最新刊期
卷 44 ， 期 12 ， 2019
- 摘要：Brain science is the"ultimate territory"for human beings to understand the nature. In the present paper,the authors introduce the current state of brain science research projects in the USA,European countries,Japan and China. In recent years,with the continuous innovations of technologies in brain imaging,biosensors,human-computer interaction and big data,the brain science has become an important frontier field with interdisciplinarity and a focus of science and technology strategies in various countries. As a scientific and technological resource with original advantages in China,traditional Chinese medicine(TCM)is abundant in knowledge of brain,almost covering all kinds of encephalopathy in modern medicine. At present,TCM is increasingly becoming an effective tool to conquer mental and nervous diseases. With the intersection and penetration of multi-disciplines,an increasing close association between the traditional theory of TCM about prevention and treatment of encephalopathy and modern basic biological research appears,and new ideas,new technologies and new achievements have constantly been coming out,particularly in the field of acupuncture medicine. In the present historical juncture when the development of science and technology in China is changing from the"follower"to the"parallel runner",even the"top runner"in some fields,the progress of brain science research in TCM will make enormous contributions to explore brain disease and exploit cutting-edge technologies of TCM,as well as accelerate the modernization of TCM.关键词：Brain science;Treatment of brain diseases;Traditional Chinese medicine;Acupuncture-moxibustion;Development722|851|11更新时间：2023-08-10
- 摘要：Ischemic stroke is a type of clinical syndrome caused by brain blood supply disorders due to various cerebrovascular diseases,which lead to local cerebral ischemia,hypoxic necrosis,and corresponding neurological defects. In recent years,the neurovascular unit mechanism of ischemic stroke has been proposed in modern medicine.With the principles of syndrome differentiation-based treatment and holistic view in traditional Chinese medicine,acupuncture has the advantage of multi-target and multi-link effect and good clinical efficacy on this disease,and current studies have shown that acupuncture has a marked effect on each component and the whole of neurovascular unit. This article reviews the effect of acupuncture on the regulation of blood-brain barrier,astrocytes,microglial cells,neurons,and neurovascular units.关键词：Ischemic stroke;Neurovascular unit mechanism;Acupuncture;Multi-target862|856|7更新时间：2023-08-10
- 摘要：ObjectiveTo investigate the effect of electroacupuncture(EA)preconditioning on autophagy in cerebral cortex tissues of rats with cerebral ischemia-reperfusion injury(CIRI),so as to explore its mechanisms underlying improvement of CIRI.MethodsThirty-three male Sprague-Dawley rats were randomly divided into sham operation,model and EA groups(n=11 in each group). EA(2 Hz/15 Hz,1 mA)was applied to"Baihui"(GV20),"Quchi"(LI11)and"Zusanli"(ST36)for 30 min,once daily for 5 days,followed by establishment of CIRI model by occlusion of the middle cerebral artery(MCAO)for 1. 5 h and reperfusion for 24 h. The neurological deficit score was assessed in reference to Longa's methods,and the infarct volume assessed by 2,3,5-triphenyltetrazolium chloride staining. The density of dendrite spines of neurons in the ischemic cerebral cortex tissue was detected by Golgi's staining,the autophagosome observed by electron microscopy,and the expression levels of microtubule-associated protein 1 light chain 3(LC3)and Compared with the sham operation group,the neurological deficit score and infarct volume were significantly increased(P<0. 01),the number of autophagosomes and the ratio of LC3-Ⅱ/LC3-Ⅰ also significantly increased(P<0. 01),while the expression level of p62 was notably decreased in the model group(P<0. 01). Following the intervention and in comparison with the model group,the neurological deficit score and infarct volume were significantly reduced(P<0. 01),the number of autophagosomes and the ratio of LC3-Ⅱ/LC3-Ⅰ obviously decreased(P<0. 01),and the expression of p62 was significantly up-regulated in the EA group(P<0. 01).ConclusionEA pretreatment is effective in improving CIRI in rats,which may be realized through suppressing autophagy in the ischemic cerebral cortex tissue.关键词：Electroacupuncture;Autophagy;Cerebral ischemia-reperfusion injury;Microtubule-associated protein 1 light chain 3;Sequestosome-1761|619|10更新时间：2023-08-10
- 摘要：ObjectiveTo observe the effect of electroacupuncture(EA)on expression of eukaryotic initiation factor 2α(EIF2α),activating transcription factor 4(ATF4),glucose regulator protein-78/immunoglobulin heavy-chainbinding protein(GRP78/Bip)in the substantia nigra(SN)in rats with Parkinson's disease(PD),so as to explore its mechanism underlying improvement of PD.MethodsForty-eight male SD rats were randomly divided into control,sham-operation,model and EA groups(n=12 in each group). The PD model was established by 28-day consecutive subcutaneous injection of rotenone(1 mg/kg dissolved in dimethyl sulfoxide and normal saline)at the back shoulder. EA(2 Hz,1 mA)was applied to"Fengfu"(GV16)and"Taichong"(LR3)for 30 min,once daily for 2 weeks. The behavioral changes of rats in each group were measured and scored at 28 thday and 44 thday,respectively. The expressions of tyrosine hydroxylase(TH)and α-synuclein(α-syn)in the SN were observed by immunohistochemistry,and the expressions of EIF2α,ATF4 and GRP78/Bip were detected by Western blot.ResultsFollowing modeling and compared with the control and sham-operation groups,the behavioral scores of rats in the model group were elevated(P<0. 01),which were significantly decreased by EA intervention(P<0. 01). The expression of TH decreased whereas the α-syn,EIF2α,ATF4 and GRP78/Bip increased in the rats of model group,and EA intervention reversed these changes(all P<0. 01).ConclusionEA at GV16 and LR3 can improve PD rats' behavioral changes,which is probably related with its effects in up-regulating the expression of TH in the SN and down-regulating the expression of α-syn and EIF2α-ATF4-GRP78/Bip signaling.关键词：Parkinson's disease;Eukaryotic initiation factor 2α;Activating transcription factor 4;Glucose-regulated protein 78701|587|14更新时间：2023-08-10
- 摘要：ObjectiveTo explore the correlation between blood oxygen level dependent functional magnetic resonance imaging(BOLD-fMRI)signal and neurotransmitter γ-aminobutyric acid(GABA)concentration in the prefrontal cortex area after acupuncture or Von Frey filament stimulation(epidermal stimulation)at the right Hegu(LI4).MethodsA total of 76 healthy volunteers(23 men and 53 women,24. 5±1. 4 years in age)were recruited in the present study. Each volunteer received two sessions of fMRI magnetic resonance scanning(MRS)examinations,with an interval of one week between two sessions. The MRI scan sequences included pre-task MRS,resting state BOLD and task MRS,BOLD. A region of Interest(ROI)of 35 mm×30 mm×25 mm was located at the bilateral medial prefrontal cortex areas. In the two sessions of examinations,the right LI4 point was stimulated by manual acupuncture or Von Frey filament-pressing. The tasks were designed as the block design. Each block contained 3 intermittent acupoint stimulations,lasting 30 s in each stimulation and with two minutes' pause between two stimulations. The MRS data were processed by using Linear Combination(LC)Model software(for assessing GABA content),and the BOLD data of fMRI was analyzed by using SPM12 software(comparison within each group),REST1. 8(comparison between two groups),separately.ResultsExtensive deactivations were induced by both stimulations,mainly involving the midline regions as the medial prefrontal lobe,and limbic lobe. The deactivation effect of manual acupuncture stimulation was more extensive and intensive than that of Von Frey filament stimulation,especially in the medial prefrontal lobe. Data from 66 volunteers(after exclusion of 10 participants due to bigger standard deviation of GABA/Glx)showed no marked correlation between the GABA concentration and BOLD activation in the anterior cingulate cortex area in both groups(manual acupuncture stimulation group:r=-0. 07,-0. 08,0. 04;P=0. 57,0. 88,0. 74;Von Frey filament epidermal stimulation group:r=-0. 10,-0. 09,-0. 01;P=0. 43,0. 46,0. 96).ConclusionAcupuncture of LI4 elicits a stronger and broader negative activation effect in the limbic-paralimbic-neocortical network including the medial prefrontal cortex in comparison with Von Frey filament stimulation,but no apparent correlation was found between the GABA concentration and BOLD activation in the anterior cingulate cortex after manual acupuncture and Von Frey stimulation.关键词：Manual acupuncture stimulation;Von Frey filament epidermal stimulation;Hegu(LI4);Blood oxygen level dependent functional magnetic resonance imaging;Magnetic resonance scanning;γ-aminobutyric acid;Anterior cingulate cortex868|471|3更新时间：2023-08-10
- 摘要：ObjectiveTo investigate the immediate brain effect of auricular electroacupuncture(EA) in the treatment of primary insomnia(PI).MethodsIn this study,15 subjects with PI who were diagnosed according to Pitsburgh Sleep Quality Index(PSQI),and other 15 age-and gender-matched subjects without insomnia were recruited in the present study. The PI patients received EA(4 Hz/20 Hz,a tolerable electrical current strength)of auricular concha for 30 min,and their resting state functional magnetic resonance imaging(fMRI)data before and after treatment were collected. The healthy subjects received no any treatment and their resting state fMRI data were collected. The difference of default mode network functional connectivity between the patients and healthy subjects,and changes of the patient's brain functional connectivity after EA treatment were estimated by using seed-point-based analysis(SPBA).ResultsAnalysis by taking the posterior cingulate gyrus as the seed-point showed that compared with the healthy participants before treatment,the patient's brain functional connectivity between the posterior cingulate gyrus and the right insula,or the inferior frontal gyrus of the right opercularis region,or the right rolandic operculum was increased. After 30 minutes' EA treatment,the functional connectivity between the posterior cingulate gyrus and the precuneus,the left angular gyrus,the left frontal superior gyrus,the left frontal middle cortex,the right temporalis inferior gyrus,the right temporalis middle gyrus or the left medial orbitofrontal cortex was decreased,while the functional connectivity between the posterior cingulate gyrus and the right lingual gyrus,or the cortex surrounding the right calcarine fissure was increased.ConclusionEA of auricular concha has an instant effect in modulating the brain default mode network in PI patients,which may be its brain mechanism underlying improvement of PI.关键词：Auricular electroacupuncture;Primary insomnia;Instant adjustive effect;Resting-state functional magnetic resonance imaging;Brain default mode network777|512|8更新时间：2023-08-10
- 摘要：ObjectiveTo observe the efficacy of"Tongdu Tiaoshen"(dredging Governor Vessel and regulating mind,needling on the cognitive function of patients with sepsis associated encephalopathy(SAE).MethodsA total of 64 patients with SAE were enrolled in the present study,and randomly and equally divided into a control group and a treatment group. Patients in the control group received conventional medicines and conventional needling treatment. The patients of the treatment group received conventional medicines and"Tongdu Tiaoshen"needling treatment. The treatment was conducted once daily for 10 days. The Montreal Cognitive Assessment(MoCA)scale was used to assess the therapeutic effect after the treatment. Serum interleukin-6(IL-6)was detected by radioimmunoassay,serum C-reactive protein(CRP)was detected by immuno-scattering method,and arterial blood lactic acid(Lac)content was detected by blood gas analyzer.ResultsThe effective rate in the treatment group was obviously higher than that in the control group(P<0. 01). After the treatment,the MoCA scores were considerably increased in both groups compared with their own pre-treatment(P<0. 01),and the MoCA scores in the treatment group were obviously higher than those of the control group in the visual space and executive function,attention and computational power,language,abstraction and delayed recall dimensions(P<0. 01). The contents of IL-6,CRP and Lac in both groups were significantly decreased after the treatment relevant to those of their own pre-treatment(P<0. 01),and were obviously lower in the treatment group than those in the control group(P<0. 01).Conclusion"Tongdu Tiaoshen"needling can significantly improve the cognitive function of SAE patients,which may be associated with its effect in reducing inflammatory reaction of sepsis.关键词："Tongdu Tiaoshen" needling;Sepsis associated encephalopathy;MoCA scale;Inflammatory factor571|262|6更新时间：2023-08-10
- 摘要：ObjectiveTo observe the effect of electroacupuncture(EA)on changes of expression of L-Arg transporter 2(CAT-2)m RNA and nitric oxide synthase(i NOS)m RNA and protein and contents of NO and c GMP of L4—L6 segments of spinal cord in rats with spared nerve injury(SNI),so as to reveal its mechanism underlying reducing neuropathic pain.MethodsA total of 120 male SD rats were randomly divided into sham operation,model,EA and NOS inhibitor(N omega-Nitro-L-arginine methyl ester hydrochloride,L-NAME)groups,with 30 rats in each group. The neuropathic pain model was established by ligating and cutting the tibial nerve and the common peroneal nerve. EA(2 Hz,1—3 m A)was applied to"Weizhong"(BL40)and"Huantiao"(GB30)on the damaged hindlimb for 30 min,once daily from day 11 to 17 after SNI. Rats of the L-NAME group received i. p. of L-NAME(60 mg·kg(-1)·d(-1)·d(-1))for 7 consecutive days.The mechanical pain threshold(PT)was determined before and 10 and 16 d after SNI,respectively. The expression levels of CAT-2 m RNA and i NOS m RNA,and i NOS protein in the L4—L6 segments of the spinal cord were detected by using reverse transcription-polymerase chain reaction(RT-PCR)and Western blot,respectively,and the contents of NO and cGMP of L4—L6 assayed using nitrate/nitrite reductase method and radioimmunoassay,respectively.Results After modeling,the PT was significantly decreased on day 10 and 16 after SNI in comparison with the sham operation group and their own baseline data of pre-operation in each group(P<0. 01),and remarkably increased in the EA and L-NAME groups relevant to the model group on day 16(P<0. 01,P<0. 05). Compared with the sham operation group,the expression levels of CAT-2 mRNA and i NOS m RNA and protein,as well as the contents of NO_2(-1))for 7 consecutive days.The mechanical pain threshold(PT)was determined before and 10 and 16 d after SNI,respectively. The expression levels of CAT-2 m RNA and i NOS m RNA,and i NOS protein in the L4—L6 segments of the spinal cord were detected by using reverse transcription-polymerase chain reaction(RT-PCR)and Western blot,respectively,and the contents of NO and cGMP of L4—L6 assayed using nitrate/nitrite reductase method and radioimmunoassay,respectively.Results After modeling,the PT was significantly decreased on day 10 and 16 after SNI in comparison with the sham operation group and their own baseline data of pre-operation in each group(P<0. 01),and remarkably increased in the EA and L-NAME groups relevant to the model group on day 16(P<0. 01,P<0. 05). Compared with the sham operation group,the expression levels of CAT-2 mRNA and i NOS m RNA and protein,as well as the contents of NO_2-/NO_3-/NO_3-and c GMP were significantly up-regulated in the model group(P<0. 05,P<0. 01). Following EA intervention,the levels of CAT-2 m RNA and i NOS m RNA and i NOS protein,and NO_2-and c GMP were significantly up-regulated in the model group(P<0. 05,P<0. 01). Following EA intervention,the levels of CAT-2 m RNA and i NOS m RNA and i NOS protein,and NO_2-/NO_3-/NO_3-and cGMP contents were all reversed in both EA and L-NAME groups(P<0. 05,P<0. 01). The effect of EA was significantly superior to that of L-NAME in raising the PT on day 16 after SNI(P<0. 05),but obviously inferior to that of L-NAME in down-regulating the expression of CAT-2 m RNA and i NOS m RNA and protein(P<0. 05). No significant differences were found between the EA and L-NAME groups in down-regulating NO2-/NO3-and c GMP contents(P>0. 05).ConclusionEA intervention can effectively relieve neuropathic pain in SNI rats,which may be closely related to its function in suppressing L-Arg/NO/c GMP pathway in the lumbar spinal cord.关键词：Electroacupuncture;Neuropathic pain;Spinal cord;L-Arg transporter;Nitric oxide synthase;Nitric oxide;cGMP712|300|2更新时间：2023-08-10
- 摘要：ObjectiveTo observe the effect of electroacupuncture(EA)on inflammatory reaction and insulin sensitivity in insulin-resistant obese(OIR)rats.MethodsThirteen male Wistar rats were randomly selected as the control group and fed with common diet. The other 39 rats were fed with high-fat diet for 8 weeks to establish OIR model and then randomized into model,EA and sham EA groups. EA(2 Hz,1 mA)was applied to unilateral"Zusanli"(ST36),"Fenglong"(ST40),"Zhongwan"(CV12)and"Guanyuan"(CV4)for 15 min,once every other day for 8 weeks,and sham EA was applied to unilateral 4 control spots about 5 mm lateral to the aforementioned 4 acupoints after shallowly inserting acupuncture needles,but without electric current output. After 8 weeks' intervention,the body weight was recorded and the glucose infusion rate(GIR)measured using hyperinsulinemic-euglycemic clamp technique. At the 6 th week of intervention,glucose contents of intraperitoneal glucose tolerance test(IPGTT)and intraperitoneal insulin tolerance test(IPITT)were measured. The levels of serum insulin(INS)and inflammatory factors as C-reactive protein(CRP),IL-6 and TNF-α were measured by using ELISA at the end of the treatment. The expression levels of IL-6,TNF-α,monocyte chemoattractant protein-1(MCP-1),IL-10 and IL-1β proteins and mRNAs in the abdominal adipose tissues were detected by Western blot and quantitative real time-PCR,separately. The CD68 expression(displaying infiltration of macrophages)of adipose tissue was detected using immunohistochemistry.ResultsAfter modeling,the contents of glucose of IPGTT at 30,60 and 120 min and those of IPITT at 15,30,60 and 120 min,serum INS,CRP,IL-6 and TNF-α,as well as the expression levels of IL-6,TNF-α,IL-1β and MCP-1 proteins and mRNAs and CD68 protein were significantly increased(P<0. 01,P<0. 05),while the levels of GIR and IL-10 protein and mRNA were obviously decreased in the model group in comparison with those of the control group(P<0. 01),suggesting an increase of inflammation and a decline of INS sensitivity. Following the interventions,the increased contents of glucose of IPGTT and IPITT,serum INS,CRP,IL-6 and TNF-α,expression levels of IL-6,TNF-α,IL-1β and MCP-1 proteins and mRNAs and CD68 protein,and the decreased levels of GIR and IL-10 protein and mRNA were evidently reversed in the EA group compared with the model group(P<0. 01,P<0. 05)rather than those in the sham EA group(P>0. 05).Conclusion EA can reduce the level of inflammation and improve insulin sensitivity in OIR rats.关键词：Acupuncture;Obesity;Insulin resistance;Adipose tissue;Inflammatory reaction677|351|8更新时间：2023-08-10
- 摘要：ObjectiveTo observe the effect of acupoint application at bilateral"Tianshu"(ST25)on intestinal mobility and immunoactivity of vasoactive intestinal peptide(VIP)and substance P(SP)in colonic myenteric plexus of rats with functional constipation(FC),so as to analyze its mechanisms underlying improving FC.MethodsForty male SD rats were randomly divided into 4 groups,namely normal control,model,acupoint application and medication,with 10 rats in each group. The FC model was established by gavage of Loperamide Hydrochloride suspension fluid(0. 5 mg/mL,3 mg·kg-1·d-1)for 7 days. Herbal medicine paste(composed of Rheum Officinale,Sodium Sulfate,Mangnolia Officinalis,etc.)was applied to bilateral ST25 for 6 h,once daily for 4 weeks. Rats of the medication group were treated by gavage of Mosapride suspension fluid(0. 15 mg/mL,1. 58 mg·kg-1·d-1)for 4 weeks. After the treatment,the rats were deprived of water for 12 hours,and then treated by gavage of 2 mL of activated carbon suspension,followed by recording the first black defecation time and the number of fecal particles and water content of feces within 6 h so as to assess the intestinal mobility. The immunoactivity and average surface density of VIP and SP positive granules in the colonic myenteric plexus were detected by immunohistochemistry.ResultsCompared with the normal control group,the first black defecation time was significantly prolonged,and the number and water content of fecal particles within 6 h,and the expression and the average surface density of VIP and SP were significantly reduced in the model group(P<0. 01). After the treatment and compared with the model group,the first black defecation time was shortened,and the fecal water content and fecal particle number within 6 h,as well as the expression and the average surface density of VIP and SP were considerably increased in both acupoint application and medication groups(P<0. 01). There were no significant differences between the acupoint application and medication groups in all the indexes mentioned above after the interventions(P>0. 05).ConclusionAcupoint application may improve the intestinal motility in FC rats,which may be associated with its effects in up-regulating the immunoactivity of VIP and SP in colonic myenteric plexus of the large intestine.关键词：Functional Constipation;Tianshu(ST25);Acupoint application with Chinese herbal medicine;Va-soactive intestinal peptide;Substance P828|701|3更新时间：2023-08-10
- 摘要：ObjectiveTo observe the effect of electroacupuncture(EA)on blood pressure,renal fibrosis and expression of tissue inhibitors of metalloproteinase-1(TIMP-1),plasminogen activator inhibitor 1(PAI-1),and alpha smooth muscle actin(α-SMA)in spontaneous hypertension rats(SHR),so as to explore its mechanisms underlying improving hypertensive renal damage.MethodsForty male SHR(15 weeks in age)were randomly divided into 5 groups:model,medication(Losartan),Shenshu,Geshu,and Shenshu+Geshu groups(n==8 rats in each group),and the same age-old male 8 Wistar-Kyoto(WKY)rats were used as the normal control group. Rats of the medication group were treated by gavage of Losartan potassium solution(3 mg/mL,30 mg·kg(-1)·d(-1)·d(-1),once a day for 12 weeks),and those of the3 EA groups treated by EA stimulation of bilateral"Shenshu"(BL23),"Geshu"(BL17)or both BL23 and BL17(2 Hz/100 Hz,1 mA,15 min each time,once every other day for 12 weeks). The systolic blood pressure of the tail artery was measured before,and 4,8 and 12 weeks after the intervention. The expression of TIMP-1,PAI-1 and α-SMA proteins of the right kidney tissue was measured by immunohistochemistry. Histopathological changes of the right renal tissue were observed under light microscope after H. E. stain.ResultsThe blood pressure was significantly higher in the model group than those in the normal control group(P<0. 01),and considerably decreased at the 4(-1),once a day for 12 weeks),and those of the3 EA groups treated by EA stimulation of bilateral"Shenshu"(BL23),"Geshu"(BL17)or both BL23 and BL17(2 Hz/100 Hz,1 mA,15 min each time,once every other day for 12 weeks). The systolic blood pressure of the tail artery was measured before,and 4,8 and 12 weeks after the intervention. The expression of TIMP-1,PAI-1 and α-SMA proteins of the right kidney tissue was measured by immunohistochemistry. Histopathological changes of the right renal tissue were observed under light microscope after H. E. stain.ResultsThe blood pressure was significantly higher in the model group than those in the normal control group(P<0. 01),and considerably decreased at the 4(th),8(th),8(th),and 12(th),and 12(th) week of the interventions in the medication and 3 EA groups(P<0. 01). The expression levels of renal TIMP-1,PAI-1 and α-SMA proteins were notably higher in the model group than those in the normal control group and considerably decreased at the 12(th) week of the interventions in the medication and 3 EA groups(P<0. 01). The expression levels of renal TIMP-1,PAI-1 and α-SMA proteins were notably higher in the model group than those in the normal control group and considerably decreased at the 12(th) week of the interventions in the medication and 3 EA groups than in the model group(P<0. 01). H. E. staining of the renal tissue showed disordered arrangement of the renal cells,congestion and dilation of capillaries with thickened vascular wall,renal tubule atrophy and lumen stenosis with some necrosis of renal tubules,protein tubule and cell tubules,increase of some glomerular mesangial matrix and hyperplasia of fibrous tissue in the model group,which was relatively milder in the medication and 3 EA groups.ConclusionEA of BL23 and BL17 can reduce the blood pressure in SHR,which may be related to its function in down-regulating expression of TIMP-1,PAI-1 and α-SMA proteins.关键词：Spontaneous hypertension rats;Electroacupuncture;Tissue inhibitors of metalloproteinase-1;Plasminogen activator inhibitor 1;Alpha smooth muscle actin;Renal fibrosis624|315|5更新时间：2023-08-10
- 摘要：ObjectiveTo compare the differences in clinical effects on hyperlipidemia of turbid phlegm obstruction pattern/syndrome treated with the different Jin's three-needle therapies so as to provide a new approach and theoretic evidence for the clinical optimal scheme of acupuncture on hyperlipidemia.MethodsA total of 90 patients were randomly divided into education group,electroacupuncture group and catgut embedding group(30 cases in each). The routine health education was given to the education group. On the base of the treatment as the education group,electroacupuncture was applied to the electroacupuncture group for 30 min each time,twice a week;and the catgut embedding was applied to the catgut embedding group at the same acupoints as the electroacupuncture group,once a week.The treatment was given consecutively for 8 weeks in each group. Before and after treatment,the obesity indices[weight,waistline,body mass index(BMI)],blood lipid indices[serum total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)]and insulin resistance indices[fasting blood glucose(FBG),fasting plasma insulin(FINS),homeostasis model assessment-estimated insulin resistance(HOMA-IR)]were observed in the three groups before and after treatment.ResultsAfter treatment,in the electroacupuncture group and the catgut embedding group,the results of the obesity indices,e. g. weight,waistline and BMI,the levels of blood lipid,e. g. TC,TG,LDL-C and the insulin resistance indices,e. g. FINS and HOMA-IR were all obviously decreased compared with those before treatment(P<0. 05,P<0. 01),and the level of HDL-C apparently increased than that before treatment(P<0. 01). In the catgut embedding group,FBG was obviously decreased after treatment as compared with that before treatment(P<0. 01). After treatment,the improvements in LDL-C and HDL-C in the catgut embedding group were superior to those in the electroacupuncture group(P<0. 05). Regarding the obesity indices and insulin resistance indices,the differences were not statistically significant in comparison between the catgut embedding group and the electroacupuncture group(all P>0. 05). The total effective rate was 90. 0% in the catgut embedding group(27/30)and it was 83. 3%(25/30)in the electroacupuncture group,either of them was better than 60. 0%(18/30)in the education group,indicating the statistical significance(P<0. 01,P<0. 05).ConclusionOn the base of health education,either the catgut embedding therapy or electroacupuncture of Jin's three-needle treatment achieves the positive regulation on the abnormal lipid metabolism and insulin resistance. The hypoglycemic effect and the improving effect in LDL-C and HDL-C of the catgut embedding therapy are superior to electroacupuncture.关键词：Jin's three-needle;Hyperlipidemia;Catgut embedding;Eletroacupuncture;Turbid phlegm ob-struction624|559|0更新时间：2023-08-10
- 摘要：Compared with acupuncture research,moxibustion research has made slow progress with great obstacles. With randomized controlled trials as the widely accepted gold standard for the evaluation of clinical effect,moxibustion therapy is facing a great challenge:how to establish a reasonable placebo control group. This article reviewed the current application of placebo moxibustion,analyzed the difficulties in setting up placebo moxibustion,and explored corresponding solutions,in order to attract more attention to moxibustion therapy among traditional Chinese medicine practitioners.关键词：Placebo moxibustion;Controlled setting;Necessity;Moxibustion therapy637|396|2更新时间：2023-08-10
- 摘要：ObjectiveTo collect literatures on the application of neural tracing technique in experimental acupuncture research,and summarize its application status in acupoints,meridians and Zang-fu organs.Methods collected papers published from databases of CNKI(1979—2017),Wan-Fang(1990—2017),VIP(1989—2017)and PubMed(1997—2017)by using keywords of"neural tracing technique""neuroanatomic tracing""neural tracers"and"acupuncture""electroacupuncture""auricular acupuncture""eye acupuncture""meridians""acupuncture points""acupoint injection",and made a summary about the current state of application of neural tracing technique in the fields A total of 94 articles were collected,the most commonly used neural tracers were horseradish peroxidase and cholera toxin subunit B. The experimental animals used were rat,rabbit,cat,monkey,etc.,and injection site was acupoint. After the injection of neural tracers,the survival time of animals was range from 1 day to 12 weeks,and the labelled tissues included neurons and nerve fibers of the sensory,motor,and autonomic systems. The outcomes of neural labeling mainly revealed the segmental pattern,neuroanatomical connection(neural pathways/circuits)and chemical features(shown by immunohistochemical staining)of neurons and nerve fibers innervating both the acupoints and visceral organs,suggesting their involvement in the effect of acupuncture and moxibustion treatment.ConclusionThis application of neural tracing technology help us understand the underlying mechanisms of acupuncture and moxibustion interventions from different perspectives of neural pathways/circuits and related chemical properties,which also lays a greater role for this technology in future experimental acupuncture research.关键词：Neural tracing technique;Acupuncture-moxibustion;Acupoint;Visceral organs;Neuroanatomy;Neural pathway/circuit697|803|6更新时间：2023-08-10
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