最新刊期
卷 40 ， 期 4 ， 2015
- 摘要：Objective To explore the role of 26 Sproteasome and nuclear factor kappa B(NFκB)in substantia nigra in the management of Parkinson's disease(PD)by acupuncture.Methods Forty-eight male SD rats were randomly divided into normal,sham operation,model and electroacupuncture(EA)groups(12rats/group).The PD model was established by 40-day consecutive subcutaneous injection of rotenone(1mg/kg dissolved in dimethyl sulfoxide and normal saline)at the back shoulder.The rats in the sham operation group were treated by subcutaneous injection of dose of saline."Fengfu"(GV 16)and"Taichong"(LR 3)acupoints were stimulated with EA at 2Hz,1mA,20 min of duration in each treatment,and daily for 28 consecutive days.The behavioral changes of rats in each group were measured and scored at 40 th day and 68 th day,respectively.Immunohistochemistry was used to determine the expression of tyrosine hydroxylase(TH)used to detect the expression of 26 Sproteasome and NFκB and TH were measured by Western blot.Results In comparison with the normal and sham operation groups,the behavioral scores of rats in the model group were elevated,which were significantly decreased by EA intervention(P<0.05).The expression of TH and 26 Sproteasome decreased whereas the NFκB increased in the rats of model group(P<0.05),and EA intervention reversed these changes(all P<0.05).Conclusion EA intervention can improve PD rats' behavioral changes,which is pobably related to its effects in rcducing loss of TH-positive neurons,down-regulating NFκB protein expression,and upregulating 26 Sproteasome protein expression in the substantia nigra.关键词：Parkinson's disease;Tyrosine hydroxylase;Proteasome;Nuclear factor kappa B;Acupuncture therapy851|357|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)intervention on the levels of CD 4+and CD 8+lymphocytes in the plasma and thymus in anxiety disorder rats,so as to explore its mechanism underlying favorable regulation of immune function.Methods Thirty-four SD rats were randomly divided into control(n=10),model(n=12)and EA(n=12)groups.The anxiety model was established by using chronic unpredictable emotional stress stimulation(fasting,water-deprivation,shaking,tail-clamping,forced warm-and cool-water swimming,electrical shock stimulation,etc.)for 15 days.EA(15Hz/25Hz)was applied to"Neiguan"(PC 6)and"Shenmen"(HT 7)for 15 min,once every other day for 15 days.The anxiety-like behavior was measured by elevated plus maze test.Anxiety reduction in the plus-maze is indicated by an increase in the proportion of time spent in the open arms(time in open arms/total time in open or closed arms),and an increase in the proportion of entries into the open arms(entries into open arms/total entries into open or closed arms).While the contents and expression of CD 4+and CD 8+in the plasma and thymus tissues were measured by ELISA and immunohistochemistry,respectively.Results The values of proportions of open-arm entries(OE%)and the content of plasma CD 4+lymphocytes were obviously lower in the model group than in the control group(P<0.05),and were significantly higher in the EA group than in the model group(P<0.05).Whereas,the content of plasma CD 8+lymphocytes was obviously higher in the model group than in the control group(P<0.05)and markedly down-regulated in the EA group after the treatment(P<0.05).The ratio of CD 4+/CD 8+was decreased in the model group in comparison with the control group(P=0.054),and was significantly up-regulated in the EA group after EA stimulation(P<0.01).Compared with the control group,the expression levels(optical density,OD values)of CD 4+and CD 8+lymphocytes in the thymus tissue were obviously decreased in the model group(P<0.01).After EA,the expression levels of thymus CD 4+and CD 8+were remarkably up-regulated in the EA group(P<0.05).No significant changes were found in proportion of open-arm time(OT%,P>0.05).Conclusion EA can effectively relieve anxiety disorder in anxiety rats,which may be related to its effects in up-regulating plasma CD 4+,thymus CD 4+and CD 8+levels as well as CD 4+/CD8+ratio,and down-regulating plasma CD 8+content.关键词：Electroacupuncture;Anxiety disorder;Thymus;Lymphocytes713|324|1更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupuncture plus moxibustion on mitochondrial dynamics-related proteins(OPA 1,Fis 1)of hippocampal neurons in rat with Alzheimer's disease(AD),and to explore the potential mechanism underlying acupuncture for the protection of hippocampal neuronal mitochondria.Methods Eighty male Wistar rats were randomly divided into normal,sham-operation,model and acu-moxibustion groups.AD model was made by injecting Aβ1-42 into the hippocampus."Baihui"(GV 20)and"Shenshu"(BL 23)acupoints were stimulated by manual acupuncture(15min)in combination with moxibustion(15min)for two sessions of treatment,with seven consecutive treatments for one session and one day break between the two sessions.The expression of hippocampal OPA 1and Fis 1was assessed by means of Western blot and immunofluorescence technique.Results The expression level of OPA 1and Fis 1of rats in the model group was significantly lower and higher,respectively,than those of the normal and sham-operation groups(P<0.01).Acupuncture plus moxibustion intervention notably increased OPA 1and decreased Fis 1expression levels in the acu-moxibustion group compared to those of the model group(P<0.01).Conclusion Acupuncture combined with moxibustion produce benefit to hippocampal neurons in AD rats probably via the regulation of the mitochondrial dynamics(imbalance between fission and fusion proteins)and improvement of the mitochondrial damage of hippocampus.关键词：Kidney-reinforcement and Govenor Vessel-regulation;Acu-moxibustion;Alzheimer's disease;Fis 1;OPA 11135|790|13更新时间：2023-08-11
- 关键词：Acupotome;Neck acupoint;Cervical spondylosis;Cervical intervertebral disc degeneration;Staticdynamic imbalance;Extracellular matrix;Type Ⅰ andⅡ collagens924|406|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)stimulation of"Baihui"(GV 20)+"Anmian"(EX-HN 16)and"Baihui"(GV 20)+"Zusanli"(ST 36)on behavior reactions and plasma ghrelin level in depression rats,so as to explore the correlation between its antidepressant effect and plasma ghrelin level.Methods A total of 45 SD rats were randomly divided into 5groups:normal control,model,Baihui(GV 20)+Anmian(EX-HN 16),Baihui(GV 20)+Zusanli(ST 36)and medication(clomipramine)groups,with 9rats in each group.The depression model(unpredictable chronic mild stresses,UCMS)was established by giving the animals with higher temperature environment(45 ℃,5min),forced ice-water swimming(0-4 ℃,5min),day and night reversal environment(12h),stroboflash stimulation(12h),noisy stimulation(12h),rocking-bed movement(30min)and damp pad dwelling(6-24h),etc.for 4weeks.EA was applied to GV 20-EX-HN 16,and GV 20-ST 36 for 30min once every other day for 4weeks after modeling.For rats of the medication group,clomipramine(5mg/kg)was given(i.p.)once a day for 4weeks after modeling.The forced swimming test,sucrose preference test and open field test were used to evaluate the rats' depressive-like behavior.Plasma ghrelin content was assayed by ELISA.Results After exposure to UCMS for4 weeks,the immobility time was significantly increased,and the struggling time was significantly decreased in the model group(P<0.05,P<0.01).In comparison with the model group,the immobility time levels were obviously decreased,while the struggling time and sucrose preference were markedly increased in the Baihui(GV 20)+Anmian(EX-HN 16),Baihui(GV 20)+Zusanli(ST 36)and medication groups(P<0.05,P<0.01).No significant changes were found in the rearing times and total distance of open-field test(locomotor activity)and plasma ghrelin content among the 5groups among all the groups(P>0.05).No significant differences were found among the two EA and medication groups in the decreased immobility time and the increased struggling times and sucrose preference levels(P>0.05).Conclusion EA intervention can improve the depression rats' hopeless behavior of forced swimming test and anhedonia behavior(sucrose preference test),which may be not correlated to plasma ghrelin level at the late-stages and the antidepressant effect of EA intervention.关键词：Depression;Electroacupuncture;Plasma ghrelin;Forced swimming test;Open field test849|548|1更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)stimulation of"Zusanli"(ST 36),"Liangmen"(ST 21)and"Sanyinjiao"(SP 6)on gastrointestinal motility and expression of ghrelin and growth hormone secretagogue receptor(GHSR)mRNA in diabetic gastroparesis(diabetic gastroparesis,DGP)rats,so as to explore its mechanism underlying improvement of diabetic gastroparesis.Methods Sixty SD rats were randomly and equally divided into normal control,model,EA acupoint,EA non-acupoint,medication(metoclopramide)groups(n=12rat/group).The DGP model was established by intraperitoneal injection of streptozotocin(STZ,55mg/kg,2%)and raised by high-sugar and high-fat fodder irregularly for 8weeks.EA was applied to"Zusanli"(ST 36),"Liangmen"(ST 21)and"Sanyinjiao"(SP 6),and non-acupoints(about 5mm lateral to the 3acupoints,respectively).Those rats of the medication group were given with metoclopramide(1mL/100g).The blood sugar level was measured by glucometer,and the urine sugar level measured by Tes-Tape [urine glucose test paper].The intestinal propulsion rate(IPR)was identified as ratio of the phenolsulfonphthalein promoting distance and the total length of the small intestine,and the gastric emptying rate(GER)was assessed by gavage of a liquid test meal(1.5mL)containing a nonabsorbable marker(0.5mg/mL of phenol red in 5% glucose solution)and identification after being sacrificed 72 hafter modeling.The expression levels of ghrelin mRNA and GHSR mRNA of gastric antrum tissue were examined by Quantitative real-time PCR.Results In comparison with the normal control group,the blood sugar and urine sugar levels of the model group was significantly increased in the model group(P<0.01),while the GER and IPR and the expression level of ghrelin mRNA and GHSR mRNA in the gastric antrum were significantly decreased in the model group(P<0.01,P<0.05).Following EA stimulation of acupoint,the blood sugar and urine sugar levels were obviously down-regulated(P<0.05),both GER and IPR,and ghrelin mRNA and GHSR mRNA expression levels in the EA-acupoint group were significantly up-regulated(P<0.05,P<0.01).No significant changes were found in both blood sugar and urine sugar levels,in both GER and IPR,and ghrelin mRNA and GHSR mRNA expression levels of both EA non-acupoint and medication groups after the intervention(P>0.05).The GER and IPR were significantly higher in the EA acupoint group than in the EA non-acupoint group(P<0.05,P<0.01).Conclusion EA stimulation of ST 36,ST 21 and SP 6can promote the gastrointestinal motility of DGP rats,which may be closely associated with its effects in up-regulating the expression level of ghrelin mRNA and GHSR mRNA in gastric antrum.关键词：Electroacupuncture;Diabetic gastroparesis;Gastric emptying rate;Propulsion rate of small Intestine;Ghrelin;GHSR;Gastric antrum818|680|10更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)stimulation of"Yifen"(TE 17),"Shenshu"(BL 23)on the expression of 5-hydroxytryptamine receptor 1B(5-HTR 1B)mRNA and 5-hydroxytryptamine receptor 2C(5-HTR2C)mRNA in the cochlear nucleus tissue in mice experiencing radiation from mobile phone,so as to explore its mechanisms underlying improvement of tinnitus.Methods Thirty Kunming mice were randomly divided into control group(n=6)and modeling group(n=24).The tinnitus model was established by giving the mice with mobile phone-radiation for 1hin the morning and 1h in the afternoon,continuously for 40 days.EA stimulation was applied to"Yifeng"(TE 17)group(n=6)and"Shenshu"(BL 23)group(n=6)for 20 min,once a day for 7days.The expression of 5-THR 1B/2CmRNA in the cochlear nucleus was assayed by fluorescence quantitative polymerase chain reaction(real time-PCR).Results The expression level of 5-HTR 1Bwas significantly lower in the model group than in the control group(P<0.05),while that of 5-HTR 2C mRNA significantly increased(P<0.01).TE 17 group received a significant acupoint intervention effect(P<0.01).Compared with TE 17 group,BL 23 group received a weaker effect(P<0.05).Conclusion EA of TE 17 can up-regulate expression level of 5-HTR 1Band downregulate expression level of 5-HTR 2Cin the cochlear nucleus in mice experiencing mobile-phone radiation.关键词：Mobile phone radiation;Electroacupuncture;Cochlear nucleus;5-HTR 1B;5-HTR 2C847|187|1更新时间：2023-08-11
- 摘要：Objective To observe the clinical effect of acupuncture plus shock-wave(SW)intervention for osteoarthritis(OA),so as to explore its practicability in clinical practice.Methods A total of 120 cases of knee OA patients were randomly divided into 4groups,namely acupuncture(acupunct)+LFSW,acupunct+ MFSW,acupunct+HFSW and routine acupunct groups,with 30 cases in each group.Xuehai(SP 10),Liangqiu(ST 34),Yanglingquan(GB 34),Xiyan(ST 35)and Ashi-point were punctured with filiform needles which were manipulated with uniform reinforcing-reducing techniques for 15-20 min,once every other day for 7times.In addition,these acupoints were also respectively stimulated with shock waves(10Hz,14 Hz and18Hz,pressure:1-4bar)delivered from a DolorClastEMS therapeutic apparatus for 600 times in 3acupunct+SW groups.The patients' pain response changes of the knee-joint were assessed by using visual analog scale(VAS)and the motility was evaluated by using a 0-3grade scale.Results After 7times of treatment,the patients' VAS scores and motility scores were significantly decreased in the acupunct+LFSW,acupunct+MFSW,acupunct+HFSW and routine acupunct groups compared with their own basic values before treatment(P<0.01),and the therapeutic effect of the acupunct+MFSW group was significantly superior to those of the other 3groups in reducing both VAS and motility scores(P<0.05).Correspondingly,the Deqi sensation score of the acupunct+MFSW group was markedly higher than those of the other 3groups(P<0.05).Conclusion Shock wave acupuncture treatment is effective in relieving OA patients' knee-joint pain and functional activity,and the therapeutic effect of acupunct+14Hz-SW is better,which is closely with Deqi-sensation.关键词：Shock wave acupuncture;Osteoarthritis;Pain;Motility;Shock-wave frequency;Deqi sensation1100|806|2更新时间：2023-08-11
- 摘要：Objective To observe the curative effect of fire needle treatment on spastic hemiplegia in patients with stroke.Methods A total of 80 stroke patients with spastic hemiplegia who met the inclusion criteria were randomly divided into routine acupuncture(control)group and red-hot needle group(n=40cases in each group).Patients of the red-hot needle group were treated by pricking unilateral Jianyu(LI 15),Binao(LI 14),Quchi(LI 11),Shousanli(LI 10),Yinlingquan(SP 9),Xuehai(SP 10),etc.with a cauterized needle,once every other day for 30days;while those of the control group were treated by acupuncture stimulation of unilateral Jianyu(LI 15),Quchi(LI 11),Shousanli(LI 10),Huantiao(GB 30),Fengshi(GB 31),Yanglingquan(GB 34),etc.with filiform needles,once daily for 30 days.The muscular tension was evaluated using modified Ashworth Scale(MAS)and the limb motor function evaluated using Fugl-Meyer Assessment Scale(FMA).Results After the treatment,the muscular tension of both upper and lower limbs in the red-hot needle and routine acupuncture groups was significantly reduced(P<0.05),exhibiting an appearance of the stroke patients with MAS grade 0(upper and lower limbs:7and 6cases,15 and 12cases in the control and red-hot needle groups).The FMA scores of both upper and lower limbs were remarkably increased in both control and red-hot needle groups after the treatment(P<0.01,P<0.05),suggesting an improvement of the patients' motor function.The improvement of the muscular tension and motor function of upper limbs in the red-hot needle group was superior to that in the routine acupuncture group(P<0.05,P<0.01).No significant differences were found between the two groups in both MAS grades and FMA scores of lower limbs after the treatment(P>0.05).Of the two 40 cases in the control and red-hot needle groups,5and 13 were basically cured,11 and 8had marked improvement,10 and 14were improved,14 and 5ineffective,with the effective rates being 65.0% and 87.5%,respectively.Conclusion Red-hot needle therapy is effective in reducing muscular tension and improving motor function of the limbs in hemiplegia patients.关键词：Red-hot needle therapy;Stroke;Spastic hemiplegia;Muscular tension;Motor function869|1462|2更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)stimulation at Zhongwan(CV 12)on the skin microcirculatory blood flow along the Conception Vessel(CV)in yin-deficiency constitution volunteers.Methods A total of 16yin-deficiency constitution volunteers(9woman and 6men)from 200 students of Fujian University of Traditional Chinese Medicine finished a body constitution questionnaire and showed a yin-deficiency constitution.Skin microcirculatory blood perfusion units(MBPU)at Danzhong(CV 17),Xiawan(CV 10),and Qihai(CV 6)of the CV were measured by using a Laser Doppler Flowmetry(Peri Flux 5000)in normal constitution,before and after EA stimulation of Zhongwan(CV 12)for 20 min.Results Under normal condition,the cutaneous MBPU values were significantly lower in the Qihai(CV 6)than in both Danzhong(CV 17)and Xiawan(CV 10)(P<0.01).After EA stimulation of CV 12 for 20min,the MBPU values were significantly decreased in the CV 17 and CV 6acupoint regions compared with pre-stimulation(P<0.05).No significant changes of skin MBPU were found in Xiawan(CV 10)after EA stimulation of CV 12(P>0.05).Conclusion EA at Zhongwan(CV 12)can reduce the skin MBPU values of CV 6and CV 17 of the Conception Vessel in yin-deficiency constitution volunteers.关键词：Skin microcirculatory blood flow;Conception Vessel;Zhongwan(CV 12);Electroacupuncture;Yin-deficiency constitution900|338|5更新时间：2023-08-11
- 摘要：Proper combination of acupoints is one of the core issues of acupuncturology,and is also one of the factors affecting clinical outcomes.In the present paper,the authors make a review on the development of researches on the underlying mechanisms of acupoint combination for some clinical disorders from nerve system,humoral factors and immunological regulation.The neural mechanism involves both the peripheral nervous system(mainly the segmental innervation)and central nervous system(spinal cord,brainstem,hypothalamus,cerebral cortex and cerebellum),while the humoral factors chiefly contain neurotransmitters and hormones of the endocrine system.The immunological mechanisms involve immunocytes and cytokines.Generally speaking,following acupuncture stimulation of different combined-acupoints or acupoint groups,some synergistic effects may be produced.In fact,the relatively specific clinical effect may be easy to be obtained at the peripheral segmental innervations level.关键词：Combination of acupoints;Neural mechanism;Humoral mechanism;Immune mechanism828|945|11更新时间：2023-08-11
- 摘要：Objective To assess the efficacy and safety of acupuncture in treating attention-deficit/hyperactivity disorder(ADHD)children.Methods A literature search was conducted to retrieve randomized cotrolled clinical trials of acupuncture in treating ADHD covering the period of the years of establishment of the databases to January 2014 from database of CBM,CNKI,PubMed,Cochrane Library by using key words"attention deficit hyperactivity disorder""hyperactivity""minimal brain dysfunction""acupuncture".Two independent researchers extracted data from located articles in a pre-defined structured way,and consulted the third researcher if necessary.Results Thirteen original trials including 1 304 cases of children with ADHD were obtained in this study according to our included criteria and excluded criteria.In these trials,acupuncture intervention alone,or acupuncture plus pharmacotherapy(methylphenidate,haloperidol)or acupuncture plus behavioral therapy were compared with simple pharmacotherapy or behavioral therapy alone.Results of Meta-analysis indicated that the total effective rate and Conners' index of hyperactivity(CIH)score-reduction rate in the acupuncture group were significantly superior to those of the other treatment groups[OR=2.22,95%CI(1.65,3.00),Z=5.22,P<0.00001][SMD=-0.94,95%CI(-1.41,-0.47),Z=3.89,P<0.0001].Acupuncture treatment is more effective than haloperidol in reducing the score of Conners' Rating Scale for ADHD [SMD=-7.28,95%CI(-8.32,-6.23),Z=13.62,P<0.00001].Acupuncture is similarly effective as Methylphenidate(Ritalin)in improving the Chinese medicine syndrome(liver-kidney yin hypoactivity)of children with ADHD [SMD=-1.14,95%CI(-2.53,0.25),Z=1.60,P=0.11].Less severe adverse effects were reported with acupuncture therapy than the pharmacotherapy(poor appetite,dry mouth,nausea and constipation).These effects were not likely due to publication bias(approximately symmetry funnel plot,Egger's test P>0.1).Conclusion Acupuncture is an effective and safe therapy in treating ADHD,combined administration of acupuncture and pharmacotherapy or behavioral therapy is more effective than the pharmacotherapy or behavioral therapy alone.However,more rigorously designed and high-quality RCTs are needed to confirm the above conclusion.关键词：Attention deficit hyperactivity disorder;Acupuncture intervention;Combined treatment;Meta-analysis763|1236|4更新时间：2023-08-11
- 摘要：The national standard of"Regulations of Acupuncture-needle Manipulating Techniques"is one of the national Criteria of Acupuncturology for which a total of 22 items have been already established.In the process of formulation,a series of common and specific problems have been met.In the present paper,the authors expound these problems from 3aspects,namely principles for formulation,methods for formulating criteria,and considerations about some problems.The formulating principles include selection and regulations of principles for technique classification and technique-related key factors.The main methods for formulating criteria are 1)taking the literature as the theoretical foundation,2)taking the clinical practice as the supporting evidence,and 3)taking the expounded suggestions or conclusions through peer review.关键词：Acupuncture;Moxibustion;Formulating standards;Formulating principles;Formulating methods830|854|5更新时间：2023-08-11
- 摘要："Feishu"(BL 13)is a commonly used acupoint in experimental study,but its definite position has not been described in current books about acupoints.In the present paper,the authors introduced three methods for determining the anatomical location of"Feishu"(BL 13)acupoint in rats.The Wistar rats(200±20)g were anesthetized with 10% chloral hydrate first,and then,fixed at the prone position.The highest point of the spinous process of the second thoracic vertebra was used as the marker for positioning the spinal vertebra.The point,7mm lateral to the site below the spinous process of the 3rd thoracic vertebra is just the"Feishu"(BL 13).In order to determine the 3rd thoracic vertebra,three methods are recommended to be adopted:1)finding the 5th thoracic vertebra process parallel to the inferior angle of the scapula first,then going upwards to find the 3rd thoracic vertebra,2)finding the 1st thoracic vertebra along the 1st rib,then going downward to find the 3rd thoracic vertebra,and 3)taking the 6th lumbar vertebra(parallel to the hip-joint)as the bone-marker and going upward to find the 3rd thoracic vertebra.When"Feishu"(BL 13)punctured,a filiform needle was straight inserted into the skin,then downward to the subcutaneous tissue,muscular layer(including the trunk cutaneous muscle,trapezius muscle,broadest muscle of back,serratus muscle of back,atalanto-longest muscle,longest muscle of neck,longest muscle of thorax,lumbar longest muscle,the medial part of the longest muscle,cervico-spinal muscle of back,semispinal muscle of neck,biventer cervicis,and multifidus muscles)about 6 mm in depth.关键词：Feishu(BL 13);Positioning method;Rats665|222|3更新时间：2023-08-11
- 摘要：Long-lasting hypertension results in ventricular remodeling characteristic of myocardial hypertrophy including myocyte hypertrophy and myocardial fibrosis,apathological process failed to be blocked by the current biomedical means and could eventually lead to heart failure.It has been shown that acupuncture can excite the parasympathetic nerve to counter the overtonic activity of sympathetic nerve,elicit antihypertensive effect and produce cardioprotection via the regulation of calcium signaling-related proteins in myocytes,suggesting its potential role in the management of these disorders.In this paper,the authors review relevant studies and propose,with respect to the autonomic nerve,endocrine system,cytokines and intracellular calcium signaling pathways,several novel ideas concerning the treatment of hypertensive myocardial hypertrophy and cardiac malfunction by acupuncture.关键词：Acupuncture;Hypertension;Myocardial hypertrophy;Heart failure;Calcium signaling989|766|6更新时间：2023-08-11
- 摘要：In the initial stage(1950s)of the establishment of the People's Republic of China,the Pavlov's theory played an important influence on Chinese biology and medical science fields.At that time,many schools or colleges of traditional Chinese medicine were set up one after another,the first edition of teaching materials or textbook was complete,and a lot of advanced training courses and training classes were developed.In that specific period of"acupuncture scientification",Mr.MA Ji-xing,a professor from China Academy of Traditional Chinese Medicine,is a representative scholar who employed Pavlov's theory to make a scientific explanation about the underlying physiological mechanisms of acupuncture-moxibustion therapy.For example,he employed nerve network or nerve system to explain topical acupuncture stimulation and distal stimulation to induce local effect or distal curative effect,employed the cutaneous-visceral reflex to explain the therapeutic effect of acu-moxibustion for visceral disorders,used the viscera-cutaneous reflex to explain the tender point(sensitized region)or Ashi-point,used the"predominant factor mechanism"or excitation transfer of the stimulated non-sensitized cutaneous region close to the diseased locus to explain the painrelief of acupuncture stimulation,used the stimulation strength,duration,frequency and distance(to the locus)to explain the needling reinforcing or reducing effect,and so on and so forth.He wrote many articles and books about acupuncturology,one of which was named Jianyao Zhenjiu Xue(Concise Acupuncturology),a well-known demonstration teaching material for advanced training courses,inducing a significant influence on the acu-moxibustion field in both academic field and clinical practice.Looking back this period of history may provide a helpful reference for current research on academic development of acupuncturology.关键词：Acupuncture scientification;Professor MA Ji-xing;Pavlov's theory754|334|0更新时间：2023-08-11
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