最新刊期
卷 37 ， 期 5 ， 2012
- 摘要：Objective To observe the effect of electroacupuncture(EA) on expression of neuronal nitric oxide synthase(nNOS) protein and mRNA in the spinal cord in rats with chronic constrictive injury(CCI) of the sciatic nerve so as to explore its mechanisms underlying pain relief.Methods Thirty-six male SD rats were randomly divided into sham operation(control) group(n=12),CCI model group(n=12) and EA group(n=12).EA was applied to bilateral "Weizhong"(BL 40) and "Huantiao"(GB 30) on the injured side for 30 min,once a day for 7 days(from the 11th day on after CCI).The mechanical and thermal pain thresholds were measured before and after CCI.Spinal nNOS protein and mRNA expression levels were detected by Western blot and reverse transcription-polymerase chain reaction(RT-PCR),respectively.Results In comparison with the control group,both mechanical and thermal pain thresholds were significantly lower in the model group(P<0.01).Compared with the model group,the two types of pain threshold were increased considerably on the 16th day in the EA group(P<0.01).In comparison with the control group,the spinal nNOS protein and mRNA expression levels were increased significantly in the model group(P<0.05,P<0.01).In comparison with the model group,both nNOS protein and mRNA expression levels in the spinal cord were down-regulated obviously in the EA group(P<0.05).Conclusion Electroacupuncture can alleviate neuropathic pain in CCI rats,which is closely related to its effect in down-regulating the expression of nNOS protein and mRNA in the spinal cord.关键词：Electroacupuncture;Neuropathic pain;Spinal cord;Neuronal nitric oxide synthase1000|296|9更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) of "Futu"(LI 18),etc.on the expression of genes of glial cell line-derived neurotrophic factor(GDNF),brain-derived neurotrophic factor(BDNF) and their receptors in the cervico-spinal cord in neck-incision pain rats,so as to study its mechanism underlying incision-pain relief.Methods A total of 50 Sprague Dawley male rats were randomly divided into normal,model(incision pain),EA-Futu(LI 18),EA-Hegu(LI 4)-Neiguan(PC 6,LI 4-PC 6) and EA-Zusanli(ST 36)-Yanglingquan(GB 34,ST 36-GB 34) groups(n=10/group).A 1.5 cm long longitudinal incision was made along the midline of the neck under anesthesia to duplicate neck-incision pain model.Thermal pain threshold(PT) was measured before and after modeling and after the treatment,respectively.EA(1-2 mA,2 Hz/100 Hz) was applied to bilateral LI 18,PC 6-LI 4 and ST 36-GB 34 for 30 min.The expression of genes of GDNF and its receptor GFRα-1,and BDNF and its receptors TrkA,TrkB in the spinal cord(C1-C4) tissue was detected by quantitative real-time-PCR.Results In comparison with pre-modeling in the same one group,the thermal PT levels were decreased obviously in the model,LI 18,LI 4-PC 6 and ST 36-GB 34 groups after neck incision(P<0.05).Compared with the model group,the PT levels were increased markedly in LI 18,LI 4-PC 6 and ST 36-GB 34 groups after the EA treatment(P<0.05).Correspondingly,the expression levels of spinal GDNF mRNA and GFRα-1 mRNA were obviously lower,as well as BDNF mRNA was markedly higher in the model group than in the control group(P<0.05),and those of TrkA mRNA and TrkB mRNA were increased slightly in the model group than in the control group(P>0.05).In comparison with the model group,the expression levels of spinal GDNF mRNA and GFRα-1 mRNA were up-regulated considerably(P<0.001),whereas those of BDNF mRNA,TrkA mRNA and TrkB mRNA were decreased slightly(P>0.05) in the LI 18,LI 4-PC 6 and ST 36-GB 34 groups after EA treatment.Conclusion EA stimulation can significantly suppress pain reaction of neck incision,which is closely associated with its effects in up-regulating the expression of GDNF and its receptor GFRa-1 genes in the cervical spinal cord(C1-C4).关键词：Acupuncture analgesia;Neck-incision pain;Cervical spinal cord;Glial cell line-derived neurotrophic factor;Brain-derived neurotrophic factor;Gene expression1568|265|2更新时间：2023-08-11
- 摘要：Objective To observe the effect of autoblood acupoint-injection(ABAI) on expression levels of pulmonary transacting T-cell-specific transcription factor GATA 3(involving Th 2 cytokine expression),Th 1-specific T-box transcription factor T-box expressed in T-cells(T-bet) proteins and genes in asthmatic rats so as to explore its mechanisms underlying asthma relief.Methods Forty-eight male SD rats were randomized into normal control(n=8),model(n=10),saline acupoint-injection(SAI,n=10),ABAI(n=10),and Dexamethasone(DXM,n=10) groups.Asthma model was established during 28 days by 10% Ovalbumin+10% aluminium hydroxide solution injection(i.p.) and vapourized 2% Ovalbumin inhaling for 14 days.For rats of the ABAI group,0.4 mL autoblood was injected into the bilateral "Feishu"(BL 13) or "Shenshu"(BL 23) alternately,once every other day for six times.For rats of the DXM group,50% DXM solution(0.5 mg/kg,i.p.) was given from the 17th day on after starting the modeling,once every other day for 11 days.Pulmonary GATA 3 and T-bet protein expression was detected by immunohistochemistry,and GATA 3 mRNA and T-bet mRNA expression detected by real time-PCR.Results In comparison with the normal group,pulmonary GATA 3 protein and mRNA expression levels in the model group were up-regulated significantly(P<0.01),while T-bet mRNA expression in the model group was down-regulated obviously(P<0.01).Compared to the model group,GATA 3 protein and mRNA expression levels were down-regulated significantly in both ABAI and DXM groups(P<0.01),while T-bet protein expression in ABAI group and T-bet mRNA expression in both ABAI and DXM groups were up-regulated significantly(P<0.01,P<0.05).No significant differences were found between model and SAI groups,and between ABAI and DXM groups in GATA 3 protein expression levels;and between ABAI and DXM groups in GATA 3 mRNA expression levels;between normal and model groups,and between SAI and ABAI groups in T-bet protein expression levels;between model and SAI groups and between ABAI and DXM groups in T-bet mRNA expression levels(P>0.05).The ratio of GATA 3 mRNA/T-bet mRNA expression was significantly higher in the model group than in the normal group(P<0.01),while obviously lower in the SAI,ABAI and DXM groups than in the model group(P<0.05,P<0.01).Additionally,the ratios of GATA 3 mRNA/T-bet mRNA in ABAI and DXM groups were comparable(P>0.05).Conclusion Autoblood acupoint injection is comparable to DXM intraperitoneal injection in down-regulating asthma-induced increase of pulmonary GATA 3 protein and mRNA expression as well as ratio of GATA 3 mRNA/T-bet mRNA,and in up-regulating asthma-induced decrease of T-bet mRNA expression in asthma rats,which may contribute to their effects in relieving asthma.关键词：Asthma;Autoblood acupoint-injection;Th 2-specific transcription factor GATA 3;Th 1-specific transcription factor T-bet;GATA 3 mRNA/T-bet mRNA985|326|3更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupuncture of "Zusanli"(ST 36) and "Taichong"(LR 3) on gastrointestinal hormone levels in diarrhea type irritable bowel syndrome(IBS-D) rats so as to provide experimental evidence for acupuncture treatment of IBS-D.Methods Forty-eight Wistar rats were randomly divided into control,model,acupuncture and medication groups,with 12 rats in each group.IBS-D model was established by chronic mild restraining stress combined with isolated raising and intragastric administration of Folium Sennae(10 mL/kg).For rats of the acupuncture group,bilateral "Zusanli"(ST 36) and "Taichong"(LR 3) were punctured and stimulated for 30 min,once daily for 14 days.The rats of the medication group were treated by gavage of Pinaverin bromide,once daily for 14 days,and those of the control and model groups were given with equal volume of saline.Somatostatin(SS),substance P(SP) and vasoactive intestinal peptide(VIP) in the rats' plasma and ileum tissues were detected by sandwich enzyme-linked immunosorbent assay(ELISA).Results Compared with the control group,the body weight and food intake quantity were reduced significantly,while the diarrhea index was increased significantly in the model group(P<0.05,P<0.01).In comparison with the model group,the body weight and food intake volume in both acupuncture and medication groups were increased remarkably after the treatment(P<0.05,P<0.01) whereas the diarrhea index in the latter two groups was reduced obviously(P<0.01).Compared with the control group,plasma VIP level was increased significantly in the model group(P<0.01),while those in both acupuncture and medication groups were decreased remarkably compared with the model group(P<0.05).No significant changes of plasma SP and SS levels were found after modeling and after both acupuncture and medication treatments.In comparison with the control group,ileum SP,VIP and SS levels in the model group were up-regulated significantly(P<0.01),while those in both acupuncture and medication groups were down-regulated considerably compared with the model group(P<0.01).No significant differences were found between acupuncture and medication groups in the levels of ileum SP,VIP and SS(P>0.05).Conclusion Acupuncture of ST 36 and LR 3 can effectively down-regulate ileum SP,VIP and SS levels in IBS-D rats,which may contribute to its effect in relieving IBS-D.关键词：Acupuncture therapy;Diarrhea type irritable bowel syndrome;Gastrointestine hormones1318|861|14更新时间：2023-08-11
- 摘要：Objective To observe the influence of electroacupuncture(EA) of "Chize"(LU 5,He-sea acupoint) and "Shangjuxu"(ST 37,lower He-sea acupoint) on mesenteric microcirculation,vasoactive intestinal peptide(VIP) levels in the lung,colon and hypothalamus tissues in rats with chronic obstructive pulmonary disease(COPD),so as to investigate its mechanism underlying improvement of lung derived intestinal disorders in clinical practice.Methods Thirty-two male Wistar rats were randomly divided into normal control,model,EA-Chize(LU 5,EA-LU 5) and EA-Shangjuxu(ST 37,EA-ST 37) groups,with 8 rats being in each group.COPD model was established by intratracheal infusion of Lipopolysaccharide(LPS,1 mg/mL,0.2 mL/rat) and forced inhaling smoke,once daily for 28 days.EA was applied to bilateral LU 5 and ST 37 for 20 min,once every other day for 12 sessions.The state of mesenteric microcirculation was observed under microscope and divided into grade 0(stagnation of blood flow),Ⅰ(slow flowing and silt-like state),Ⅱ(faster flowing with slight or obvious grainy feeling) and Ⅲ(fast flowing without grainy feeling).The contents of VIP in the lung,colon and hypothalamus were detected using radioimmunoassay(RIA).Results Following modeling,the microvascular calibers were increased slightly in the model,EA-LU 5 and EA-ST 37 groups.Compared with the normal group,the blood flow velocity was increased significantly in model group(P<0.05).In comparison with the model group,the blood flow velocity was reduced significantly in EA-LU 5 and EA-ST 37 groups(P<0.01).There were no significant differences between EA-LU 5 and EA-ST 37 groups in blood flow velocity,among the four groups in VIP contents of the lung tissue(P>0.05).The content of VIP in the colon was markedly higher in the model group than in the normal group,and that in the hypothalamus was obviously lower in the EA-LU 5 group than in the model group(all P<0.05).Conclusion EA stimulation of "Chize"(LU 5) can notably reduce hypothalamic VIP content and slow down blood flow velocity of the mesenteric microvessels in COPD rats.关键词：Chronic obstructive pulmonary disease;Electroacupuncture intervention;Mesenteric microcirculation;Vasoactive intestinal peptide;Lung;Colon;Hypothalamus1522|394|3更新时间：2023-08-11
- 摘要：Objective To observe the effect of scalp cluster-needle intervention on cognitive ability and hippocampal vascular endothelial growth factor(VEGF) expression in cerebral ischemia(CI) rats.Methods Forty Wistar rats were rando-mized into sham operation(sham),model,scalp-acupuncture and medication groups.Chronic CI model was established by occlusion of the bilateral common carotid arteries.Acupuncture needles were inserted into "Baihui"(GV 20) and its left and right points(2 mm beside GV 20) and manipulated leftward and rightward for 3 min at a frequency of about 200 times/min,retained for 30 min.The treatment was conducted once daily,for 4 weeks.For rats of the medication group,Nimodipine(1 mg/kg) was gi-ven to the animal by gavage,once a day,for 4 weeks.The rats' learning ability was measured by Morris water maze.Changes of hip-pocampal cellular morphology were observed by HE staining and light microscope,and hippocampal VEGF expression was detected by immunohistochemistry.Results In comparison with the sham group,the escape latency of rats in the model group was prolonged significantly(P<0.05),suggesting a decrease of learning ability after CI.Compared with the model group,the escape latency of both acupuncture and medication groups were reduced markedly after the treatment(P<0.05).In comparison with the sham group,the number of VEGF immunoreaction(IR) positive cells in the model group was up-regulated significantly(P<0.05),while compared with the model group,the numbers of both acupuncture and medication groups were increased further(P<0.05).No significant differences were found between the acupuncture and medication groups in escape latency and VEGF expression levels(P>0.05).HE staining showed that in the model group the hippocampal pyramidal cells were reduced in number,became vaguer in layers and nucleole,and got deformed in structure with karyopycnosis and disappearance of endochylema,and cavitation.These situations were relatively lighter in both acupuncture and medication groups.Conclusion Scalp acupuncture intervention can significantly improve CI rats' congnitive ability and pathological changes,which may be related to its function in increasing the expression of VEGF in the hippocampus.关键词：Scalp acupuncture;Chronic cerebral ischemia;Cognitive function;Hippocampus;Vascular endothelial growth factor;Pathological changes1310|311|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) preconditioning on cerebral ischemia and the role of cerebral neuroglobin(NgB) in EA-induced brain protection in focal cerebral ischemia and reperfusion injury(CI/RI) rats.Methods Male SD rats were randomly assigned to sham control,CI/RI 6 h,CI/RI 24 h and CI/RI 72 h groups(n=6) for observing changes of NgB at different time-points.Additional SD rats were randomly assigned to sham,model,and EA preconditio-ning(EA-PC) groups(n=16) for observing changes of cerebral NgB positive cell counts in the ischemic penumbra region 24 h after reperfusion.EA pre-conditioning was applied to "Baihui"(GV 20) for 30 min,once daily for 5 days before CI/RI.CI/RI model was established by occlusion of the right middle cerebral artery and reperfusion for 6 h,24 h and 72 h respectively.The neurological behavior scores(NBS) of all the rats were evaluated according to Garcia's methods.The cerebral infarct volume was determined by 2,3,5-triphenyltetrazolium chloride(TTC) staining.The number of cerebral NgB positive cells was detected by immunofluorescent staining.Results No infarct loci were found in the sham group.The cerebral infarction volume percentage was significantly higher in the model group than in the EA-PC group(P<0.01),while the NBS was significantly lower in the model group than in the EA-PC group(P<0.01).The number of cerebral NgB positive cells in the ischemic penumbra was up-regulated 6 h after CI/RI injury,peaked at 24 h and continued at 72 h.Compared with the sham group,the number of cerebral NgB positive cells of the model group was increased significantly,whereas that of the EA-PC group up-regulated further obviously in comparison with the model group(P<0.01).Conclusion EA pretreatment has a significant neuroprotective effect on cerebral ischemia-reperfusion,which is closely related to its effect in up-regulating NgB protein expression.关键词：Cerebral ischemia-reperfusion;Electroacupuncture preconditioning;Cerebral neuroglobin;Neuroprotection1572|320|4更新时间：2023-08-11
- 摘要：Objective To explore the mechanism of electroacupuncture(EA) of scalp-point in the management of myocardial ischemia-reperfusion injury(MI/RI) by examining its effects on left cardiac sympathetic nerve activity,myocardial β1-adrenaline receptor(AR) protein expression and plasma norepinephrine(NE) concentration in MI/RI rats.Methods Eighteen Wistar rats were randomly divided into sham,model and EA groups(n=6).MI/RI model was induced by ligation of the left anterior descending coronary artery for 30 min,followed by release of the ligation for 15 min.EA was applied to bilateral Epangxian I(MS 2) for 15 min.The left cardiac sympathetic nerve activity was recorded with BL-420 E+ biological signal acquisition system.Myocardial β1-AR protein expression was examined by western blot and plasma NE level detected by enzyme-labeled immunosorbent assay.Results Compared with the sham group,the left cardiac sympathetic discharges and plasma NE levels and myocardial β1-AR protein expression were markedly increased in the model group(P<0.01),whereas in comparison with the model group,the sympathetic discharges,plasma NE level and myocardial β1-AR protein expression in the EA group were down-regulated significantly(P<0.05).Conclusion Scalp-point EA intervention can suppress MI/RI induced increase of sympathetic nerve activity and plasma NE level,and β1-AR protein expression,which may contribute to its effect in relieving myocardial ischemia.关键词：Myocardial ischemia reperfusion;Electroacupuncture;Scalp-point;Sympathetic nerve activity;Myocardial β1-adrenoceptor protein expression;Plasma norepinephrine content1243|351|4更新时间：2023-08-11
- 摘要：Objective To observe hemodynamic changes in the local sucked tissue of lower back undergoing negative pressure after cupping in patients with lumbago.Methods Twenty-two lumbago outpatients were recruited in the present study and 32 sucked tissues accepted measurements.The cupping was applied to the tenderpoint of the patients' lower back for 10 min by using a glass-mug(5 cm in diameter).Hemodynamic indexes [peak systolic velocity(PSV),end-diastolic velocity(EDV) and resistance index(RI)] of the sucked skin and subcutaneous tissues at the lower back were detected before and after cupping by using a color Doppler flow imaging.Results After cupping intervention at the lower back,the PSV[(14.2±1.8) cm/s] and EDV [(5.5±0.7) cm/s] levels were increased significantly in comparison with those [(5.9±0.9) and(1.9±0.3) cm/s] before cupping(P<0.01),while RI was reduced evidently after cupping(0.61±0.05 vs 0.68±0.06,P<0.01),suggesting an increase of the regional blood flow.Conclusion Cupping therapy can increase the peak systolic velocity and end-diastolic velo-city and lower vascular resistance of the subcutaneous arterioles in the regional tissue,which may contribute to its effect in relieving lumbago.关键词：Lumbago;Cupping therapy;Sucked tissue hemodynamics;Peak systolic velocity;End-diastolic velocity;Resistance index884|502|2更新时间：2023-08-11
- 摘要：Objective To observe the therapeutic effect of scalp-acupoint catgut embedding in the treatment of insomnia.Methods Sixty-four insomniacs were randomly divided into catgut embedding group(n=33) and routine acupuncture group(n=31).Baihui(GV 20),Shenting(GV 24) and bilateral Fengchi(GB 20) were selected for subcutaneous embedding of catgut,once a week for 4 weeks.GV 20,GV 24,bilateral GB 20,bilateral Shenmen(HT 7),bilateral Neiguan(PC 6) and bila-teral Sanyinjiao(SP 6) were punctured with filiform needles for patients of the acupuncture group.The treatment was performed once every other day,3 times a week for 4 weeks.The therapeutic effect was evaluated by using International Unified Sleep Efficiency Value and Pittsburgh Sleep Quality Index(PSQI).Results After the treatment,the falling asleep latency and PSQI scores of both catgut embedding and routine acupuncture groups were decreased significantly(P<0.01) while the sleep duration and sleep efficiency increased considerably(P<0.01) in comparison with pre-treatment.The effect of catgut embedding was obviously better than that of routine acupuncture in prolonging sleep duration and improving sleep efficiency(P<0.05).No significant differences were found between the two groups in the falling asleep latency and the PSQI scores(P>0.05).Conclusion Both routine acupuncture and scalp-acupoint catgut embedding interventions can effectively reduce falling asleep latency and prolong sleep duration.The therapeutic effect of scalp-acupoint catgut embedding is relatively better in improving sleep duration and sleep efficiency.关键词：Insomnia;Scalp-acupoint catgut embedding;Routine acupuncture;Falling asleep latency;Sleep duration;Sleep efficiency1117|505|0更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupuncture of Jianjing(GB 21) and non-acupoint on gallbladder volume and clinical symptoms of chronic cholecystitis patients.Methods Sixty cases of chronic cholecystitis patients were equally randomized into Jianjing(GB 21) group and non-acupoint group.A filiform needle was inserted into Jianjing(GB 21) or non-acupoint(2 cun lateral to the mid-point between the spinous processes of the 6th and 7th cervical vertebrae) on the right side,manipulated for a while till "Deqi",and retained for 30 min.A color Doppler ultrasound scanner was used to detect the volume of the gallbladder before and 15 min after acupuncture stimulation and 30 min after withdrawal of the acupuncture needle.Changes of the patients' symptoms of shoulder-back pain,stomachache,distension and nausea were evaluated according to the patients' complaints.Results After acupuncture intervention,the remission rates of shoulder-back pain and stomachache in non-acupoint and GB 21 groups were 56.67% and 90.00% respectively,while the effective rates of the patients' gastric distention and nausea in non-acupoint and GB 21 groups were 16.67% and 23.33%,respectively.The therapeutic effect of Jianjing(GB 21) was appa-rently superior to that of non-acupoint in pain relief(P<0.05).Fifteen min following acupuncture stimulation and 30 min after with-drawal of the acupuncture needle,the gallbladder volume in cholecystitis patients with deflated gallbladder was increased appa-rently in GB 21 group(P<0.01),and that in patients with expanded gallbladder was decreased significantly(P<0.01).No significant differences were found among pre-,during and post-treatment in the non-acupoint group in the effects of acupuncture on regulation of the deflated and expanded gallbladder volume(P>0.05).Conclusion Acupuncture stimulation of Jianjing(GB 21) can effectively relieve shoulder-back pain and stomachache,and regulate the volume of the deflated and expanded gallbladder in cholecystitis patients.The effect of acupuncture of non-acupoint is relatively poorer in relieving the cholecystitis patients' symptoms and regulating the gallbladder volume.关键词：Cholecystitis;Acupuncture;Jianjing(GB 21);Gallbladder volume;Clinical symptoms741|396|1更新时间：2023-08-11
- 摘要：Objective To compare the therapeutic effects of different types of acupuncture therapy on herpes zoster(acute stage).Methods A total of 189 cases of acute herpes zoster outpatients and inpatients were recruited in the present multicenters(3 hospitals) randomized controlled clinical trials.They were divided into(computer-aided random allocation):basic acupuncture(n=36),cotton moxibustion(n=35),fire needle(n=43),tapping-cupping(n=39) and medication(n=36) groups.Ashi-points(around the locus),Jiaji(EX-B 2),Zhigou(SJ 6) and Houxi(SI 3) were used in this study.For patients of the acupuncture group,the abovementioned acupoints were punctured with filiform needles(encircled needling around the affected loci) and also stimulated with electroacupuncture(EA).For patients of the cotton moxibustion group,thin defated dry cotton pieces put over the Ashi-point were ignited,3 times altogether,followed by EA and encircled needling stimulation which were the same to those in the basic acupuncture group.Patients of the fire needle group were treated by pricking the herpes(3-5 in number) with a hot-red needle,followed by EA and encircled needling treatment.Patients of the tapping-cupping group were treated by tapping Ashi-points repeatedly with a percussopunctator and cupping over the pricked region,followed by EA and encircled needling treatment.Patients of the medication group were treated by oral administration of Valaciclovir Hydrochlordide(300 mg/time,twice a day) and vitamin B1(10 mg/time,t.i.d.) for 10 days.The acupuncture-moxibustion treatment was given once daily for 10 days.The time of blister-occurrence cease,scab formation and decrustation was recorded,and pain degree was evaluated using visual analog scale(VAS).The therapeutic effect was assessed according to the related standards.Results There were no significant differences among the 5 groups in the time of blister-occurrence cease,scab formation and decrustation,and in the therapeutic effect(P>0.05).The VAS scores of the 5 groups were decreased gradually and apparently along with the treatment(P<0.05),suggesting a pain relief after the treatment.In comparison with the medication group,the VAS scores of the basic acupuncture group,cotton moxibustion group,fire needle group and tapping-cupping group were significantly lower from the 7th day on following the treatment(P<0.05).Conclusion Acupuncture plus encircled needling and acupuncture plus encircled needling combined with cotton-moxibustion,or with fire needle stimulation,or with tapping and cupping are effective in the treatment of herpes zoster at the acute stage,being comparable to the medication in the clinical curative effect and improvement of blisters,and better than medication in pain relief.关键词：Herpes zoster;Acupuncture;Clinical therapeutic effect;Visual analog scale;Blister changes2050|2188|5更新时间：2023-08-11
- 摘要：Objective To observe the therapeutic effect of umbilicus moxibustion for sub-health people with yang-deficiency constitution.Methods Sixty sub-health volunteers with yang-deficiency constitution were equally and randomly divided into treatment and control groups.The subjects of the two groups were treated conventionally with Jingui Shenqi Pill(Goldern Chamber Pill for strengthening the Kidney-qi),8 pills each time,3 times a day.Additionally,those subjects of the treatment group were also treated by moxibustion over the umbilicus,twice a week,3 months altogether.The integrative score was assessed before and after the treatment in accordance with the criteria of "Quantization Diagnosis of Chinese Medicine".Results After umbilicus moxibustion intervention for 3 months,the integrative scores of symptoms of mental fatigue,cold limbs and warmth preference,lassitude in loin and limbs,and loose stool were decreased significantly in the treatment group(P<0.05),suggesting an improvement of these symptoms and being superior to those of the control group in the curative effect(P<0.05).Simple Jingui Shenqi Pill treatment was also effective in reducing scores of cold limbs and warmth preference,and lassitude in loin and legs after the treatment(P<0.05).Of the two 30 cases in the treatment and control groups,18(60.0%)and 7(23.3%)expe-rienced marked improvement in their symptoms,10(33.3%) and 12(40.0%) had an improvement,2(6.7%) and 11(36.7%) were failed,with the effective rates being 93.3% and 63.3%,respectively.Conclusion Umbilicus moxibustion therapy can effectively improve clinical symptoms of sub-health subjects with yang-deficiency constitution.关键词：Umbilicus moxibustion therapy;Sub-health;Yang-deficiency constitution;Clinical symptoms889|992|1更新时间：2023-08-11
- 摘要：Bi-directional regulation is referred to a balancing effect of both acu-moxibustion and Chinese materia medica interventions when the human body is experiencing a hyperactivity or hypoactivity due to abnormal intrinsic or external factors.In the present paper,the authors analyze their identical and different characteristics from: 1) definition;2) characters of regulative effects of acu-moxibustion therapy: A) differentiation of meridian and zangfu-organs being the basis of treatment,B) four factors(acupoint-location,body's functional state,acupoint-formula and needle-manipulation techniques) dependant,C) entirety regulation,and D) centrotaxis modulation;3) characters of Chinese materia medica intervention:including a)correspondence between the drug property and the syndrome being the basis of the regulative effect,b) multi-factors [components(antagonist and agonist),combination,dosages and processing quality of Chinese materia medica,and functional state of the human body] depen-dant,c) entirety regulation,and d) both centrotaxis and deviation adjustment.In one word,the bi-directional regulation effect is one of the basic characteristics of both acu-moxibustion and Chinese materia medica in clinical practice,but their basis and modes for inducing effects are different.关键词：Acu-moxibustion therapy;Chinese materia medica;Bi-directional regulation;Identification and difference1158|797|4更新时间：2023-08-11
- 摘要：Objective To analyze the basic characteristics of effects of acupoint application therapy in order to guide clinical decision better.Methods A database on acupoint application therapy was established first by collection,sorting,screening,recording,collation,data extraction,and statistical analyses of the related literature published in recent 60 years,and using modern computer system.Then,its predominant indications and application rules in clinical practice were analyzed using data mining techniques.Results Outcomes of data mining showed that the acupoint application therapy was extensively utilized in the treatment of a variety of diseases or clinical conditions(142 in total) in different clinical departments,particularly in the internal medicine which contains 51 types of clinical conditions or diseases(accounting for 35.92%).Among them,the top 3 are asthma,cough,and abdominal pain,with the appearance frequency being 161,79 and 45 times(=articles) in the domestic journals,respectively.The second one is the paediatric department,containing 30 kinds of diseases or clinical conditions(accounting for 21.13%).Among them,cough(106 articles),asthma(104 articles) and diarrhoea(82 articles) are frequently seen.The surgery department takes the third place,involving 27 disorders(accounting for 19.01%),with lumbago-leg pain being the most(31 articles).In the departments of ophthalmology and otorhinolaryngology,14 types of disorders(accounting for 9.86%) have been reported,with nasosinusitis being the most(56 papers).This therapy has also been used to treat 10 types of gynecopathy(7.04%) and 10 kinds of dermopathy(7.04%),with dysmenorrhea(37 articles) and shingles(6 articles) being the most.For acupoint application,complex prescriptions of Chinese herbal medicines in the forms of paste and cataplasm are frequently adop-ted,but with fewer application of enhancer of cutaneous penetration.Regarding the utilized acupoint,local points are often chosen.In the light of the collected papers,the highest effective rate is for dermopathy,followed by surgical problems,gynecopathy,paediatric conditions,and disorders of the internal medicine,ophthalmology and otorhinolaryngology.Conclusion Acupoint application therapy has been used for 142 kinds of disorders of different clinical departments,with the dominant indications being asthma,cough,abdominal pain,facial paralysis and constipation in the internal medicine,cough,asthma and diarrhoea in the paediatrics,lumbago-leg pain in the surgery,nasosinusitis in the otorhinolaryngology,and dysmenorrhea of gynecopathy.关键词：Acupoint application;Database;Data mining;Clinical indications;Literature research2529|2960|30更新时间：2023-08-11
- 摘要：Alzheimer's disease(AD) is one of the major diseases threatening the aged people's health.In the present paper,the authors reviewed development of studies on acupuncture treatment of AD from: 1) regulating release of neurotransmitters(cholinergic,amino-acids and monoamine neurotransmitters),2) protecting cerebral neurons from apoptosis(anti-oxidative stress,improving synaptic plasticity,and suppressing apoptosis),3) improving levels of neurotrophic factors,4) regulating hip-pocampal intracellular signaling,5) inhibiting inflammatory reactions of the brain tissue,6) adjusting the level of abnormal proteins(microtubule-associated protein,β-amyloid),and 7) up-regulating the level of autophagy activity.However,current experimental studies can not completely answer clinical questions due to limited model designs and complicated pathological mechanisms of AD.Many findings of biological indexes need being verified further.Reasonable therapeutic regimens of acupuncture formulated according to syndrome differentiation will help improving clinical curative effect and the corresponding research on new therapeutic targets may be helpful to our understanding about the mechanism of acupuncture.关键词：Alzheimer's disease;Acupuncture therapy;Neurotransmitters;Neurotrophic factors;Protection mechanism;Review2338|1834|18更新时间：2023-08-11
- 摘要：In the present paper,the authors make a bibliometrics study on clinical indications of acupuncture therapy based on the published foreign articles about acupuncture clinical trials collected from PubMed database and Excerpta Medica database(EMbase).In 1996,64 acupuncture indications were declared by WHO in Milan conference.But in recent 15 years,clinical trials have been conducted extensively in the foreign countries.Till now,77 new indications for acupuncture therapy have been found in the foreign journals.The authors recommended that 29 indications(knee osteoarthritis,critique age problems,muscular fasciae ache,anxiety,etc.) should be added to the first class,4 indications(irritable bowel syndrome,malposition,backache,simple obesity) should be upgraded from the second class to the first class,and the other 3 indications(childbirth pain,male and female barren) should be upgraded from the third class to the first class due to their application frequency in clinical trials.Increase of clinical indications reflects extensive application of acupuncture therapy and may help providing a better service for people's health.关键词：Acupuncture therapy;New clinical indications;Foreign countries;Bibliometrics1283|957|5更新时间：2023-08-11
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