最新刊期
卷 38 ， 期 6 ， 2013
- 摘要：Objective To observe the effects of transcutaneous acupoint electrical stimulation(TAES)combined with general anesthesia(acupuncture analgesia combined with general anesthesia)on postoperative pain,nausea and vomiting and exhausted defecation symptoms in patients undergoing gynecological laparoscopic operation.Methods Sixty patients with gynecological laparoscopic operation were randomly divided into TAES group and control group,with 30cases in each group.Patients of the control group received simple general anesthesia and those of the TAES group were treated with general anesthesia and TAES of bilateral Zusanli(ST 36)and Liangqiu(ST 34).Visual Analogue Scale(VAS)was used for measuring the patients' pain reaction at 8h,24hand 72hafter surgery.Symptoms of patients' nausea and vomiting,post-operation exhaust and defecation time were recorded after operation.Results The VAS scores at time-points of 8h,24hand 72hand nausea level in the TAES group were significantly lower than those of the control group(P<0.01,P<0.05).The vomiting severity of the TAES group was also relatively lower in comparison with the control group,but without significant difference between the two groups(P>0.05). The post-operation exhaust and defecation time of patients in the TAES group apparently appeared earlier than those of patients in the control group(P<0.01).Conclusion TAES combined with general anesthesia is effective in reducing post-operative pain and nausea,and improving gastrointestinal function in patients undergoing laparoscopic operation.关键词：Transcutaneous acupoint electrical stimulation;Gynaecology;Laparoscopic operation;Compound acupuncture anesthesia1252|630|8更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)intervention on dynamic changes of neurological function,blood glucose and insulin levels in rats with focal cerebral ischemia(CI),so as to explore its mechanism underlying improvement of ischemic cerebral vascular disease.Methods Male Wistar rats were randomly divided into four groups:normal, sham-operation(sham),model and EA.CI model was induced by middle cerebral artery occlusion(MCAO).The four groups were further randomized into 5subgroups according to time-points of MCAO:6hour,day 1,day 3,day 7and day 14(8rats/ group).EA(2Hz/15Hz,1mA)was applied to bilateral"Neiguan"(PC 6)and"Quchi"(LI 11)for 30min,once daily for 1day to 14days.Neurological impairment was evaluated by Zea Longa 5-point scoring system.Local cerebral blood flow(LCBF)of the cerebral pia mater was determined using Laser Doppler Flowmetry.The levels of abdominal cavity venous blood glucose and serum insulin were measured by using aglucose meter and radioimmunoassay,respectively.Results In comparison with the normal and sham groups,the rats' body weights and LCBF levels at time-points of day 1,3,7and 14,and blood glucose and serum insulin levels at most time-points of 6h,day 1,3,7and 14after CI were significantly decreased in the model group(P<0.05), and neurological scores at time-points of 6h,day 1,3,7and 14were markedly increased in the model group(P<0.05).After EA intervention,compared with the model group,the rats' body weights at time-points of day 3,7and 14,LCBF levels on day 7 and 14,blood glucose on day 14,and serum insulin contents at time-points of day 1,3,7and 14were considerably increased in the EA group(P<0.05),while Zea Longa scores at time-points of day 3and 7were evidently decreased in the EA group(P<0.05).Conclusion EA intervention is effective in improving neurological function in CI rats,which is probably associated with its functions in improving cerebral blood flow,and up-regulating blood glucose and insulin levels.关键词：Focal cerebral ischemia;Electroacupuncture intervention;Body weight;Neurological function;Local cerebral blood flow;Serum insulin;Blood glucose1385|253|2更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)at"Dazhui"(GV 14)on the contents of extracellular matrix(ECM),collagen typeⅡ(COL-Ⅱ),collagen type V(COL-V),matrix metalloproteinase(MMP)-13,tissue inhibitor of metalloproteinase(TIMP)-1in rats with cervicovertebral disc degeneration so as to explore its mechanism underlying relief of intervertebral disc degeneration.Methods A total of 28SD rats were randomly divided into sham group(n=7),model group(n=7),EA group(n=7)and medication group(n=7).The model of cervical intervertebral disc degeneration was established by trans-section of the deep neck splenius,the longest muscles of head,neck costocervicalis,head semi-spinatus muscle,supraspinous ligament and interspinal ligaments of cervical 2-7segments,etc.to produce imbalance between the dynamic and static force.EA was applied to"Dazhui"(GV 14)for 30min,once daily for 28days,with a 2days' interval between two courses.Animals of the medication group were treated by oral administration of meloxicam tablets(0.75mg/kg)once daily for 28 days,with a 2days' interval between two courses.Immunohistochemistry was used to measure the expression of ECM,COL-Ⅱ, COL-V,MMP-13and TIMP-1in the cervicovertebral disc tissue.Results Compared with the sham group,the expression levels of ECM and COL-Ⅱproteins in the cervicovertebral disc tissue were significantly decreased in the model group(P<0.01),while COL-V and MMP-13expression levels in the model group were significantly increased(P<0.01,P<0.05).Compared with the model group,both ECM and COL-Ⅱ expression levels were considerably increased in the EA group and medication group(P<0.01),while COL-V and MMP-13expression levels were considerably down-regulated(P<0.01,P<0.05).No significant differences were found among the four groups in TIMP-1expression levels(P>0.05).Conclusion EA of"Dazhui"(GV 14) can effectively regulate extracellular matrix system in rats with cervical intervertebral disc degeneration,which is possibly related to its effect in relieving cervical spondylosis.关键词：Cervical intervertebral disc degeneration;Electroacupuncture intervention;Extracellular matrix;Collagen;Metabolic enzymes947|277|6更新时间：2023-08-11
- 摘要：Objective Previous studies indicated a close involvement of reflex activities of motoneurons in the spinal cord in the mechanism of meridian phenomena.The present study was designed to investigate the dendrite projections of meridianrelated motoneurons among the motoneurons and sympathetic preganglionic neurons in the spinal cord.Methods A total of 41 Sprague-Dawley rats were used in the present study.Cholera toxin B-subunit conjugated horseradish peroxidase(CB-HRP)containing 1.0% HRP was respectively injected to acupoint"Chengman"(ST 20),"Liangmen"(ST 21),"Guanmen"(ST 22), "Taiyi"(ST 23),"Huaroumen"(ST 24),"Tianshu"(ST 25)and"Wailing"(ST 26)of the Stomach Meridian,and"Ganshu"(BL 18),"Danshu"(BL 19),"Pishu"(BL 20),"Weishu"(BL 21)and"Sanjiaoshu"(BL 22)of the Bladder Meridian,and"Daimai"(GB 26),"Wushu"(GB 27),"Weidao"(GB 28),"Juliao"(GB 29),"Huantiao"(GB 30),"Fengshi"(GB 31),"Zhongdu"(GB 32),"Xiyangguan"(GB 33)and"Yanglingquan"(GB 34)of the Gallbladder Meridian(for labeling preganglionic neurons),and the celiac ganglion and superior mesenteric ganglion for labeling sympathetic preganglionic neurons.Three days after injection,the animals anesthetized were transcardia-cally perfused with 1.5%paraformaldehyde,the spinal cord was removed to be fixed routinely and then cut into sections for observing the labeled cells under microscope.Results In the ipsilateral ventral horn of the spinal cord,the motoneurons retrogradely labeled by CB-HRP formed dendritic projections oriented only to those motoneurons innervating the same meridian.In the longitudinal sections of spinal cord,the labeled motoneurons formed a bead-like column with a prominent network of longitudinal dendrites connecting the motoneurons innervating acupoints from the same meridian.In the transverse sections of spinal cord,two groups of dendrites from the labeled motoneurons projected to the identified sympathetic preganglionic regions:one group exten-ded dorsolateraly to the intermediolateral gray,another group extended intermediolateraly toward the central canal.In rats with injection of CB-HRP into both acupoint regions and ipsilateral celiac ganglion,the dendrites originated from the labeled motoneurons projected directly to the labeled sympathetic preganglionic neurons.Conclusion Each of the ST,BL and GB meridians is innervated by a specific group of motoneurons in the spinal cord.The motoneurons form a column with distinct border in the ventral horn of spinal cord,and the dendritic projections from the motoneurons oriented only to those innervating the same meridian.The dendrites from the meridian-related motoneurons can specifically project to the sympathetic preganglionic neurons at the thoracolumbar level.关键词：Meridian-related motoneurons;Preganglionic sympathetic neurons;Dendritic projections;Spinal cord;Neuro-tracing945|234|1更新时间：2023-08-11
- 摘要：Objective According to the theory of traditional Chinese medicine about"close association between the lung and the large intestine",the present study was designed to investigate the functional relationship between the Lung and Large Intestine Meridians and the colorectum by using electrophysiological methods.Methods A total of 40SD rats were used in the present study.Under anesthesia,the cardiopulmonary branch of the left sympathetic nerve(CPSN)was separated for recording the electrical activities with a pair of platinum wire electrodes.Intra-colorectal pressure was recorded using a water-balloon inserted into the anus and connected to a pressure-transducer for observing rectocolonic pressure changes(mobility).Electroacupuncture(EA)stimulation was applied to bilateral"Taiyuan"(LU 9)-"Jingqu"(LU 8)of the Lung Meridian,"Yangxi"(LI 5)-"Pianli"(LI 6)of the Large Intestine Meridian,and"Shangjuxu"(ST 37)-"Zusanli"(ST 36)of the Stomach Meridian,respectively.Colorectal distension(CRD,visceral pain stimulation,60mmHg and 80mmHg)was performed using an air-balloon for observing its influence on EA stimulation of LU 9-LU 8induced changes of electrical activities of CPSN.Results Under anesthesia conditions,no spontaneous electrical activities of the CPSN were found in rats.After EA stimulation(3times of the threshold intensity)of the bilateral"Taiyuan"(LU 9)-"Jingqu"(LU 8)of the Lung Meridian,and"Yangxi"(LI 5)-"Pianli"(LI 6)of the Large Intestine Meridian,the evoked discharge numbers of the cardiopulmonary sympathetic nerve were(11.26±2.34)and(10.73± 2.62)spikes,respectively,without significant differences between the two groups(P>0.05).Compared with pre-stimulation, the colorectal motility(amplitudes of the intra-colorectal pressure waves)was obviously increased following EA stimulation of LU 9-LU 8of the Lung Meridian,LI 5-LI 6of the Large Intestine Meridian and"Shangjuxu"(ST 37)-"Zusanli"(ST 36),Lower-Ho (Sea)acupoints of the Large Intestine Meridian(P<0.05).After CRD stimulation at 60mmHg and 80mmHg,the LU 9-LU 8-stimulation evoked discharge rates of CPSN were reduced by 43.46% and 67.42%,respectively.Conclusion EA stimulation of LU 9-LU 8of the Lung Meridian and LI 5-LI 6of the Large Intestine Meridian can activate discharges of CPSN,and increase the colorectal motility in the rat.CRD stimulation inhibits the activated effect of EA on electrical activities of CPSN.These results show a functional communication or cross-talk between the lung and the colorectum.关键词：Lung;Large intestine;Cross-talk;Functional relationship;Electroaucpuncture943|920|3更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)stimulation of"Fenglong"(ST 40)on blood lipid contents and inflammatory factor levels in hyperlipemia rats so as to elucidate its mechanism underlying improvement of hyperlipemia.Methods Fifty male SD rats were randomized into 5groups:normal,model,diet-control,EA intervention(EA), diet-control+ EA groups,with 10rats in each group.Hyperlipemia model was established by feeding the animals with high-fat diet for 30days.After modeling,rats in the diet-control group were fed with routine fodder.EA was applied to bilateral"Fenglong"(ST 40)for 30min,once daily for 30days.Following intraperitoneal injection of 1640culture fluid,the peritoneal fluid was collected and centrifuged for extracting macrophages.Flow cytometry(FCM)was employed to determine the levels of tumor necrosis factor alpha(TNF-α)and interleukin-6(IL-6)after adding fluoresce-labeled antibodies.Results The contents of serum TC and LDL-C were remarkably higher and HDL-C level was significantly lower in the model group than in the normal group(P<0.01).After EA intervention,serum TC and LDL-C showed an apparent decrease(P<0.01).Compared with the normal group,percentages of CD11b,TNF-αand IL-6were significantly increased in the model group(P<0.01),while in comparison with the model group,percentages of CD11bin both EA and diet-control+EA groups,TNF-αand IL-6percentages of macrophages in the diet-control,EA and diet-control+EA groups were notably decreased(P<0.05,P<0.01).The effects of the dietcontrol+EA group were considerably superior to those of the diet-control group in lowering CD 11b,TNF-αand IL-6percentages(P<0.05,P<0.01).No significant differences were found between the diet-control and EA groups in the aforementioned indexes(P>0.05).CD11blevel indicates changes of macrophage level due to its specific marker character.Conclusion EA stimulation of"Fenglong"(ST 40)is effective in lowering serum TC,LDL-C,and macrophage TNF-αand IL-6levels in hyperlipemia rats.关键词：Hyperlipemia;Electroacupuncture intervention;Fenglong(ST 40);Macrophages;TNF-α;IL-61473|235|3更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)on ovarian P 450arom and P 450c17α(aromatases)expression and related sex hormone levels in polycystic ovary syndrome(PCOS)rats.Methods Thirty SD rats were randomly divided into normal control group,model group and EA group(10rats/group).PCOS model was made by intragastric administration of letrozole at 1mg/kg per day for consecutive 21days."Guanyuan"(CV 4)and"Zhongji"(CV 3)acupoints were stimulated 20min by EA(2mA,2Hz),once daily for consecutive 14days.The damp ovarian weight was weighed and the pathological changes of the ovarian tissue were observed after H.E.staining.Ultrastructural changes of the ovarian tissue were observed by transmission electron microscope.Immunohistochemical staining was adopted to detect ovarian follicle granulosa cell P 450arom and follicle membrane cell P 450c17αexpression.The contents of estradiol(E 2),estrone(E 1),androstenedione(ASD),testosterone(T),follicle-stimulating hormone(FSH)and luteinizing hormone(LH)in the ovarian tissue were measured by ELISA.Results Compared with the normal group,there was a significant increase in the damp weight of both left and right ovarian tissues in the model group(P<0.01).After EA,the ovarian weight was remarkably reduced(P<0.01).Pathological changes of the ovarian tissue such as thickening of the superficial albugineous coat of the ovary,thinning of the granular cell layer, and disappearance of the intraovular oocytes and coronaradiata under light microscope,and mitochondrion swelling,fracture or disappearance of mitochondrial cristae,and enlargement of the endoplasmic reticulum,etc.after modeling were obviously improved in the EA group.In comparison to the control group,the expression of the follicle granulosa cell P 450arom was significantly down-regulated and that of follicle membrane cell P 450c 17αwas significantly upregulated in the model group(P<0.01).After EA intervention these changes were obviously reversed(P<0.05,P<0.01).In the model group,there was a significant increase in the levels of ASD,T and LH in the ovarian tissues(P<0.01)and a marked decrease in the contents of ovarian E 1and E 2(P<0.01)in comparison to the control group.After EA,the ovarian ASD,T and LH levels were notably decreased(P<0.05,P<0.01)and the E 1and E 2levels apparently increased(P<0.01)compared with the model group.Conclusion EA can improve letrozole-induced pathological changes of ovarian morphology and ultrastructure and obviously promote P 450arom expression in the follicle granulosa cell layer and inhibit P 450c17αexpression in the follicle membrane cell layer,as well as regulate sex hormone levels in PCOS rats,facilitating the normal transformation of ovarian androgen to estrogen and restoring the local endocrine disorders.881|519|6更新时间：2023-08-11
- 摘要：Objective To observe the anatomic structure of the Five Shu-acupoints:"Shaoze"(SI 1),"Qiangu"(SI 2), "Houxi"(SI 3),"Yanggu"(SI 5)and"Xiaohai"(SI 8)regions of the Taiyang Meridian in the rabbit's forelimb.Methods Thirty rabbits(half male and half female)were used in the present study.The Five Shu-acupoints regions were located first based on the atlas of rabbits,stimulated by needling and confirmed later by using an electronic acupoint detector.Under anesthesia,the rabbit was perfused with warm normal saline via the common carotid artery and the internal jugular vein,followed by arterial perfusion of dental base acrylic resin powder(30g),dibutylphthalate(6mL),red couring agent liquid for denture acrylic and acetoacetate(2mL),respectively;and venous perfusion of 30%gelatin(filtered)and black ink(filtered)and formaldehyde(8%).After fixing in 8%formaldehyde for 10days,the rabbit's forelimb containing the aforementioned Five Shu-acupoints were carefully dissected layer by layer,followed by observing the local anatomic structure under microscope.Results The superficial layers of these acupoint regions mainly contained the basilic vein and its branches,and the superficial branch of the ulnar nerve.The deep layers chiefly comprised of the ulnar artery,the ulnar vein and their branches,and the ulnar nerve.Conclusion In"Shaoze"(SI 1),"Qiangu"(SI 2),"Houxi"(SI 3),"Yanggu"(SI 5)and"Xiaohai"(SI 8)acupoint regions,the ulnar artery,basilic vein,ulnar vein and their branches,the ulnar nerve and its superficial branches are found,which constitute the morphological basis of the five acupoints of the Hand-Taiyang Meridian for treating some related clinical disorders.关键词：Five Shu-acupoints;Topographic anatomy;Forelimb;Rabbits747|302|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupuncture intervention on learning-memory ability and cerebral superoxide dismutase(SOD)activity and malonaldehyde(MDA)content in chronic fatigure syndrome(CFS)rats so as to reveal its mechanism underlying improvement of clinical CFS.Methods Thirty-six male SD rats were randomly divided into control group, model group and acupuncture group(n=12in each group).CFS model was established by double stress stimulation of suspending(1.0-2.5hincreasing gradually)and forced swimming[Morris water maze tasks,7min in(10±1)°C water],once daily for 12 days.Manual acupuncture stimulation was applied to"Baihui"(CV 20),bilateral"Zusanli"(ST 36)and"Sanyinjiao"(SP 6), once daily for 21days(with 3days' interval between every two weeks).Learning-memory ability was determined by Morris water maze tests,and SOD activity and MDA concentration in the brain tissues were detected by xanthine oxidase method and thiobarbiturif acid method,respectively.Results Compared with the control group,the escape latencies at time-points of day 1, 2,3,4and 5of Morris water maze tests were significantly longer,the target platform crossing times were markedly fewer and the target platform quadrant staying time obviously shorter,cerebral SOD activity was considerably decreased,and cerebral MDA content remarkably increased in the model group(P<0.05,P<0.01).Following acupuncture intervention,the escape latencies at time-points of day 1,2,3,4and 5were significantly decreased,both target platform crossing times and staying time,and cerebral SOD activity were apparently increased,as well as cerebral MDA level was markedly lowered in comparison with the model group(P<0.05,P<0.01).Conclusion Acupuncture intervention can improve the learning-memory ability in CFS rats, which may be related to its effect in regulating metabolism of free radicals in the brain tissues.关键词：Acupuncture intervention;Chronic fatigue syndrome;Learning-memory ability;Cerebral superoxide dismutase;Malonaldehyde1317|384|6更新时间：2023-08-11
- 摘要：Objective To observe the effects of electroacupuncture(EA)stimulation of"Neiguan"(PC 6)and"Shenmen"(HT 7)on 5-hydroxytryptamine(5-HT)levels in the paraventricular nucleus(PVN)region of hypothalamus and serum in hyperlipidemia rats with acute myocardial infarction(AMI).Methods A total of 80SD rats with hyperlipidemia were used in the present study.Among them,20rats were randomly selected to be the sham-operation group,and the rest 60cases were used to make the AMI model by occlusion of the anterior descending branch of the left coronary artery.The 60rats who were identified to be successful in AMI were randomly divided into model group,EA-PC 6group and EA-HT 7group(20rats/group).EA(2Hz,2 mA)was applied to bilateral PC 6and HT 7for 20min,once daily for 5days.The contents of 5-HT of hypothalamic PVN region and serum were examined by enzyme linked immunosorbent assay(ELISA)and radioimmunoassay,respectively.Results Following AMI,marked myocardial injury(swelling,breakage,disappearance of local transverse striations and necrosis of myocytes)with infiltration of neutrophil granulocytes was found in the model group,while in both EA-PC 6group and EA-HT 7group, moderate swelling(no breakage)of fewer myocardial fibers with mild infiltration of neutrophil granulocytes was found,indicating a marked improvement of myocardial injury after EA treatment.Compared with the sham-operation group,the content of 5-HT was obviously decreased in the hypothalamic PVN region and significantly increased in serum in the model group(P<0.01).After EA intervention,the content of 5-HT was considerably up-regulated in the hypothalamic PVN region and apparently down-regulated in serum in both EA-PC 6and EA-HT 7groups in comparison with the model group(P<0.01).No significant differences were found between EA-PC 6and EA-HT 7groups in regulating hypothalamic and serum 5-HT levels(P>0.05).Conclusion EA stimulation of both PC 6and HT 7can relieve acute ischemic injury of the myocardium in hyperlipidemia rats,which is probably partially related to its effect in promoting the release of 5-HT from the hypothalamic PVN region.1500|473|10更新时间：2023-08-11
- 摘要：Objective To observe the clinical effect of acupoint heat-sensitive moxibustion for acute knee arthralgia and to analyze its effect on serum osteopontin(OPN)and matrix metalloproteinase-3(MMP-3)contents in patients with knee osteoarthritis so as to study its mechanism underlying improving arthralgia.Methods One hundred and forty-four patients with acute knee osteoarthritis were randomly allocated to acupoint heat-sensitive moxibustion(moxibustion),electroacupuncture(EA)and medication groups.Patients of the moxibustion group were treated by suspended moxibustion over bilateral Weizhong(BL 40)for 40min each point,once daily for 15days.Patients of the EA group were treated by EA stimulation of Neixiyan(EX-LE 4),Dubi(ST 35),Xuehai(SP 10)and Liangqiu(ST 34)for 30min,once daily for 15days;and those of the medication group treated by oral administration of Sanqi Tongshu capsules(Panax Notoginseng,etc.used for promoting blood circulation and removing blood stasis),3times daily for 15days.Serum OPN and MMP-3levels were detected with ELISA.Results Following the treatment, of the 50,50and 44cases in the moxibustion,EA and medication groups,24,20and 14were excellent,18,16and 13were good in the therapeutic effect,7,4and 3were effective,and 1,10and 14invalid,with the excellent and good rates being 84%, 72.0% and 61.4%,respectively.Serum OPN content of the moxibistion and EA groups,and serum MMP-3content of the moxibustion group were reduced considerably in comparison with pre-treatment in the same one group(P<0.01),while serum OPN level of the medication group and MMP-3of the EA group were decreased slightly.The effect of moxibustion was evidently superior to that of medication in lowering serum OPN level(P<0.05)and superior to that of both EA and medication in lowering serum MMP-3content(P<0.05).Conclusion Acupoint heat-sensitive moxibustion has a good therapeutic effect in relieving acute knee arthralgia,which may be related to its effects in decreasing serum OPN and MMP-3levels.关键词：Acupoint heat-sensitive moxibustion;Acute knee pain;Serum osteopontin;Matrix Metalloproteinase-31451|295|2更新时间：2023-08-11
- 摘要：Objective To compare the outcome difference between the heat-sensitive and non-sensitive moxibustion stimulation of Yifeng(TE 17)in the treatment of peripheral facial palsy.Methods A total of 43patients with peripheral facial paralysis were divided into heat-sensitive moxibustion(n=21)and non-sensitive moxibustion(n=22)groups in accordance with their reactions to moxa-heat stimulation.Mild moxibustion was applied to bilateral Yifeng(TE 17)for 45minutes,followed by mild acupuncture stimulation of Cuanzhu(BL 2),Yangbai(GB 14),Sibai(ST 2),Hegu(LI 4),etc.Moxibustion treatment was conducted once daily for 10days,and acupuncture treatment given once daily for 20days(with 2days interval between every 10 days).Following moxibustion,if the patient felt regional heat penetrating to the deep tissue,extending peripherally,or propagating to other part of the body,or felt mild warm in the stimulated region but warmer in the slightly distant part,or felt mild warm on the skin surface but warmer in the deep tissue,it was considered to be heat-sensitivity.Patients with occurrence of heat-sensitivity being equal to and more than 3times during the 10sessions of treatment were assigned to heat-sensitive group,and those with occurrence of heat-sensitivity being equal to or less than 2times assigned to non-sensitive moxibustion group.According to Portmann Scale(including movement and resting posture)for the voluntary movement state of the face,forehead,winkles eye closure,open mouth smile,snarl,and pucker;points 0,1,2and 3indicate no muscular movement,marked asynersis,asynersis and normal,respectively.In the light of resting posture of the eye,the nasolabial fold and mouth corner,0,1,and 2points indicate severe,mild dissymmetry and normal,separately.In evaluation of the therapeutic effect,twenty points(at most)indicate cured,17-19points marked improvement;14-16points improved,and≤13points failure.Results Compared with pre-treatment,Portmann scores of both heat-sensitive moxibustion and non-sensitive moxibustion groups were significantly increased after the treatment(P<0.001),and the score of the heat-sensitive moxibustion group was markedly higher than that of the non-sensitive moxibustion group(P<0.05).Of the 21and 22facial palsy patients in the heat-sensitive moxibustion and non-sensitive moxibustion groups,8and 5cases were cured,10and 7were markedly effective,3and 10were improved,with the markedly effective rates being 85.71% and 54.55%,respectively.The therapeutic effect of the heat-sensitive moxibustion group was statistically better(P<0.05).Conclusion Heat-sensitive moxibustion is significantly superior to non-sensitive moxibustion in improving symptoms of peripheral facial palsy patients,suggesting a necessity for paying attention to patients' reactions during moxibustion treatment.关键词：Peripheral facial palsy;Heat-sensitive moxibustion;Clinical therapeutic effect;Patients' sensation to moxibustion1031|1017|10更新时间：2023-08-11
- 摘要：Objective To observe the clinical effect of moxibustion of different acupoints undergoing heat-sensitive state and resting state in the treatment of knee osteoarthritis(KOA)patients.Methods A total of 60cases of KOA patients were enrolled in the present trial.They were divided into heat-sensitive moxibustion(heat-sensitive)group and non-sensitive moxibustion group(resting group).Moxibustion was applied to Neixiyan(EX-LE 4),Waixiyan(i.e.Dubi,ST 35)and Heding(EX-LE 2)for about 45min,once daily for 20days.The heat-sensitive state was evaluated according to the patient's feeling.After moxibustion stimulation at the acupoint area,if the patient feels the heat penetrating from the skin surface to the deep tissue,or/and extending peripherally around the moxibustion site,or/and transmitting toward a certain direction,it is considered to be heat sensitization state.The therapeutic effect was evaluated by using visual analogue scale(VAS)for pain severity changes and by Guiding Principles for Clinical Trials of New Drugs of Chinese Materia Medica for evaluating functional activity of the knee-joint.Results After 20sessions of treatment and after a half year's follow-up,the total integrated scores of VAS in the heat-sensitive group were all lower than those of the resting group(P<0.01).Following 20sessions of treatment,of the two 30KOA patients in the heat-sensitive group and resting group,14(46.67%)and 5(16.67%)experienceda marked improvement,10(33.33%)and 9(30.00%) were effective,6(20.00%)and 16(53.33%)were invalid,with the effective rates being 80.00% and 46.67%,respectively. Half-year's follow-up showed that the effective rates of the heat-sensitive group and resting group were 79.17%(19/24)and 42.86%(6/14),respectively,suggesting a better therapeutic effect of heat-sensitive moxibustion.Conclusion The clinical effect of heat-sensitive moxibustion is significantly superior to that of non-sensitive moxibustion in the treatment of KOA patients, being worthy of clinical application.关键词：Knee osteoarthritis;Different sensitive status of acupoint;Heat-sensitive moxibustion;Visual analogue scale score;Knee-joint functional activity1165|712|5更新时间：2023-08-11
- 摘要：In order to clarify the connotation and academic significance of the term Qijie(pathway of qi)in Chinese medicine,the author of the present article collected related ancient literature and made a theoretical analysis on its concept,its relevance to the content of Sihai(four seas i.e.:1)the brain,the sea of marrow,2)Danzhong,the sea of qi;3)stomach:the sea of water and food;4)Chongmai,the sea of the 12meridians),its related application and the evolution of the relationship between acupoints and their subordinated meridian.The author holds that the four Qijie aims at explaining the underlying mechanism of acupoints located on the head,chest and abdominal regions.The four Qijie theory was established in the transition period of the developmental process of meridian-acupoint theory,and is of realistic significance in elucidating the correlation between the back shu-acupoints and zang-fu organs.关键词：Qijie;Four Qijie;Sihai;Acupoint functions;Acupoint indications;Meridian;Weiqi(Defensive qi)832|1274|10更新时间：2023-08-11
- 摘要：Bioinformatics analysis of the molecular network regulation is the main content of systems biology,may reveal the complex life phenomena from interactions among molecules and will bring about a far-reaching impact on our current understanding about life activities of organism.MicroRNAs(functional RNAs)can regulate mRNA transcription through inhibition of posttranscriptional protein-coding gene expression,target degradation,etc.,and are extensively involved in various biological processes in the cells.It is generally held that the therapeutic effect of acu-moxibustion intervention involves multi-channels,multitargets,and multi-levels of both peripheral and central nervous systems of the body but has not been fully revealed,being similar with functional forms of molecular regulatory networks.Thus,it is necessary to introduce new ideas and methods for studying the underlying mechanism of acu-moxibustion therapy.The molecular regulatory networks of microRNA would provide a new way for revealing the mechanism of acu-moxibustion interventions.关键词：MicroRNA;Molecular network regulation;Acu-moxibustion therapy;Researching ideas1053|399|3更新时间：2023-08-11
- 摘要：Acupoints,the local initial site of signals of acupuncture or moxibustion stimulation,play an important role in producing clinical therapeutic effects.The whole process of acupuncture stimulation induced improvement of the related visceral dysfunction or regional disorders includes 3key links:1)initiation of acupuncture/moxibustion signals from the stimulated acupoints;2)conduction,coordination and integration of the complicated peripheral and central networks;and 3)responses of the target organs.Abundant research results indicate that acupuncture or moxibustion stimulation can induce specific changes in the regional micro-environment such as excitement of the peripheral cells,release of chemical substances,excitement of the afferent nerve,etc.,which constitutes the important biological basis of the initial process of regional acupoint signals for producing therapeutic effects.关键词：Acupuncture therapy;Acupoints;Initiation of acupuncture effect;Peripheral cells and chemical substances1524|770|9更新时间：2023-08-11
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