最新刊期
卷 40 ， 期 3 ， 2015
- 摘要：Objective To observe the effect of electroacupuncture(EA)on cytotoxic activity of splenic natural killer(NK)cells after surgical trauma via extracellular signal-regulated kinase(ERK)5pathway in the rats' hypothalamus,so as to explore its mechanism underlying improving immune disorders after surgery.Methods Sprague-Dawley rats were randomly divided into the following 6groups:control,trauma model,EA,sham EA,4nmol-BIX 02188(an inhibitor for ERK 5catalytic activity)and 20nmol-BIX 02188(n=6rats per group).The surgical trauma model was established by making a longitudinal incision(6cm in length)along the median line of the back to expose the spinal column and another longitudinal incision along the abdominal median line.EA(2Hz/15 Hz,1-2mA)was applied to bilateral"Zusanli"(ST 36)for 30 min immediately after surgery.For rats of the BIX groups,intra-lateral ventricular microinjection of BIX 02188(10μL,4nmol or 20 nmol,or saline for control rats)was conducted 30 min before the surgery.The expression level and protein of phosphorylated ERK 5(p-ERK 5)and corticotropin-releasing factor(CRF)protein were measured by immunohistochemistry and Western blot,respectively.The cytotoxicity of splenic NK cells and the expression of splenic Perforin and Granzyme-B genes were measured by lactate dehydrogenase(LDH)release assay and real-time PCR,respectively.Results In comparison with the control group,hypothalamic p-ERK 5immunoactivity,p-ERK5 protein and CRF protein expression levels were significantly up-regulated in the model group(P<0.01,P<0.05),while splenic NK cell cytotoxicity and Perforin mRNA and Granzyme-B mRNA expression levels were notably down-regulated in the model group(P<0.05,P<0.01).Following EA and administration of ERK 5antagonist,the increased expression levels of p-ERK 5immunoactivity in the EA group,and p-ERK 5and CRF proteins in both EA and 20nmol-BIX 02188 groups were obviously down-regulated(P<0.05,P<0.01),without changes in the sham EA and 4nmol-BIX 02188groups(P>0.05)except the increased p-ERK 5protein in the 4nmol-BIX 02188 group.In addition,the down-regulated NK cell activity,Perforin mRNA and Granzyme-B mRNA expression levels were significantly reversed in the EA and 20nmol-BIX 02188groups(P<0.05,P<0.01).No significant differences were found between the EA group and 20nmol-BIX 02188 group in down-regulating hypothalamic p-ERK 5and CRF protein expression and up-regulating splenic NK cytotoxicity and Perforin and Granzyme-B gene expression(P>0.05).Conclusion EA can promote the cytotoxicity of splenic NK cells in surgical trauma rats,which may be closely associated with its functions in down-regulating trauma-induced activation of ERK 5pathway and production of CRF in the hypothalamus.关键词：Electroacupuncture;Surgical trauma stress;Hypothalamus;ERK 5;Corticotropin-releasing factor;Splenic NK cell972|287|3更新时间：2023-08-11
- 摘要：Objective To observe the dynamic distribution of the extravasated Evans Blue(EB)dye points at the skin after acute colorectal mucosal injury(AIMI)so as to reveal characteristics of acupoint sensitization.Methods Forty adult male SD rats were randomly divided into control(n=10),AIMI(n=20)and AIMI-recovery(n=10)groups.According to the reaction state(EB-dye extravasation),each group was further divided into resting state(control),sensitized state(appearance of extravasated EB points),recovery state(disappearance of the extravasated EB points),non-sensitization(NS,no extravasated EB points)state and NS recovery state.The AIMI model was induced by perfusion of 2.5% mustard oil into the colorectum via a thin tube.Evans blue dye was injected into the caudal vein 4hafter AIMI modeling.The distribution of plasma extravasated EB dye points at the skin of the lower limbs was observed.The C-fiber discharge of the separated ipsilateral sciatic nerve was induced by electrical stimulation of the EB-extravasated acupoints and non-acupoint at the threshold and double-fold threshold using an electric stimulator and recorded using a bioelectric amplifier-computer system.Results In AIMI rats,the extravasated EB-dye points were found to overlap the"Xiqian"and"Zusanli"(ST 36)-"Shangjuxu"(ST 37)regions.Moreover,the thresholds of C-fiber discharges induced by electrical stimulation of"Xiqian"and"Zusanli"(ST 36)-"Shangjuxu"(ST 37)regions were significantly lower than those of the regions without extravasated EB dye acupoint and non-acupoint(P<0.01,P<0.05).The numbers of C-fiber discharges evoked by 2-fold threshold electro-stimulation at the "Xiqian"and "Zusanli"(ST 36)-"Shangjuxu"(ST 37)regions were obviously more than those of stimulation of non-acupoint which were experiencing sensitized state(P<0.01,P<0.05).Conclusion In rats with acute colorectal mucosal injury,electrical stimulation of the acupoints where the extravasated EB-dye points appear may produce an obvious increase of C-fiber discharges under lower electro-stimulation threshold,suggesting a larger action of the sensitized acupoint.关键词：Acute colorectal mucosal injury;Evan's blue extravasation;Sensitization of acupoints;C-fiber discharges962|753|10更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)intervention on the neurological function and the expression change of Slit-Robo GTPase-activating protein-1(srGAP 1)and cell division-cycle 42(Cdc 42)in the cortex of rats with cerebral ischemic injury(CIRI),so as to explore the mechanism of EA in the management of cerebral infarction.Methods A total of 48 male Sprague Dawley(SD)rats were randomly and equally divided into control,model,non-acupoint EA and EA groups(n=12/group).The CIRI model was established based on the modified Zea Longa method.EA intervention was applied for 30 min,once a day for 14 days.Modified neurologic severity scores(mNSS)were assessed on day 1,3,7and 14 after modeling.Immunofluorescence assay was used to detect the immunoactivity and distribution of srGAP 1and Cdc 42 in the cortical ischemic region.Western blot was employed to detect the expression of srGAP 1and Cdc 42 in the affected cortex.Results The mNSS displayed that the neurological score in the EA group was significantly lower than that in the model group and non-acupoint EA group at the 7th d and 14 th d(P<0.01).Immunofluorescence results showed that cerebral srGAP 1and Cdc 42 were expressed mainly in the cytoplasm.The fluorescence intensity of srGAP 1of the EA group was significantly lower than that of the model group and non-acupoint EA group(P<0.01).Meanwhile the fluorescence intensity of Cdc 42 of the EA group was markedly higher than that in the model group and non-acupoint EA group(P<0.01).Western blot assay indicated that the expression level of srGAP 1in the model group was significantly higher than that of the control group(P<0.01),and that of the EA group was much lower than those of the model group and non-acupoint EA group(P<0.01).There was no significant difference of srGAP 1expression levels between the non-acupoint EA group and the model group(P>0.05).Additionally,the protein expression of Cdc 42 in the model group was slightly higher than that of the control group(P>0.05),and that of the EA group was significantly higher than those of the model group and non-acupoint EA group(P<0.01).There was no significant difference of Cdc 42 expression levels between the non-acupoint EA group and the model group(P>0.05).Conclusion Cerebral infarction induced increase of cerebral srGAP 1and decrease of Cdc 42 can be reversed by acupoint EA intervention in CIRI rats,which may be responsible for its effect in improving impaired neurological function after cerebral infarction.关键词：Cerebral ischemia-reperfusion;Electroacupuncture;srGAP 1;Cdc 42999|286|7更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)on changes of ultrastructure of oligodendrocytes in the marginal zone of the cerebral ischemia(CI)locus in rats with cerebral infarction so as to reveal its mechanism underlying improving ischemic cerebral diseases.Methods Ninety male SD rats were randomized into sham operation,model and electroacupuncture(EA)groups which were further divided into five subgroups:1h,1d,3d,7d,and 21 dafter CI(n=6in each subgroup).The CI model was established by occlusion of the middle cerebral artery.EA(1-3mA)was applied to"Baihui"(GV20)and"Dazhui"(GV 14)for 30 min,once a day for 1h,1d,3d,7dand 21 d,respectively.The ultrastructural changes of oligodendrocytes in the marginal zone of the ischemic cerebral tissue were observed by transmission electron microscope.The immunoactivity levels of A2B5,O4 and 2',3'-cyclic-nucleotide 3'-phosphodiesterase(CNPase)for labeling the oligodendrocyte precursor cells,immature oligodendrocytes,and mature oligodendrocytes respectively were detected by immunohistochemistry.Results The oligodendrocytes were swelling in structure and increased in number after cerebral ischemia.Compared with the model group,the degree of swelling of oligodendrocytes was obviously decreased and new oligodendrocyte proliferation was found in the EA group.In comparison with the sham group,the immunoactivity levels of cerebral A2B5 and CNPase proteins on day 3and7 were significantly higher in the model group(P<0.05),while those of O4 on day 1,3,7and 21 were obviously lower in the model group(P<0.01).Following EA intervention,the immunoactivity levels of cerebral A2B5,O4 and CNPase proteins were significantly up-regulated in the EA group in comparison with the model group(P<0.01,P<0.05).Conclusion EA intervention may reduce the structural damage of oligodendrocytes in CI rats,which may be associated with its effects in promoting the expression of cerebral A2B5,O4 and CNPase proteins,suggesting an involvement of glial cells in the protective effect of EA.关键词：Electroacupuncture;Cerebral ischemia;Oligodendrocyte;Ultrastructure;Protein expression856|474|6更新时间：2023-08-11
- 摘要：Objective To observe the effect of moxibustion intervention on the expression of toll-like receptor-4(TLR 4),myeloid differentiation factor 88(MyD 88),and nuclear factor kappa B p 65(NF-κB p 65)genes of knee-joint synovial cells in rheumatoid arthritis(RA)rats,so as to explore its molecular mechanism underlying improving RA.Methods Forty SD rats were randomly divided into normal control,RA model,moxibustion and medication groups(n=10).The RA model was duplicated by raising the rats in a windy,cold and wet environment,followed by injecting Freund's complete adjuvant(0.15mL)into the rat's foot.Moxibustion was applied to"Shenshu"(BL 23)and"Zusanli"(ST 36)for 20 min,once daily for 15 days.Rats of the medication group were treated by intragastric administration of tripterygium wilfordii(8.75mL/kg),once daily for 15 days.Pathological changes of the synovial tissues were detected by H.E.stain,the contents of serum TNF-αand IL-1detected by radioimmunoassay,and the expression levels of TLR 4mRNA,MyD 88 mRNA and TRAF-6mRNA of synovial tissue were analyzed by real time-PCR,and the NF-κB p 65 immunoactivity was assayed by immunohistochemistry.Results In comparison with the normal control group,the synovial tissue of the knee-joint was impaired remarkably and infiltrated by numerous inflammatory cells,and the synovial surface got thickening because of hyperplasia in the model group.Following moxibustion and medication,these situations such as synovial infiltration of inflammatory,synovial cell proliferation were alleviated.The serum TNF-αand IL-1contents and synovial TLR 4mRNA,MyD 88 mRNA,TRAF-6mRNA and NF-κB p 65 expression levels were remarkably higher in the model group than in the control group(P<0.01).After moxibustion and medication,the contents of serum TNF-αand IL-1,the expression levels of TLR 4mRNA,MyD 88 mRNA,TRAF-6mRNA and NF-κB p 65 were significantly down-regulated(P<0.01,P<0.05).Conclusion Moxibustion intervention can improve pathological changes of the knee-joint synovial membrane tissue in RA rats,which may be related with its effect in inhibiting abnormal activation of TLR 4-MyD 88-NF-κB pathway in synovial tissue.关键词：Moxibustion;Rheumatoid arthritis;Synovial tissue;TLR 4-MyD 88-NF-κBpathway1390|1980|16更新时间：2023-08-11
- 摘要：Objective To observe the effect of moxibustion on mRNA expression of signal transducers and activators of transcription 1(STAT 1),suppressors of cytokine signaling(SOCS)in synovium of rheumatoid arthritis(RA)rats,and to investigate its mechanism for relieving RA.Methods 40 Wistar rats were equally and randomly divided into control,model,moxibustion,acupuncture and infrared groups(n=8in each group).RA model was developed by putting rats in windy,cold and damp room and injection of Freund's complete adjuvant.Bilateral"Shenshu"(BL 23)were stimulated by the respective means for20 min in duration,once every other day,ten times in total.The swelling degree of voix pedis(perimeter)of rats was measured.The contents of serum interleukin-1(IL-1)and interleukin-2(IL-2)were detected by radioimmunoassay,and expression of STAT 1,SOCS mRNA in synovium were assessed by RT-PCR.Results Rats in model group had acute and severe swelling of voix pedis,together with the increase of serum IL-1content and decrease of IL-2content,and down-regulation of mRNA expression of both STAT 1and SOCS in synovium(all P<0.01).All three modalities of treatment alleviated the swelling and reversed the relevant changes(P<0.05,P<0.01),however,moxibustion produced greater effects than acupuncture or infrared in elevating IL-2content and up-regulating mRNA expression of both STAT 1and SOCS.Conclusion Moxibustion achieves the effects of anti-inflammation and joint swelling reduction of RA via decrease of IL-1,increase of IL-2in serum and up-regulation of STAT 1,SOCS mRNA expression in synovium.关键词：Moxibustion;Rheumatoid arthritis;STAT 1;SOCS967|771|12更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)on the spatial learning-memory ability and the expression of NR 2Bsubunit of NMDA receptor in the amygdala(AMG)in rats with morphine withdrawal.Methods A total of40 SD rats were randomized into control,model,manual acupuncture and EA groups(n=10in each group).The morphine withdrawal model was established by subcutaneous injection of morphine hydrochloride injection at doses of 20,30,40,50and50mg·kg-1·d-1 continuously for 5days,followed by injection of naloxone(i.p.,3mg/kg)for rapid induction of withdrawal syndrome.Manual acupuncture or EA stimulation was applied to bilateral"Shenshu"(BL 23)and "Zusanli"(ST 36),once daily for 6days.Morris water maze swimming test was conducted for detecting the rats' spatial learning-memory ability.The expression levels of NR 2Bprotein and mRNA in AMG was measured by Western blot and Real time-PCR,respectively.ResultsCompared to the control group,the escape latency on day 5of swimming tests was obviously prolonged in the model group(P<0.01),while in comparison with the model group,the escape latencies in both manual acupuncture and EA groups were obviously shortened(P<0.01),suggesting an improvement of the rats' learning-memory ability.In addition,the expression levels of NR 2Bprotein in both manual acupuncture and EA groups and that of NR 2BmRNA in the EA group were significantly higher than those of the model group(P<0.01,P<0.05).Conclusion Both manual acupuncture and EA interventions can improve the learning-memory ability in morphine withdrawal rats,which is probably partially related to their effects in up-regulating the expression of NR 2Bin the AMG.关键词：Electroacupuncture;Morphine withdrawal;Learning-memory ability;NR 2 B receptor;Amygdala1047|258|3更新时间：2023-08-11
- 摘要：Objective To observe the influence of"Tong Du Tiao Shen"(Governor-Vessel-Dredging and Mental Activity Regulating)acupuncture method on dynamic changes of cerebral TNF-αand C-reaction protein(CRP)levels in focal cerebral ischemia-reperfusion(CI/R)rats,so as to master the optimal time point of acupuncture therapy for cerebral infarction.Methods A total of 72 adult male Wistar rats were randomly divided into blank control,sham-operation,model and acupuncture groups which were further divided into 6h,24 hand 48hsubgroups(n=6in each subgroup).The CI/R model was established by occlusion of the middle cerebral artery.Acupuncture stimulation of"Baihui"(GV 20),"Fengfu"(GV 16)and "Dazhui"(GV 14)was conducted for 30 min.Neurological deficit symptoms were assessed with the Zea-Longa neurological deficit score and TNF-αand CRP contents in the brain tissue were detected using double sandwich ABC-ELISA method.Results In comparison with the model group,the Zea-Longa neurological deficit score was significantly decreased in the acupuncture group(P<0.01).Cerebral TNF-αand CRP levels at time-points of 6h,24 hand 48hafter CI/R were significantly increased in the model group than in both control and sham groups(P<0.01).In the acupuncture group,cerebral TNF-αand CRP levels were obviously lower than those of the model group(P<0.01).Conclusion Manual acupuncture stimulation of GV 20,GV 16 and GV 14 can relieve neurological deficit function in CI/R rats,which may be related to its function in suppressing TNF-αand CRP levels.关键词：Cerebral ischemia/reperfusion;Acupuncture;Neurological function;Cerebral TNF-α;C-reaction protein971|402|7更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)intervention on expression and content of protein kinase C(PKC)in the middle cerebral artery in acute cerebral infarction(ACI)rats so as to explore its mechanism underlying improvement of ACI.Methods Wistar rats were randomly divided into normal control(n=6),sham operation(n=30),ACI model(n=30),and EA(n=30)groups,and the latter three groups were further divided into 0.5h,1h,3h,6hand 12hsubgroups(n=6in each subgroup).The ACI model was established by occlusion of the middle cerebral artery(MCAO).EA(15Hz,1mA)was applied to"Shuigou"(GV 26)for 20 min.The PKC expression levels and activity in the vascular smooth muscle of the middle cerebral artery were detected using immunohistochemistry and ELISA,respectively.Results In comparison with the control group,the immunoactivity and activities of PKC in the middle cerebral artery tissue at 0.5h,1h,3h,6hand 12 hwere significantly increased in the model group(P<0.05).After EA intervention,the expression levels and activities of PKC at the 5time-points were markedly down-regulated in comparison with the model group at the same corresponding time-point(P<0.05).No significant changes of PKC expression and activity were found in the sham operation group(P>0.05).Conclusion EA intervention can up-regulate the immunoactivity and activity of PKC in the vascular smooth muscle of the middle cerebral artery in ACI rats,which may contribute to its effect in improving ACI by relieving arterial spasm.关键词：Acute cerebral infarction;Electroacupuncture;Middle cerebral artery;Protein kinase C897|330|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of preventative moxibustion on cardiomyocytes in mice experiencing different intensities of exercise.Methods Kunming mice were randomly divided into blank control(n=10),blank-moxibustion(n=10),moderate-intensity exercise(MIE)model(n=8),MIE-moxibustion(n=9),exhausted-exercise model(n=8),and exhausted-exercise moxibustion(n= 8)groups.Preventative moxibustion was applied to "Zusanli"(ST 36)and "Guanyuan"(CV 4)for 5min,once daily(except Saturdays or Sundays)for 3weeks.The apoptotic cardiomyocytes were detected by light microscope after terminal deoxynucleotidyl transferase mediated dUTP-biotin nick end labeling(TUNEL staining),and the ultrastructure of cardiomyocytes was observed by using transmission electron microscope.Results Compared with the blank control group,the rates of the apoptotic cardiomyocytes were considerably increased in both MIE and exhausted-exercise model groups(P<0.05).Comparison between the MIE model and MIE-moxibustion groups and between the exhausted-exercise model and exhausted-exercise moxibustion groups showed that the apoptotic rates of cardiomyocytes were significantly lower in the two moxibustion groups than in the two model groups(P<0.05).In mice experiencing preventative moxibustion,the injured state of the cardiomyocytes including dissolved myofilaments of myocardial fibers,disorder of arrangement and increased interspace of myofilaments,and decreased number of partial myocardial bundles,and the increase of matrix electron density was relatively milder in comparison with their individual exercise model groups.Conclusion Preventative moxibustion may reduce MIE and exhausted exercise induced apoptosis of cardiomyocytes in mice and lessen myocardial injury.关键词：Preventative moxibustion;Moderate-intensity exercise;Exhausted exercise;Myocardial cell;Apoptosis;Ultrastructure of cardiomyocyte880|363|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of warm-needle moxibustion on transfer growth factor-β1(TGF-β1)and insulin-like growth factorⅠ(IGF-Ⅰ)expression in knee cartilage of knee osteoarthritis(KOA)rabbits so as to explore its underlying mechanism in improving osteoarthritis.Methods Thirty Japanese white rabbits were randomly and equally divided into control,model and warm-needle moxibustion(treatment)groups(n=10in each group).The KOA model was made by immobilization of the rabbit knee.Warm-needle moxibustion was applied to internal and external Dubi(ST 35),Yanglingquan(GB 34)and Xuehai(SP 10)on the affected side for 30 min in each session and for consecutive 4weeks.The expression levels of TGF-β1and IGF-Ⅰin the knee cartilage tissue were assessed by means of radioimmunoassay.HE staining was carried out to examine the morphological changes of knee cartilage.Results In comparison with the control group,the expression levels of both TGF-β1and IGF-Ⅰ were up-regulated in the model group(P<0.05)and then down-regulated after the warm-needle moxibustion treatment(P<0.05).In addition,after the treatment the surface of the knee cartilage of rabbits became smoother and less cell proliferations and clusters were found in the cartilage in the warm-needle moxibustion group compared to those of the model group.Conclusion Warm-needle moxibustion therapy can inhibit the overexpression of TGF-β1and IGF-Ⅰin the knee cartilage of rabbits with KOA,which may be responsible for its effect in improving pathological changes of the cartilage.关键词：Knee osteoarthritis;Warm-needle moxibustion;TGF-β1;IGF-Ⅰ980|731|5更新时间：2023-08-11
- 摘要：Objective To observe the effects of electroacupuncture(EA)at"Yanglingquan"(GB 34)acupoint on white blood cell(WBC)count and gallbladder wall thickness in rabbits with acute cholecystitis,so as to explore the inherent correlation between the gallbladder and GB 34 acupoint according to the theory of Chinese medicine.Methods Thirty-two male rabbits were randomly and equally divided into control group,model group,EA "Yanglingquan"(GB 34)group(EA-GB 34)and EA "Yinlingquan"(SP 9)group(EA-SP 9).The acute cholecystitis model was induced by intra-gallbladder injection of escherichia coli liquid.EA stimulation was delivered once per day for consecutive 7days.WBC count and gallbladder wall thickness were measured to assess the effects of EA treatment.HE staining was carried out to examine the pathological changes of the gallbladder tissue.Results Compared with the control group,WBC count and gallbladder wall thickness of the model group were significantly increased(P<0.05),and those changes were reversed by EA intervention at either GB 34 or SP 9acupoints(P<0.05).As to WBC count,there was no significant difference between EA-GB 34 and EA-SP 9groups(P>0.05),whereas for reducing gallbladder wall thickness,EA stimulation at GB 34 acupoint resulted in a better effect than that of EA at SP 9acupoint(P<0.05).Conclusion EA produces positive therapeutic benefits on acute cholecystitis in rabbits.It seems that stimulation at"Yanglingquan"acupoint gives rise to a better effect than that of"Yinlingquan"acupoint in particular for the reduction of gallbladder wall thickness.关键词：Acute cholecystitis;Electroacupuncture;Gallbladder wall thickness;GB 34;SP 9848|350|1更新时间：2023-08-11
- 摘要：Objective To observe the clinical effect of acupuncture combined with neck-skin electrical stimulation(NSES)on dysphagia in patients with cerebral infarction(CI).Methods A total of 120 CI patients with dysphagia were randomly divided into acupuncture group,NSES group and acupuncture+NSES group(combined treatment group,n=40in each group).Acupuncture stimulation of Fengchi(GB 20),Yifeng(TE 17),etc.,and blood-letting of Jinjin(EX-HN 12)and Yuye(EXHN 13)were administrated.NSES was applied to the bilateral sites of the neck-median line.The treatment was given once daily for two weeks.The swallow function and swallow dysfunction degree of the dysphasia patients were evaluated by water swallow test and food-intake scale,respectively.Results After one week's and two weeks' treatment,the water swallow score and swallow dysfunction score were significantly improved in the acupuncture,NSES and combined treatment groups(P<0.01),and the difference values between pre-and post-treatment of the water swallow score and swallow ability score in the combined treatment group were obviously higher than those of the acupuncture and NSES groups(P<0.01,P<0.05).No significant differences were found between the acupuncture and NSES groups in both the water swallow score and swallow ability score after one and two weeks' treatment(P>0.05).Of the three 40 cases in the acupuncture,NSES and combined treatment groups,16,18 and 27were basically cured,2,3and 5experienced marked improvement,15,13 and 7were improved,and 7,6and 1failed in the treatment,with the effective rates being 82.5%,85.0% and 97.5%,respectively.The therapeutic effect of the combined treatment group was apparently superior to that of the simple acupuncture and simple NSES groups(P<0.01).Conclusion Acupuncture and NSES intervention is effective in improving dysphasia in CI patients and the effect of combined treatment of acupuncture and NSES is obviously better than that of the simple acupuncture and simple NSES.关键词：Acupuncture;Cerebral infarction;Dysphagia;Cutaneous electrical stimulation715|641|3更新时间：2023-08-11
- 摘要：Objective To observe the clinical effect of slow-rapid reinforcing-reducing needling manipulation at Jiaji(EX-B 2)acupoint for lumbar intervertebral disc protrusion.Methods Sixty subjects met the inclusion criteria of disc herniation were randomly divided into treatment group(n=30)and control group(n=30).In the treatment group,the stimulation mode(slow or fast,reinforcement or reduction)of Jiaji acupoints(EX-B 2)was based on the status of the patients by an overall analysis of symptoms and signs.Other acupoints such as Huantiao(GB 30),Weizhong(BL 40),etc.were stimulated with uniform reinforcing-reducing manipulation.In the control group,all the acupoints were stimulated in uniform reinforcing-reducing mode.The treatment was conducted once a day,continuously for 18 days with 1day's break between every 6days.The clinical efficacy appraisal,visual analogue scale(VAS)and Japanese orthopaedic association(JOA)scores and traditional Chinese medicine(TCM)syndrome scores were used for outcome assessment.Results In comparison with pretreatment,the VAS scores and TCM syndrome scores were significantly decreased in both control and treatment groups(P<0.05),and the JOA scores were markedly increased after the treatment(P<0.05).The therapeutic effects of the treatment group were obviously superior to those of the control group in down-regulating the VAS score and TCM syndome score and up-regulating JOA score(P<0.05).ConclusionSlow-fast reinforcing-reducing needling manipulation is superior to the routine acupuncture in the management of lumbar intervertebral disc protrusion.关键词：Lumbar intervertebral disc protrusion;Manual acupuncture;Slow-fast reinforcing-reducing needling ma-nipulation;Jiaji(EX-B 2)of lumbar segment875|1049|7更新时间：2023-08-11
- 摘要：Objective To observe the clinical effect of auricular pressure combined with Chinese herbal medicine for amblyopia.Methods A total of 66 child patients with amblyopia were randomly divided into Chinese herbal medicine(control)and herbal medicine+auricular pressure(treatment)groups,with 33 patients in each group.The patients in the control group were treated with Chinese medical herbs as Danggui(RadixAngelicae Sinensis),Gouqizi(Fructus Lycii),Baijuhua(Flos Chrysanthemi),Baizhu(Rhizoma Atractylodis Macrocephalae),Shudi(Radix Rehmanniae Praeparata),Baishao(Radix Paeoniae Alba),etc.according to syndrome differentiation,while the patients in the treatment group were treated by auricular pressure of otopoints Yan(Eye),Gan(Liver),Shen(Kidney),Xin(Heart),Mu 1(Eye-1),Mu 2(Eye-2),and Pi(Spleen)and herbal medicines(being the same to the control group).The treatment was conducted for 6months.After the treatment,the clinical effect,improvement degree of vision,onset time of improvement,and recurrence rate in the 3and 6months' follow-up visit were analyzed.Results Of the 45 and 47eyes in the treatment and control groups,22 and 15 were basically cured,12 and 5had marked improvement,9and 20 were improved,2and 7failed in the treatment,with the effective rates being 75.56% and42.55%,respectively.In comparison with pre-treatment,the visual acuity in both control group and treatment group were improved(P<0.05).The numbers of children who had improvement of visual acuity after 2weeks,one month in the control group and treatment group were 26 and 31eyes,10 and 11eyes,respectively.The recurrence rate 6months after the treatment was50.00%in the control group and 16.28%in the treatment group.The effective rate of the treatment group was significantly superior to that of the control group(P<0.05).Conclusion Auricular pressure combined with Chinese medical herb treatment is effective in improving visual acuity,and had a higher efficacy,faster action,and lower recurrence rate in amblyopia children in comparison with simple herbal medicine treatment.关键词：Amblyopia;Auricular pressure;Chinese herbal medicine852|322|0更新时间：2023-08-11
- 摘要：Objective To analyze the therapeutic regularities and characteristics of blood-letting therapy for acne in the past clinical practice by using data mining.Methods Original papers about acne treated by pricking blood therapy were searched and screened from common databases as Chinese National Knowledge Infrastructure Database(CNKI),WanFang Data,SinoMed,Ovid,ScienceDirect,Socolar,SciFinder,Foreign Medical Journal Full-Text Service(FMJS)and PubMed using keywords of acne+bleeding therapy,acne+blood-letting,acne+pricking blood,followed by establishing a data plateform to conduct a data mining using Online Analytical Processing(OLAP).Results A total of 230 original journal articles about acne treated by pricking blood therapy were collected.The included acne cases with wind-heat pattern were predoment,being 56 in frequency-times and acounting for 24.78%.In the treatment of acne,the therapeutic tool,three-edged needle was often used,being168 in frequency and acounting for 71.79%.The frequently employed acupoints were those of the Governor Vessel and Bladder Meridian,such as Dazhui(GV 14)and back-shu points.When auricular points used for blood-letting,Erjian(EX-HN 6)and the Vena of the auricular back were most frequently selected.In addition to blood-letting,other therapies such as Chinese herbal medicines,filiform needles,and otopoint-pellet pressure were also used in combination,being 166 in items and constituting72.17%.Generally,blood-letting treatment was conducted once every three days(twice a week)or once every two days(three times a week)for about 20 sessions for each acne patient.Conclusion Blood-letting therapy is effective in the treatment of acne.But if used in combination with other therapies,the therapeutic effect would be better.关键词：Acne;Blood-letting therapy;Data mining;Therapeutic characteristics891|1329|9更新时间：2023-08-11
- Postal code：100700
- Tel：010-64089344,84014607 Email：zcyjbjb@vip.163.com
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05017590号-8
京公网安备11010802020460号 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
0