最新刊期
卷 43 ， 期 8 ， 2018
- 摘要：Along with advances in pain medicine,people have a deep understanding about pain.It is now considered that pain is a complex activity of the nerve system,particularly the high nerve centers,and is composed of sensory,affective,cognitive,and social interaction.By the help of new techniques and instruments of brain science,the neural circuits involved in pain generation have been understood intensively,partially explaining why pain is composed of multiple components and how the sensation,emotion and cognition of pain are influenced each other.Acupuncture analgesia is widely used in clinical treatment and has a definite therapeutic effect.Along with the revision of definition of pain,the research of acupuncture analgesia needs to accommodate the so-called multiple dimensions and their interactions,will effectively deepen its connotation and denotation,and expand its application range,opening up a wider clinical prospect.关键词：Pain;Acupuncture analgesia;Multiple dimensions;Neural circuit595|1744|19更新时间：2023-08-11
- 摘要：Although acupuncture,especially electroacupuncture(EA)is widely used to treat pain,its mechanisms have not been completely understood.In the present paper,we review the development of researches on the underlying mechanisms of EA in relieving inflammatory pain in recent years from a)peripheral inflammation-mediated immune response and neuro-immune interaction of receptors on primary nociceptors,b)crosstalk of neurotransmitters or neuromodulators,cellular signaling pathways,other related bioactive molecules,as well as glial activation in the dorsal horns of spinal cord,and c)supraspinal modulation of both sensory and affective components of pain.Inflammatory pain involves complex neuro-immune networks of neurons and nonneurons,various inflammatory mediators,neurotransmitters,neuromodulators and cellular signaling molecules in the peripheral and central nervous systems.Therefore,the analgesic mechanism of acupuncture still needs to be studied in depth at multi-levels and multi-targets,for instance,the reciprocal actions of peripheral opioid peptide,adenosine and TRPV 1(which have been demonstrated to be involved in EA analgesia individually),the roles of spinal cord adenosine A 1 receptor(A 1 R)and A 2 R(for which fewer studies have been conducted),the interactions of classical neurotransmitters/neuromodulators/neuropeptides and their receptors,changes of intracellular molecules at transcriptional and translation levels,etc.during acupuncture analgesia.Furthermore,the mechanisms underlying reciprocal actions of neurotransmitters,neuromodulators and their receptors complicated in acupuncture-induced relief of pain affection in the higher brain regions also need to be explored further.关键词：Acupuncture analgesia;Inflammatory pain;Mechanism research;Review928|2684|15更新时间：2023-08-11
- 摘要：Since the invention of optogenetic technology,it has greatly promoted the development of neuroscience.Currently,optogenetic approaches have been mostly used to map neural circuits and new neuropharmacology but are rarely seen in the research field of acupuncture analgesia.The mechanism of neural circuits contributing to acupuncture analgesia,an important research hotspot in recent years,has not been fully determined.The optogenetic techniques can be used to modulate and control specific cells,provides highly precise spatial and temporal resolution,is repeatable,and may functionally dissect neuronal networks in vivo.The neuronal activities and their information transmission,processing and storage in intercluster neural networks in different brain regions,and the correlation between behavioral changes and electrical activities of neurons in vivo studies are mainly captured by the implanted microelectropode array,etc.If these two(or more)approaches are combined together,it is definitely and highly helpful to reveal the driving dynamics of neural circuits,plasticity and temporal-spatial activity mode of neurons,as well as behavioral reactions of animals with chronic pain during acupuncture analgesia and may open a new prospect for the application of acupuncture analgesia study.关键词：Optogenetics;Pain;Acupuncture analgesia;Feasibility analysis576|727|3更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)on expression of high mobility group protein 1(HMGB 1)and related downstream effectors of proinflammatory cytokines in the hippocampus in chronic neuropathic pain rats,so as to investigate its mechanism underlying neuropathic pain relief.Methods Male SD rats were randomized into sham,model,and EA groups,with 12 rats in each group.The neuropathic pain model was established by ligature of the left sciatic nerve to induce chronic constriction injury(CCI).EA was applied to bilateral"Zusanli"(ST 36)and "Yanglingquan"(GB 34)for 30 min,once daily for 7 days.The mechanical withdrawal threshold(WMT)was detected using an electronic von Frey anesthesiometer.The expression level of HMGB 1 in the hippocampus was determined using quantitative RT-PCR and Western blot,separately,and the contents of hippocampal TNF-αand IL-1β were detected by ELISA.Results Compared with the sham group,the MWT values were markedly decreased on day 7,10 and 14 after modeling in the model group(P<0.001).On day 10 and 14 after modeling,the MWT values were significantly up-regulated in the EA group relevant to those of the model group(P<0.05,P<0.01).The expression levels of HMGB1 mRNA and protein,and the contents of hippocampal TNF-αand IL-1βwere markedly increased in the model group relevant to the sham group(P<0.001),and significantly down-regulated in the EA group relevant to the model group(P<0.001,P<0.01,P<0.05).Conclusion EA stimulation of ST 36-GB 34 can relieve pain in chronic neuropathic pain rats,which may be related to its actions in down-regulating the levels of HMGB 1 and its downstream proinflammatory cytokines TNF-αand IL-1βin the hippocampus.关键词：Electroacupuncture analgesia;Chronic neuropathic pain;Hippocampus;High mobility group protein 1;TNF-α;IL-1β609|321|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)stimulation of "Shangjuxu"(ST 37,Lower Confluent point) and "Tianshu"(ST 25,Front-Mu point)on visceral pain and expression of colonic tryptase(Try),proteinase-activated receptor 2(PAR-2),transient receptor potential channel vanilloid subfamily member 1(TPRV 1),substance P(SP)and calcitonin gene-related peptide(CGRP)in rats with irritable bowel syndrome(IBS),so as to explore its mechanisms underlying improvement of IBS.Methods Forty male Sprague Dawley rats were equally randomized into normal control(control),model,medication and EA groups(n=10 in each).The IBS model was established by chronic acute combining stress(CACS,water deprivation,fasting,tail clamping,forced swimming in ice water,restraint,etc.)for 21 days.Rats of the medication group were treated by gavage of Pinaverium Bromide(1 mg/mL,15 mg/kg),once daily for 14 d.EA(10 Hz/50 Hz,0.2-0.3 mA)was applied to bilateral ST 37 and ST 25 for 30 min,once daily for 14 d.The muscular withdrawal reflex(AWR)of both abdomen and buttock was detected by colorectal distension(CRD)with a water-filled balloon for examining the visceral hypersensitivity.The number of mast cells in the colonic tissue was counted after toluidine blue stain.The immunoactivity of colonic Try was determined by immunochemistry and the expression of colonic PAR-2,TRVP 1,SP and CGRP proteins detected by Western blot.Results After modeling,the body weight was significantly decreased in IBS rats of the model,medication and EA groups compared with their own individual pre-treatment and with the control group(P<0.01),and markedly higher in both medication and EA groups than in the model group(P<0.05,P<0.01).The intra-colonic volume thresholds for inducing abdominal and hip AWR were significantly lower in the model group than in the normal control group(P<0.01),and obviously higher in both medication and EA groups than in the model group(P<0.05,P<0.01).The AWR scores of intra-colorectal balloon at volumes of 0.5,1.0 and 1.5 mL of water were significantly higher in the model group than in the control group(P<0.01),and considerably lower in the EA and medication groups than in the model group(P<0.01).The number of colonic MC and the expression levels of colonic Try,PAR-2,TRPV 1,SP and CGRP proteins were significantly higher in the model group than in the control group(P<0.01),and obviously decreased in both medication and EA groups relevant to the model group(P<0.01).Comparison between the medication and EA groups showed that the decreased expression levels of colonic PAR-2,TRPV 1,SP and CGRP proteins were significantly lower in the EA group than in the medication group(P<0.05),but no significant differences were found between the two groups in intracolonic volumes for inducing AWR,AWR scores,body weight,and colonic MC number and Try immunoactivity levels(P>0.05).Conclusion EA of ST 37 and ST 25 can relieve visceral hypersensitivity in IBS rats,which may be associated with its effects in down-regulating the number of MC and the expression of PAR-2,TRVP 1,SP,CGRP and Try proteins in the colonic tissue.关键词：Electroacupuncture;Irritable bowel syndrome;Visceral pain;Colonic tissue;Mast cells;PAR-2/TRVP 1 signaling782|813|13更新时间：2023-08-11
- 摘要：Objective To observe the influence of repeated shallow fire-needle acupuncture stimulation plus cupping on local neuralgia and serum substance P(SP)content in patients with acute herpes zoster(AHZ).Methods A total of 60 cases of AHZ patients were randomly divided into control(medication)group and treatment(medication plus fire-needle)group(n=30 in each).Patients of both groups were ordered to take Famciclovir(0.25 g/time,three times a day)and Mecobalamin(0.5 g/time,three times a day)orally for 7 days.In addition,patients of the treatment group were also treated by repeated shallow fire-needle stimulation and cupping,once a day for 7 days.Before and after the treatment,the patient's pain severity was assessed using visual analogue scale(VAS)and serum SP concentration was measured using ELISA.Results After the treatment,the VAS scores and serum SP concentrations in both groups were significantly decreased in comparison with those of their own pre-treatment(P<0.01),and were significantly lower in the treatment group than in the control group(P<0.01).There was a highly positive correlation between the decreased VAS score and serum SP content in the treatment group(P<0.01).Conclusion Repeated shallow fire-needle stimulation plus cupping can accelerate the relief of local neuralgia in AHZ patients,which may be associated with its effect in down-regulating serum SP level.关键词：Herpes zoster;Shallow fire needle stimulation plus cupping;Neuralgia;Serum SP625|690|6更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)on the activities of peroxisome proliferatoractivated receptor gamma coactivator-1 alpha/uncoupling protein-1(PGC-1α/UCP-1)signaling pathway in white adipose tissue(WAT)of diet-induced obesity(DIO)rats,so as to reveal its underlying mechanism in body weight loss.Methods Thirty-four male Wistar rats were randomly divided into normal diet(control,n=10),high fat diet(model),sham EA-acupoint and EA groups(n=8 in each of the latter 3 groups).The obesity model was established by feeding the rats with high fat diet containing lard oil,sugar,albumen powder,cholesterol,salt and sodium cholate for 12 weeks.EA(2 Hz/15 Hz,1 mA)was applied to bilateral"Zusanli"(ST 36)and "Tianshu"(ST 25)or sham acupoints(about 5 mm beside ST 36 and ST 25)for 30 min,once daily,5 times per week for a total of 8 weeks.During the treatment,all rats were fed with normal diet,and their body weight and length were measured once a week for calculating the Lee's index.The contents of serum total cholesterol(TC)and triglyceride(TG)were measured by using biochemical methods.The immunoactivity of PGC-1αand UCP-1 in the abdominal WAT was detected by immunohistochemistry.Results After modeling,the Lee's index,serum TC and TG contents were significantly increased,and the levels of serum HDL-C,and PGC-1αand UCP-1 immunoactivity in WAT considerably decreased in the model group relevant to the control group(P<0.05).Following the treatment,the Lee's index,TC and TG contents were significantly down-regulated while HDL-C and PGC-1αand UCP-1 immunoactivity were obviously up-regulated in the EA-acupoint group relevant to the model group(P<0.05).Conclusion EA can effectively reduce the body weight and adipose content in obesity rats,which may be closely related to its effect in up-regulating PGC-1α/UCP-1 signaling in WAT,suggesting an efficacy of EA in promoting the browning of WAT.关键词：Electroacupuncture;Obesity;White adipose tissue;PGC-1α;UCP-1606|659|10更新时间：2023-08-11
- 摘要：Objective To observe the effect of fire-needle acupuncture of"Zusanli"(ST 36) and "Kunlun"(BL 60)on ankle-joint swelling and serum tumor necrosis factor-α(TNF-α)and anti-cyclic citrullinated peptide antibody(ACPA)contents in collagen-induced arthritis(CIA)rats,so as to study its mechanism underlying improvement of rheumatoid arthritis(RA).Methods Thirty-two male Wistar rats were randomized into control,model,medication(Methotrexate)and fire-needling groups(n=8 in each).The RA model was established by injecting typeⅡchicken collagen(0.1 mol/L)plus Freund's complete adjuvant(primary immunization)and Freund's incomplete adjuvant(immunization once more)into the subcutaneous tissues of the right foot bottom,back and tail root of rats.Fire-needling was applied to the left and right "Zusanli"(ST 36) and "Kunlun" (BL 60)alternatively for3 times in each acupoint,once daily for 10 days.For rats of the medication group,Methotrexate sodium chloride solution(0.1 mg/100 g)was administrated by gavage,once every 5 days,twice together.The rats' right hind ankle diameter was measured before and after the treatment.The X-ray film of the right ankle was taken,and the contents of serum TNF-αand ACPA were assayed by ELISA.Results The ankle diameter and serum concentrations of TNF-αand ACPA were significantly increased in the model group compared to the control group(P<0.05),and X-ray film showed swollen and deformed tarsus joints,and narrowing of the joint space.After the intervention,the ankle diameter,serum TNF-αand ACPA levels were considerably decreased in both medication and fire-needle groups compared with the model group(P<0.05).Meanwhile,the joint swelling and bone deformity became relatively milder.There were no significant differences between the medication and fire-needling groups in the ankle diameter and the contents of serum TNF-αand ACPA(P>0.05).Conclusion Fire-needling stimulation of ST 36 and BL 60,similar to Methotrexate,can relieve the inflammatory reactions of hind-ankle joint in CIA rats,which may be related to its effect in down-regulating ACPA and TNF-αlevels.关键词：Fire-needle acupuncture;Collagen-induced arthritis;Ankle-joint swelling;Tumor necrosis factor-α;Anticyclic citrullinated peptide antibody730|262|2更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupuncture of Feishu(BL 13),Pishu(BL 20),etc.on body weight,blood lipid,leptin(LP)and soluble leptin receptor(sOB-R)levels in prediabetic patients,so as to explore its mechanisms underlying treatment and prevention of prediabetes.Methods A total of 100 prediabetic patients were randomly assigned to medication(Metformin)group(n=35),acupuncture group(n=35)and simple lifestyle intervention group(n=30)with random number table method.All the patients of the 3 groups were treated with lifestyle intervention(reasonable diet and moderate physical exercise)and ordered to stop administration of any hypoglycemic drugs during the treatment period.Bilateral Feishu(BL 13),Pishu(BL 20),Weishu(BL 21),Shenshu(BL 23),Zusanli(ST 36)and Sanyinjiao(SP 6)were punctured with filiform needles which were manipulated by lifting,thrusting and twirling repeatedly for about 2 min every 5 min during 30 minutes' needle retaining.The acupuncture treatment was conducted once every other day for 12 weeks.Patients of the medication group were ordered to orally take Metformin tablets(0.5 g/time,twice a day)for continuous 12 weeks.Body mass index(BMI),waist circumference(WC),waist-to-hip ratio(WHR),2 h-postprandial blood glucose(2 h-PBG),fasting blood glucose(FBG),glycosylated hemoglobin(HbA1 c),total cholesterol(TC),triglyceride(TG),fasting insulin(FINS),serum LP and sOB-R levels were measured before and after the treatment.Results After the treatment,the BMI in the acupuncture group,and BMI,WC and WHR in the medication group were significantly decreased relevant to their own pre-treatment in each group(P<0.05,P<0.01).Following the treatment,the levels of FBG,2 h-PBG,HbA1 C,TC,TG,FINS,HOMA-IR and LP in both acupuncture and medication groups,and FBG in the simple lifestyle intervention group were significantly decreased in comparison with their own pre-treatment in each group(P<0.01,P<0.05),and the levels of FBG,2 h-PBG,HbA1 C,TC and TG,HOMA-IR and LP in both acupuncture and medication groups were all considerably lower than those of the simple lifestyle intervention group(P<0.01,P<0.05).The level of FINS in the medication group was significantly lower than that of the simple lifestyle intervention group(P<0.05).Additionally,following the treatment,serum sOB-R contents in both acupuncture and medication groups were obviously increased compared with their own pre-treatment in each group and also relevant to the simple lifestyle intervention group(P<0.01).No significant changes were found in the simple lifestyle intervention group in all the above-mentioned blood indexes except FBG(P>0.05).Conclusion Acupuncture can induce body weight loss,down-regulate FINS,insulin resistance and LP resistance,and up-regulate sOB-R content in prediabetic patients,displaying apositive role in the treatment of prediabetes.关键词：Prediabetes;Acupuncture treatment;Leptin;Soluble leptin receptor;Insulin resistance555|404|3更新时间：2023-08-11
- 摘要：Objective To analyze the effect of warming needle moxibustion of Jiaji(EX-B 2),Huantiao(GB 30),etc.on lumbago and other symptoms of lumbar disc herniation(LDH)patients and changes of plasmaβ-endorphin(β-EP)content.Methods A total of 60 LDH patients were equally randomized into warming needle moxibustion group and conventional acupuncture group.Patients of the conventional acupuncture group were treated by puncturing lumbar Jiaji(EX-B 2),Huantiao(GB 30),Weizhong(BL 40),and Yanglingquan(GB 34)with filiform acupuncture needles.Patients of the warming needle moxibustion group were treated by puncturing the same 4 acupoints,and with the acupuncture needle in lumbar EX-B 2 attached an ignited moxa-stick segment.The treatment in both groups lasted for 30 min every time,once every other day for 15 times,with 5 times being a therapeutic course and two days' rest between every two courses.The therapeutic effect was evaluated according to the"Criteria for Evaluating the Therapeutic Effect of Disorders of Traditional Chinese Medicine".The lumbago severity was assessed using visual analogue scale(VAS),and the lumbar functional activity assessed using modified Oswestry dysfunction(in objectslifting,sitting,standing,walking,sleeping,pain,activity of daily living,social activity,outing,etc.)index(ODI).The plasmaβ-EP content was assayed using ELISA.Results After the treatment,of the two 30 cases in the conventional acupuncture and warming needle moxibustion groups,8(26.67%)and 12(40.00%)were under control,8(26.67%)and 10(33.33%)had a marked improvement,3(10.00%)and 4(13.33%)were effective,and 11(36.66%)and 4(13.33%)ineffective,with the effective rates being 63.34% and 86.66%,respectively.The effective rate of the warming needle moxibustion was significantly higher than that of the conventional acupuncture(P<0.05).The VAS scores and ODI values of the two groups were gradually decreased along with the prolongation of treatment,and significantly lower in the warming needle moxibustion group than in the acupuncture group at the 1st,2nd and 3rd course of treatment(P<0.01).The levels of plasmaβ-EP were gradually increased in the two groups at the 1 st,2 nd and 3 rd course of treatment,and were obviously higher in the warming needle moxibustion group than in the conventional acupuncture group at each of the 3 courses(P<0.01).No obvious adverse reactions were observed in the two groups.Conclusion Warming needle moxibustion has a better therapeutic effect in relieving lumbago and lumbar dysfunction,and can up-regulate bloodβ-EP level.关键词：Warming needle moxibustion;Lumbar disc herniation;Pain;β-endorphin(β-EP)579|832|8更新时间：2023-08-11
- 摘要：Objective To observe the curative effect of needling stimulation of the back segment(10 spots below the spinous processes from T 3 to T 12)of the Governor Vessel in the treatment of gastroesophageal reflux disease(GERD)accompanied with somnipathy.Methods A total of 58 patients of GERD accompanied with somnipathy were randomly divided into acupuncture group(n=28)and medication group(n=30)according to random number table method.For patients of the acupuncture group,the spots below the spinous processes from T 3 to T 12,including acupoints Shenzhu(GV 12),Shendao(GV 11),Lingtai(GV 10),Zhiyang(GV 9),Jinsuo(GV 8),Zhongshu(GV 7)and non-acupoints(T 4,T 8,T 12)were punctured with filiform needles,once every other day for 8 weeks.Patients of the medication group were ordered to take Omeprazole capsules(20 mg/time),twice a day for 8 weeks.The therapeutic effect was assessed by"Reflux Diagnostic Questionnaire"(RDQ,scores of symptoms of heartburn,retrosternal pain,acid regurgitation and food regurgitation,0-40 points),GERD symptom scale(scores of symptoms of the digestive system,five-sense organs,cardiovascular system,etc.,0-84 points)and Pittsburgh Sleep Quality Index(PSQI,scores of sleep quality,fall asleep time,sleep duration,sleep efficiency,etc.,0-21 points),respectively.Results After the treatment,RDQ score,GERD symptom scale score and PSQI score were significantly decreased in both acupuncture and medication groups compared with their own pre-treatment(P<0.01),and the decreased scores of RDQ,GERD scale and PSQI were significantly lower in the acupuncture group than in the medication group(P<0.01).The cured plus markedly effective rates for RDQ in the two groups were 43.3%(13/30)and 71.4%(20/28),respectively,and the effective rates of the medication and acupuncture groups were 56.7%(17/30)and 89.3%(25/28)for GERD scale,and 60.0%(18/30)and 92.9%(26/28)for PSQI,respectively.The cured plus markedly effective rate for RDQ,and the effective rates for GERD scale and PSQI were significantly higher in the acupuncture group than in the medication group respectively(P<0.05,P<0.01).Conclusion Acupuncture stimulation of acupoints of Governor Vessel at the back segment is effective in improving symptoms of GERD patients with somnipathy.关键词：Acupuncture therapy;Gastroesophageal reflux disease;Somnipathy;Acupoints of Governor Vessel at back segment;Clinical trial537|376|1更新时间：2023-08-11
- 摘要：Objective To observe the therapeutic effect of warming needle moxibustion stimulation of Hegu(LI 4),Tianshu(ST 25),Zhongwan(CV 12),Zusanli(ST 36),etc.for simple obesity patients with phlegm dampness stagnation syndrome(PDSS).Methods A total of 60 simple obesity patients with PDSS were equally randomized into control group(13 men and 17 women,18-53 years in age)and treatment group(14 men and 16 women,19-45 years in age).All the patients of both groups were treated by diet control(trying their best to reduce high fat,high glucose and high salt foods,supplementing proteins).Patients of the treatment group received additional treatment of warming needle moxibustion,i.e.,the inserted acupuncture needles in bilateral Hegu(LI 4),Tianshu(ST 25),Zhongwan(CV 12),and Zusanli(ST 36),Fenglong(ST 40),etc.,were manipulated for a while with reducing technique after"deqi",followed by attachment of ignited moxa-cones at each of the needle handles for 30 min.The treatment was conducted once every other day for 8 weeks.The therapeutic effect was assessed according to the"Criteria for Diagnosis and Therapeutic Effect Evaluation of Simple Obesity"(1998).Before and after the treatment,body fat percentage(F%),body adiposity index(BAI),and body mass index(BMI)were calculated,serum triglyceride(TG),total cholesterol(CHO),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)were detected using a biochemical analyzer.Results Following the treatment,of the two 30 cases of obesity patients in the control and treatment groups,0(0.0%)and 1(3.3%)was under control,11(36.7%)and 16(53.3%)had a marked improvement,8(26.7%)and 10(33.3%)were effective,and 11(36.7%)and 3(10.0%)failed in the treatment,with the effective rates being 63.3% and 90.0%,respectively.The effective rate of the warming needle moxibustion plus diet control was significantly superior to that of the simple diet control(P<0.01).After the treatment,the BMI,F%,serum CHO and TG levels and BAI in the treatment group were significantly decreased in comparison with its own pre-treatment in treatment group(P<0.05,P<0.01),while serum HDL-C of the treatment group was obviously increased compared with its own pre-treatment(P<0.01).The decreased F%,CHO and TG levels were markedly lower in the treatment group than in the control group(P<0.05,P<0.01).Conclusion Warming needle moxibustion has a positive effect for simple obesity patients with PDSS in controlling their symptoms.关键词：Warming needle moxibustion;Simple obesity;Phlegm dampness stagnation syndrome;Therapeutic effect;Clinical trial608|801|4更新时间：2023-08-11
- 摘要：Objective To observe the therapeutic effect of"Huayu Tongluo"(blood stasis-removing and meridian-collateraldredging)moxibustion for vascular cognitive impairment(VCI)patients and changes of insulin like growth factor-1(IGF-1)levels in serum after the treatment.Methods Sixty patients with VCI were randomly divided into medication(control)and moxibustion groups(n=30 in each group).Cotton cloth-separated moxibustion was applied to Baihui(GV 20)and Shenting(GV 24),and conventional moxibustion applied to Dazhui(GV 14)and Yongquan(KI 1)for 30 min,once daily,6 times a week and for 30 days.Patients of the control group were treated by oral administration of Donepezil hydrochloride at the dose of 5 mg/night for 30 days.The core symptoms of traditional Chinese medicine(TCM),mini-mental state examination(MMSE),activity of daily living(ADL)and Montreal cognitive assessment(MoCA)scales were used to assess the therapeutic effect after the treatment.The content of serum IGF-1 was determined by ELISA.Results Of the two 30 cases in the control and moxibustion groups,9 and 17 experienced marked improvement,13 and were effective,8 and 3 ineffective,with the effective rates being 73.33% and90.00%,respectively.The effective rate in the moxibustion group was obviously higher than that in the control group(P<0.05).After the treatment,the TCM symptom scores were significantly decreased,and the MMSE,ADL and MoCA scores considerably increased in both groups compared with those of their own individual pre-treatment(P<0.01).The TCM symptom score of the moxibustion group was significantly lower,and the MMSE and ADL scores were obviously higher than those of the control group(P<0.01).The serum IGF-1 content in both groups was significantly increased after the treatment relevant to that of their own individual pre-treatment(P<0.01),and was obviously higher in the moxibustion group than in the control group(P<0.01).No significant difference was found between the two groups in the MoCA score after the treatment(P>0.05).Conclusion "Huayu Tongluo"moxibustion has a positive effect for patients with VCI,which may be associated with its effect in up-regulating serum IGF-1 level.关键词："Huayu Tongluo" moxibustion;Vascular cognitive impairment;Insulin like growth factor-1502|635|6更新时间：2023-08-11
- 摘要：China is in the "high death zone" of the world cerebrovascular disease(CVD)map.The prevention and treatment of ischemic CVD(ICVD)have become the top priority in clinical practice.It has been demonstrated that acupuncture therapy has a positive role in bettering clinical symptoms of ICVD patients.Findings of recent experimental studies displayed that electroacupuncture(EA)intervention is effective in reducing the cerebral infarcted volume and cellular injury,promoting proliferation,migration and differentiation of nerve stem cells,facilitating the regeneration of nerve tissue,bettering dysneuria and limb locomotor ability,etc.in ICVD rats,which are closely associated with its effects in regulating different intracellular signaling pathways.In the present study,we review the progress of recent experimental studies on the underlying mechanisms of EA in improving ICVD from six major signaling pathways including Notch,mitogen-activated protein kinases(MAPK)/extracellular signal regulated protein kinases(ERK),phosphatidy linositol-3-kinase(PI3K)/protein kinase B(Akt),Janus kinase-signal transducer and activator of transcription(JAK-STAT),erythropoietin-producing hepatocyte receptor(Eph)/Ephrin,nuclear factor of kappa B(NF-κB)and their compositions,which may provide new therapeutic targets for acupuncture treatment of ICVD.More attention should be paid to the comparison of the efficacy of acupuncture of different acupoint combinations(traditional acupoint formulas)in relieving ICVD.关键词：Acupuncture;Ischemic cerebral vascular disease;Intracellular signaling pathways;Review516|712|5更新时间：2023-08-11
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