the normal control and sham groups in neurologic impairment score and the expression levels of the ICAM-1 protein and ICAM-1 mRNA(P>0.05).Conclusion Eye-acupuncture therapy can improve the cerebral ischemia-reperfusion injury induced behavior changes,which may be related to its effects in down-regulating the expression of cerebral ICAM-1 protein and gene.关键词：Eye-acupuncture;Cerebral ischemia-reperfusion injury;intercellular adhesion molecule;Cerebral tissue1257|225|7更新时间：2023-08-11
- 摘要：Objective To observe the anti-seizure effect of electroacupuncture(EA) at differentsites regions of the auricle in awake rats.Methods Sixty male SD rats were randomly divided into model,ear-apex,ear-outer-margin,earlobe,cymba-concha,cavitas-conchae groups(n=10 in each group).A metal microelectrode(diameter: 50μm) was implanted into the somatosensary cortex for recording the field potentials(FPs).Epileptic seizure model was established by intraperitoneal injection of pentylenetetrazol(PTZ,60mg/kg).EA(20Hz,1mA) was applied to ear-apex,ear-outer-margin,earlobe,cymaba-concha and cavitas-conchae for 30min,respectively.The epileptic behavior changes(scores) were determined in the light of Racine's method,and the epileptic seizure was assessed according to the epileptic FPs(5-folds above the basic amplitude) of the cerebral cortex.Results In comparison with the model group,the latency of the first seizure of epilepsy in the ear-outer-margin,earlobe,cymba-concha,cavitas-conchae groups were increased significantly(P<0.01),while the scores of epileptic behavior and the duration of seizure shown by FPs decreased considerably in the ear-apex,ear-outer-margin,earlobe,cymba-concha,cavitas-conchae groups(P<0.01).Comparison among the five EA treatment groups showed that the effects of both cymba-concha and cavitas-conchae groups were significantly superior to those of ear-apex,earlobe and ear-outer-margin groups in increasing the latency of the first seizure of epilepsy,and reducing the scores of the epileptic behavior and seizure duration(P<0.01).No significant differences were found between the cymba-concha and cavitas-conchae groups in the above-mentioned 3 indexes(P>0.05).Conclusion EA of cymba-concha and cavitas-conchae has a good effect in suppressing epileptic seizures,which may be mediated via the auricular branch of the vagus nerve.关键词：Epilepsy;Auricular acupuncture;Cerebral cortical field potential;Cymba-concha;Cavitas-conchae1398|356|2更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) of "Taichong"(LR3) on liver function in rats with mild alcoholic liver injury(MALI) so as to explore the feasibility of acupuncture in improving mild alcoholic liver injury.Methods Forty SD rats were randomly divided into control,model,EA-LR3 and EA-non-acupoint groups(10rats/group).MALI model was duplicated by intragastric administration of distillate spirit(14mL/kg) for 12 hours.Rats of the control group were fed with the same volume of normal saline.EA(2Hz,6V) was applied to bilateral "Taichong"(LR3) and non-acupoint(the interspace between the 4th and 5th bones of toes in parallel with LR3) for 30min,respectively.At the end of experiments,rats were sacrificed for collecting liver tissues.The activities of alanine aminotransferase(ALT),aspartate aminotransferase(AST) of the liver supernatant were detected by using Lai's method.Results IIn comparison with the control group,liver ALT and AST activities in the model group were increased significantly(P<0.05),while in comparison with the model group,liver ALT and AST levels in the EA-LR 3 group were down-regulated remarkably(P<0.05).No significant changes were found in liver ALT and AST level in the EA-non-acupoint group(P>0.05).There was no significant improvement in the pathological changes of liver in the EA-LR 3 and EA-non-acupoint groups.Conclusion EA of "Taichong"(LR3) may reduce distillate-spirit induced mild alcoholic liver injury in rats.关键词：Electroacupuncture;Taichong(LR 3);Mild alcoholic liver injury;ALT;AST1020|168|1更新时间：2023-08-11
- 摘要：Objective To observe the influence of electroacupuncture(EA) of "Zusanli"(ST 36) and ST 36 + "Neiguan"(PC 6) on gastric distention induced transient lower esophageal sphincter relaxation(TLESR) in cats.Methods Forty cats were randomly divided into model(gastric distension) group,EA-ST 36 group,EA-PC 6 group,EA-ST 36+PC 6 group,EA-non-acupoint group,EA-ST 36+saline(2mL i.v.) group,EA-ST 36+L-arginine(precusor of nitric oxide,200mg/kg i.v.) group,and EA-ST 36+Tacrine(cholinesterase inhibitor,5.6mg/kg i.p.) group,with 5 cats being in each group.TLESR model was established by extending the stomach with an air balloon.EA(2Hz/100Hz,3-4mA) was applied to bilateral ST 36,PC 6 and ST 36+PC 6 and non-acupoint(exterior-superior site of the hip) while gastric distension.L-Arginine was given 10min before EA,and Tacrine was given 30 min before EA.The frequency of TLESR and lower esophageal sphincter pressure(LESP) were recorded by using a perfused sleeve assembly.Results Compared with the model group,the frequency of TLESR in 60min as well as the percentage of common cavity during TLESR were significantly decreased in the EA-ST 36,EA-PC 6,EA-ST 36+PC 6,EA-ST 36+saline groups(P<0.05).Compared with the EA-ST 36+saline group,the frequency of TLESR in 60 min was up-regulated significantly in the EA-ST 36+Tacrine group(P<0.01) rather than in the EA-ST 36+L-Arginine group,suggesting a reduction of the efficacy of EA-ST 36 by cholinergic suppression(not by nitric oxide).No significant differences were found among the EA-ST 36,EA-PC 6 and EA-ST 36+PC 6 groups in the frequency of TLESR and the percentage of common cavity(P>0.05).In comparison with the baseline level,LESP was increased significantly only in the EA-ST 36 group(P<0.05).Conclusion EA at ST 36 can reduce both the frequency of TLESR and the percentage of common cavity during TLESR in gastric distension cats,which may be mediated by cholinergic pathway.关键词：Electroacupuncture;ST 36;Transient lower esophageal sphincter relaxation;Common cavity;Lower esophageal sphincter pressure;Cholinergic pathway;Nitric oxide pathway1194|164|0更新时间：2023-08-11
- 摘要：Objective To observe clinical efficacy of electroacupuncture(EA) for post-stroke urinary incontinence in patients.Methods A total of 111 stroke inpatients with urinary incontinence were randomly divided into EA group(n=56) and control group(n=55).Patients of the control group were treated by administration of calcium ion antagon,angiotensin-converting enzyme inhibitor,angiotensin Ⅱ receptor antagonist,compound thromb-clearing agent(i.v.),etc.,and acupuncture of Jianyu(LI 15),Xuehai(SP10),etc.Patients of the EA group were treated by EA of bilateral Shenshu(BL23),Huiyang(BL35),etc.,combined with the treatment as the control group.The treatment was conducted once daily for 4 weeks.Crooks(1995) Scores of the clinical symptoms and clinical efficacy assessment were given before and after the treatment.Results After the treatment,the severity of urinary incontinence and symptom scores in both control and EA groups were decreased significantly in comparison with pre-treatment(P<0.01).Following the treatment,of the 55 and 56 stroke patients in the control and EA groups,0 and 4(7.1%) were cured in the symptoms of frequent micturition,urgency of micturition and incontinence of urine,20(36.4%) and 35(62.5%) were effective,35(63.6%) and 17(30.4%) were invalid,with the effective rates being 36.4% and 69.6%,respectively.The therapeutic effect of EA group was apparently superior to that of the control group(P<0.01).In addition,the infection rate of the EA group was strikingly lower than that of the control group(P<0.05).Conclusion EA can lower the severity of urinary incontinence and improve clinical symptoms of micturition in stroke patients.关键词：Electroacupuncture;Stroke;Urinary incontinence1199|513|1更新时间：2023-08-11
- 摘要：Objective To compare the therapeutic effects of plum-blossom needle therapy with cupping and laser irradia-tion in the treatment of acute facial paralysis with ipsilateral peri-auricular pain.Methods Sixty outpatients with acute facial paralysis and ipsilateral peri-auricular pain were divided into plum-blossom needle(treatment) group(n=28) and laser-irradiation(control) group(n=32).In the acute stage,patients of the treatment group were treated with plum-blossom needle tapping in combination with cupping at Yifeng(TE 17) and Wangu(GB 12),while those of the control group treated with He-Ne laser irradiation over the same two acupoints until the peri-auricular pain disappeared.The treatment was given once daily.Following disappearance of the pain,routine acupuncture treatment of Yifeng(TE 17),Wangu(GB 12),Dicang(ST 4),etc.was given conti-nuously to patients of the two groups,once daily for 20 times.The treatment times for healing ipsilateral peri-auricular pain,and the electromyogram(EMG,compound muscle action potential) of the ipsilateral musculus orbicularis oris were recorded.Scores of the facial nerve function were given to House-Brackmann Facial Nerve Grading System.Results The treatment times for healing peri-auricular pain in the treatment group and laser irradiation group were 2.9±1.0 and 6.0±2.2 respectively(t=6.816,P=0.000).The scores of House-Brackmann scale of the paralyzed side in the treatment group and control group were(3.3±1.5) points and(3.3±1.4) points(P>0.05) before the treatment;(1.8±1.1) points and(2.5±1.2) points(P<0.05) one month after the treatment,and(1.5±0.9) points and(2.2±1.5) points(P<0.05)three months after the treatment,respectively.The amplitude ratios of compound muscle action potential between the affected side and the healthy side in the treatment group and control group were(52.1±20.5)% and(51.2±22.6)%(P>0.05) during the first two weeks after onset,and(79.2±11.3)% and(69.8±17.9)%(P<0.05)three months after the treatment,respectively.Conclusion Plum-blossom needle tapping plus cupping is significantly superior to that of He-Ne laser irradiation in reducing the treatment sessions for relieving peri-auricular pain during acute stage,and improving facial and muscular functions in the treatment of acute facial paralysis patients.关键词：Facial paralysis;Acute stage;Pulm-blossom needle therapy;Laser irradiation;Facial nerve function;Facial muscular function1131|307|0更新时间：2023-08-11
- 摘要：Objective To observe the therapeutic effect and safety of acupuncture of Back-shu points [Xinshu(BL 15),Pishu(BL 20),etc.]in the treatment of chronic fatigue syndrome(CFS).Methods A total of 120 CFS patients were equally randomized into acupuncture and control groups.Acupuncture needles were inserted into bilateral Xinshu(BL 15),Pishu(BL 20),and Gaohuang(BL 43) points,once daily for 4 weeks except weekends.For patients of the control group,acupuncture needles were inserted into the shallow layer of the non-acupoints(two mid-points of the horizon lines passing through the crossing-points of the 1st and 2nd branches of the Gallbladder Meridian and the crests of 4th,5th and 11th thoracic vertebrae).General health scale(SF-20) and Chalder fatigue scale were used to measure the CFS patients' degree of general health.A follow-up survey was carried out 3 months after the last treatment.Results In comparison with pre-treatment,the scores of Chalder fatigue scale were decreased significantly in both treatment and control groups(P<0.01),while the scores of physiological function(PF) and general health(GH) of SF-20 in both acupuncture groups and those of the role function(RF),social function(SF),mental health(MH) and pain sensation(PS) in the treatment group were increased apparently after the treatment(P<0.05,P<0.01).The scores of Chalder Scale and PF,RF,SF,GH,MH,PS and the CFS patients' satisfication degrees 4 weeks(64.4% and 36.7%) and 3 months(62.3%and 32%)after the treatment in the treatment group were significantly superior to those of the control group(P<0.05).Conclusion Acupuncture at Back-shu point has a good therapeutic effect(including immediate and mid-term effect) in the treatment of chronic fatigue syndrome patients.关键词：Chronic fatigue syndrome;Acupuncture;Back-shu point;Randomized controlled trial1083|595|2更新时间：2023-08-11
- 摘要：Objective To analyze the regularities and characters of clinical application of red-hot needle therapy in ancient and modern literature of Chinese medicine by using data mining techniques,so as to provide a reference for study on the specificity of efficacy of red-hot needle therapy.Methods Sample data was collected from some medical books,medical cases,reports of modern journals for calculating frequent item sets by using methods of association rules of data mining.Then,the collected data was extracted,sorted out,and summed up by using our newly developed literature database platform of red-hot needle therapy in order to find out the most suitable indications of this therapy in clinical practice.Results A total of 6 categories of clinical conditions treated by red-hot needle therapy were found.Among them,the frequency times(percentages) of red-hot needle application for surgical problems appeared in journals,medical cases and medical books are 287 times(49.83%),235 times(48.96%),154 times(41.73%),respectively.The frequency times of red-hot needle application for disorders of internal medicine and dermatology are 276 times and 360 times.Among the 115 categories of clinical conditions or diseases treated by red-hot needle appeared in journals,arthromyodynia and struma are frequently found,with the frequency being 115 and 46 times,separately.The total effective rates of the present therapy from higher to lower are 99.46% for pediatric problems,98.65% five sensory organs department,97.32% surgery,96.66% dermatology,96.34% gynecology,and 93.95% internal medicine,respectively.Among the 97 types of clinical conditions recorded in the literature on medical cases,aural verruca is more frequently seen apart from arthromyodynia and struma.In medical books,94 types of clinical conditions treated by red-hot needle therapy are found,including 32 types of problems of internal medicine.Conclusion Data mining results show that red-hot needle therapy has been widely used in different clinical departments,and more frequently used in surgery(mainly orthopedic and general surgery),internal medicine(mainly neurology and gastroenterology),dermatology.关键词：Red-hot needle therapy;Data mining;Literature research;Clinical application1181|1039|29更新时间：2023-08-11
- 摘要：Acupuncture manipulation skills are the core of acupuncture therapy.Traditional acupuncture skills evaluation is based on experts' subjective assessment which is deficient in reliability and validity.Certain progresses on the quantitative research on acupuncture skills have been made in China,while there is still a long way to go before the formation of the consummate standardization evaluation system on acupuncture skills.Actually,quantitative appraisal on surgical skills has been developed for a long time in Europe and North America.Since acupuncture could be considered as a kind of skills of minimally invasive surgery because small wounds would be generated by needles,the theories and methods in surgical quantitative appraisal could be utilized.For instance,scales could be designed to evaluate the operation modes in acupuncture skills and precise instruments could be used in the measurement of acupuncture skills.Then standard databases on common acupuncture manipulations would be built.Moreover,in terms of the characteristics of acupuncture skills,high-fidelity simulators should be designed or standardized patients should be trained for the assessment of "Deqi"(arrival of qi)feelings.Thereby,an appropriate standardization evaluation system for acupuncture skills would be created gradually.关键词：Acupuncture;Manipulation skills;"Deqi";Objective assessment system931|215|6更新时间：2023-08-11
- 摘要：Vasoactive intestinal peptide(VIP) is a widely studied peptide hormone,distributes in multiple systems of the human body and plays a variety of biological effects in many diseases.In recent years,there have been abundant researches about the regulative effect of acupuncture on changes of VIP activities.The authors of the present paper make a review about its research progress in recent ten years from(1) effect of acupuncture on VIP functional activities of the gastrointestinal tract;(2) involvement of VIP in electroacupuncture(EA) induced improvement of gastric mucosal and cerebral blood flow;(3) effect of EA on functions of VIP being as a neurotransmitter;(4) effect of EA on VIP-involved immune regulation function.Moreover,the authors also make a prospect on the correlation between the effect of acupuncture and VIP.Currently,the mechanism of VIP underlying the efficacy of acupuncture still remains unknown,and needs further investigation.关键词：Acupuncture;Vasoactive intestinal peptide;Gastrointestinal tract;Vascular regulation;Neuroimmune regulation957|531|2更新时间：2023-08-11
- 摘要：Along with the modernization and internationalization of acupuncture-moxibustion(acu-moxibustion),the issue of intellectual property rights has been becoming prominent and remarkable increasingly.In the present paper,the authors explain the basic issues of acu-moxibustion learning from the concept,scope,subject,object,contents and acquisition way of intellectual property rights.To make clear these questions will help us inherit and carry forward the existing civilization achievements of acu-moxibustion,and unceasingly bring forth new ideas and further improvement in clinical application,so as to serve the people's health in a better way.关键词：Intellectual property rights;Acu-moxibustion learning;Concept;Scope;Subject;Object;Content;Acquisition way1051|271|3更新时间：2023-08-11
- 摘要：Objective To observe the therapeutic effect of otopoint-pellet pressure(OPP) combined with patient controlled intravenous analgesia(PCIA) for lower-limb surgery of orthopedics.Methods A total of 120 lower-limb orthopedic operation patients were randomized into OPP+PCIA group(n=60) and PCIA group(n=60).The patient's pain degree was evaluated by visual analogue score(VAS).Results In comparison with the simple PCIA group,VAS levels were significantly lower in the OPP+PCIA group than in the PCIA group 2,6,24 and 48 h after operation.The number of patients with post-operative reactions of nausea,vomiting and urinary retention in the OPP+PCIA group was remarkably lower than that of OPP group(P<0.05).Conclusion OPP+PCIA is superior to simple PCIA in post-operative analgesia and reducing post-operative adverse reactions in lower-limb orthopedic operation patients.关键词：Lower-limb orthopedic surgery;Post-operative analgesia;Post-operative adverse reactions;Otopoint-pellet pressure;Patient controlled intravenous analgesia.850|170|4更新时间：2023-08-11
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