最新刊期
卷 43 ， 期 9 ， 2018
- 摘要：Objective To observe the effect of electroacupuncture(EA)on the expression of high mobility group box 1(HMGB 1)and its receptor CD 24 proteins andβ-endorphin(β-EP)content in"Zusanli"(ST 36)region in rats with chronic constriction injury(CCI),so as to explore its mechanisms underlying pain relief.Methods Thirty male Wistar rats were randomized into control,CCI model and EA groups(n=10 rats in each).The neuropathic pain model was established by ligature of the left sciatic nerve to induce CCI in the model and EA groups,and sham operation was performed in rats of the control group.Paw with drawal latency(PWL,thermal pain threshold)of the bilateral hind-limbs was detected by using an algesia-detector.Eight days after CCI operation,EA was applied to bilateral"Zusanli"(ST 36)and"Yanglingquan"(GB 34)for 30 min,once daily for5 days.The acetylated-HMGB 1 expression was determined by immunoprecipitation,and the expression of HMGB 1 and toll like receptor 4(TLR 4)proteins and CD 24 mRNA were detected using Western blot and fluorescent quantitative real time-PCR,respectively,and the content ofβ-EP in the acupoint region was assayed by enzyme linked immunosorbent assay(ELISA).AntiCD 24 neutralizing antibody(200 !L,100!g/mL)was injected into ST 36 region once daily for 3 days for verifying the involvement of HMGB 1/CD 24 signaling in EA analgesia.Results Compared with the control group,the bilateral PWL difference values in the other two groups were significantly increased(P<0.05),meaning an occurrence of hyperalgesia after CCI.In comparison with the CCI model group,the hyperalgesia in the EA group was obviously decreased(P<0.05).After CCI,the expression levels of HMGB 1 and TLR 4 proteins were considerably increased compared with those in the control group(P<0.05).After 5-times' EA,the acetylated-HMGB 1,the expression of CD 24 mRNA,and the content ofβ-EP were notably up-regulated(P<0.05),and there were no obvious changes in the expression levels of HMGB 1 and TLR 4 proteins(P>0.05).After local injection of anti-CD 24 antibody,EA-induced increases ofβ-EP content and reduction of thermal pain threshold were significantly suppressed(P<0.05).Conclusion EA of ST 36 and GB 34 can alleviate neuropathic pain in CCI rats,which is associated with its effects in up-regulatingβ-EP content,and HMGB 1 protein and CD 24 mRNA expression levels in ST 36 region.The activated HMGB 1/CD 24/β-EP signaling contributes to EA-ST 36 induced analgesia.关键词：Chronic neuropathic pain;Acupuncture analgesia;High mobility group box 1;CD 24;Toll like receptor 4;β-endorphin540|368|3更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)at different acupoints on hyperandrogenism and ovarian androgen receptor(AR)expression in rats with polycystic ovary syndrome(PCOS),so as to explore its mechanisms underlying improvement of PCOS.Methods Sixty female SD rats were randomly divided into control,model,Zusanli(ST 36),Sanyinjiao(SP 6),Guanyuan(CV 4)and comprehensive groups(10 rats/group).The PCOS model was established by giving(gavage)the animals with Letrozole solution(1.0 mg/kg),once daily for 21 consecutive days.EA stimulation was applied to ST 36,SP 6,or CV 4 respectively,once daily for 14 days.The comprehensive group was treated by EA treatment of the abovementioned three acupoints in the meantime.Before and after the treatment,the body mass and the ovary weight were measured.The morphological structure of the ovary was observed under microscope after H.E.staining.The levels of serum hormone and sex hormone binding globulin(SHBG)were assayed by ELISA.Free androgen index(FAI)was calculated and the expression of AR in the ovary was detected by immunohistochemistry.Results After modeling,the body mass,ovary weight,serum testosterone(T)and FAI levels and the expression of AR protein in late ovarian follicles were significantly increased(P<0.01,P<0.05),and serum estradiol(E2)and SHBG contents were significantly decreased relevant to the control group(P<0.01).Following EA intervention and compared with the model group,the body weight of each EA group was significantly reduced(P<0.05),the ovarian pathological changes were improved,and serum T and FAI levels were significantly decreased(P<0.01),and serum E2 and SHBG contents significantly increased in the ST 36,CV 4 and comprehensive groups(P<0.01,P<0.05).The ovary weight of only CV 4 group was significantly lower than that of the model group(P<0.01).The expression of AR protein in late follicles of both CV 4 and SP 6 groups was markedly decreased(P<0.05,P<0.01).Conclusion EA at ST 36,SP 6,and CV 4 all can improve the hyperandrogenism and ovarian polycystic morphological changes of PCOS rats,while different acupoints have different functional characteristics.关键词：Polycystic ovarian syndrome;Electroacupuncture;Hyperandrogenism;Androgen receptor519|647|7更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA)at different time-points on the injured myocardium and expression of myocardial Bax/Bcl-2 and Lc 3Ⅱ/Ⅰ proteins in acute myocardial ischemia-reperfusion injury(MIRI)rats so as to explore its mechanisms underlying myocardial protective effect via reducing cardiomyocyte autophagy and apoptosis.Methods A total of 66 adult SD rats were randomly divided into sham operation(sham),model,EA-R 0 min(R=reperfusion),EA-R30 min,EA-R 60 min,and EA-R 120 mingroups,with 6 rats being in the sham group and 12 rats being in each of the other 5 groups.The MIRI model was prepared by ligating the anterior descending branch(ADB)of the left coronary artery for 30 min followed by reperfusion for 4 h.In the sham group,the ADB was only threaded without ligation.EA was applied to bilateral"Neiguan"(PC 6)for 20 min at 0,30,60,and 120 min when reperfusion.Evans Blue-triphenyltetrazolium chloride(TTC)double staining was performed to determine the myocardial infarction area(MIA)and the ratio of the infarct size of the area at risk(IS/AAR).ELISA was performed to measure serum cardiac troponin 1(cTn-Ⅰ)content,and Western blot was used to measure the expression of apoptosis-related proteins Bax and Bcl-2 and autophagy related proteins Lc 3 Ⅱ and Lc 3 Ⅰin the left cardiac ventricle tissue.Results Compared with the model group,the percentages of MIA in the EA-R 30 min,EA-R 60 min,and EA-R 120 mingroups,and the IS/AAR in the EA-R 0 min,EA-R 30 min,EA-R 60 minand EA-R 120 mingroups were significantly reduced(P<0.05,P<0.01).Comparison among the 4 EA groups showed that the percentages of MIA and the IS/AAR were considerably lower in the EA-R 30 min,EA-R60 min,and EA-R 120 mingroups than in the EA-R 0 mingroup(P<0.05,except IS/AAR in the EA-R 120 mingroup),but significantly higher in the EA-R 60 minand EA-R 120 mingroups than in the EA-R 30 mingroup(P<0.05,P<0.01),suggesting a better therapeutic effect of EA intervention at 30 min of MIRI in improving MI.In comparison with the sham group,myocardial cTn-Ⅰ content and Bax/Bcl-2 and Lc 3Ⅱ/Ⅰlevels in the model group were significantly increased(P<0.01).After EA intervention,the increased cTn-Ⅰ content and Bax/Bcl-2 and Lc 3 Ⅱ/Ⅰlevels in the EA-R 0 min,EA-R 30 min,EA-R 60 min,and EA-R 120 mingroups were significantly reduced(P<0.05,P<0.01).The cTn-Ⅰ content was obviously lower at EA-R 30 min,but markedly increased at EAR 120 minthan at EA-R 0 min(P<0.05).The expression of Bcl-2 was obviously higher at EA-R 30 minthan at EA-R 0 min(P<0.05).No significant differences were found among the 4 EA intervention time-points in the levels of Bax/Bcl-2 and Lc 3Ⅱ/Ⅰ(P>0.05).Conclusion EA intervention can reduce MIA in MIRI rats,which is possibly closely related to its effects in reducing apoptosis and autophagy.The best intervention time is at 30 min after MI reperfusion,but the difference of effects of EA at different timepoints is independent of Bax/Bcl-2 and Lc 3 Ⅱ/Ⅰ expression.关键词：Electroacupuncture;Myocardial ischemia reperfusion injury;Intervention time-points;Autophagy;Apoptosis523|529|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of scalp-acupuncture intervention on the expression of parahippocampal factor-κB p 65 mRNA(NF-κB p 65 mRNA),IκB mRNA,interleukin-1β(IL-1β )and tumor necrosis factor-α(TNF-α)in rats with cerebral ischemia(CI),so as to investigate its molecular mechanisms underlying improving CI by reducing inflammatory response.Methods A total of 64 SD rats were randomized into normal control,model,medication and scalp-acupuncture groups,with 16 rats in each group.The focal CI model was established by middle cerebral artery occlusion(MCAO).Intraperitoneal injection of Pyrrolidine Dithiocarbamate(100 mg·kg-1·d-1)was administrated for rats in the medication group,once a day for 7 days.For rats of the scalp-acupuncture group,the acupuncture needles were rapidly inserted into bilateral Dingnieqianxiexian(MS 6)and Dingniehouxiexian(MS 7),followed by twirling the needles at 200 cycles/min for 1 min,once again every 10 min during 30 min's needle retention.The treatment was conducted once a day for 7 days.The neurologic deficit score(0-5 points,impaired consciousness,death,etc.)and neurological function score(motor,sensory and sensory tests,0-10 points)were assessed according to Longa's(1989)and Schbitz's(2004)methods,respectively.The expression levels of NF-κB p 65 mRNA and IκB mRNA in the parahippocampus gyrus tissue were detected by fluorescence quantitative reverse transcription-PCR,and IL-1β and TNF-αproteins in the parahippocampus gyrus tissue were detected by immunohistochemistry.Results After modeling,the neurologic deficit and neurological function scores and the expression levels of NF-κB p 65 mRNA,IL-1β and TNF-αin the parahippocampus were significantly increased in the model group than in the normal group(P<0.01),while the expression of IκB mRNA was considerably down-regulated(P<0.01).Following treatment intervention,the neurologic deficit and neurological function scores as well as NF-κB p 65 mRNA,and IL-1β and TNF-αprotein expression were significantly decreased in both scalp-acupuncture and medication groups compared with the model group(P<0.05,P<0.01),and the decreased expression of IκB mRNA was obviously increased(P<0.05).Conclusion Scalp-acupuncture can improve neurologic function in cerebral ischemic rats,which is related with its effects in up-regulating the expression of IκB to inhibit the dissociation of NF-κB,then decreasing the expression of IL-1β and TNF-α(reducing inflammatory response)in the parahippocampal gyrus tissue.关键词：Scalp acupuncture;Acute cerebral ischemia;Neurologic deficit;Parahippocampus gyrus;NF-κB p 65 mRNA;IκB mRNA;Interleukin-1β(IL-1β);Tumor necrosis factor-α(TNF-α)563|462|4更新时间：2023-08-11
- 摘要：Objective To observe the therapeutic effect of acupuncture in the treatment of post-traumatic stress disorder(PTSD)-induced abnormal behavior reactions and learning-memory ability in rats with traumatic injury.Methods Sixty male SD rats were randomly divided into control,model,model+animal capturing(capturing),medication and acupuncture groups(n=12 rats in each).The PTSD model was established by "electric shock plus incarceration"method.Acupuncture was applied to"Baihui"(GV 20),and unilateral"Neiguan"(PC 6),"Shenmen"(HT 7)and"Taichong"(LR 3)once daily for 12 days.The rats in the medication group were treated by gavage of Paroxetine Hydrochloride solution(0.42 mg/mL),once daily for 12 days.The open field test containing horizontal(crossing grid lines)and rearing tests was performed for examining the rats' locomotor activity and anxiety-like behavior;and location navigation(escape latency)and special probe tests(platform quadrant crossing times)of Morris water maze tasks were detected for assessing the rats' learning-memory ability.On day 12 of the experiments,the rats were submitted to 3 consecutive sessions of open field tests for observing the time of familiar objects(TF)and the time of novelty object(TN)of exploration in 5 min(an object-location and an object-recognition tasks),followed by calculating the discrimination index[DI=(TN-TF)/(TN+TF)x100%].Results After modeling,compared with the control group,the numbers of crossed grids and rearing,and DI were significantly decreased(P<0.05),while the number of fecal pellets and escape latency were significantly increased in both the model and capturing groups(P<0.05).After the intervention,the number of both crossed grids and rearing,platform quadrant crossing times,and DI were considerably increased(P<0.05),and the rats' escape latency and fecal pellet number were obviously decreased in both medication and acupuncture groups relevant to the model and capturing groups(P<0.05).No significant differences were found between the acupuncture and medication groups in the above mentioned5 indexes(P>0.05).Conclusion Acupuncture can effectively reduce anxiety-like behavior and improve the impaired learningmemory ability in PTSD rats.关键词：Acupuncture;Post-traumatic stress disorder;Anxiety-like behavior;Locomotor activity;Learning-memory ability535|740|8更新时间：2023-08-11
- 摘要：Objective To investigate the therapeutic effect of acupuncture combined with rehabilitation and neuro-immune functional activities in elderly patients with stroke.Methods A total of 196 elderly stroke patients were randomly divided into control(rehabilitation exercise)and observation(acupuncture+ rehabilitation exercise)groups(n=98 in each).Patients of the control group were treated by general healing treatment including good limb placement,timely conversion of body position,joint-motor exercise,sitting balance exercise,sitting-standing-walking,walking up and down stairs,daily life ability exercise,etc.and those of the observation group were treated by using the same methods mentioned in the control group and manual acupuncture stimulation of Sishencong(EX-HN 1),Xuanli(GB 6),the midpoint of EX-HN 1 and GB 6,Baihui(GV 20),Qubin(GB7),and the midpoint between GV 20 and GB 7 on the affected side(once a day for three 10-day courses).Serum interleukin-2(IL-2),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and high-sensitive C-reactive protein(hs-CRP)contents were assayed using ELISA,and serum CD 3+ rehabilitation exercise)groups(n=98 in each).Patients of the control group were treated by general healing treatment including good limb placement,timely conversion of body position,joint-motor exercise,sitting balance exercise,sitting-standing-walking,walking up and down stairs,daily life ability exercise,etc.and those of the observation group were treated by using the same methods mentioned in the control group and manual acupuncture stimulation of Sishencong(EX-HN 1),Xuanli(GB 6),the midpoint of EX-HN 1 and GB 6,Baihui(GV 20),Qubin(GB7),and the midpoint between GV 20 and GB 7 on the affected side(once a day for three 10-day courses).Serum interleukin-2(IL-2),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and high-sensitive C-reactive protein(hs-CRP)contents were assayed using ELISA,and serum CD 3+,CD 4+,CD 4+and CD 8+and CD 8+contents assayed using flow cytometry.The disability severity was assessed by using National Institutes of Health Stroke Scale(NIHSS,for dysneuria),modified Rankin Scale,(mRS,stroke severity),and Barthel Index(BI,performance in activities of daily living),separately.The therapeutic effect was determined according to NIHSS score,clinical symptoms and daily activity ability.Results On day 30 after the treatment,serum IL-2,IL-6,TNF-αand hs-CRP contents were significantly decreased in the observation group in comparison with its own pre-treatment and day 10 after the treatment,and on day 10 and 30 after the treatment,the above were lower than the control group(P<0.05).On day 30 after the treatment,serum CD 3+contents assayed using flow cytometry.The disability severity was assessed by using National Institutes of Health Stroke Scale(NIHSS,for dysneuria),modified Rankin Scale,(mRS,stroke severity),and Barthel Index(BI,performance in activities of daily living),separately.The therapeutic effect was determined according to NIHSS score,clinical symptoms and daily activity ability.Results On day 30 after the treatment,serum IL-2,IL-6,TNF-αand hs-CRP contents were significantly decreased in the observation group in comparison with its own pre-treatment and day 10 after the treatment,and on day 10 and 30 after the treatment,the above were lower than the control group(P<0.05).On day 30 after the treatment,serum CD 3+,CD 4+,CD 4+and CD 4+and CD 4+/CD 8+/CD 8+levels were significantly increased in both control and observation groups in comparison with their own pre-treatment and 10 days' treatment(P<0.05),while CD 8+levels were significantly increased in both control and observation groups in comparison with their own pre-treatment and 10 days' treatment(P<0.05),while CD 8+levels obviously decreased in both groups relevant to their own pre-treatment and 10 days' treatment(P<0.05),and the increased CD 3+levels obviously decreased in both groups relevant to their own pre-treatment and 10 days' treatment(P<0.05),and the increased CD 3+,CD 4+,CD 4+and CD 4+and CD 4+/CD 8+/CD 8+levels were significant higher in the observation group than in the control group(P<0.05),and the CD 8+levels were significant higher in the observation group than in the control group(P<0.05),and the CD 8+level was obviously lower in the control group than in the observation group(P<0.05).On day 30 after the treatment,the NIHSS and mRS scores were significantly decreased in both groups(P<0.05),and significantly lower in the observation group than in the control group(P<0.05);the BI scores were evidently increased in both groups relevant to their own pre-treatment(P<0.05),and the BI level was considerably higher in the observation group than in the control group(P<0.05).The total effective rate was 72.4%(71/98)and 93.9%(92/98)respectively in the control and observation groups,being obviously higher in the latter group than in the former(P<0.05).Conclusion Acupuncture combined with rehabilitation therapy is effective in promoting the recovery of neurological function and in regulating T lymphocyte subsets and the expression of inflammatory factors in elderly patients with stroke.关键词：Stroke;Acupuncture;Rehabilitation;Neurological function;Immune function496|331|2更新时间：2023-08-11
- 摘要：Objective To compare the therapeutic effect of thermosensitive moxibustion(TSM)and medication in the treatment of insomnia patients with the syndrome of stagnation of liver-qi.Methods A total of 60 insomnia patients with the syndrome of liver-qi stagnation were randomly divided into TSM group and medication group(n =30 in each).Mild moxibustion was applied to bilateral Taichong(LR 3)and Qiuxu(GB 40)alternatively till the patient experienced an intense warmth(diathermic,heat transmission,etc.)feeling in the local region.The treatment was conducted once daily for 15 d.Patients of the medication group were ordered to take Estazolam tablets(1 mg/d)1 hbefore sleeping,once daily for successive 15 days.The sleep quality(sleeping quality,falling asleep time,sleep duration,sleep efficiency,sleep disorders,hyponotic and day time dysfunction,0-21 points)was evaluated by using Pittsburgh Sleep Quality Index(PSQI).The therapeutic effect was assessed in accordance with the"Guide Principles for Clinical Trials on New Drugs of Chinese Materia Medica(1993)"and international united sleep efficiency value.Results Following the treatment,the PSQI of both groups were significantly decreased relevant to their own pre-treatment(P<0.05),but without significant difference between the two groups(P>0.05).Of the two 30 cases in the medication and moxibustion groups,12(40.00%)and 20(66.67%)had marked improvement,7(23.33%)and 6(20.00%)were effective,and 11(36.67%)and 4(13.33%)were invalid,with the effective rates being 63.33 %(19/30)and 86.67%(26/30),respectively.The effective rate of the TSM group was significantly higher than that of the medicine group(P <0.05).Conclusion Thermosensitive moxibustion applied to the source points of the Liver and Gallbladder Meridians can improve the quality of sleep in insomnia patients with syndrome of liver-qi stagnation.关键词：Thermosensitive moxibustion;Insomnia of liver-qi stagnation type;Clinical trial;Source points of Liver and Gallbladder meridians518|650|0更新时间：2023-08-11
- 摘要：It has been shown that ischemia preconditioning(IPC)can attenuate the myocardial injury induced by ischemic and reperfusion.But it was rarely used in clinic due to its inoperability.Previous studies indicate that electroacupuncture(EA)pretreatment can mimic myocardial ischemia preconditioning(MIPC)to produce cardioprotective effect.The activated adenosine A 2 b receptor has been proven to be involved in mediating the cardioprotection of IPC.In the studies on acupuncture analgesia,it was reported that adenosine receptor was activated by acupuncture stimulation,and acupuncture pretreatment can affect the activities of intracellular A 2 b receptor.Based on those mentioned above,it is highly likely that the A 2 b receptor may also participate in the cardioprotection produced by acupuncture pretreatment.In this paper,we comprehensively reviewed relevant studies regarding 1)the cardioprotective effect of IPC and its limitations,2)the similar cardioprotection produced by both acupuncture pre-treatment and IPC,3)the mechanism underlying myocardial ischemic injury and intracellular calcium regulation,4)the activation of adenosine receptors and effects of acupuncture,5)the relationship between adenosine receptors and intracellular calcium ion,and 6)the effect of acupuncture on adenosine receptors,so as to provide a novel assumption that A 2 b receptor may be a key factor in mediating the cardioprotection of acupuncture pretreatment.Our future research will systematically explore the mechanism of acupuncture pretreatment in protecting ischemic myocardium from myocardial cell adenosine A 2 b receptor and intracellular calcium signal transduction related factors.关键词：Silent myocardial ischemia;Acupuncture pretreatment;Ischemia preconditioning;Intracellular calcium;Adenosine receptors503|314|2更新时间：2023-08-11
- 摘要：Laser scanning confocal microscope(LSCM)has been used in the field of morphological research of acupuncture and moxibustion for more than 20 years.It is one of the important tools for revealing the structure of acupoints and the effect of acupuncture from histological perspective.With the help of technical advantages of LSCM,the quality of morphological research of acupuncture and moxibustion has been greatly improved,helping us gain a deeper understanding about the structure of acupoints and meridians as well as histochemical changes induced by acupuncture/moxibustion intervention.In order to promote the application of LSCM in acupuncture and moxibustion,we simply reviewed some recent studies in this field and combined them with our experience,trying to provide some technical suggestions.We expect that the technique of LSCM could be integrated into more experiments in acupuncture medicine to provide more powerful morphological evidence for exploring the underlying mechanisms of acupuncture and moxibution therapies.关键词：Laser scanning confocal microscope;Acupuncture-moxibustion;Morphological study;Visualization524|506|2更新时间：2023-08-11
- 摘要：Objective To analyze the core acupoints and acupoint combinations of catgut embedding for simple obesity based on the complex network technology.Methods Articles about acupoint catgut embedding for simple obesity were collected from databases of PubMed,CNKI,Wanfang and VIP from 1980 to 2016 by using keywords"simple obesity""obesity""acupoint embedding""acupuncture"and"traditional Chinese medicine",followed by constructing a database of acupoint prescription.Acupoint node(one node means an acupoint)weighted complex network was constructed by using complex network technique,followed by conducting centrality analysis and clustering analysis about the nodes using Matlab 2014,a software for revealing the core acupoint node and compatibility relations.At last,the results(complex network diagram)were displayed using software Gephi 0.9.1.Results A total of 238 articles(all in Chinese)including 278 acupoints(of which 115 are meridian acupoints)were collected.The top 15 core acupoints are Tianshu(ST 25),Zusanli(ST 36),Zhongwan(CV 12),Fenglong(ST 40),Sanyinjiao(SP 6),Quchi(LI 11),Yinlingquan(SP 9),Guanyuan(CV 4),Pishu(BL 20),Qihai(CV 6),Shenshu(BL 23),Shangjuxu(ST 37),Daheng(SP 15),Shuifen(CV 9),and Ganshu(BL 18),mainly distributing in the abdomen,lower limbs and back.Those acupoints with the highest core degree are attributed to the Stomach Meridian,Conception Vessel,Bladder Meridian,Spleen Meridian and Large Intestine Meridian.Regarding the compatibility of these acupoints,ST 25 and CV 12 have the highest correlation frequency,followed by ST 25 and ST 36,and ST 40 and ST 25,indicating the principle of different combinations being regional acupoints and meridian acupoints.Conclusion In the treatment of simple obesity with catgut embedding,top 15 core acupoints as ST 25,ST 36,CV 12,ST 40,etc,and acupoint recipes as ST 25 and CV 12,ST 25 and ST 36,ST 40 and ST 25 are most frequently used in clinical practice.关键词：Acupoint catgut embedding;Simple obesity;Complex network technology;Rule of acupoint selection555|985|3更新时间：2023-08-11
- 摘要：Objective To evaluate the effectiveness and superiority of acupoint catgut-embedding in the treatment of insomnia.Methods Randomized controlled trials(RCTs)for insomnia treated by acupoint implantation of catgut were included in the present study.We searched the related articles from 6databases(PubMed,Google Scholar,CBM,CNKI,VIP and Wanfang) from the date of inception to March 19,2017by using keywords“catgut implantation at acupuncture point”or“catgut implantation at acupoint”and“insomnia”or“agrypnia”and“randomised(or randomized)clinical trial”.The Cochrane risk bias tool was used to evaluate the quality of evidence in the literature.Data were analyzed using software Revman 5.3and STATA 14.0.Results Twenty-two trials met the inclusion criteria were included.They recruited 1 714cases of insomnia.Heterogeneous test(numerical test)showed χ2=31.11,P=0.07,I 2=32%.Gabriz chart and sensitivity analysis ultimately determined that these trials have smaller or no heterogenity.The effective rate of acupoint catgut embedding for insomnia was higher than that of the control group (OR=3.77;95% CI:2.63-5.41;P<0.00001).Conclusion Acupoint catgut embedding therapy has a positive role in clinical treatment of insomnia.But due to lower quality of current literature,more high-quality randomized controlled clinical trials are required.关键词：Insomnia;Acupoint catgut embedding;Systematic review591|1045|0更新时间：2023-08-11
- 摘要：Acupuncture therapy has a positive effect in the treatment of amblyopia.This article summarizes findings of the research on brain mechanisms underlying the regulatory effect of acupuncture on visual plasticity of amblyopia.In a multi-system and multi-level viewpoints,we elaborated brain mechanism underlying the regulatory effect of acupuncture on visual plasticity in amblyopia from the perspective of ultrastructure,plasticity,electrical activities,neural coding and visual microcirculation of the neurons of the visual cortex,and the targeting points from the visual center to the effector organ.关键词：Acupuncture;Amblyopia;Visual deprivation;Visual plasticity;Visual electrophysiology;Neural coding;Brain function mechanism547|558|4更新时间：2023-08-11
- 摘要：Acupuncture has been used to treat diabetes mellitus(DM)for more than one thousand years.In the present paper,we review new progress of researches on the underlying mechanism of acupuncture intervention for DM.Results showed that acupuncture intervention can relieve DM by 1)reducing body weight through up-regulating leptin level,suppressing insulin resistance and appetite to reduce food intake possibly by way of down-regulating expression of neuropeptide Y in the hypothalamus,retarding gastric emptying velocity,increasing small intestinal peristalsis,raising plasma levels of glucagon-like peptide-1(GLP-1)and peptide YY,etc.;2)improving pancreas function,raising insulin sensitivity to improve insulin resistance possibly by activating AMP-activated protein kinase and sirtuin 1/peroxisome proliferator-activated receptorγcoactivator 1αsignaling,up-regulating activities of cholinergic nerve activity and nitric oxide synthase,and inhibiting apoptosis of pancreatic beta-cells;3)lowering blood glucose possibly by increasing anaerobic glucose metabolism,regulating activities of vagal and sympathetic nerves;4)adjusting the levels of related hormones such as melatonin,insulin,glucocorticold,epinephrine,etc.Moreover,acupuncture treatment combined with hypoglycemic drugs has a synergic effect in lowering blood glucose,suggesting apotentially effective approach for improving DM and being worthy of further studying in clinical practice.关键词：Acupuncture therapy;Diabetes mellitus;Mechanism;Research progress638|1802|4更新时间：2023-08-11
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