最新刊期
卷 37 ， 期 3 ， 2012
- 摘要：Objective To observe the effect of encircled needling plus electroacupuncture(EA) of the second pair of nipples on hyperplastic mammary glands,serum estradiol(E2),progesterone(P),prolactin(PRL)and testosterone(T)contents,estrogen receptor(ER) expression of the mammary glands in mammary hyperplasia rats.Methods Forty Wistar rats were equally randomized into normal control,model,acupuncture and medication groups.Mammary gland hyperplasia model was established by intramuscular injection of diethylstilbestrol(0.5 mg/kg,once daily for 25 days) and progesterone(4 mg/kg,once daily for 5 days).For rats of the acupuncture group,4 filiform needles were inserted into the surrounding tissues of the second pair of breasts,respectively,followed by giving the animal with EA stimulation for 30 min.Another one acupuncture needle was inser-ted into "Danzhong"(CV 17) and retained for 30 min.For rats of the medication group,tamoxifen solution(1.8 mg/kg) was given by gavage.Both medication and EA intervention were given once daily for 30 days.The diameter and height of the second pair of nipples were measured before and on the 10th,20th and 30th days of the treatment.Serum E2,P,PRL and T levels were assayed by radioimmunoassay,and the tissues of the second pair of nipples were stained with H.E.method.Estrogen receptor immunoactivity of the breast tissue was detected by immunohistochemistry.Results The diameter and height of the second pair of nipples,serum E2,PRL and T contents,and breast ER protein expression level were significantly higher in the model group than in the normal control group(P<0.05),while serum P content was remarkably lower in the model group than in the normal control group(P<0.05).In comparison with the model group,the diameter and height of the second pair of nipples,serum E2,PRL and T contents,and breast ER protein expression level were considerably lower in both acupuncture and medication groups(P<0.05),and serum P contents were significantly higher in the latter two groups(P<0.05).In addition,H.E.staining showed that the numbers of the lobule,alveolus and ducts of mammary glands were significantly increased,and the expansion of the acinar lumina and ducts was found in the model group.These pathological changes were relatively milder in both acupuncture and medication groups.Conclusion Encircled needling plus EA stimulation of the surrounding tissues of the nipples can improve the hyperplasic nipples and pathological changes of the breast tissue in mammary gland hyperplasia rats,which is closely asso-ciated with its functions in lowering serum estradiol,prolactin,testosterone contents and estrogen receptor protein expression of the breast,and in increasing serum progesterone level.关键词：Acupuncture therapy;Mammary gland hyperplasia;Serum estradiol;Progesterone;Prolactin;Testosterone;Pathological changes of breast tissue;Estrogen receptor expression1460|554|2更新时间：2023-08-11
- 摘要：Objective To observe the influence of electroacupuncture(EA) of "Hegu"(LI 4) on blood stromal cell-derived factor 1α(SDF-1α),CXC chemokine receptor 4+(CXCR 4+) positive cells and endothelial progenitor cells(EPCs) and bone marrow(BM) EPCs levels in local cerebral ischemia/reperfusion injury(CI/IR) rats,so as to study its mechanisms underl-ying improvement of cerebral ischemia.Methods A total of 54 SD rats were randomly divided into normal control,model,and EA groups.The latter two groups were further divided into 1 d,2 d,3 d and 7 d subgroups(4 time-points),respectively.CI/RI model was established by occlusion of the middle cerebral artery.EA(40 Hz/60 Hz,1-2 mA) was applied to bilateral "Hegu"(LI 4) for 15 min,once daily,1,2,3 and 7 days,respectively.Flow cytometer was used to detect the counts of EPCs and CXCR 4+ cells in the peripheral blood,and BM EPCs.Serum SDF-1α was detected by enzyme linked immunosorbent assay(ELISA).Results Compared with the normal control group,the percentages of blood EPCs and CXCR 4+ cells and BM EPCs,and serum SDF-1α content on the 1st day,and the percentage of blood CXCR 4+ cells on the 2nd day were increased significantly in the model group(P<0.01,P<0.05).In comparison with the model group,percentages of blood EPCs and CXCR 4+ cells on the 1st day of EA group were reduced significantly(P<0.01),but the percentage of blood EPCs on the 2nd day,those of blood CXCR 4+ cells on the 2nd day and 3rd day,serum SDF-1α content on the 2nd day,and the percentage of BM EPCs on the 2nd day in the EA group were all up-regulated significantly(P<0.05,P<0.01).No significant differences were found among the 3 groups in blood EPCs percentages on the 3rd day and 7th day,in blood SDF-1α content and BM EPCs percentage on the 7th day(P>0.05).Conclusion Generally,2 days' EA of LI 4 can up-regulate the percentages of blood and BM EPCs and blood CXCR 4+ cells as well as blood SDF-1α protein content in CI/RI rats,which may contribute to its effect in improving cerebral ischemia.关键词：Electroacupuncture;Cerebral ischemia/reperfusion;Hegu(LI 4);Stromal cell-derived factor 1α;Endothelial progenitor cell;Peripheral blood;Bone marrow1163|364|10更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupuncture of "Baihui"(GV 20),"Fengfu"(GV 16) and "Yanglingquan"(GB 34) on behavior and striatal apoptosis in Parkinson disease(PD) mice.Methods Twenty-eight adult male C57/BL mice were randomly divided into normal control,PD model,acupuncture and medication(Levodopa and Benserazide Hydrochloride) groups.Acupuncture was applied to "Baihui"(GV 20),"Fengfu"(GV 16) and electroacupuncture(2 Hz,1 mA) was applied to "Yanglingquan"(GB 34) for 15 min,once a day for 14 days.PD model was duplicated by intragastric administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP).The locomotor test,pole test and swimming test were conducted for assessing the animals' locomotion behavior before and after MPTP administration and after the treatment.The apoptotic neurons of the striatum were detected by terminal deoxyncleotidyl transferase-mediated dUTP-biotin nick end labeling assay.Results In comparison with the normal control group,the pole test score and apoptotic neuronal percentage were increased significantly(P<0.01),and the locomotor count,swimming test score were decreased remarkably in the model group(P<0.01).Compared with the model group,the locomotor counts and swimming test scores were increased obviously(P<0.05,P<0.01)and the pole test scores decreased apparently(P<0.05) in both acupuncture and medication groups after the treatment.No significant differences were found between the acupuncture and medication groups in the motor behavior(P>0.05).The effect of acupuncture was significantly superior to that of the medication in reducing neuronal apoptosis of the striatum(P<0.01).Conclusion Acupuncture of "Baihui"(GV 20),"Fengfu"(GV 16) and "Yanglingquan"(GB 34) can improve PD mice's locomotor function,which is closely associated with its function in reducing neuronal apoptosis of the striatum.关键词：Parkinson disease;Acupuncture;Neuronal apoptosis;Motor function;Striatum1201|669|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) at "Futu"(LI 18),etc.on the pain threshold and expression of metabotropic glutamate receptor subtype 5(mGluR 5),cyclic adenosine monophosphate(cAMP),mitogen-activated protein kinase(MAPK),cAMP responsive element binding protein(CREB) genes in the cervico-spinal dorsal region in rats with neck incision pain so as to analyze its underlying analgesic mechanism in performing thyroid surgery.Methods Forty male Wistar rats were randomly divided into control,model,Futu(LI 18),Hegu(LI 4)-Neiguan(PC 6),Zusanli(ST 36)-Yanglingquan(GB 34) groups,with 8 cases in each group.Neck-incision pain model was established by making a longitudinal incision along the midline of the neck under anesthesia(isoflurane) except rats in the control group.EA(2 Hz/15 Hz,1-2 mA) was applied to bila-teral LI 18,LI 4-PC 6 and ST 36-GB 34 for 30 min,4 h,24 h and 48 h after modeling,respectively.The thermal pain threshold was detected before modeling,and before and after each treatment.After removing the ventral part,the spinal tissue of the cervical 1-4 segments was collected for detecting the expression of mGluR 5,cAMP,MAPK,CREB genes by using quantitative real-time-PCR technique.Results In comparison with the control group,the pain threshold of the model group was decreased obviously(P<0.05).Compared with the model group,the pain thresholds of the LI 18 and LI 4-PC 6 groups were upregulated markedly after treatment(P<0.05).No significant differences were found between the LI 18 and LI 4-PC 6 groups,and between the model and ST 36-GB 34 groups in pain thresholds(P>0.05).Compared with the control group,the expression le-vels of mGluR 5 mRNA,cAMP mRNA and CREB mRNA in the cervico-spinal cord were upregulated significantly in the model group(P<0.05).While in comparison with the model group,cervico-spinal cAMP mRNA,and CREB mRNA were down-regulated markedly(P<0.05) and mGluR 5 mRNA was down-regulated moderately(P>0.05) in the LI 18 group,rather than in the LI 4-PC 6 and ST 36-GB 34 groups(P>0.05).Conclusion EA-LI 18 can significantly suppress neck incision pain induced pain reaction,which may be closely associated with its functions in down-regulating expression levels of intracellular cAMP mRNA and CREB mRNA in the cervico-spinal cord.1421|306|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of Electroacupuncture(EA) of "Quze"(PC 3) and "Neiguan"(PC 6) on cerebral angiogenesis in cerebral ischemia(CI) rats,so as to research its mechanisms underlying improvement of stroke.Methods Fifty SD rats were randomized into normal control,sham,model,EA-PC 3-PC 6,and EA-Hegu(LI 4)-Quchi(LI 11) groups.CI model was established by occlusion of the middle cerebral artery.EA(2-4 V,20 Hz) was applied to PC 3,PC 6,LI 4 and LI 11 respectively 6 h,24 h,48 h and 72 h after modeling,30 min for each time.Serum vascular endothelial growth factor(VEGF) content was assayed by enzyme linked immunosorbent assay(ELISA),and cerebral VEGF immunoactivity was detected by immunohistochemistry.Results Compared to the normal control group,serum VEGF content,cerebral VEGF expression level,and the number of VEGF-positive microvessels in the ischemic cerebral region in the model,EA-PC 3-PC 6 and EA-LI 4-LI 11 groups were increased significantly(P<0.01).In comparison with the model group,serum VEGF content,cerebral VEGF expression level,and the number of VEGF-positive microvessels in the EA-LI 4-LI 11 and EA-PC 3-PC 6 groups were up-regulated further(P<0.01),and the effects of the EA-PC 3-PC 6 group were obviously superior to those of the EA-LI 4-LI 11 group in up-regulating VEGF expression and the number of VEGF-positive microvessels(P<0.01).No significant difference was found between the EA-LI 4-LI 11 and EA-PC 3-PC 6 groups in serum VEGF levels(P>0.05).Conclusion EA of acupoints of both Large Intestine Meridian and Pericardium Meridian can up-regulate serum VEGF,cerebral VEGF expression and the number of VEGF-positive microvessels in CI rats,suggesting an increase of cerebral angiogenesis after the treatment.The effect of EA-PC 3-PC 6 is markedly superior to that of EA-LI 4-LI 11.关键词：Cerebral ischemia;Electroacupuncture;Acupoints of the Pericardium Meridian;Acupoints of the Large Intestine Meridian;Vascular endothelial growth factor;Angiogenesis1226|452|11更新时间：2023-08-11
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Effects of Different Quantity of Moxibustion at "Dazhui" (GV 14) on Cellular Immunity in Asthma Rats
摘要：Objective To observe the effects of different quantity of moxibustion of "Dazhui"(GV 14)on the levels of serum interleukin-4(IL-4),interferon-γ(IFN-γ),and immunoglobulin E(IgE) in asthma rats,so as to reveal its mechanisms underlying immune regulation.Methods Sixty male SD rats were randomly divided into control,model,moxibustion-15 min(M-15 min),M-30 min,M-60 min,and M-120 min groups(10 rats/group).Asthma model was established by intraperitoneal injection of sensitized-suspension(containing egg albumin,aluminium hydroxide,and deactivated Bacillus pertussis) and ovalbumin-aerosol inhalation.Moxibustion was applied to "Dazhui"(GV 14) for 15,30,60 and 120 min,respectively.Serum IL-4,IFN-γ and IgE contents were assayed by ELISA(enzyme-linked immunosorbent assay).Results Compared with the control group,serum IL-4,IFN-γ and IgE levels were increased significantly(P<0.01),and serum IFN-γ/IL-4 level was down-regulated obviously(P<0.01)in the model group.After the moxibustion treatment,the levels of serum IL-4 and IgE in the M-15 min,M-30 min,M-60 min,and M-120 min groups were reduced significantly compared with the model group(P<0.01,P<0.05).The ratios of IFN-γ/IL-4 in the M-15 min,M-30 min,M-60 min,and M-120 min groups were significantly higher than that in the model group(P<0.05,P<0.01).Comparison among the M-15 min,M-30 min,M-60 min,and M-120 min groups showed that the therapeutic effects of the M-30 min group were evidently superior to those of the M-15 min group,and those of the M-60 min group were significantly superior to those of the M-30 min group in lowering serum IL-4 and IgE contents and up-regulating IFN-γ/IL-4(P<0.05,P<0.01).No significant differences were found between the M-60 min and M-120 min groups in down-regulating IL-4 and IgE levels,and in raising IFN-γ/IL-4 level,as well as among the M-15 min,M-30 min,M-60 min and M-120 min groups in elevating se-rum IFN-γ levels(P>0.05).Conclusion Moxibustion can restrain the secretion of IL-4,relieve the inflammatory reaction of IgE,and enhance the ratio of IFN-γ/IL-4 in asthma rats,which presents an increase tendency of the curative effect along with the extension of the treatment time from 15 min to 60 min.Excessively long time(>60 min)of treatment is not necessary.关键词：Asthma;Moxibustion;"Dazhui"(GV 14);Quantity of moxibustion;Serum IL-4;IFN-γ;IgE;Cellular immunity1727|869|19更新时间：2023-08-11 - 摘要：Objective To investigate the influence of electroacupuncture(EA) on lipid metabolism in both sexes of obesity model rats.Methods A total of 30 male and 30 female SD rats were randomized into normal control,model and EA groups respectively,with 10 rats in each group.EA(2 Hz,1-2 mA) was applied to the ipsilateral "Zusanli"(ST 36)-"Sanyinjiao"(SP 6) and bilateral "Fenglong"(ST 40) for 30 min,once daily for 28 days.In addition,"Quchi"(LI 11),"Zhongwan"(CV 12)and"Guanyuan"(CV 4) were punctured with filiform needles and stimulated by manipulating the needle for 1 min,separately.Obesity model was duplicated by subcutaneous injection of 15% glutamic sodium(0.2 mL/10 g) once daily for 5 days and by feeding the animal with high fat forage for 36 days.Lee's index was calculated,and plasma triglyeride(TG) concentration detected by glycerol-phosphoric acid oxidase-peroxydase method,total cholesterol(TC) detected by cholesterol oxidase method,and plasma low-density lipoprotein-cholesterol(LDL-C) and high-density lipoprotein-cholesterol(HDL-C) contents were assayed by one-step method,respectively.Results In both male and female rats,compared to their own normal groups,the Lee's index,plasma TG,TC and LDL-C contents were increased significantly and plasma HDL-C contents decreased obviously in the model groups(P<0.01),while compared to their own model groups,the Lee's index,plasma TG,TC and LDL-C levels in the EA groups were down-regulated considerably and plasma HDL-C contents up-regulated remarkably after the treatment(P<0.01,P<0.05).The efficacies of the EA intervention were obviously better in reducing Lee's index for male rats,and in down-regulating plasma TG and TC contents in female rats(P<0.05).No significant differences were found between male and female rats in EA intervention for plasma LDL-C and HDL-C levels.Conclusion EA intervention can effectively regulate obesity rats' Lee's index and plasma TG,TC,LDL-C and HDL-C levels.The effects are different in male and female rats.关键词：Electroacupuncture;Obesity;Male and female rats;Lee's index;Lipid metabolism;Weight reduction990|244|2更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)of auricular point "Xin"(Heart),"Neiguan"(PC 6) and "Zusanli"(ST 36) on electrical activities of the pressor reflex-related neurons in the nucleus of the solitary tract(NTS)in rats.Methods A total of 47 SD rats were used in the present study.Extracellular electrical activities of neurons in the NTS(AP:1.0 mm,Left and right:0-1.0 mm,depth:0.3-0.8 mm)were recorded by using glass microelectrodes(10-15 MΩ).Carotid arterial pressure changes were monitored and recorded by using a pressure transducer.EA(2 mA,10 Hz,duration: 500 ms)was randomly applied to the left auricular point "Xin","Neiguan"(PC 6)and "Zusanli"(ST 36) for 30 s,respectively.Elevation of arterial pressure was induced by intravenous injection of Phenylephrine(PE,6-12 μg/kg,2 μg/mL).Results Of the 67 NTS neurons,15 were activated by intravenous injection of PE(which were called as pressor reflex-related neurons).Following EA of the auricular point "Xin" and ST 36,the mean arterial pressure(MAP) levels in normal rats and PE-induced MAP increase rats were lowered significantly(P<0.001,P<0.05).Concomitantly,the firing rates of pressor reflex-related NTS neurons were increased considerably by EA stimulation of auricular point "Xin" and ST 36,but not by EA of PC 6.EA of PC 6 had no apparent influence on MAP in normal rats and in PE-induced MAP increase rats(P>0.05).Conclusion Electroacupuncture stimulation of auricular point "Xin" and "Zusanli"(ST 36) can lower MAP in normal rats and PE-induced MAP elevation rats,and enhance pressor reflex induced increase of firing rates of NTS neurons,suggesting an interaction between signals from electroacupuncture sti-mulation of "Xin" and "Zusanli"(ST 36) and from cardiovascular activities in the NTS neurons.关键词：Electroacupuncture;Extracellular discharge;Nucleus of the solitary tract;Mean arterial pressure;Pressor reflex-related neurons;Auricular point "Xin";Zusanli(ST 36)1314|503|6更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupunctur(EA) of Shuigou(GV 26)on the expression of vascular protein kinase C(PKC) in the focal ischemia cerebral tissue in rats so as to study its dynamic regulation mechanism.Methods A total of 78 Wistar rats were randomly divided into model group(n=24),EA group(n=24),sham operation(sham) group(n=24) and control group(n=6).The first 3 groups were further divided into 0.5 h,1 h,3 h and 6 h subgroups,with 6 cases in each.Cerebral ischemia(CI) model was established by occlusion of the middle cerebral artery.EA(15 Hz,1.0 mA) was applied to "Shuigou"(GV 26) for 20 min.The anterior,middle and posterior cerebral arteries on the infarct side of the brain were collec-ted for assaying the expression of PKC protein by using Western blot,and the formalin-fixed artery samples were embedded with paraffin,followed by sectioning and staining with immunohistochemistry.Results Compared with the control group,the expression levels of cerebral vascular smooth PKC protein shown by both immunohistochemistry and Western blot were upregulated significantly at the time-points of 0.5 h,1 h,3 h and 6 h after CI in the model group(P<0.05,P<0.01).In comparison with the model group,the expression levels of PKC protein in the cerebral vascular smooth muscle shown by the aforementioned two metho-ds were down-regulated considerably in the EA group(P<0.01,P<0.05).No statistic differences were found between the control and sham groups in the expression of vascular PKC protein at different time-points(P>0.05).Conclusion EA intervention can significantly inhibit PKC expression in the cerebral vascular smooth muscle in CI rats,which may be responsible for its efficacy in improving ischemic stroke.关键词：Cerebral infarction;Electroacupuncture intervention;Protein kinase C;Vascular smooth muscle;Focal ischemic cerebral tissue1492|367|6更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) preconditioning of "Neiguan"(PC 6) on myocardial enzyme levels in acute recurrent myocardial ischemia rabbits so as to study its mechanisms underlying protection of ischemic myocardium.Methods A total of 40 healthy rabbits were randomized into normal control,myocardial ischemia(MI) model,EA preconditioning(EA-P),recurrent MI(RMI),EA-P+RMI groups.MI model was duplicated by auricular intravenous administration of Posterior Pituitary Injection(PPI,0.3 mL/kg).EA(2 Hz/70 Hz,2-4 mA)was applied to bilateral PC 6 for 30 min,once daily for 7 d before MI.The contents of serum aspartate aminotransferase(AST),isoenzymes of creatine kinase(CK-MB),lactate dehydrogenase(LDH),creatine kinase(CK),α-hydroxybutyrate dehydrogenase(α-HBD) were detected by automatic biochemistry analyzer.Results Following administration of PPI,ECG-STⅡ,serum AST,CK-MB,LDH,CK and α-HBD levels were increased significantly in the MI and RMI groups(P<0.01).Compared with the MI model group,ECG-STⅡ,serum AST,CK-MB,LDH,CK and α-HBD levels were down-regulated considerably in the EA-P group(P<0.01),and ECG-STⅡ,serum AST,CK-MB,LDH,CK and α-HBD levels were obviously lower in the EA-P+RMI group than in the RMI group(P<0.01).No significant differences were found between the MI and RMI groups,and between EA-P and EA-P+RMI groups in the above-mentioned 6 indexes(P>0.05).Conclusion Electroacupuncture preconditioning has a remarkable effect in the prevention of ischemic myocardial injury of both acute and recurrent myocardial ischemia in the rabbit,which is closely associated with its functions in lowering serum AST,CK-MB,LDH,CK and α-HBD contents.关键词：Electroacupuncture preconditioning;Neiguan(PC 6);Acute myocardial ischemia;Myocardial enzymes;Preventive treatment1307|358|3更新时间：2023-08-11
- 摘要：Objective To observe the curative effect of autologous blood point injection on diabetic gastroparesis and to study its underlying mechanism.Methods A total of 42 type-Ⅱ diabetes outpatients and inpatients were randomly and equally divided into treatment group and control group according to a random digit table.Patients of the treatment group were treated by injection of the patient's own venous blood(2 mL/acupoint)into the unilateral Zusanli(ST 36),Zhongwan(CV 12)and Weishu(BL 21),once every week,4 times together.Patients of the control group were ordered to take motilium(10 mg/time),3 times daily for 4 weeks.Plasma motilin and gastrin were detected by radioimmunoassay before and 4 weeks after the treatment.Results Of the two 21 cases in the control and treatment groups,3 and 7 experienced marked improvement in their symptoms,4 and 8 were effective,14 and 6 were failed in the treatment,with the effective rates being 33.3% and 71.4% respectively.The effective rate of the treatment group was significantly higher than that of the control group(P<0.05).The contents of plasma motilin and gastrin in both control and treatment groups were reduced obviously after the treatment(P<0.01),and the effect of the treatment group was significantly superior to that of the control group in lowering plasma motilin and gastrin levels(P<0.01).Conclusion Acupoint injection of the diabetes patients' own blood can obviously alleviate the symptoms of diabetic gastroparesis,which is closely associated with its effects in lowering plasma motilin and gastrin levels.关键词：Diabetic gastroparesis;Acupoint injection;Autologous blood;Plasma motilin;Gastrin1152|507|3更新时间：2023-08-11
- 摘要：Objective To observe the effect of needle-retention duration at Baihui(GV 20)and Sishencong(EX-HN 1)on blood pressure in hypertension patients.Methods Twenty-four patients with essential hypertension were randomly divided into acupuncture group and medication group.For patients of the acupuncture group,single-use sterilized filiform needles were inserted into Baihui(GV 20)and Sishencong(EX-HN 1)and manipulated for about 10 s till "Deqi",and retained for 8 h.Patients of the medication group were treated by oral administration of Nifedipine tablets(20 mg)in the morning.Blood pressure(right brachial artery)was detected 0.5,2,4,6 and 8 h after the treatment respectively.Results In comparison with pre-treatment,the systolic pressure levels at the time-points of 0.5,2,4,6 and 8 h after taking Nifedipine in the medication group,and the systolic pressure levels at the time-points of 2,4 and 6 h after the treatment in the acupuncture group,and the diastolic pressure levels at the time-points of 2,4,6 and 8 h in both acupuncture and medication groups were decreased obviously(P<0.05,P<0.01).The effect of acupuncture group was significantly weaker than that of the medication group in lowering systolic pressure at the time-points of 0.5 and 8 h after the treatment(P<0.01).No significant differences were found between the acupuncture and medication groups in lowering systolic pressure at the time-points of 2,4 and 6 h after the treatment,and in lowering diastolic pressure at the time-points of 0.5,2,4,6 and 8 h after the treatment(P>0.05).Conclusion Acupuncture stimulation of Baihui(GV 20)and Si-shencong(EX-HN 1)with sustained needle-retention works well in lowering blood pressure in hypertension patients,but is relatively slower and has a shorter period of time in lowering blood-pressure efficacy.关键词：Hypertension;Acupuncture;Needle-retaining;Blood pressure;Baihui(GV 20);Sishencong(EX-HN 1)1133|574|3更新时间：2023-08-11
- 摘要：Objective To observe the therapeutic effect of thermal acupuncture needle muscular stimulation for treatment of knee osteoarthritis patients.Methods A total of 120 outpatients with knee osteoarthritis were randomly and equally divided into control and treatment groups.Patients of the treatment group were treated by inserting the acupuncture needles into the attached sites of the quadriceps femoris,musculus vastus medialis,vastus lateralis,etc.around the knee joint.The needles were manipulated repeately till "Deqi",followed by attaching a piece of ignited moxa-roll(about 2 cm length) to the needle handle.The treatment was conducted once a week,4 weeks altogether.Patients of the control group were treated by oral administration of Celebrex(a specific inhibitor of COX-2,200 mg/time,once daily,4 weeks together).The therapeutic effect was evaluated by using visual analogue scale(VAS),Lequesne Index(Chinese Version) of osteoarthritis after 4 weeks' treatment and 3 months after the treatment.Results After 4 weeks' treatment and 3 months after the treatment,the effective rates were 78.3%(47/60) and 81.7%(49/60) in the control group,and 96.6%(58/60) and 96.6%(58/60) in the treatment group,respectively,being significantly higher in the treatment group(P<0.05).Both VAS scores and Lequesne Indexes in the treatment group,and VAS scores in the control group were decreased significantly after 4 weeks' treatment and 3 months' follow-up(P<0.05).The effects of the treatment group were considerably superior to those of the control group(P<0.05).Conclusion Thermal needle muscular stimulation therapy is effective for relieving knee osteoarthritis patients' symptoms of pain,knee-joint stiffness,swel-ling,walking capability,etc.关键词：Acupuncture therapy;Muscular stimulation therapy;Osteoarthritis of knee1221|554|4更新时间：2023-08-11
- 摘要：With the development of autism therapy,acupuncture,an alternative therapy,is becoming popular for autism children.There have been many papers found about the treatment of autism by acupuncture therapy so far.In the present review,the authors briefly introduce the theoretical basis of autism in traditional Chinese medicine and the application history,and sum up the acupoint prescriptions,effectiveness as well as the assessment tools of acupuncture therapy for autism.It is suggested that acu-puncture therapy is a relatively effective therapy for autism children.It has positive roles in improving autistic syndromes without any side-effects,especially in improving language development,daily-life self-care,and social communications.The underlying mechanism of this therapy may be explained by acupuncture intervention induced favorable changes of neurochemistry,cerebral blood flow,and cerebral functional activities.Although there are lots of questions to be answered about acupuncture treatment of autism,we hold a positive opinion that this therapy might be a green effective therapy for autistic children in the future.关键词：Acupuncture therapy;Childhood autism;Curative effect;Prospect718|718|4更新时间：2023-08-11
- 摘要：As for an important central regulatory neurotransmitter involving acupuncture effect,serotonin(5-HT)is worthy of being paid with more attention.In the present paper,the authors review development of researches on the involvement of 5-HT and its receptor subunits in pain perception,acupuncture analgesia,and other effects of acupuncture(anti-depression,weight-reduction,etc.).Many studies showed that acupuncture intervention could modulate the content and activity of central 5-HT,and these changes varied under different conditions.Hence,the relationship between 5-HT and other neurotransmitters in acupuncture analgesia and its different functions in different regions of the central nervous system should be considered comprehensively.关键词：Serotonin;Central nervous system;Acupuncture analgesia;Electroacupuncture1269|832|10更新时间：2023-08-11
- 摘要：One of the fundamental factors for achieving a better clinical efficacy of acupuncture therapy is to compose an appropriate acupoint recipe or a set of acupoint recipes for an illness or a clinical condition.The present article reviews recent development of researches about acupoint combination from the methods of combination style,properties and functions(synergic or antagonistic role) of different acupoints,etc.,and holds that "integrity" and "nonlinear" ideas are probably the key factors for composing reasonable acupoint prescriptions.Moreover,with reference to the achievements got in the field of complex network researches of Chinese medicine,the authors discuss the applicability of studies about acupoint combination literature,and biological data integration for acupoint compatibility.The authors point out that the current complex network analysis approach may be an effective measure for understanding the regularities and mechanisms of reasonable combination of acupoints.关键词：Acupuncture therapy;Acupoint combination;Complex network analysis technique;System biology1742|796|12更新时间：2023-08-11
- 摘要：In the present article,the authors summarized the state of acupuncture therapy in the United States of America from 1) history and current state,2) legislation and its contents,management system and introduction of health insurance system,and 3) standardization.Acupuncture therapy,as a complementary or alternative therapy,has been widely supported and approved by majority of states in the USA.The authors hold that due to differences between the oriental and western cultures and difficulties of Chinese medicine in quantitative and qualitative studies,the legislation on acupuncture therapy for approval of the American Parliament needs paying more efforts.关键词：Acupuncture therapy;Legislation;Standardization;The United States of America862|656|3更新时间：2023-08-11
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