最新刊期
卷 39 ， 期 3 ， 2014
- 摘要：Objective To observe the effect of acupuncture stimulation of"Changqiang"(GV 1)on learning-memory ability and gap junction-related protein expression in the prefrontal cortex in autism rats.Methods Forty Wistar rats were equally randomized into control,model,GV 1and non-acupoint groups.For establishing autism model,Valproate acid(VPA)sodium(600mg/kg)was given(i.p.)to pregnancy rats whose intimate filial generation was confirmed to be successful autism by eyeopen tests,swimming test and Morris water maze swimming tasks.GV 1or non-acupoint(the spot below the costal region,i.e.,2cm superior to the posterior superior iliac spine and about 3cm lateral to the spine)was punctured and stimulated for about 1min by using a filiform needle,once daily for 30days except the weekends.The rats' learning-memory ability was detected by Morris water maze tasks.The expression of gap junction-related proteins connexin 43(CX 43),CX 32and CX 36in the frontal cortex tissue was detected by immunohistochemistry.Results After modeling,the postnatal rats' eye-open time on day 14,15and 16was significantly later(P<0.05);and the swimming ability on postnatal day 13and 15was obviously lower in comparison with that of the control group(P<0.05).After acupuncture treatment,the increased escape latency and the decreased swimming velocity of the autism rats were obviously suppressed in the GV 1group,rather than in the non-acupoint group(P<0.05).It suggests an improvement of learning-memory ability after acupuncture stimulation of GV 1.In comparison with the control group,the expression levels of cerebral CX 43,CX 32and CX 36proteins(mean grey values)were considerably down-regulated in the model group(P<0.05).While compared to the model group,their expression levels were apparently up-regulated in the GV 1group(P<0.05)but not in the non-acupoint group.Conclusion Acupuncture intervention of GV 1can improve the learningmemory ability in autism rats,which may be closely related to its effects in up-regulating expression levels of CX 43,CX 32and CX 36in the frontal cortex.关键词：Autism;Acupuncture intervention;Changqiang(GV 1);Gap junction-related proteins;Connexin(CX) 43;CX 32;CX 36;Learning-memory ability1971|640|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of needle pricking therapy on the expression of thymic stromal lymphopoietin(TSLP)protein,T-box expressed in T cells(T-bet)mRNA and GATA-binding protein-3(GATA 3)mRNA in the lung tissue of mice with asthma,so as to explore its mechanism underlying improvement of asthma.Methods Thirty female BALB/c mice were randomly divided into control,model and needle pricking groups(10mice/group).The asthma model was established by i.p.of Ovalbumin(OVA)suspension fluid(containing Aluminium Hydroxide 400μg and OVA 100μg,50μg/L)and forced inhalation of atomized OVA.A sharp needle was held to prick"Dazhui"(GV 14),"Feishu"(BL 13),"Dingchuan"(EX-B 1),"Fengmen"(BL12),"Shenshu"(BL 23)and"Pishu"(BL 20)acupoint regions to let a little bit of white fibrous tissue out,then to insert into the acupoints to about 1mm in depth,once a day for seven times.The lung tissue was taken for detecting the expression of T-bet mRNA and GATA-3mRNA by RT-PCR and for determining the immunoactivity of TSLP by immunofluorescence method.In addition,HE staining was used to examine the pathologic changes of the lung tissue.Results Compared with the control group,the expression levels of GATA-3mRNA and TSLP protein of the lung tissue in the model group were significantly increased(P<0.01),whereas that of T-bet mRNA was remarkably decreased(P<0.05).Following needle prick stimulation treatment,the expression levels of GATA-3mRNA and TSLP protein were markedly down-regulated(P<0.01)and that of T-bet mRNA was obviously upregulated(P<0.05).After the treatment,pathological changes including hyperemia of the pulmonary alveoli,epithelial thickening,narrowing of the lumina,and infiltration of many inflammatory cells around the tracheal blood vessels were improved.Conclusion Needle pricking therapy can regulate the expression of pulmonary TSLP protein and GATA 3and T-bet genes in mice with asthma,which may contribute to its effect in improving pulmonary pathological changes of asthma mice.关键词：Asthma;Needle pricking therapy;Zhuang minority medicine;Thymic stromal lymphopoietin;T-box expressed in T cells;GATA-binding protein-3;Pulmonary pathological change1213|245|0更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)on superoxide(SOD),glutathione peroxidase(GSH-Px)activity,contents of glutathione(GSH)and malondiadehyde(MDA),and expression of tyrosine hydroxylase(TH)and apoptosis of Dopaminergic(DA)neurons in Substantia Nigra of rats with Parkinson's disease(PD).Methods Adult male Wistar rats were randomly divided into normal(10rats),model(11rats),EA(11rats)and medication(11rats)groups.The PD model was established by i.h.of Rotenone(0.8mg/kg)for 28days.EA stimulation(2Hz/80Hz,2mA)was applied at"Baihui"(GV 20),"Sanyinjiao"(SP 6)and"Taichong"(LR 3)acupoints for 10min,once per day for 14times.For rats in the medication group,Madopar suspension fluid(1.67mg/kg)was given by gavage for 14days.Xanthine oxidase method and colorimetric analysis method were used to examine the SOD,GSH-Px activity and contents of GSH and MDA in the Substantia Nigra tissue of the right brain,respectively.Immunohistochemical technique was used to detect the TH positive neurons and TUNEL method was used to examine the apoptosis of DA neurons of the Substantia Nigra in the left brain.Results Following the intervention,the decreased SOD and GSH-Px activity,GSH contents,and the increased MDA content of the Substantia Nigra in PD rats were obviously reversed by EA intervention(P<0.05)but not by medication except MDA content(P>0.05).In comparison with the model group,the decreased TH immunoactivity,and the increased numbers of apoptotic cells of DA neurons were apparently suppressed in both EA and medication groups(P<0.05),but without significant differences between the EA and the medication groups(P>0.05).In addition,HE stain showed that EA intervention could improve PD-induced impairment of Substantia Nigra neurons(mild swelling of neurons with large nucleus and deranged fibers).Conclusion EA intervention can reduce pathological changes of Substantial Nigra in PD rats,which is probably associated with its effects in up-regulating the SOD and GSH-Px activity,GSH contents,and down-regulating MDA level,and reducing the apoptosis of DA neurons of the Substantia Nigra,suggesting an anti-oxidative stress effect of EA therapy.1793|592|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)stimulation of"Jiaji"(EX-B 2)on the expression of matrix metalloproteinase-13(MMP-13)and tissue inhibitor of metalloproteinase-1(TIMP-1)proteins in the lumbar disc in rabbits with lumbar intervertebral disc degeneration so as to explore its mechanism in relieving intervertebral disc degeneration.Methods A total of 36New Zealand rabbits were randomly divided into normal,sham operation(sham),model,and EA groups,with 9rabbits in each group.The lumbar intervertebral disc degeneration model was established by using a custom-made external loading device to axially compress the lumbar discs(L 4,L 5)for 28days in reference to Kroeber and colleagues' methods.After modeling,EA stimulation(2Hz/15Hz,1-2mA)was applied to bilateral"Jiaji"(EX-B 2)areas for 20min,once daily for 28days.The expression levels of MMP-13and TIMP-1proteins of the lumbar intervertebral disc(L 4-L 5)tissues were assayed by Western blot and immunoflorescence methods,separately.Results Compared to the normal and sham groups,MMP-13expression levels at the time-points of day 28in the model group,on day 28(pre-EA)in the EA group were significantly up-regulated(P<0.01);and TIMP-1expression levels on day 28in both model and EA groups were significantly decreased(P<0.01).Following EA treatment,the expression level of MMP-13was notably lower in the EA group than in the model group,and that of TIMP-1was remarkably higher in the EA group than in the model group(P<0.01).No significant differences were found in the expression levels of MMP-13and TIMP-1from day 1to day 56in the same one group of both normal and sham groups,and between these two groups(P>0.05).Conclusion Electroacupuncture at"Jiaji"(EX-B 2)can effectively suppress intervertebral disc degeneration induced up-regulation of MMP-13protein and down-regulation of TIMP-1protein in the disc tissue in rabbits,which may contribute to its effect in bettering lumbago in clinic.关键词：Intervertebral disc degeneration;Electroacupuncture;Jiaji(EX-B 2);Matrix metalloproteinase-13;Tissue inhibitor of metalloproteinase-11268|311|5更新时间：2023-08-11
- 摘要：Objective To observe the effects of electroacupuncture(EA)at"Sanyinjiao"(SP 6)on hypothalamus-pituitary-ovary(HPO)axis in perimenopausal rats so as to study its underlying mechanisms in improving dysfunction of HPO axis.Methods Eight female SD rats with an age of 3months were used as the normal control group,other 16perimenopausal SD rats with an age of 11-15months were equally randomized into model group and EA group.The menopause model was confirmed by vaginal smear tests for successive 15days.EA(2Hz/100Hz)was applied to bilateral"Sanyinjiao"(SP 6)for 20min,once every other day for 30days.After the treatment,the rats' hypothalamus,pituitary and left ovary tissues were collected for detecting the contents of gonadotropin releasing hormone(GnRH),follicle-stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)by ELISA.Results Compared with the normal control group,the ovary E2content of the model group was significantly decreased(P<0.01),and the pituitary FSH and LH contents,and hypothalamic GnRH content were obviously increased in the model group(P<0.01).Following EA intervention,the ovary E2level was obviously elevated(P<0.05),while pituitary FSH and LH and hypothalamic GnRH levels were significantly down-regulated in comparison with the model group(P<0.05).Conclusion EA of"Sanyinjiao"(SP 6)can suppress menopause-induced down-regulation of ovary E2and increase of pituitary FSH and LH and hypothalamic GnRH levels in perimenopausal rats,suggesting a favorable regulation of EA on HPO axis dysfunction.关键词：Perimenopausal syndrome;Electroacupuncture;Sanyinjiao(SP 6);Hypothalamus-pituitary-ovary axis1128|661|8更新时间：2023-08-11
- 摘要：Objective To observe the therapeutic effect of electroacupuncture(EA)stimulation of"Daimai"(GB 26)on metabolic syndrome in rats.Methods SD rats were randomly divided into blank control group(n=9),model group(n=9)and EA group(n=9).The metabolic syndrome model was established by feeding the rats with high fat and sugar forage(containing 20%lard,10%cane sugar,10% defatted milk powder,2% cholest,3% yolk powder and 55% normal forage)for 12weeks.EA(2Hz/100Hz,1-2mA)was applied to bilateral"Daimai"(GB 26)for 20min,once daily for 4weeks.Fasting blood glucose(FBG),serum triglyceride(TG),total cholesterol(TC),high density lipoprotein-cholesterol(HDL-C),lower density lipoprotein-cholesterol(LDL-C)contents were detected using chemical methods,fasting serum insulin(FINS)was determined by using radioimmunoassay.Homeostasis model assessment-index of resistance(HOMA-IR,insulin resistance index=FBG×FINS/22.5)was calculated.Results Compared to the blank control group,the body weight(from the 8th week on),abdominal circumference(from the 4th week on),and FBG,FINS,TG,TC,LDL-C contents as well as HOMA-IR in the model group were significantly increased(P<0.05,P<0.01),while the HDL-C content was considerably lowered after modeling(P<0.05).In comparison with the model group,the body weight on the 16th week,FBG,FINS,HOMA-IR,TG,TC and LDL-C levels were evidently down-regulated in the EA group(P<0.05,P<0.01).No significant differences were found between the model and EA groups in the abdominal circumference and HDL-C content(P>0.05).Conclusion Electroacupuncture stimulation of"Daimai"(GB 26)can reduce insulin resistance,regulate blood lipid,and lower blood glucose in metabolic syndrome rats.关键词：Metabolic syndrome;Electroacupuncture intervention;Blood glucose;Blood lipid;Insulin resistance1570|419|7更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)on serum insulin-like growth factor-1(IGF-1)content and bone biomechanics in osteoporosis rats so as to explore its mechanism underlying improvement of postmenopausal osteoporosis(PMOP).Methods Forty female SD rats(4.5months old)were randomly divided into sham-operation(sham),model,medication and EA groups(10rats/group).The rat's bilateral ovaries were removed to establish the PMOP model.For rats in the sham group,similar procedures were conducted except removing comparable weight of fat tissues around the ovaries.For rats in the EA group,"Guanyuan"(CV 4)was punctured with filiform needles and stimulated electrically(1mA,2Hz)for20min,once a day for 30days.For rats in the medication group,pentanoic acid estradiol(50μg/500g)was administrated by gavage.The serum IGF-1content was examined by ELISA and the bone biomechanics measured by three-point bending tests,respectively.Results Compared with the sham group,the serum IGF-1level,femoral maximum load and fracture load were significantly reduced in the model group(P<0.05,P<0.01).In comparison with the model group,these indexes were significantly increased in rats of the EA and medication groups(P<0.05,P<0.01),but without significant difference between the EA and medication groups(P>0.05).Conclusion EA produces benefits on postmenopausal osteoporosis through increasing the serum IGF-1contents and bone strength.关键词：Postmenopausal osteoporosis;Electroacupuncture intervention;Insulin-like growth factor-1;Bone bio-mechanics1317|321|3更新时间：2023-08-11
- 摘要：Objective To observe the effect of moxibustion at"Ganshu"(BL18)on levels of Livin(a novel member of the inhibitors of apoptosis family and plays crucial roles in apoptosis,cell proliferation,and cell cycle control)in the liver tissue in rats with precancerous lesion of primary hepatocellular carcinoma(HCC),so as to explore its mechanism underlying improvement of HCC.Methods Sixty male Wistar rats were randomly divided into control group(n=10),model group(n=20),moxibustion-20dgroup(n=15)and moxibustion-40dgroup(n=15).HCC model was established by intraperitoneal injection of diethylnitrosamine(DEN,50mg/kg),once every 3days for 12weeks.Moxibustion was applied to bilateral"Ganshu"(BL 18),once every other day for 10times(moxibustion-20dgroup)and 20times(moxibustion-40dgroup),respectively.Serum alpha-fetoprotein(AFP)content was detected with ELISA and Livin immunoactivity of the liver tissue detected using immunohistochemistry.Results After modeling,serum AFP content and liver Livin immunoactivity of the model group were significantly increased in comparison with the control group(P<0.01).After moxibustion treatment,serum AFP content in the moxibustion-20dgroup and liver Livin immunoactivity in both moxibustion-20dand moxibustion-40dgroups were remarkably down-regulated in comparison with the model group(P<0.05).No significant differences were found between the moxibustion-40dgroup and the model group in serum AFP content(P>0.05).Conclusion Moxibustion can down-regulate liver Livin protein expression,which probably has a role in promoting hepatocellular apoptosis to inhibit precancerous lesion and to postpone hepatocarcinogenesis.关键词：Moxibustion therapy;Primary hepatocellular carcinoma;Precancerous lesion;Inhibitor of apoptosis;Liver Livin;Alpha-fetoprotein1576|454|7更新时间：2023-08-11
- 摘要：Objective To evaluate the effect of Dexmedetomidine and Midazolam on respiratory and circulation in patients experiencing open heart surgery under acupuncture-assisted general anesthesia.Methods Sixty patients undergoing open heart surgery(cardiac valve replacement surgery and aortic valve replacement surgery)were randomly and equally divided into Dexmedetomidine(D)and Midazolam(M)groups.Electroacupuncture(EA)was applied to bilateral Yunmen(LU 2),Zhongfu(LU 1),Lieque(LU 7)and Neiguan(PC 6).For patients of group D,Dexmedetomidine(i.v.,loading dose:1μg/kg,and succedent dose:0.21μg·kg-1·h-1)was given.For patients of group M,Midazolam(i.v.,loading dose:0.05mg/kg,succedent dose:0.011μg·kg-1·h-1)was given.For patients of group M,Midazolam(i.v.,loading dose:0.05mg/kg,succedent dose:0.010.03mg·kg-1·h-1)was given.Arterial oxygen pressure(PaO2),arterial carbondioxide tension(PaCO2),O2saturation(SPO2),mean arterial pressure(MAP),heart rate(HR),anesthetic effect,time of spontaneous breathing recovery,and time of resuscitation were recorded before operation(T0),immediately after skin incision(T1),immediately after sternotomy(T2),before suspension of cardiopulmonary bypass(CPB,T3),immediately after cardiac re-beating(T4),immediately after CPB cessation(T5),and at the end of surgery(T6).Results Before operation,no significant differences were found between the group D and M in the levels of PaO2,PaCO2and SPO2(P>0.05).The PaO2and SPO2levels after skin incision,sternotomy,before suspension of CPB and at the end of surgery were significantly lower in group M than in group D(P<0.05),while the levels of PaCO2after skin incision,sternotomy,before suspension of CPB and at the end of surgery,and HR after skin incision,sternotomy,before suspension of CPB,after heart re-beating,after CPB cessation and at the end of surgery in group M were considerably higher than those in group D(P<0.05).In addition,the time of spontaneous breathing recovery of group M was significantly later than that of group D(P<0.05).No significant differences were found between the two groups in MAP levels at the 6time-points during surgery,in the PaO2,PaCO2and SPO2levels at the time-points of post-cardiac re-beating,and after CPB cessation(P>0.05).It suggested that the respiration and circulation states in group D were more smoothly than those in group M.There was no significant difference between the two groups in the time of resuscitation(P>0.05).Conclusion Dexmedetomidine is superior to Midazolam in analgesia,and improving respiration and circulation functions for open heart surgery patients under acupuncture-assisted general anesthesia.关键词：Open heart surgery;Dexmedetomidine;Midazolam;Acupuncture-assisted general anesthesia1091|214|2更新时间：2023-08-11
- 摘要：Objective To observe the influence of different skin reactions of acupoint-application in summer on outcomes of prevention and treatment of bronchial asthma.Methods All of the bronchial asthma patients were treated with acupoint-application therapy in the dog-days of summer,once every ten days,3times altogether.After the treatment,according to scores of the skin reactions including flush,itching,pain,vesicles,etc.induced by acupoint-application of prepared Chinese medical herb paste,164cases were divided into four groups:no reaction(n=43),mild reaction(n=42),moderate reaction(n=39)and severe reaction(n=40).One-year's follow-up was conducted after the treatment for assessing the asthma patients' cough-asthma score,wheezing rale score,and for recording the attack times.Results After the treatment,the cough-asthma scores,wheezing rale scores,and asthmatic attack times were obviously decreased in all the 4groups compared to pre-treatment(P<0.05,P<0.01).Comparison among the 4groups showed that the levels of the 3indexes were significantly higher in the no reaction group and mild reaction group than in the moderate and severe reaction groups after the treatment(P<0.05,P<0.01),suggesting a better therapeutic effect in patients undergoing moderate and severe skin reactions.There were no significant differences between the no reaction and mild reaction groups,and between the moderate reaction and severe reaction groups in the levels of the 3indexes(P>0.05).The total effective rates of the no reaction,mild reaction,moderate reaction and severe reaction groups were 58.14%,88.10%,94.87%and 97.50%,respectively.The mild,moderate and severe reaction groups were better than the no reaction group in the therapeutic effect(P<0.01).The mild reaction group was poorer than the moderate and severe reaction groups in clinical efficacy(P<0.05).There was no marked difference between the moderate and severe reaction groups in clinical outcomes(P>0.05).Conclusion Acupoint-application in the dog-days can effectively improve the asthma patients' symptoms,and the therapeutic effect of patients experiencing moderate and severe skin reactions was better.关键词：Bronchial asthma;Acupoint-application;Treating winter-disease in summer;Skin reaction;Thera-peutic effect1561|818|8更新时间：2023-08-11
- 摘要：Objective To evaluate the therapeutic effect of warm acupuncture(moxa-heated acupuncture)needle stimulation of Waiguan(TE 5)acupoint in the treatment of shoulder-hand syndrome(phaseⅠ)in patients with stroke.Methods Sixty stroke patients with shoulder-hand syndrome(phaseⅠ)were equally randomized into control group and warm acupuncture group.Patients of the warm acupuncture group were treated by warm acupuncture stimulation of the affected TE 5in combination with routine acupuncture stimulation of Jianyu(LI 15),Jianjing(GB 21),Quchi(LI 11),Wangu(SI 4),Yangchi(TE 4)and Hegu(LI 4),and rehabilitation training(passive and active upper-limb motion exercise for 30min,once daily),and patients of the control group treated with routine acupuncture stimulation of the same acupoints mentioned above,and rehabilitation training.The treatment was conducted once daily,5times per week for two weeks.The patients' clinical conditions were evaluated by using Visual Analogue Scale(VAS,0-10points,shoulder pain degree),edema severity score(0point:normal,2points:mild,4points:moderate,and 6points:severe)and simplified Fugl-Meyer motor assessment scale(0,1and 2points,upper-limb motor function)before and after the treatment.Results After the treatment,the scores of VAS and edema severity of the two groups were significantly decreased in comparison with pre-treatment in the same one group(P<0.01),and the Fugl-Meyer motor scores were considerably increased(P<0.01),suggesting an improvement of the shoulder-hand syndrome after two weeks' treatment.Of the two 30patients in the control group and warm acupuncture group,0and 2(6.7%)were cured,7(23.3%)and25(83.3%)experienced marked improvement,17(56.7%)and 2(6.7%)were effective,6(20.0%)and 1(3.3%)invalid,with the effective rates being 80.0%and 96.7%,respectively.The effect of warm acupuncture group was superior to that of the control group(P<0.05).Conclusion Warm acupuncture combined with routine acupuncture and rehabilitation training is effective in improving shoulder pain,hand edema and limb motor function in stroke patients with shoulder-hand syndrome at phaseⅠ.关键词：Stroke;Shoulder-hand syndrome;Warm acupuncture therapy;Waiguan(TE 5);Shoulder pain;Hand edema;Limb motor function1371|886|8更新时间：2023-08-11
- 摘要：Objective To evaluate the therapeutic effect of pricking blood therapy for migraine.Methods We searched all the original papers about pricking blood therapy for migraine in common databases as the Chinese National Knowledge Infrastructure Database(CNKI),Chinese Biomedical Library(CBM),Ovid,Science Direct,Socolar,and Sci Finder(1949-2012),Wanfang Data(1998-2012)and Foreign Medical Journal Service(FMJS,1990-2012).The original articles were searched in accordance with a pre-defined standards(simple pricking blood treatment,or the pricking blood therapy was the principal approach),while those about other diseases(such as cerebrovascular disease,cervical spondylosis,etc.)evoked migraine,pricking blood used as a complementary therapy,case report,specialists' experience summary,reviews,surveys,news articles,animal studies were excluded.Then,a Meta-analysis was made by software Review Manager 5.1.Results A total of11clinical trial papers involving 826cases of migraine were included in the present paper.Three of them were high-quality researches,and the other eight were low quality researches.Results of Meta-analysis indicated that the therapeutic effect of the pricking blood therapy was significantly superior to that of non-bleeding therapies in relieving migraine[OR=6.23,95%CI:(4.03,9.63),Z=8.24,P<0.00 001].However,the poor symmetry of funnel plot suggested a risk of bias.Conclusion The pricking blood therapy is effective for relieving migraine,but larger sample clinical trials,particularly randomized controlled trials are definitely needed for confirming the conclusion.关键词：Migraine;Pricking blood therapy;Meta-analysis;Systematic review1406|1394|2更新时间：2023-08-11
- 摘要：Objective To evaluate the effect and safety of acupuncture treatment of polycystic ovary syndrome(PCOS)by using systematic review in view of evidence-based medicine(EBM).Methods Original articles about acupuncture treatment of PCOS published from the database-established year to November of 2013were searched from the Chinese National Knowledge Infrastructure Database(CNKI),Chongqing VIP Chinese Science and Technology Periodical Database(VIP),Chinese Biomedical Library(CBM),Wanfang Data,PubMed,and the Cochrane Library and the associated references-indicated papers by using keywords of polycystic ovary syndrome,randomization,acupoint,acupuncture,acupuncture plus moxibustion,acupuncture plus acupoint-embedment of catgut,and acupuncture plus otopoint application.Those articles about treatment of PCOS with simple abdominal acupuncture,simple acupoint-embedment of catgut,simple otopoint-pellet-pressure,and simple moxibustion treatment,and simple abstracts were excluded.If the articles re-published in both Chinese and English and in academic conferences and journals,one of them with higher quality was included.Two independent reviewers extracted data from located articles in a pre-defined structured way,and the Meta-analysis was conducted using software RevMan 5.2,otherwise using the qualitative analysis.Results A total of 31articles(28in Chinese,3in English)containing 2 321cases of PCOS patients met the included criteria.Meta-analysis showed that the clinical efficacy of simple acupuncture was the same as that of western medicine,and the efficacy of acupuncture combined with Chinese herbal medicine interventions was obviously higher than that of western medicine(P<0.05).In addition,simple acupuncture intervention and acupuncture combined with Chinese herbal medicines or with moxibustion treatment have advantages in reducing serum luteinizing hormone/follicle-stimulating hormone(LH/FSH),insulin resistance(IR),testosterone(T),and body mass index(BMI).However,the quality of the collected articles is generally lower due to unclear bias,no sample quantity estimation,incorrect randomization methods,no follow-up survey,etc.Conclusion Acupuncture therapy may be effective for PCOS,but needs to be confirmed further by larger sample randomized controlled trials.关键词：Polycystic ovary syndrome;Acupuncture intervention;Randomized controlled trials;System review;Meta-analysis2438|2887|10更新时间：2023-08-11
- 摘要：The research on indications of acu-moxibustion is very important for effectively guiding clinical practice.In the present paper,the authors retrieved domestic literature about researches on the disease-spectrum or indications of acu-moxibustion therapy in recent 10years,and made a bibliometrics analysis according to the described research methods,publishing year,quantity and their proportionate relationship.A total of 18qualified original papers involving 414illnesses or clinical conditions were included in the present paper.Among the 414kinds of clinical conditions or illnesses,72were considered to be suitable candidates for acu-moxibustion therapy,including functional dyspepsia,herpes zoster,irritable bowel syndrome,gastrointestinal dysfunction,scapulohumeral periarthritis,cervical syndrome,dyssomnia,acne(cyst type),chronic urticaria,regional neurodermatitis,pain,itching,etc.which belong to illness-spectrum grade-I.Generally,the acu-moxibustion therapy is,in clinical effects,relatively poorer for structural diseases which are attributed to grade-II or grade-III type.Nevertheless,the diversity of clinical indications of acu-moxibustion has been confirmed nowadays.Current studies on illness-spectrum are of certain uniformity and comprehensiveness,but need further extending and perfecting,and need more standardized methods corresponding to principles of the evidence-based medicine.关键词：Illness-spectrum;Bibliometrics analysis;Evidence-based medicine;Research methods;Develop-mental tendency1541|1358|13更新时间：2023-08-11
- 摘要：Along with the application of genetic polymorphism techniques to individualized treatment of clinical disorders,the screening of polymorphisms markers of serotonin(5-HT)transporter(SERT)is a hot-spot of researches on irritable bowel syndrome(IBS).In the present paper,the authors introduce 1)optimized schemes of diagnosis and treatment of IBS on the basis of syndrome-differentiation for acupuncture in combination with Chinese herbal medicines,and application of 5-HT transporter polymorphism,2)application of genetic polymorphism to researches on IBS,and 3)feasibility of genetic polymorphism techniques for guiding individualized treatment of IBS.Up to now,serotonin transporter length polymorphic region(5-HTTLPR),serotonin transporter intron 2variable number of tandem repeat(Stin 2VNTR)and single nucleotide polymorphism rs 25531in the long allele of the 5-HTTLPR have been identified.On the basis of the treatment of IBS,we need establishing a set of guide lines for the individualized acupuncture treatment.The genotyping methods for genetic polymorphism should be widely used in this research field.5-HT TLPR/Stin 2VNTR/rs 25531polymorphisms would have a bright future in the field of IBS research and treatment.关键词：Irritable bowel syndrome;Acupuncture combined with Chinese herbal medicines;Genetic polymorphism techniques;Serotonin transporter;Serotonin transporter length polymorphic region(5-HTTLPR);Serotonin transporter intron 2 variable number of tandem repeat(Stin 2VNTR);Single nucleotide polymorphism rs 25531in the long allele of the 5-HTTLPR1406|337|1更新时间：2023-08-11
- 摘要：The patient's expectations(placebo effects)refer to the anticipation or the belief about what is to be encountered in a consultation in the healthcare system.Currently,it is a hot-spot for researching its influence on clinical outcomes of acupuncture and moxibustion interventions.How to evaluate the magnitude of patients' expectations is a problem needing to be solved urgently at the moment.The authors of the present paper make a summary about researches on the mechanism of expectations.For example,placebo analgesia was related to decreased brain activity in pain-sensitive brain regions(thalamus,insula,and anterior cingulate cortex),and to the increased activity of the prefrontal cortex showed by fMRI,and to the release of endogenous opioids.In addition,the authors also introduce some methods(psychological scales)for assessing expectations and related influencing factors(physicians or acupuncturists,and medical environment)for future research in this area.In the coming clinical trials on acupuncture or moxibustion treatment of clinical disorders,we should further better our experimental design,and try our best to exclude placebo effect-associated or expectation-induced bias of clinical outcomes for confirming the therapeutic effects in the treatment of different clinical problems.关键词：Acupuncture-moxibustion;Expectation;Therapeutic effect;Influencing factor;Mechanism;Assessment methods;Review1027|395|1更新时间：2023-08-11
- Postal code：100700
- Tel：010-64089344,84014607 Email：zcyjbjb@vip.163.com
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05017590号-8
京公网安备11010802020460号 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
0