最新刊期
卷 40 ， 期 6 ， 2015
- 摘要：Objective To observe the effect of electroacupuncture(EA)therapy on levels of oxygen free radicals(OFR)and hippocampal apoptosis-related protein expression in ischemic learning-memory disorder rats so as to investigate its mechanisms underlying improvement of ischemic learning-memory impairment.Methods A total of 60 SD rats were randomly divided into sham operation(sham),model,medication,and EA groups,with 15 rats in each group.The learning-memory disorder model was made by occlusion of bilateral carotid arteries.EA(2-3Hz,2mA)was applied to"Zhi San Zhen"["Shenting"(GV 24)and bilateral"Benshen"(GB 13)]for 30 min,once a day for 3weeks.The rats of the medication group were treated by lavage of Aricept(0.03mg·kg-1·d-1),once daily for 3weeks.The rats' learning-memory ability was detected by Morris water maze tests and the state of hippocampal apoptosis cells was observed by light microscope after TUNEL staining and the expression of hippocampal Bcl-2,Bax and Caspase-3proteins was detected by immunohistochemistry.Serum and hippocampal superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)activity and malondialdehyde(MDA)contents were detected by chemical colorimetric analysis.Results Compared with the sham group,the escape latencies(place-navigation)after modeling were evidently prolonged,and the times of target-platform crossing in 90sec(spatial probe test)considerably reduced in the model group(P<0.01),suggesting an impairment of learning-memory ability.After the treatment for 21 d,the increased escape latency and the reduced target-platform crossing time in both EA and medication groups were reversed in comparison with the model group(P<0.01),suggesting an improvement of memory ability,and the effect of the EA group was significantly superior to that of the medication group(P<0.05).Compared with the sham group,the number of apoptotic cells in hippocampal CA 1-CA 3regions,and the expression levels of hippocampal Bcl-2,Bax and Caspase-3proteins,and serum and hippocampal MDA contents were significantly increased in the model group(P<0.01),while serum and hippocampal SOD and GSH-Px levels obviously decreased in the model group(P<0.01).After the treatment for 21 days,compared to the model group,the number of the apoptotic cells,the expression levels of hippocampal Bax and Caspase-3proteins,and the contents of serum and hippocampal MDA were notably decreased in the EA and medication groups(P<0.01),whereas,Bcl-2protein expression levels,and serum and hippocampal SOD and GSH-Px activity were notably up-regulated in the EA and medication groups(P<0.01).The effects of EA group were obviously superior to those of medication group in increasing hippocampal Bcl-2immunoactivity,serum SOD and GSH-Px and hippocampal GSH-Px activity and in down-regulating serum MDA level(P<0.01,P<0.05).Conclusion Electroacupuncture intervention can improve learning-memory ability in ischemic learning-memory disorder rats which may be associated with its effects in reducing blood and hippocampal OFR contents and hippocampal cellular apoptosis.关键词：Electroacupuncture;Cerebral ischemia;Learning-memory disorder;Apoptosis;Oxygen free radicals900|534|11更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)stimulation of"Neiguan"(PC 6),etc.on expression levels of myocardial chloride(CL-)channel-related genes and intracellular protein kinase C(PKC)protein in myocardial ischemia(MI)rats.Methods Seventy SD rats were randomly divided into control group(n=10),model group(n=15),Neiguan(PC 6)group(n=15),Lieque(LU 7)group(n=15)and non-acupoint group(n=15).The MI model was established by i.p.of isoproterenol(ISO,a sympathomimetic beta adrenergic agonist).Electroacupuncture stimulation was applied to bilateral"Neiguan"(PC 6),"Lieque"(LU 7),or non-acupoint[the mid-point between"Tianshu"(ST 25)and"Shenque"(CV 8)]for 15 min,once a day for 7days.Quantitative RT-PCR was employed to detect the expression levels of cystic fibrosis transmembrane conductance regulator(CFTR,a CL-channel)mRNA and chloride channel calcium-activated 1(CLCa 1,a member of the family of calcium-activated chloride channels,CLCa)mRNA in the left cardiac ventricle tissue,and Western blot was used to detect the expression level of myocardial PKC protein of the left ventricle.Results Compared with the control group,the expression levels of myocardial PKC protein,and CLCa 1and CFTR genes were significantly increased in the model group(P<0.05).In comparison with the model group,the expression levels of myocardial PKC protein,and CFTR mRNA and CLCa 1mRNA in the Neiguan group,and PKC protein and CLCa 1mRNA in the Lieque and non-acupoint groups,as well as CFTR mRNA in the Lieque group were notably down-regulated(P<0.05).No significant change was found in the expression of CFTR mRNA in the non-acupoint group(P>0.05),and no significant differences were found between Neiguan and Lieque groups in the expression levels of PKC protein(P>0.05).The effects of"Neiguan"(PC 6)were obviously superior to those of non-acupoint in down-regulating myocardial PKC protein,CLCa 1mRNA and CFTR mRNA(P<0.05).Conclusion EA stimulation of"Neiguan"(PC 6)can down-regulate the expression of myocardial PKC protein,CFTR and CLCa 1genes in MI rats,which may contribute to its effect in protecting myocardium from ischemic injury.关键词：Myocardial ischemia;Electroacupuncture;Neiguan(PC 6);Left cardiac ventricle;Cystic fibrosis transmembrane conductance regulator(CFTR)mRNA;Chloride channel calcium-activated 1(CLCa 1)mRNA672|455|6更新时间：2023-08-11
- 摘要：Objective To screen the effective acupoints for anti-depression in depression rats and to explore the mechanisms of acupuncture for relieving depression.Methods Fifty rats were randomly divided into normal control,model,"Yintang"(EX-HN 3)-"Baihui"(GV 20,2-acupoints),EX-HN 3-GV 20-"Fengchi"(GB 20)-"Shenshu"(BL 23,4-acupoints)and medication groups,with 10 rats in each group.The depression model was established by unpredictable chronic mild stress(UCMS)for28days.For rats of the 2-acupoints and 4-acupoints groups,EX-HN 3and GV 20,and EX-HN 3,GV 20,GB 20 and BL 23 were punctured with filiform needles respectively before performing mild stress every time.The acupuncture needles were retained for30 min during each intervention and the treatment was conducted once daily for 28 days.The rats of the medication group were treated by intragastric administration of Fluoxetine(0.18mg/kg)once a day for 28 days.The rats' anxiety-like behavior(rearing and crossing times)was detected by open-field test.The contents of adrenocorticotropic hormone(ACTH)in the pituitary,5-hydroxytryptamine(5-HT)in the hippocampus,the cortisol(CORT)in the adrenal gland,and the brain derived neurotrophic factor(BDNF)in the serum were examined by ELISA.Results Compared to the normal control group,the numbers of both rearing and crossing motions in the model group were significantly decreased(P<0.01,P<0.05),while in comparison with the model group,the rearing and crossing numbers of rats in the 2-acupoints and 4-acupoints and medication groups were significantly increased(P<0.01).ELISA showed that after modeling,the content of adrenal CORT was significantly increased(P<0.01),and those of hippocampal 5-HT and serum BDNF were obviously down-regulated in the model group(P<0.01).After the treatment,the adrenal CORT levels in the three intervention groups were notably down-regulated,and hippocampal 5-HT and serum BDNF evidently up-regulated in these 3intervention groups(P<0.05,P<0.01).No marked changes were found in the pituitary ACTH contents of the model and 3intervention groups(P>0.05),and no significant differences were shown among the three intervention groups in the levels of the aforementioned 6indexes(P>0.05).Conclusion Acupuncture intervention can effectively improve the unprompted activates of the depression rats,which may be related to its effects in up-regulating hippocampal 5-HT and serum BDNF levels,and in down-regulating adrenal CORT content.关键词：Depression;Acupuncture;Hypothalamic-pituitary-adrenal axis;Serum brain-derived neurotrophic factor;Hippocampal 5-HT;Open-field test905|836|11更新时间：2023-08-11
- 摘要：Objective To explore the innervation and biochemical characteristics associated with acupoint"Sanyinjiao"(SP 6)in the rat by using neural tracing and immunofluorescence techniques.Methods Five male SD rats were used in the present study.Alexa Fluor 488 conjugated cholera toxin subunit B(AF 488-CTB,5L,1%)was injected into the site superior to the prominence of the medial malleolus,a corresponding site to acupoint SP 6in the human body.After 3surviving days,the rat's local tissue of SP 6region,spinal cord and dorsal root ganglia(DRGs)at lumbar(L)segments(L 1-S 1)were dissected following perfusion with 4% paraformaldehyde,cut into sections(20μm for DRG and SP 6,and 40μm for spinal cord)and observed under light microscope.In addition,substance P(SP)immunoreaction in the spinal cord,DRG and SP 6region tissues was examined with immunofluorescence.Results All the labeling of AF 488-CTB appeared on the ipsilateral side of the injection.The labeled sensory and motor neurons distributed in L 3-L 6DRGs and spinal ventral horns with high concentration in the L 4and L 5segments.In addition,SP-positive neural labeling was found in small sensory neurons in DRG,axonal terminals in laminaⅠ-Ⅱof spinal dorsal horns,and free nerve fibers in local subcutaneous tissues.Additionally,24.1% of AF 488-CTB labeled sensory neurons simultaneously presented a SP-positive expression.Conclusion These findings reveal that the sensory and motor neurons associated with acupoint SP 6distribute in L 3-L 6DRGs and spinal ventral horns of rats,concentrating in the L 4and L 5segments,and 24.1% sensory neurons show SP-positive,suggesting apossible involvement of the primary SP-positive sensory neurons in the transmission of acupuncture stimulation signals.关键词：Sanyinjiao(SP 6);Substance P(SP);Neural tracing;Alexa Fluor 488conjugated cholera toxin subunit B(AF 488-CTB);Spinal cord;Dorsal root ganglia770|581|7更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)combined with medication on changes of expression of Nestin,glial fibrillary acidic protein(GFAP)and neuron specific enolase(NSE)in the hippocampal CA 1and CA 3regions of focal cerebral ischemia(FCI)rats,so as to analyze its mechanisms underlying neuroprotection.Methods Fifty male SD rats were randomly divided into normal control,model,EA,medication,and EA+medication groups(n=10in each group).The FCI model was established by middle cerebral artery occlusion(MCAO)with thread embolus.EA(2Hz,2V)was applied to the left"Hegu"(LI 4)and"Quchi"(LI 11)for 30 min,once daily for 14 days after MCAO.Rats of the medication group were given with intraperitoneal injection of gastrodin(10mg/kg).The expression of Nestin,GFAP and NSE in the hippocampal CA 1and CA 3regions were detected by immunohistochemistry.Results Compared with the normal control group,the numbers of Nestinand GFAP-immunoreaction(IR)positive cells in both CA 1and CA 3regions of the hippocampus were significantly increased in the model group(P<0.05),while those of NSE-IR positive cells in both CA 1and CA 3regions were significantly decreased in the model group(P<0.05).After EA and medication interventions,the numbers of Nestin-and NSE-IR positive cells in the CA 1and CA 3regions were evidently increased and GFAP-IR positive neurons were considerably reduced in the EA,medication and EA+medication groups(P<0.05).The effects of EA+medication were significantly superior to those of both EA and simple medication in up-regulating the number of Nestin-and NSE-IR positive cells and down-regulating the number of GFAP positive neurons in CA 1and CA 3regions(P<0.05).Conclusion EA and EA intervention combined with gastrodin can significantly up-regulate the number of Nestin-and NSE-IR positive cells,and down-regulate the number of GFAP positive cells in the CA 1and CA 3regions of hippocampus in focal cerebral ischemia rats,which may contribute to their effects in promoting the differentiation and proliferation of mature neurons in the hippocampus for improving cerebral functions.The effects of EA+medication are obviously better than simple EA intervention.关键词：Focal cerebral ischemia;Gastrodin;Electroacupuncture combined with medication;Hippocampus;Nestin;Glial fibrillary acidic protein;Neuron specific enolase850|500|6更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)stimulation of bilateral Taichong(LR 3),Yanglingquan(GB 34),Waiguan(TE 5)and Chize(LU 5)on pain and post-surgical gastrointestinal reactions in patients undergoing pneumectomy.Methods Sixty patients with pneumectomy were randomly divided into EA group(30cases)and control group(30cases).For patients of the EA group,EA stimulation(2Hz,3-5mA)was applied to bilateral LR 3,GB 34,TE 5and LU 5once every 12 hin the following two days after the surgery.For patients of the control group,the filiform needles were just adhered to the abovementioned acupoints without electrical stimulation.In addition,patients of both groups were treated first with lower dose of anesthetics including Fentanyl(250μg)+Flurbiprofen axetil(25mg)+normal saline(i.v.,2mL/h),and Sauteralgyl(muscular injection if necessary).The visual analogue scale(VAS)was used for measuring the patients' pain reaction at24 th h and 48 th h after surgery.The contents of plasmaβ-endorphine(EP)and leu-enkephalin were assayed by ELISA,the times of vomiting and nausea,and the time of postoperative exhaust and defecation were recorded.Results Compared with the control group,the VAS score at 48 hafter surgery,and the dosage of the supplemented Sauteralgyl were evidently lower,and the time of both exhaust and defecation after surgery was significantly earlier,and the degree of nausea after surgery was obviously milder in patients of the EA group(P<0.05,P<0.01).Compared with 0hpost-operation,theβ-endorphin and leu-enkephalin levels were significantly increased in the EA group(P<0.01).No significant difference was found between the control and EA groups in the vomiting rating(P>0.05).Conclusion EA intervention combined with anesthetics is effective in reducing the dosage of the supplemented Sauteralgyl and the degree of postoperative nausea,and in improving postoperative gastrointestinal functional recovery in patients undergoing pneumectomy.706|367|4更新时间：2023-08-11
- 摘要：Objective To compare the effectiveness difference between the"heat-sensitive"sensation and conventional warm sensation of moxibustion stimulation of Guanyuan(GV 4)in primary dysmenorrhea(PD)patients.Methods Cohort study design was used in the present study.A total of 189 PD patients were divided into heat-sensitive group(n=148)and conventional warm sensation group(n=41)according to the patients' subjective feeling to moxibustion stimulation and the sequence of treatment.The Propensity Score Match(PSM)function of SPSS 19.0software was used to match the patients of the two groups for balancing their baseline data(age,duration of illness,McGill and CMSS scores).Thus,35 cases in each group were subjected into the analysis at last.Heat-sensitive moxibustion was applied to Guanyuan(GV 4)for 40 min beginning 5days before dysmenorrheal attack,once daily for(7±2)days in one menstrual cycle,and for 3menstrual cycles for heat-sensitive group,wheras routine moxibustion for conventional warm sensation group.The McGill Pain Questionnaire(MPQ)composed of pain rating index(PRI),visual analogue scale(VAS)and present pain intensity(PPI)and COX Menstrual Symptom Scale(CMSS)containing 18items(0-4grades/item)were used to evaluate the therapeutic effect of moxibustion treatment.Follow-up visit was conducted 3months after the treatment.Results Compared to pre-treatment,MPQ and CMSS scores were significantly decreased in both groups after the treatment(P<0.01),and the effects of heat-sensitive group were significantly superior to those of conventional warm sensation group in lowering MPQ and CMSS scores(P<0.01).Follow-up survey showed that both MPQ and CMSS scores were still considerably lower in the heat-sensitive group than in the conventional warm sensation group(P<0.01,P<0.05).Conclusion The heat-sensitive moxibustion is superior to conventional warm moxibustion in improving symptoms in primary dysmenorrhea patients.关键词：Primary dysmenorrhea;Moxibustion;Heat-sensitive reaction;Propensity score;Cohort study825|1090|3更新时间：2023-08-11
- 摘要：Objective To observe the effect of transcutaneous acupoint electrical stimulation(TAES)of Zusanli(ST 36)on gastrointestinal activities in organophosphorus pesticide poisoning(OPP)patients undergoing emergency treatment so as to explore its action in scavenging gastrointestinal toxicant.Methods A total of 116 OPP patients were randomly divided into control group and TAES group(n=58in each group)according to the simple random sampling method.All the patients received comprehensive treatment including gastric lavage,catharsis,oral administration of atropine Pralidoxime Chloride,Omeprazole,etc.For patients of the TAES group,TAES stimulation(30Hz/60 Hz,15-20mA)was applied to bilateral Zusanli(ST 36)for 30 min,3times a day till black stool was discharged.The vomiting times after catharsis,the time of the first defecation and black stool discharge,the dosage of atropine and the length of patient stay in hospital were recorded.Results Of the two 58 cases of OPP patients in the control and TAES groups,11(18.9%)and 3(5.2%)underwent vomiting after catharsis,being significantly lower in the TAES group(P<0.05).Compared with the control group,the time of first defecation and black stool discharge,the dosage of the administrated atropine and the time of hospitalization were significantly lower in the TAES group(P<0.05).Conclusion TAES of ST 36 may lower incidence of emesis,enhance the cathartic effect,promote gastrointestinal poison discharge,reduce total atropine dosage and shorten the hospitalization time in OPP patients,favoring the patient's rehabilitation.关键词：Organophosphorus pesticide poisoning;Transcuataneous acupoint electrical stimulation;Zusanli(ST 36);Catharsis732|168|2更新时间：2023-08-11
- 摘要：Objective To observe the influence of acupuncture stimulation of lateral side of Tianzhu(para-BL 10),electroacupuncture(EA)stimulation of scalp-point Balance Area(MS 14),Motor Area(MS 6)and body acupoints combined with rehabilitation training on standing-balance and walking ability in stroke patients.Methods A total of 145 stroke inpatients were randomly assigned to rehabilitation group(n=48),routine acupuncture group(n=49)and para-BL10group(n=48).Patients of the rehabilitation group received balance training and routine rehabilitation training treatment,those of the routine acupuncture group received acupuncture stimulation of scalp-points(MS 14,MS 6),body acupoints,balance training and routine rehabilitation training,and those of the para-BL10 group received acupuncture stimulation of lateral side of BL 10 combined with scalp-points of MS 14 and MS 6and body acupoints,and balance training and routine rehabilitation training.The treatment was conducted once daily,5times per week,8weeks altogether.The patients' balancing function,lower-limb motor function and walking ability were assessed using Berg Balance Scale(BBS),Sheikh Trunk Control Ability Scale(STCAS),Fugl-Meyer Assessment Scale(FMAS),and Holden Functional Ambulation Classification(FAC),respectively.Results After 4and 8weeks' treatment,the scores of BBS,STCAS,FMAS and FAC in patients of the rehabilitation,routine acupuncture and para-BL10 groups were significantly increased and 10meters-walking time obviously reduced in comparison with pre-treatment in the same one group(P<0.01).The effects of acupuncture stimulation of para-BL 10 were considerably better than both rehabilitation and routine acupuncture groups in raising BBS,STCAS,FMAS and FAC scores and in reducing 10m-walking time(P<0.05).Conclusion Acupuncture stimulation of lateral side of BL 10 combined with scalp-points has a significant benefit for stroke patients in standing-balance ability and walking ability.关键词：Stroke;Acupuncture therapy;Tianzhu(BL 10);Scalp-points;Electroacupuncture;Standing-ba-lance ability;Walking ability734|387|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupuncture stimulation of acupoints of the Conception Vessel,Kidney Meridian,Spleen Meridian,and Bladder Meridian on menstrual cycles and duration,and serum follicle-stimulating hormone(FSH),luteinizing hormone(LH)and estrogen 2(E2)levels in patients with diminished ovarian reserve(DOR).Methods A total of 96 patients with DOR of both yin and yang deficiency were randomly divided into medication group and acupuncture group(n=48cases in each group).Patients of the medication group were treated by Estradiol Valerate tablets,2mg/d on the first 10 days,and Estradiol Cyproterone,3mg/d from day 11 to 21,followed by 5-7days' rest,and the next therapeutic course,continuously for 6months.For patients of the acupuncture group,filiform acupuncture needles were separately inserted into every 5points of the Conceptional Vessel,Kidney,Spleen and Bladder Meridians,manipulated with uniform reinforcing and reducing methods till Deqi,and retained for 40 min.The treatment was conducted once daily for consecutive 10 days in one menstrual cycle,beginning from the 10 th day on after menstruation,which was repeated for 6months.The integrative scores(normal=0,mild=2,moderate=4and severe=6points)of menstrual cycle,menstrual duration,amount,color,quality[blood blot or amenia,symptoms of traditional Chinese medicine(TCM)]were assessed according to"Guiding Principles for Clinical Trials of New Drugs of Chinese Materia Medica".Serum FSH,LH and E2 contents were detected by Roche's electrochemical luminescence method.Results After the treatment,of the two 48 cases in the medication and acupuncture groups,12(25.0%)and 20(41.7%)were cured,11(22.9%)and 12(25.0%)experienced marked improvement in their symptoms,20(41.7%)and 10(20.8%)were effective,and 5(10.4%)and 6(12.5%)failed,with the effective rate being 89.6% and 87.5%,respectively.The integral score of TCM symptoms,menstrual cycle,serum FSH,LH and E2 contents were considerably diminished in both groups after 6months of treatment(P<0.05),and the TCM symptom score,menstrual cycle,and serum FSH,LH and E2 levels were significantly lower in the acupuncture group than in the medication group 6months after cease of the treatment(P<0.05),while the menstrual duration in each cycle was notably longer in both groups after the treatment,and evidently longer in the acupuncture group than in the medication group 6months after cease of the treatment(P<0.05).No significant differences were found between the two groups in the effective rate,score of TCM symptoms,menstrual cycle and duration,and serum FSH,LH and E2 contents following the treatment(P>0.05).Conclusion Acupuncture stimulation of acupoints of the Conception Vessel,Kidney,Spleen,and Bladder Meridians is effective in improving clinical symptoms of DOR patients with deficiency of both yin and yang,and has a longer effect,which may be closely associated with its functions in lowering serum FSH,LH and E2 levels through regulating the hypothalamic-pituitary-ovarian axis.关键词：Diminished ovarian reserve;Acupuncture therapy;Row acupuncture needles stimulation;Score of TCM symptoms;Menstrual cycle and duration;Sex hormones720|697|1更新时间：2023-08-11
- 摘要：Objective To evaluate the efficacy of acupuncture therapy in decreasing visceral fat thickness(VFT)in patients with simple central obesity.Methods Sixty patients with simple central obesity(syndrome of stomach and intestinal excessive heat)were randomly divided into control and acupuncture groups.Patients of the control group were treated with diet control and physical exercise procedure(basic treatment)for 6months,and those of the acupuncture group treated with basic treatment combined with acupuncture stimulation of main acupoints Shuifen(CV 9),Yinjiao(CV 7),and bilateral Tianshu(ST 25),Huaroumen(ST 24)and bilateral Wailing(ST 26),etc.,in combination with electroacupuncture(EA,50-100 Hz,1-5mA)of bilateral ST 25,CV 9and CV 7for 30 min,once every other day for 3months.The VFT(1cm above the umbilicus)was detected by using an ultrasonic diagnosis instrument,and the body mass index(BMI,body weight/height 2),and waist circumfe-rence(WC)were measured before treatment,3and 6months after the treatment,respectively.Results Following 3and 6months' treatment,the VFT,BMI and WC of both groups were significantly decreased(P<0.01),and the effects of the acupuncture group were significantly superior to those of the control group in lowering VFT [(51.5±6.5)mm vs(48.3±4.7)mm)]and WC [(88.2±3.6)cm vs(85.9±4.3)cm]6months' after the treatment(P<0.05).There was no significant difference between the control and acupuncture groups in BMI fowllowing 6months' treatment[(31.0±4.3)vs(30.1±3.2),P>0.05].Conclusion Acupuncture intervention combined with diet control and physical exercise can effectively decrease VFT and WC in simple central obesity patients.VFT is a sensitive and better parameter for evaluating the effect of obesity treatment.关键词：Acupuncture therapy;Obesity;Visceral fat;Body mass index;Waist circumference743|499|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of electro-elongated needle intervention on rehabilitation of upper limb motor function in patients with ischemic stroke.Methods A total of 100 ischemic stroke patients were equally and randomly divided into manual acupuncture group and electro-elongated needle group(n=50cases/group).For patients of the manual acupuncture group,filiform needles were respectively inserted into Jianyu(LI 15),Jiquan(HT 1),Shousanli(LI 10),Neiguan(PC 6)and Hegu(LI 4)on the affected side,manipulated with lifting-thrusting reinforcing or reducing method for 40 min,once daily for two weeks except the weekends,and for those of the electro-elongated needle group,elongated needles were repeatedly penetrated from LI 15 to Binao(LI 14),and from LI 10 to Waiguan(TE 5)on the affected side,followed by electrical stimulation for 40 min,once daily for two weeks except weekends.The therapeutic effect of manual acupuncture and electro-elongated needle for upper extremity rehabilitation was assessed according to the modified upper-extremity Fugl-Meyer Assessment(FMA)and Wolf Motor Function Test(WMFT)separately.The surface electromyogram(sEMG)of the deltoid muscle was recorded by using a Megawin Surface Electrogram System and the root mean square(RMS)of the amplitude of sEMG was used to evaluate the functional state of the deltoid muscle.Results After the treatment,the score of FMA and WMFT in both manual acupuncture and electro-elongated needle groups were significantly increased compared with pre-treatment in the same one group(P<0.01),suggesting an improvement of the motor function of the upper limbs,but RMS ratios of the amplitude of sEMG were evidently decreased in both groups(P<0.05,P<0.01),suggesting a relief of the abnormal muscular tension.The therapeutic effects of the electro-elongated needle were obviously superior to those of manual acupuncture in up-regulating FMA and WMFT scores and down-regulating RMS ratio(P<0.01).Conclusion Electro-elongated needle therapy can effectively improve the motor function of upper limb in ischemic stroke patients and has a better effect in comparison with simple manual acupuncture.关键词：Ischemic stroke;Acupuncture therapy;Electro-elongated needle intervention;Upper limb function756|398|4更新时间：2023-08-11
- 摘要：Objective To observe the clinical efficacy of triple-puncture stimulation of Zhibian(BL 54),etc.combined with moxibustion therapy for patients with benign prostatic hyperplasia(BPH).Methods Two hundred patients with BPH who met the inclusive criteria were randomized into control(acupuncture)and treatment(acupuncture plus moxibustion)groups(n=100cases in each one).Patients of both the control and treatment groups were treated by puncturing the sensitive spot of bilateral Zhibian(BL 54,with triple filiform needles),and other main acupoints as Pang-Shuidao(ST 28,one cun beside ST 28),Pang-Guilai(ST 29,one cun beside ST 29),Shenshu(BL 23),Sanyinjiao(SP 6),Guanyuan(CV 4),Zhongji(GV 7),and some supplemented acupoints selected according to the syndrome identification.In addition,for patients of the treatment group,bird-pecking moxibustion was applied to bilateral Zhibian(BL 54),and the rest acupoints were punctured with filiform needles which were attached with ignited moxa stick-segments.The treatment was conducted for 30 min every time,once every day for 20 times,with 2days' rest between the two 10days' treatments.The state of the patients' prostate(micturation state)was evaluated according to the"International prostate symptom score"(I-PSS,0-35 poins,7symptom questions)and quality of life(QOL,0-6points)score before and after the treatment.Results After the treatment,both I-PSS score and QOL score of the two groups were significantly decreased compared with pre-treatment in the same one group(P<0.01),and the effect of the treatment group was evidently superior to that of the control group in lowering I-PSS score and QOL score(P<0.01).Of the two 100 cases in the control and treatment groups,23(23.0%)and 42(42.0%)experienced a marked improvement,51(51.0%)and 47(47.0%)were effective,and 26(26.0%)and 11(11.0%)invalid,with the effective rates being 74.0% and 89.0%,respectively.The therapeutic effect of the treatment group was obviously superior to that of the control group(P<0.01).Conclusion Acupuncture plus moxibustion treatment is effective in improving BPH patients' micturation symptoms,which is superior to the simple acupuncture intervention.关键词：Prostatic hyperplasia;Acupuncture + moxibustion therapy;Micturation state;International prostate symptom score;Quality of life758|422|2更新时间：2023-08-11
- 摘要：Objective To explore the regularities and features of clinical application of simplex reinforcing or reducing manipulation of filiform acupuncture needles by data mining in order to guide clinical decision in a better way.Methods A database about simplex reinforcing and reducing manipulations of filiform acupuncture needle was established first after collection,sorting,screening,type-in,and collation of the related papers,academic dissertations and theses of academic conferences published from January 1st of 1950 to January 31 of 2015by using key word "acupuncture""acupuncture and moxibustion""needle manipulation"and"filiform needle"from database of China National Knowledge Infrastructure(CNKI,a full-text database of Chinese journals),followed by data extraction and statistical analysis.Results A total of 1 304 articles were found to meet the standards formulated in the present study.Among them,800 papers belong to the internal medicine covering apoplectic sequelae(153papers),apoplexy(52),headache(63)and insomnia(60),271 to surgery involving soft tissue injury(63)and backleg pain(46);93to five-sense-organs involving nasosinusitis(14),64 gynecology involving dysmenorrhea(13),41 to dematology involving struma(20),and 35 to pediatrics covering five kinds of tardy growth and five flaccid syndromes(8).These 1 304 papers contain 2 542 of simplex reinforcing and reducing manipulations,including 895 of twirling-thrusting reducing,611 of twirling-rotating reinforcing,571 of lifting-thrusting reducing,303 of lifting-thrusting reinforcing,32 of reinforcing and 32 of reducing in cooperation with patients' respiration,23open-close reducing,12open-close reinforcing,21 reducing and 16 of reinforcing achieved by inserting the needle along or against the meridian,14rapid-slow reinforcing,and 12rapid-slow reducing.Regarding the acupoint selection,distal and local acupoints are most frequently used,followed by symptoms-determined and syndrome-determined,respectively.The acupuncture needle retained time was from 0min to 45 min,and the therapeutic effect was relatively better for poststroke.The totally therapeutic effects of the simplex reinforcing and reducing manipulations were 96.07%for problems of demotology,94.19%for gynecology,96.58%for surgery,92.85%for pediatrics,91.78%for five-sense organs and 93.70%for internal medicine,respectively.Conclusion Simplex reinforcing and reducing manipulations of acupuncture has a definite effect in the treatment of different problems particularly in the internal medicine and surgery.Often,the twirling-rotating and lifting-thrusting reinforcing and reducing manipulations of acupuncture are employed in clinical practice.关键词：Acupuncture therapy;Simplex reinforcing and reducing manipulations;Data mining;Clinical indications;Literature research911|762|10更新时间：2023-08-11
- 摘要：Moxibustion is one of the major external therapies of traditional Chinese medicine(TCM)and exerts a definite favorable effect in the treatment of patients with different problems.In the present paper,the authors reviewed 38 papers about somatic thermal intervention therapy published in recent 15 years and analyzed its biological functions from local,distal,and whole body effects.The local effects include 1)improving cutaneous inflammatory illnesses as verruca,herpes simplex,Leishmania infection,cutaneous necrosis,wound disunion,and promoting percutaneous absorption of some medicines,swelling pain;2)reliving sports fatigue and muscular injury,eliminating inflammation and pain reactions,probably by lowering local reactive oxygen species,superoxide dismutase,catalase,glutathione,etc.levels,and strengthening the flexibility of the knee-joint,and anterior and posterior cruciate ligaments;3)increasing blood perfusion of the regional arteriola,micrangium to eliminate accumulated subcutaneous blood cells,inflammatory mediators and other metabolic products.The distal effects contain 1)increase of the distal cutaneous blood flow and suppression of the arterial stenosis;and 2)improvement of the visceral functions including the heart(ischemia),liver,gastrointestinal blood flow and smooth muscles,uterus smooth muscular tension,etc.The whole body effects include raising immunoability against cancer,and reducing tumor blood flow to damage the blood vessels in the tumor tissue,etc.In addition,the effects of thermal stimulation are affected by the temperature,stimulating duration and the stimulated positions.These research results may help us to comprehensively understand the effects and mechanisms of moxibustion therapy in the treatment of different clinical disorders.关键词：Cutaneous thermal stimulation;Moxibustion;Biological effects669|1560|20更新时间：2023-08-11
- 摘要：Clinical practice shows that thiazolidinediones(TZDs)induce weight gain in patients with type-Ⅱ diabetes mellitus during treatment,which restrains its application and generalization clinically.It has been demonstrated that acupuncture therapy is useful in easing obesity in clinical trials.In the present paper,we summarize the underlying mechanism of weight gain induced by TZDs through food intake-related targets in the central nervous system and analyze the possible effects of acupuncture therapy.Acupuncture therapy is expected to reduce weight gain side effect of TZDs through 1)lowering permeability of blood brain barrier to reduce TZDs concentration in the brain,2)upregulating the expression of hypothalamic leptin and inhibiting hypothalamic neuropiptide Y expression,and 3)down-regulating activities of peroxisome proliferator-activated receptor to reduce energy intake and fat syntheses.关键词：Thiazolidinediones(TZDs);Weight gain;Acupuncture therapy;Peroxisome proliferator-activated receptor;Leptin;neuropiptide Y806|238|0更新时间：2023-08-11
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