最新刊期
卷 39 ， 期 5 ， 2014
- 摘要：Objective To observe the effect of electroacupuncture(EA)intervention on changes of neurological function and expression of cerebral cytochrome P 450 2C11(CYP 2C11)mRNA in focal cerebral ischemia(FCI)rats,so as to explore its mechanism underlying improvement of ischemic cerebral vascular disease.Methods Wistar rats were randomly divided into normal,model,EA and EA+17-ODYA(17-Octadecynoic acid,an inhibitor for the metabolism of arachidonic acid by cytochrome P 450)groups.Focal cerebral ischemia rats were induced by middle cerebral artery occlusion(MCAO)with thread embolus.EA was applied to bilateral"Neiguan"(PC 6)and"Quchi"(LI 11)after MCAO.Zea Longa's score and beam walking test(BWT)score of rats were used to evaluate the neurological impairment.Local cerebral blood flow(LCBF)of the pial tissue was monitored using Laser-Doppler Flowmetry.The expression of cerebral CYP 2C11 mRNA was examined by Real-time Quantitative PCR(qPCR).Results In comparison with the normal group,BWT score and LCBF of the model group were significantly decreased(P<0.05),and Zea Longa's score and cerebral CYP 2C11 mRNA expression level of the model group were significantly increased(P<0.05).While in comparison with the model group,BWT score,LCBF and cerebral CYP 2C11 mRNA levels were considerably up-regulated and Zea Longa's score was down-regulated in the EA group(P<0.05)rather than in the EA+17-ODYA group(P<0.05).H.E.stain showed that the nerve impairment of the ischemic cerebral tissue including the neuronal degeneration,necrosis,apoptosis,etc.was relatively milder in the EA group.Conclusion EA intervention can improve cerebral blood flow and up-regulate cerebral CYP 2C11 mRNA expression in FCI rats,which may contribute to its action in improving neurological impairment.993|422|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of moxibustion on epidermal growth factor receptor(EGFR)and phosphorylated extracellular signal regulated kinase 1/2(p-ERK1/2)protein expression in gastric ulcer(GU)rats so as to reveal its mechanisms underlying improving GU.Methods Fifty SD rats were randomly allocated to control,model,medication("Sijunzi"Decoction),non-acupoint moxibustion(non-acup-moxi),and acup-moxi groups(n=10in each group).The GU model was established by intragastric perfusion of absolute alcohol.Rats of the control group were treated by gavage of distilled water.Rats of the medication group were treated by administration of"Sijunzi"Decoction(8mL·kg-1·d-1),twice a day for 8days.Moxibustion intervention was applied to bilateral"Zusanli"(ST 36),"Zhongwan"(CV 12),and"Pishu"(BL 20),"Weishu"(BL 21)alternatively for 30 min,once daily for 8days.The animals' ulcer index(UI)was assessed by Guth's method,and gastric mucosal pathological changes were observed under light microscope following H.E.staining.The expression of gastric EGFR was detected by immunohistochemistry and that of phosphorylated ERK1/2(p-ERK1/2)protein determined by Western blot.Results Compared with the control group,the UI,gastric EGFR and p-ERK1/2protein expression levels were significantly increased in the model group(P<0.01,P<0.05);whereas in comparison with the model group,the UI was notably decreased in the medication,non-acup-moxi and acup-moxi groups(P<0.05,P<0.01),and EGFR and p-ERK1/2protein expression levels were further up-regulated in the three treatment groups(P<0.01).The effects of both medication and acup-moxi groups were obviously superior to those of the non-acup-moxi group(P<0.01,P<0.05).No significant differences were found between the medication and acup-moxi groups in the expression levels of EGFR and p-ERK1/2proteins(P>0.05).Results of H.E.staining showed that alcohol-induced gastric mucosal injury as breakage,exfoliation,inflammatory cell infiltration,etc.was milder in both medication and acup-moxi groups following the treatment.Conclusion Acupoint-moxibustion has a role in relieving alcohol induced gastric mucosal injury in the rat,which may be closely associated with its effects in up-regulating activities of the EGFR/ERK signal transduction pathway.1126|705|6更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupoint-catgut-embedding therapy on blood lipid and insulin levels in typeⅡ diabetes mellitus rats,so as to reveal its mechanism underlying improvement of pancreatic functions.Methods Thirty SD rats were divided into normal,model and treatment group.The typeⅡ diabetes model was established by feeding the rats with high-fat diet and intraperitoneal injection of streptozotocin(STZ).Catgut-embedment was performed in acupoint"Zhongwan"(CV 12)-"Xiawan"(CV 10),"Yishu"-"Ganshu"(BL 18),etc.,once every 20 days,twice altogether.Fasting blood glucose(FBG)content was assayed by glucose oxidase method;glycosylated hemoglobin A 1c(HbA 1c)assayed by ELISA,and serum fasting C-peptide(FC-p)determined by chemiluminescence method;and the triglyceride(TG),total cholesterol(TC),and serum insulin(INS)levels were detected by enzymatic method,separately.The rat's pancreas tissues were fixed with 4%paraformaldehyde and cut into sections(4μm in thickness)and stained with H.E.method.Results After modeling,the levels of FBG,HbA 1c,INS and FC-p,TG,TC were significantly increased in the model group in comparison with those of the normal group(P<0.05),while INS sensitive index was apparently decreased in the model group(P<0.05).Following catgut-embedding treatment,changes of the above-mentioned indexes were all remarkably reversed(P<0.05),and H.E.staining showed an improvement of the injured pancreatic tissue and islet cells.Conclusion Catgut-embedding therapy can reduce fasting blood glucose and insulin resistance,and improve lipid metabolism in typeⅡ diabetic rats,which may contribute to its effect in protecting pancreatic islet cells.关键词：Acupoint-catgut-embedding;Type Ⅱ diabetes;Fasting blood glucose;Blood lipids;Insulin;C-peptide;Glycosylated hemoglobin A 1c870|420|1更新时间：2023-08-11
- 摘要：Objective To observe the effect of manual acupuncture stimulation on changes of hippocampal monoamine neurotransmitter levels and expression of 5-hydorxytryptamine(5-HT)mRNA,dopamine(DA)mRNA and acetylcholine esterase(AChE)mRNA in methamphetamine addiction rats,so as to explore its mechanism underlying improvement of drug addiction.Methods SD rats were randomly divided into normal control,model and manual acupuncture groups(n=10in each group).Drug addiction model was established by i.p.of methamphetamine(5mg/kg),once a day for 15 days.Manual acupuncture stimulation was applied to"Baihui"(GV 20)and"Dazhui"(GV 14)once daily for 10 days.The contents of hippocampal 5-HT,DA,acetylcholine(ACh),AChE were measured by ELISA.The expressive levels of hippocampal 5-HT mRNA,DA mRNA and AChE mRNA were determined by fluorescence quantitative RT-PCR.Results In comparison with the normal control group,the contents of 5-HT,DA,ACh and AChE and the expression levels of 5-HT mRNA,DA mRNA and AChE mRNA were significantly increased in the model group(P<0.01,P<0.05).After acupuncture intervention,the levels of the above-mentioned 7indexes were uniformly and significantly down-regulated in the manual acupuncture group(P<0.01,P<0.05).Conclusion Manual acupuncture stimulation of GV 20 and GV 14 can adjust methamphetamine addiction-induced changes of some hippocampal monoamine neurotransmitters and expression levels of 5-HT,DA and AChE genes.关键词：Manual acupuncture;Methamphetamine addiction;Hippocampus;Dopamine;Acetylcholine esterase;5-hydorxytryptamine936|403|0更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)stimulation on the expression of metalloproteinase-9(MMP-9)and tissue inhibitor-1(TIMP-1)in the lung tissue in rats with chronic obstructive pulmonary disease(COPD),so as to reveal its mechanisms in protecting the lung tissue.Methods Forty male SD rats were equally randomized into control,model,medication and EA groups.The COPD model was established by smoke-fumigation method(passive smoking in a closed box)and endotracheal injection of lipopolysaccharide(200μg/100μL)for 30 days.Rats of the medication group were treated by i.p.of dexamethasone acetate injection(2.0mg/kg),once daily for 22 days.EA was applied to LU 9,ST 36,ST 40 and KI 3for 20 min,once daily for 22 days.Pathological changes of the pulmonary tissue were observed under optical microscope after hematoxylin and eosin(H.E.)staining.The expression of pulmonary MMP-9and TIMP-1was assayed by immunohistochemistry.Results H.E.staining showed pulmonary diffuse edema,severe inflammatory cell infiltration,and increase of the numbers of goblet cells,proliferation of fibroblasts,etc.in the model group which were relatively milder in the medication and EA groups.The expression levels of pulmonary MMP-9and TIMP-1proteins were significantly higher in the model group than in the control group(P<0.05),and were considerably down-regulated in both EA and medication groups in comparison with the model group(P<0.05).There were no significant differences between the EA and medication groups in MMP-9and TIMP-1expression levels(P>0.05).Conclusion EA can effectively suppress the increased expression of pulmonary MMP-9and TIMP-1in COPD rats,which may contribute to its effect in improving COPD-induced pathological changes.关键词：Chronic obstructive pulmonary disease(COPD);Electroacupuncture intervention;Metalloproteinase-9(MMP-9);Tissue inhibitor-1(TIMP-1)777|270|6更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)and moxibustion(Moxi)preconditioning of bilateral"Neiguan"(PC 6)on plasma endothelin(ET)and serum creatine kinase(CK)contents and myocardial hot shock protein70(HSP 70)expression in myocardial ischemia-reperfusion injury(MIRI)rabbits,so as to revel their mechanisms underlying prevention of myocardial ischemia.Methods A total of 72 New Zealand rabbits were randomly divided into sham operation,MIRI model,EA preconditioning and Moxi preconditioning groups(n=18/group).Each group was further divided into 0h,24 hand 48h(time-point)subgroups(n=6in each subgroup).The MIRI model was established by occlusion of the anterior descending branch of the left coronary artery for 40 min and reperfusion for 60 min.The contents of plasma ET and serum CK were detected by ELISA,and myocardial HSP 70 expression was detected by immunohistochemistry.EA and Moxi preconditioning were respectively applied to bilateral PC 6for 20 min,once daily for 5days.Results Following MIRI,contents of plasma ET and serum CK contents were significantly increased at 0h,24 hand 48hin comparison with the sham group(P<0.01,P<0.05),while myocardial HSP 70 expression at the 3time-points was moderately increased(P>0.05).Compared with the model groups,plasma ET contents at both 24 hand 48hin the EA preconditioning group and at 48 hin the Moxi preconditioning group,CK contents at both 24 hand 48honly in the EA preconditioning group were significantly down-regulated(P<0.01,P<0.05).Myocardial HSP70 expression levels in the EA and Moxi preconditioning groups were considerably up-regulated at the three time-points in comparison with the model group(P<0.05,P<0.01).Conclusion Acupuncture and moxibustion pretreatment may suppress MIRI-induced increase of plasma ET and serum CK and up-regulate myocardial HSP 70 protein expression in MIRI rabbits,suggesting a preventive protection action on ischemic myocardium.1015|712|13更新时间：2023-08-11
- 摘要：Objective To observe the distribution of calcitonin gene related peptide(CGRP)-positive neurofibers in local tissues of"Neiting"(ST 44),"Zusanli"(ST 36)and"Futu"(ST 32)regions in the hind limbs of rats.Methods Five adult male SD rats were used in the present study.The local skin tissues of acupoint"Neiting"(ST 44),"Zusanli"(ST 36)and"Futu"(ST 32)regions were dissected from the rat that underwent transcardiac perfusion with 4% paraformaldehyde,and cut into sections(20μm in thickness),followed by staining with CGRP fluorescent immunohistochemical method and with phalloidin and DAPI,respectively.After that,CGRP-positive neurofibers of the samples were observed and recorded using a laser confocal microscope.Results CGRP-positive nerve fibers were found to distribute in the dermis and subcutaneous layers of local tissues of acupoint ST 44,ST 36 and ST 32,mainly concentrating around the vessel-like structure.The number and length of CGRP-positive nerve fibers were most in the ST 44 region,more in the ST 36 region and fewer in the ST 32 region,in turn(P<0.01).The distribution of the vessel-like structure also presented a decreasing trend in the above-mentioned three acupoint regions in turn.Conclusion CGRP-positive neurofibers are an important element in the local tissues of acupoint ST 44,ST 36 and ST 32 regions,and present a decreasing tendency in the number from the distal to the proximal part of the hind-limb,showing a similar tendency of needling sensation in the human body in which a more hypersensitivity exists in the distal part of the limb.关键词：Acupoint region;Calcitonin gene related peptide;Phalloidin;Nerve fiber928|433|8更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)intervention on changes of spinal a-amino-3-ydroxy-5-methylisoxazole-4-propionate acid(AMPA)receptor(GluR 1)expression in rats with chronic constrictive injury(CCI)pain,so as to explore its mechanisms underlying improvement of neuropathic pain.Methods Sixty male SD rats were randomly divided into sham-operation,CCI model and EA groups(n=20).Neuropathic pain model was established by ligature of the right sciatic nerve.EA stimulation(2Hz,1-3mA)was applied to"Weizhong"(BL 40)and"Huantiao"(GB 30)on the injured limb for 30 min,once a day for 7days beginning from the 11 th day on after CCI.The mechanical and thermal pain thresholds were measured before and after the CCI procedure(baseline)and after EA intervention.The AMPA receptor subunit GluR 1protein and gene expression in L 5-L 6segments of the spinal cord was detected using Western blot(WB),immunohistochemistry and reverse transcription(RT)-polymerase chain reaction(PCR),separately.Results As the results of mechanical and thermal pain thresholds in our past study,EA intervention could markedly raise CCI-reduced decreased pain threshold.Compared with the sham-operation group,the expression levels of spinal GluR 1protein and mRNA in the model group were significantly increased(P<0.05,P<0.01).Following EA intervention,the expression levels of GluR 1protein and mRNA were remarkably down-regulated in the EA group in comparison with those of the model group(all P<0.05).Conclusion EA intervention can down-regulate CCI-induced increase of AMPA receptor GluR 1expression in the lumbar spinal cord in CCI rats,which may contribute to its effect in alleviating neuropathic pain.关键词：Electroacupuncture;Neuropathic pain;Lumbar spinal cord;AMPA receptor/GluR 1expression937|214|2更新时间：2023-08-11
- 摘要：Objective To observe the effect of manual acupuncture stimulation of"Baihui"(GV 20),etc.on serum IFN-γand IL-4contents in rats with chronic fatigue syndrome(CFS).Methods A total of 24 male SD rats were equally randomized into control group,model group and acupuncture group.CFS model was established by bounding and forced swimming in cold water once daily for 14 days.Rats in the acupuncture group were treated by manual acupuncture stimulation of bilateral"Zusanli"(ST 36),"Baihui"(GV 20),and"Guanyuan"(CV 4),once daily for 14 days.Serum IFN-γand IL-4contents were detected by ELISA.Results Compared with the control group,the contention of serum IFN-γand ratio of IFN-γ/IL-4were significant decreased in the model group(P<0.01).While in comparison with the model group,the contention of IFN-γand ratio of IFN-γ/IL-4were obviously increased in the acupuncture group(P<0.05).No significant differences were found among the three groups in serum IL-4levels(P>0.05).Conclusion Manual acupuncture can inhibit CFS induced reduction of serum IFN-γlevel and the ratio of IFN-γ/IL-4in CFS rats,suggesting a favorable adjustment of acupuncture intervention for CFS by balancing the ratio of IFN-γ/IL-4.关键词：Manual acupuncture;Chronic fatigue syndrome;Serum IFN-γ;Serum IL-4832|541|6更新时间：2023-08-11
- 摘要：Objective To observe changes of electrical activities of wide dynamic neurons(WDR)in the lumbar spinal cord after electroacupuncture(EA)stimulation of"Zusanli"(ST 36)during colorectal distension in rats,so as to analyze alternations of acupoint's functions under pathological conditions.Methods Experiments were performed in male Sprague-Dawley rats.Visceral nociceptive information input was generated by colorectal distension(CRD).Extracellular discharges of WDR neurons in the dorsal horns of L1-3spinal cord were recorded using glass micropipettes and a microelectrode amplifier.EA stimulation(15Hz,1,4,7,10mA)was applied to ipsilateral"Zusanli"(ST 36)area.Results A total of 40 neurons were recorded in the present study.Under no CRD conditions,the firing rates of WDR neurons were significantly increased by(18.12±13.56)%(1mA),(152.38±36.19)%(4mA),(231.21±49.74)%(7mA)and(331.54±61.89)%(10mA)respectively after EA stimulation of ST 36.Under CRD conditions,the firing rates of these WDR neurons were increased by(226.78±39.59)%(1mA),(282.80±47.54)%(4mA),(343.06±58.35)%(7mA),and(338.62±80.04)%(10mA)respectively after EA stimulation.It showed a considerablely increased sensitivity of electrical activities of WDR neurons to EA stimulation during CRD nociceptive stimulation.Conclusion Colorectal distension(visceral nociceptive stimulation)can strengthen the sensitivity of acupoint-EA stimulation-induced increase of firing rates of WDR neurons in the dorsal horns of the lumbar spinal cord in rats,suggesting apotentiation of the acupoint action under visceral nociceptive signal inputs.关键词：Sensitization of acupoint;Electroacupuncture stimulation;Colorectal distension;Wide dynamic range neurons;Lumbar spinal cord1264|536|10更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)intervention on renal function and expression of renalβ-catenin in rats with chronic renal failure(CRF),so as to reveal its mechanism underlying improvement of CRF.Methods Male SD rats were randomly divided into normal,model and EA groups,with 10 rats in each group.CRF model was induced by feeding the rats with 0.5% Adenine(100mg/d,in forage)for 21 days.EA(1-3mA,1.5-2Hz)was applied to bilateral"Sanyinjiao"(SP 6),"Taixi"(KI 3)and"Shenshu"(BL 23)for 20 min,once daily for 30 days.Serum creatinine(Scr)and blood urine nitrogen(BUN)contents were assayed by enzymatic method and deoxy enzymatic method,respectively,and the expression ofβ-catenin protein in the renal tissue was determined by Western blot.Results Following modeling,serum Scr and BUN contents and renalβ-catenin protein expression level were significantly increased in the model group in comparison with those of the normal group(P<0.05).After EA intervention,serum Scr and BUN contents and the expression ofβ-catenin in the renal tissue were all significantly decreased in the EA group compared to the model group(P<0.05).In addition,the animals' body weight values of both model and EA groups were apparently lower than those of the normal group before EA treatment(P<0.05).After EA intervention,the body weight values of the EA group were markedly higher than those of the model group in spite of being still lower than normal rats(P<0.05).Conclusion EA can effectively suppress CRF-induced increase of serum Scr and BUN contents and renalβ-catenin protein expression in CRF rats,suggesting an improvement of the renal function after EA intervention by reducing the expression ofβ-catenin in the renal tissue.关键词：Chronic renal failure;Electroacupuncture;Serum creatinine;Blood urine nitrogen;Renal Function;Renalβ-catenin857|139|1更新时间：2023-08-11
- 摘要：Objective To observe the reflection of dysmenorrhea in acupoint Sanyinjiao(SP 6)region(body surface)so as to verify the relationship between the acupoint and uterus.Methods A total of 60women(15-35 years in age)including30primary dysmenorrhea patients(test group)and 30 healthy subjects(control group)were enrolled in the present study.The visual analog scale(VAS)score and mechanical pain threshold of bilateral Sanyinjiao(SP 6)regions were detected to assess changes of skin sensitivity in subjects undergoing menstrual pain and in the non-menstrual period.Results The VAS value in the menstrual period of test group was significantly higher than that in the non-menstrual period of the same one group and that in the menstrual period of the control group(P<0.01),and the pain threshold in the menstrual period of test group was significantly lower than that in the non-menstrual period of same one group and that in the menstrual period of the control group(P<0.01).No significant differences of both VAS value and pain threshold were found between the two groups in the non-menstrual period(P>0.05).Conclusion An obvious tenderness at Sanyinjiao(SP 6)exists in women undergoing primary dysmenorrhea,suggesting a close correlation between Sanyinjiao(SP 6)and uterus.关键词：Dysmenorrhea;Sanyinjiao(SP 6);Tenderness;Visual analog scale;Pain threshold1444|1532|14更新时间：2023-08-11
- 摘要：Objective To observe the clinical effects of acupoint injection of metoclopramide for postsurgical gastroparesis syndrome(PGS).Methods A total of 46 patients with PGS(from abdominal surgery)were randomly divided into control and acupoint injection groups(n=23in each group).Patients of the acupoint injection group were treated by injection of Metoclopramide(5mg+ normal saline)into bilateral Zusanli(ST 36)and Weishu(BL 21)alternatively,while patients of the control group treated by injection of 10 mg of Metoclopramide into the deltoid muscle and gluteus maximus muscle alternatively.The treatment of both groups was conducted once daily for 14 days.A 3-point scale of clinical symptoms(abdominal distension,belching,nausea-vomiting,upper-abdominal distending pain,sour regurgitation and gastric burning sensation)was used to evaluate the therapeutic effect.Results There were no statistical differences between two groups in clinical symptom scores before the treatment(P>0.05).Following treatment,the clinical symptom scores of both groups were significantly decreased in comparison with pre-treatment(P<0.05)and the scores of the acupoint injection group were significantly lower than those of the control group(P<0.05).Of the 23 PGS patients in the control group and acupoint injection group,0and 2were cured,5and 10 were significantly improved,10 and 9were improved,8and 2failed,with the effective rates being 65.22%and 91.30%,respectively.Conclusion Acupoint injection of Metoclopramide is effective for improving clinical symptoms of PGS patients.关键词：Postsurgical gastroparesis syndrome;Metoclopramide;Acupoint injection;Weishu(BL 21);Zusanli(ST 36)829|299|0更新时间：2023-08-11
- 摘要：Mr.CHENG Dan-an,a famous acupuncture master,is the beginner of"Chengjiang Acupuncturological School"in China.This school of thought has a far-reaching impact on current acupunturological education,and its educational thought and teaching features chiefly reflect in CHENG's works.In the present paper,the authors analyze the influence of contemporary historical factors and sum up Mr.CHENG's educational thought on the basis of the written foundation,style and contents of his book Chinese Acupuncturologyfrom four aspects 1)the role of education,2)the process of education,3)the teacher's and students' relationship in educational activities,and 4)the compilation of teaching materials about acupuncture and moxibustion.关键词：CHENG Dan-an;Chinese Acupuncturology;Educational thought;Republic period in China855|473|1更新时间：2023-08-11
- 摘要：Basic research is an important component of acupuncture medicine,and is also the driving force for improving clinical practice.Acupuncture therapy has been used to treat hypertension for many years in China,and its underlying mechanism has also been progressively and partially explored,but its therapeutic effect remains controversial.Authors of the present paper summarize the current state of experimental researches on acupuncture treatment of hypertension from the establishment of hypertension model,acupoint selection,stimulation parameters,and related action mechanisms,and simultaneously found a disassociation between the basic research and clinical practice,particularly in the selection of acupoints and stimulation parameters.Therefore,to establish a bridge for better translation from many achievements of experimental studies to clinical application is of great practical significance.The authors hold that the existing problems of clinical practice should be the foothold of basic research,while successful transformation from basic research achievements to clinical practice is our ultimate target.Only in this way,can we incessantly achieve the goal of improving clinical therapeutic effect of acupuncture therapy from the phase of effectiveness verification,and promote the healthy development of acupuncturology.关键词：Acupuncture;Hypertension;Basic research;Clinical practice;Translational medicine1267|771|5更新时间：2023-08-11
- 摘要：Using keywords of"acupuncture,fMRI and resting state",authors of the present paper retrieved papers in both Chinese and English from CNKI and PubMed databases without time limitation.A total of 13articles(11for acupuncture and2 for moxibustion)met the standards were subjected to analysis.Of the 13 papers,6involve acupuncture analgesia,2moxibustion analgesia,3mild cognitive impairment,one involves stroke,and the rest one is for depression.Research results of acupuncture analgesia revealed that the analgesic effect is closely related to its regulation on"pain matrix"brain regions and pain-related default mode network.In the studies,a single acupoint is often used,without acupoints-combined recipes.Therefore,it is highly recommended that researchers pay more attention to1 studies on the underlying mechanism of moxibustion,and2 improvement of design protocols targeting requirements of acupuncture clinical practice.关键词：Acupuncture;Moxibustion;Functional magnetic resonance imaging;Resting-state fMRI;Pathological state;Mechanisms829|848|0更新时间：2023-08-11
- 摘要：Following retrieving articles about foreign large sample clinical trials of acupuncture(more than 500cases)from MEDLINE and EMBASE databases(1996-2012)by using keywords of"acupuncture"and"clinical trial",aquality analysis was carried out independently by two researchers.A total of 1 373 papers were collected and 37 were considered to meet our preformulated standards in accordance with the principles and methods of evidence-based medicine.Majority of these 37 articles were from some advanced countries including Germany,USA,Japan,Demark,Australia,et al.Their paper quality and research quality are varied including the methodology,standards for diagnosis,inclusive and exclusive criteria,follow-up survey,economic effectiveness,adverse effects,acupoint application and syndrome differentiation of traditional Chinese medicine.Of the 37 papers,17are multiple center clinical trials,18 are one center clinical trials,and 2are not clear.Our Chinese researchers should pay more attention to foreign well-designed,large example,randomized controlled clinical trials and draw their matured experience and strong points to compensate our weak points and to improve our levels in clinical study on acupuncture treatment of clinical disorders.关键词：Acupuncture;Large sample multiple-center clinical trials;Western countries;Quality evaluation894|373|3更新时间：2023-08-11
- 摘要：Under the condition of knowledge economy,the acu-moxibustion standardization definitely involves intellectual property rights.Then,what is the relationship between the standardization and the intellectual property rights of acu-moxibustion?The authors of the present paper hold that it is not only exclusive,but also syncretic.If their relationship cannot be handled properly,their own respective development will be affected adversely.Therefore,aproper handling of the relationship between the two is of great practical significance.The present paper makes a comprehensive analysis about their interaction(mutual promotion and mutual inhibition),similarities(systemic composition,dynamic implementation course,standardization-rated order and ultimate targets)and differences(in properties,working components,secret requirement,effectiveness-time limitation,usage cost,etc).关键词：Acu-moxibustion therapy;Standardization;Intellectual property rights;Interrelationship1020|221|1更新时间：2023-08-11
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