最新刊期
卷 45 ， 期 5 ， 2020
- 摘要：The situation of Corona Virus Disease 2019(COVID-19) is still severe at present. In order to better fight against the epidemic and give full play to the advantages of traditional Chinese medicine, we explored the feasibility of acupuncture therapy in the intervention of COVID-19 through analyzing the relevant literature in both ancient and modern time. Additionally, we analyzed the intervention scheme of acupuncture for COVID-19 developed by China Association of Acupuncture and Moxibustion and supplemented the protocol of the intervention with auricular acupuncture. It was proposed that the advantages of acupuncture and moxibustion should be fully displayed while Chinese herbal medications have been applied in the treatment of COVID-19. During treatment, acupuncture physicians should be rationally allocated to a certain proportion so as to adequately utilize comprehensive therapeutic approaches and guarantee people's safety to the greatest extent. Eventually, the clinical therapeutic effect may be improved, the national resources be economized on and the COVID-19 epidemic be conquered early.关键词：Corona Virus Disease 2019(COVID-19);Acupuncture therapy;Feasibility;Application scheme482|2067|3更新时间：2023-08-11
- 摘要：Objective To explore the effect of γ-aminobutyric acid(GABA)ergic neuronal circuit of the central amygdaloid nucleus(CeA) and the paraventricular nucleus of hypothalamus(PVN) on electroacupuncture(EA)-induced regulation of gastric function by way of CeA-PVN projection. Methods The present study included 3 parts: 1) C57 BL/6 mice were randomly divided into control and EA groups(n=6 in each group). EA was applied to right "Weishu"(BL21, Back-shu point) and "Zhongwan"(CV12, Front-mu point) for 20 min, followed by detecting the expression of c-fos in the CeA and PVN by using immunofluorescence staining; 2) Microinjection of anterograde tracer(rAAV-EF1α-DIO-mcherry-WPRE-pA) into the CeA was conducted in GAD2-Cre mice for confirming the projection of GABAergic neurons from CeA to PVN; 3) GAD2-Cre mice were randomly divided into rAAV-DIO-mcherry(intra-CeA injection of rAAV-EF1α-DIO-mcherry-WPRE-pA), rAAV-DIO-hM3 D(Gq)-mcherry(intra-CeA injection of rAAV-EF1α-DIO-hM3 D(Gq)-mcherry-WPRE-pA) and rAAV-DIO-hM3 D(Gq)-mcherry+EA groups(n=6 in each group). The food intake and gastric empty were detected, and the concentration of GABA in the PVN was assayed by using high performance liquid chromatography on the 28(th) day after intra-CeA injection. Results 1) The expression of c-fos in the CeA and PVN was significantly increased in the EA group relevant to the control group(P<0.01), suggesting an activation of neurons in both CeA and PVN after EA. 2) Following CeA injection of rAAV-EF1α-DIO-mcherry-WPRE-pA, the densely expressed virus GABAergic neurons were found in CeA and large number of projection fibers found in the PVN, suggesting a direct connection between CeA and PVN. 3) After activating the GABAergic neurons of CeA, the concentration of GABA in the PVN was obviously increased(P<0.01), the food intake and the gastric empty were considerably decreased relevant to the rAAV-DIO-mcherry group(P<0.01). Following EA intervention,the concentration of GABA in the PVN was obviously decreased(P<0.01), the food intake and the gastric empty were significantly increased relevant to the rAAV-DIO-hM3 D(Gq)-mcherry group(P<0.01). Conclusion EA of BL21 and CV12(Back-shu and Front-mu acupoints) can increase food intake and gastric empty in GAD2-Cre mice, which may be achieved by suppressing the release of GABA in PVN through CeA-PVN GABAergic neural circuit.关键词：Electroacupuncture;Gastric function;Central amygdaloid nucleus;Paraventricular nucleus of hypothalamus;Virus tracing technique;Chemical genetic technique270|807|8更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) on intestinal epithelial mucosal barrier function in diarrhea-predominant irritable bowel syndrome(IBS-D) rats, so as to explore its mechanisms underlying improvement of IBS-D.Methods Forty SD rats(half male and half female) were randomly divided into control, model, EA and medication(Pinaverium Bromide, PB) groups, with 10 rats in each group. The IBS-D model was established by chronic unpredictable mild stress combined with gavage of Senna-leaf solution. EA(2 Hz/15 Hz,0.1-1 mA) was applied to unilateral "Zusanli"(ST36),"Tianshu"(ST25), "Sanyinjiao"(SP6) and "Taichong"(LR3) alternatively for 15 min, once daily for 14 days. Rats of the medication group was treated by gavage of PB(10 mL·kg(-1)·d(-1)·d(-1)) for 14 days. The visceral sensitivity(pain) was assessed by using the pressure threshold which the inserted rectal balloon catheter air-inflation(connected to a blood pressure gauge) induced stronger abdominal muscular contraction to force the rat's abdomen to lift the experimental stand surface. The diarrhea index was used to evaluate loose stool grade. The expression of Claudin-1 and Occludin(intestinal epithelial tight junction proteins) of colon tissue was detected by immunohistochemistry. The activity of plasma diamine oxidase(DAO) was assayed by using spectrophotometry.Results Compared with the control group, the diarrhea index and plasma DAO activity in the model group were significantly increased(P<0.01), while the visceral pain threshold, expression of Claudin-1 and Occludin in the model group were significantly decreased(P<0.01). After the treatment, the diarrhea index and plasma DAO activity were significantly lower in both EA and medication groups than that in the model group(P<0.01), and the visceral pain threshold and expression levels of Claudin-1 and Occludin were obviously increased(P<0.05, P<0.01). No significant differences were found between the EA and medication groups in all the above-mentioned indexes(P>0.05).Conclusion Electroacupuncture can significantly improve abdominal pain and diarrhea in IBS-D model rats, which may be closely associated with its effects in up-regulating the expression of intestinal epithelial tight junction proteins Claudin-1 and Occludin to restore the function of intestinal epithelial mucosal barrier.关键词：Electroacupuncture;Diarrhea-predominant irritable bowel syndrome;Mucosal barrier;Diarrhea index;Claudin-1;Occludin;Diamine oxidase275|893|15更新时间：2023-08-11
- 摘要：Objective To investigate the protein expression of CC chemokine ligand 1(CCL1) and CC chemokine receptor 8(CCR8) in the lung tissue of rats and the mechanism of acupuncture and moxibustion at "Feishu"(BL13), "Dazhui"(GV14) and "Fengmen"(BL12) in the treatment of asthma. Methods Sprague-Dawley rats were randomly divided into blank, model, acupuncture and moxibustion groups,n=10 in each group. Ovalbumin sensitization via intraperitoneal injection was performed to establish a model of asthma. The rats in the acupuncture group and the moxibustion group were given acupuncture for 20 min or circling moxibustion for 10 min at BL13, GV14 and BL12, once a day for 7 days. H.E. staining was used to observe the morphological changes of lung tissue. Real-time fluorescence quantitative PCR was used to measure the mRNA expression of signal transducer and activator of transcription 6(STAT6) in lung tissue and immunohistochemistry was used to measure the protein expression of CCL1 and CCR8 in lung tissue. Results H.E. staining showed that the rats in the blank group had regular bronchial lumens and alveolar arrangement, with no inflammatory cell infiltration and aggregation around the bronchi; the rats in the model group had the infiltration and aggregation of a large number of inflammatory cells around the bronchi, stenosis of bronchial lumens, wall thickening, and alveolar structural disorder; compared with the model group, the acupuncture group and the moxibustion group had lower degrees of inflammatory cell infiltration and aggregation around the bronchi, stenosis of bronchial lumens, and wall thickening, as well as regular alveolar arrangement. The model group had significantly higher protein expression of CCL1 and CCR8 and mRNA expression of STAT6 than the blank group(P<0.05), and the acupuncture group and the moxibustion group had significantly lower protein expression of CCL1 and CCR8 and mRNA expression of STAT6(P<0.05). Conclusion Acupuncture and moxibustion can intervene against airway inflammation by inhibiting the protein expression of CCL1 and CCR8 and STAT6 signal transduction in lung tissue, which may be one of the mechanisms of acupuncture and moxibustion in the treatment of asthma.关键词：Asthma;Acupuncture;Moxibustion;Airway inflammation;CC chemokine ligand 1;CC chemokine receptor 8;Signal transducer and activator of transcription 6305|649|5更新时间：2023-08-11
- 摘要：Objective To investigate the effect of electroacupuncture stimulation at "Zusanli"(ST36) and "Kunlun"(BL60) on the morphological changes of the spinal dorsal horn and the expression of p38 mitogen-activated protein kinase(p38 MAPK) in the injured spinal cord of rats with neuropathic pain. Methods Male Sprague-Dawley rats were randomly divided into sham model group, model group, electroacupuncture group, and medication group, with 10 rats in each group. Spinal nerve ligation of the L5 lumbar vertebra was performed to establish a rat model of neuropathic pain. The rats in the electroacupuncture group were given electroacupuncture at ST36 and BL60 of the operation side with dilatational wave at a frequency of 2 Hz/100 Hz and an intensity of 1.5 mA once a day, 30 minutes each time, and those in the medication group were given intraperitoneal injection of 100 mg/mL Gabapentin solution(100 mg/kg) once a day; the one-week intervention was started at one week after surgery. Mechanical withdraw threshold(MWT) and thermal withdrawal latency(TWL) were observed and recorded before modeling and on days 1,3,5,7,10,12 and 14 after modeling, and the motor function of the affected hindlimb was scored. Methenamine silver stain was used to observe the morphological changes of the spinal dorsal horn, and Western blot was used to measure the relative protein expression of p38 MAPK and phospho-p38 MAPK(p-p38 MAPK) in L4—L6 spinal segments. Results Compared with the sham model group, the model group had significant reductions in MWT and TWL at each time point(P<0.001) and a significant increase in motor function score(P<0.001); compared with the model group, the electroacupuncture group and the medication group had significant increases in MWT and TWL and a significant reduction in motor function score after treatment(P<0.05). The model group had obvious neuronal fibrillary tangles, particle vacuolar degeneration, and vacuoles containing argyrophilic grains in the cytoplasm of neural cells under a light microscope, while there were fewer neuronal fibrillary tangles in the electroacupuncture group and reduced vacuolar degeneration in the medication group. Compared with the sham model group, the model group had significant increases in the protein expression of p-p38 MAPK in the spinal dorsal horn(P<0.001), and compared with the model group, the electroacupuncture group and the medication group had significant reductions in the protein expression of p-p38 MAPK in the spinal dorsal horn(P<0.05). Conclusion Electroacupuncture stimulation at ST36 and BL60 can increase pain threshold, improve the motor function of the affected hindlimb, and improve the necrosis of neurofibrils in the spinal dorsal horn in rats with neuropathic pain, possibly by regulating the expression of p-p38 MAPK in the spinal dorsal horn.关键词：Electroacupuncture;Neuropathic pain;p38 mitogen-activated protein kinase;Neurofibril255|433|6更新时间：2023-08-11
- 摘要：Objective To compare the therapeutic effects of "Bangci"(focal center-side needling) and encircling needling in promoting skin wound healing and local blood perfusion in diabetic mice.Methods Thirty-two male C57 BL/6 N mice were randomized into normal, diabetic model, focal center-side needling and encircling needling groups(n=8 in each group). The skin wound model was prepared by cutting a piece of full-thickness skin at the mouse's back by using a puncher. One hour after modeling, two acupuncture needles were respectively inserted into the center of the wound and the spot at the normal skin about 0.5 cm away from the edge of the wound for mice of the focal center-side needling group, followed by EA(0.5 mA, 0.5 Hz) for 30 min. For mice of the encircling needling group, 4 acupuncture needles were respectively inserted into the upper, lower, left and right normal marginal skin around the wound, followed by EA stimulation with the same parameters as those of the center-side needling group. The wound conditions, diameter and area of the wound were monitored, and the wound blood perfusion volume was measured by using a laser speckle flowmeter. Results The wound shrinkage rates were significantly higher at the time-points of 3, 5, 7, 9 and 11 d after modeling in both focal center-side needling and encircling needling groups than in the model group(P<0.05), and on day 3, 5, 7 and 9 in the encircling needling group than in the focal center-side needling group(P<0.05). The wound healing time was obviously earlier in both focal center-side needling and encircling needling groups than in the model group(P<0.05), and in the encircling needling group than in the focal center-side needling group(P<0.05). Following modeling, the volume of wound blood perfusion was considerably higher from day 1 to 9 and markedly lower on day 11 in the model group than in the normal group(P<0.01), and after the intervention, the blood perfusion volume was considerably decreased on day 3, 5, 7 and 9 in both the focal center-side needling and encircling needling groups(P<0.05, P<0.01), and obviously increased on day 11 in the encircling needling group relevant to the model group(P<0.01).Comparison between post-and pre-EA stimulation showed that the immediate blood perfusion volume was significantly increased from day 1 to 11 after EA stimulation in both the focal center-side needling and encircling needling groups(P<0.01, P<0.05). The therapeutic effect of the encircling needling group was significantly superior to that of the focal center-side needling group in lowering blood perfusion volume from day 3 to 7, and in increasing blood perfusion volume on day 9 and 11(P<0.01). Under the naked eyes, the conditions of exudation and inflammatory reaction, and the scar and granulation tissue were relatively milder and better respectively in both the center-side needling and encircling needling groups than in the model group.Conclusion Both focal center-side needling and encircling needling can promote the skin wound healing by increasing the blood perfusion in diabetic mice, and the therapeutic effect of the encircling needling method was significantly superior to that of the focal center-side needling method.关键词：Skin wound;Acupuncture;Focal center-side needling;Encircling needling;Diabetes;Wound healing;Blood perfusion volume278|645|1更新时间：2023-08-11
- 摘要：Objective To investigate the effect of acupuncture on serum inflammatory cytokines and intestinal flora in rats with stress-induced gastric ulcer(SGU), and to explore the mechanism of acupuncture in the treatment of SGU. Methods Sprague-Dawley rats were randomly divided into blank, model, acupuncture, and medication groups, with 7 rats in each group. Restraint water-immersion stress was used to establish the model of SGU. The rats in the acupuncture group were given acupuncture at "Zhongwan"(CV12) and bilateral "Zusanli"(ST36) for 20 min, once a day for 5 days, and those in the medication group were given 2 mL solution of Omeprazole enteric-coated tablets(0.2 mg/kg) by gavage, once a day for 5 days. The Guth method was used to calculate the gastric mucosa damage index, HE staining was used to observe the histopathological changes of the gastric mucosa, ELISA was used to measure the serum levels of interleukin-4(IL-4) and interleukin-6(IL-6), and 16 S rDNA sequencing method was used to observe the change in intestinal flora. Results Compared with the blank group, the model group had a significant increase in gastric mucosa damage index(P<0.01), markedly pathological changes of the gastric mucosa shown by HE staining, a significant reduction in the content of serum IL-4(P<0.01), and a significant increase in the content of serum IL-6(P<0.01), as well as a significant reduction in Bacteroidetes and Firmicutes at the phylum level. Compared with the model group, the acupuncture group and the medication group had a significant reduction in gastric mucosa damage index(P<0.01, P<0.05). HE staining showed reduced pathological changes of the gastric mucosa, as well as a significant increase in the content of serum IL-4(P<0.01, P<0.05) and a significant reduction in the content of serum IL-6(P<0.01, P<0.05). As for the intestinal flora, there was a significant increase in Bacteroidetes. Compared with the medication group, the gastric mucosa damage index was decreased(P<0.05),the content of serum IL-4 was significantly increased(P<0.05), while the content of serum IL-6 significantly decreased(P<0.05) in the acupuncture group. Conclusion Acupuncture at CV12 and ST36 can down-regulate the content of serum IL-6, up-regulate the content of serum IL-4, maintain the relative homeostasis of inflammatory cytokines, and regulate the community structure of intestinal flora, and thus help to repair the damage of gastric mucosa.关键词：Stress-induced gastric ulcer;Acupuncture;Interleukin;Intestinal flora260|895|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupoint catgut embedding on histopathological changes of gastric mucosa and expression of mucosal hypoxia inducible factor(HIF)-1α and vascular endothelial growth factor(VEGF) proteins in chronic atrophic gastritis(CAG) rats, so as to explore its mechanisms underlying improvement of CAG.Methods Male SD rats were divided into blank group(n=10) and model group(n=9) and catgut embedment group(n=10). The CAG model was established by free drinking of N-methyl-N'-nitro-N-nitroso-guanidine solution(100 μg/mL) and irregular diet. Catgut embedment was applied to "Zhongwan"(CV12) and bilateral "Zusanli"(ST36) and "Pishu"(BL20), once every 10 days, 6 times in total. Histopathological changes of gastric mucosal tissue were observed under microscope after H.E. staining. The expression of HIF-1α and VEGF proteins in the antrum of stomach was detected by Western blot.Results H.E. staining showed that compared with the blank group, the number of rats with glandular necrosis, atrophy and mucosal stasis in the model group were increased significantly(P<0.001, P<0.05).Compared with the model group, the number of rats with gland necrosis, atrophy and mucosal stasis in the catgut embedment group were significantly reduced(P<0.01, P<0.05). Western blot displayed that the expression levels of HIF-1α and VEGF proteins were significantly higher in rats with blood stasis and model group than in those without blood stasis and the blank group(P<0.01), and were considerably down-regulated in the catgut embedment group than in the model group(P<0.05, P<0.01).Conclusion Acupoint catgut embedment can improve the injury of gastric mucosa in CAG rats, which may be associated with its function in down-regulating the expression of HIF-1α and VEGF proteins in the gastric mucosa.关键词：Acupoint catgut embedding;Chronic atrophic gastritis;Gastro-mucosal blood stasis;Hypoxia inducible factor-1α;Vascular endothelial growth factor295|544|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) pretreatment at "Neiguan"(PC6) on expression profiles of myocardial long non-coding RNAs(LncRNAs) and mRNAs in myocardial ischemia-reperfusion injury(MIRI) mice, so as to explore its mechanisms underlying prevention of MIRI via regulating LncRNA expression.Methods C57 BL/6 mice were randomly divided into sham, model, and EA groups(n =4 in each group). The MIRI model was established by occlusion of the anterior descending branch(ADB) of the left coronary artery for 30 min, followed by reperfusion for 24 h. In the sham group, the ADB was only threaded beneath the artery without ligation. EA was applied to bilateral PC6 for 30 min prior to ischemia induction. Surgery was performed within 30 min at the end of EA stimulation. The expression profiles of differentially expressed LncRNAs and mRNAs in the left ventricular myocardium were analyzed by using LncRNA microarray. Results There was a significant diffe-rence in the expression pattern of LncRNAs and mRNAs among the sham, model and EA groups. A total of 1 693 LncRNAs and 2 858 mRNAs between the model and sham groups, and 3 859 LncRNAs and 1 343 mRNAs between the EA and model groups were identified to be differentially expressed candidates. According to Venn intersection analysis, LncRNAs with opposite regulative orientations in the model and EA groups were screened and defined as EA-related LncRNAs. LncRNA-mRNA co-expression analysis and Gene Ontology enrichment analysis of the EA-related LncRNAs predicted their roles to regulating post-traumatic stress and repairing of myocardial cells. Meanwhile, the proteins' function encoded by EA-related mRNAs mainly involved post-traumatic stress and inflammatory regulation.Conclusion EA pretreatment at PC6 acupoint can produce extensive regulation on myocardial LncRNAs and mRNAs in MIRI mice, suggesting an involvement of LncRNAs in EA pretreatment induced improvement of MIRI. These results may provide direction and molecular basis for subsequent in-depth studies to reveal the underlying mechanisms of EA pretreatment for MIRI.关键词：Electroacupuncture;Neiguan(PC6);Long non-coding RNAs;Myocardial ischemia-reperfusion injury272|444|4更新时间：2023-08-11
- 摘要：Objective To observe the impact of moxa-stick with different diameters and at different distances on skin temperature in local "Zusanli"(ST36) region, so as to select suitable specifications for moxibustion. Methods A total of 120 male SD rats were randomly divided into diameters of 0.5, 0.9, 1.2 and 1.8 cm, and distances of 1, 2, 3, 4 and 5 cm groups, with 6 rats in each group. Moxa-stick with different diameters mentioned above was applied to the right ST36(right hind limb) for 10 min every time at different distances(between the ignited moxa-stick tip and the skin) mentioned above, and the left ST36 was used as the control point. The skin temperature was detected by using an infrared thermometer. Results After application of moxibustion to ST36 region, the skin temperature was increased gradually along with the increased diameter of moxa-sticks and decreased along with the increased distance from the ignited moxa-stick tip to the skin. There were no significant changes in the skin temperature of the left control acupoint ST36. The skin temperature was below 40 ℃, between 43 to 55 ℃, over 43℃ and between 43 to 61 ℃, when the moxa-stick was 0.5 cm, 0.9 cm, 1.2 cm and 1.8 cm in diameter, and was kept 1, 2, 3 and 3 to 5 cm away from the skin surface, respectively. When the moxa-stick with a diameter of 1.8 cm was kept at a distance of 1 to 2 cm, the skin temperature reached 71 to 93 ℃ to cause obvious local burn lesion. Conclusion During moxibustion, the ignited moxa-sticks with diameters of 0.5, 0.9, 1.2 and 1.8 cm are suitable to be kept less than 1, 1 to 2, 2 to 3, and 3 to 5 cm away from the skin surface of ST36, respectively.关键词：Moxibustion;Skin temperature;Moxibustion distance;Moxa stick size;Zusanli(ST36)288|645|8更新时间：2023-08-11
- 摘要：Objective To investigate the clinical effect of electroacupuncture at Baihui(GV20) and Shuigou(GV26) points in the treatment of brain injury in patients with sepsis-associated encephalopathy(SAE). Methods A total of 70 patients with SAE were randomly divided into control group and treatment group, with 35 patients in each group. The patients in the control group were given routine western medicine treatment, including anti-infective therapy, nerve nutrition, and mechanical ventilation, and those in the treatment group were given electroacupuncture at GV20 and GV26 in addition to the treatment in the control group. The course of treatment was 1 week for both groups. Serum levels of C-reactive protein(CRP), interleukin-6(IL-6), and neuron-specific enolase(NSE) were measured for both groups, the Montreal Cognitive Assessment(MoCA) scale was used to assess the change in cognitive function, and Glasgow Coma Scale(GCS) score was determined before and after treatment and was used to evaluate treatment outcome after treatment. Results Both groups had significant reductions in the serum levels of CRP, IL-6, and NSE after 24 h and one week of treatment(P<0.05), and compared with the control group, the treatment group had significant reductions in the levels of CRP, IL-6 and NSE after treatment(P<0.05). The treatment group had significant increases in the total score of MoCA and the scores of all dimensions except attention after one week of treatment(P<0.05), and the treatment group had significantly higher scores than the control group after treatment(P<0.05). Both groups had a significant increase in GCS score after one week of treatment(P<0.05), and the treatment group had a significantly higher GCS score than the control group after treatment(P<0.05). The treatment group had a significantly higher total effective rate than the control group [88.6%(31/35) vs 57.1%(20/35), P<0.05]. Conclusion Electroacupuncture at GV20 and GV26 can effectively improve brain injury and effective rate in SAE patients.关键词：Sepsis-associated encephalopathy;Electroacupuncture;Montreal cognitive assessment;Glasgow coma scale279|393|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupuncture plus hyperbaric oxygen(HBO) on cerebral blood perfusion in patients with delayed encephalopathy after carbon monoxide poisoning(DEACMP).Methods Twenty-eight patients with DEACMP were randomly divided into acupuncture group(n=14 cases) and control group(n=14 cases). Patients of the acupuncture group were treated by using "Xingnao Kaiqiao" needling technique(specific set of acupuncture points as Yintang [EX-HN3], Shangxing [GV23], Baihui [GV20], Sishenchong [EX-HN1], Fengchi [GB20], Taichong [LR3], etc., and strong stimulation) combined with HBO in an air pressurized tank, and those of the control group treated by simple HBO. The treatment was conducted once a day, 5 days a week for 6 weeks. All the patients underwent head routine magnetic resonance imaging(MRI) and intravoxel incoherent motion imaging(IVIM) scan before and after the treatment. The values of pseudo-diffusion coefficient D(D*) and perfusion fraction(f) of the bilateral semi-oval centers were measured by using MITK software package to calculate the ave-rage fD*) and perfusion fraction(f) of the bilateral semi-oval centers were measured by using MITK software package to calculate the ave-rage fD* value(f×D* value(f×D*). The Barthel index(BI) score was used to assess the patients' daily living ability, and the correlation between parameter values was evaluated by Pearson method.Results After the treatment, the values of f, fD*). The Barthel index(BI) score was used to assess the patients' daily living ability, and the correlation between parameter values was evaluated by Pearson method.Results After the treatment, the values of f, fD* and BI scores were significantly increased in both acupuncture group and control groups(P<0.05). The values of the 3 indexes were significantly higher in the acupuncture group than those in the control group(P<0.05). The values of f and fD* and BI scores were significantly increased in both acupuncture group and control groups(P<0.05). The values of the 3 indexes were significantly higher in the acupuncture group than those in the control group(P<0.05). The values of f and fD* were positively correlated with BI score(P<0.05), with the correlation coefficients being 0.822, 0.636 and 0.601, respectively between the fD* were positively correlated with BI score(P<0.05), with the correlation coefficients being 0.822, 0.636 and 0.601, respectively between the fD* and f, BI and f, and BI and fD* and f, BI and f, and BI and fD*. Conclusion Acupuncture combined with HBO can significantly improve the low-perfusion of bilate-ral semi-oval center and daily living ability in patients with DEACMP, being significantly superior to simple HBO therapy in the curative effect.关键词：Carbon monoxide intoxication;Delayed encephalopathy;"Xingnao Kaiqiao" needling technique;Hyperbaric oxygen;Intravoxel incoherent motion imaging204|206|2更新时间：2023-08-11
- 摘要：Objective To explore the value of nerve trunk stimulation in the rehabilitation of lower limb function in the patients with cerebral apoplexy at convalescence stage. Methods According the random number table, the patients with the lower limb dysfunction of cerebral apoplexy at convalescence stage were divided into a control group and a treatment group, 42 cases in each group. The drug therapy and the routine rehabilitation training were provided in the two groups. Additionally, in the treatment group, the nerve trunk stimulation therapy was adopted, in which, Chize(LU5,stimulating point of radial nerve), Neiguan(PC6, stimulating point of median nerve), Xiaohai(SI8, stimulating point of ulnar nerve) were selected. In the control group, acupuncture intervention was supplemented. Before and after treatment, the peak torque(PT) of the lower flexor-extensor muscle of the knee joint, gait parameters,the score of the modified Ashworth spasm scale(MAS), the score of Fugl-Meyer motor assessment(FMA) and the score of Fugl-Meyer balance scale(FBS) were recorded. Results After the treatment, the PT of the lower flexor-extensor muscle of the knee joint,the scores of FMA and FBS,the step speed and frequency were all increased, the score of MAS and the difference in the stride between the left and the right were decreased as compared with those before treatment(P<0.01). After the treatment, The PT of the lower flexor-extensor muscle of the knee joint,the scores of FMA and FBS,the step speed and frequency in the treatment group were higher than those in the control group(P<0.01). The score of MAS and the difference in the stride between the left and the right in the treatment group were lower than those in the control group(P<0.01). Conclusion Nerve trunk stimulation therapy quite effectively increases the muscle strength and relieves the muscle tension as well as improves the motor function, the balance and the walking pattern of the lower limbs. This therapy is significantly valuable in the rehabilitation of the lower limbs in the patients with cerebral apoplexy at convalescence stage.关键词：Nerve trunk stimulation therapy;Acupuncture-moxibustion;Cerebral apoplexy at convalescence stage;Lower limb function269|553|2更新时间：2023-08-11
- 摘要：Objective To explore the anatomical structure of acupuncture point Qiuhou(EX-HN7) area for safe insertion of acupuncture needle. Methods A total of 28 orbital specimens of adult corpses(14 men and 14 women) were randomly selected to be observed by anatomical sectioning and layering methods. The acupoint EX-HN7, located at the junction between the 1/4 of the outer boundary and 3/4 of the inner boundary of the infraorbital margin according to the "Standardization of Acupoint Position" implemented by the People's Republic of China, and marked first with a color pen, followed by cutting the head into horizontal sections along the cross line by using a cadaver cutter and measuring the distance between the skin and blood vessels and main nerves with a digimatic caliper. When the anatomic hierarchy was performed, the blood vessels and nerves in the orbit, the morphological characteristics of the structure around the needle body were particularly focused. Results When an acupuncture needle was vertically inserted into EX-HN7 region, the tissues through which the needle passes are skin, subcutaneous tissue, orbicularis muscle, orbital adipose body, inferior oblique muscle and inferior orbital wall, respectively. When an acupuncture needle was inserted obliquely upward and along the inferior orbital wall to a depth of(26.5±1.7)mm, the needle tip met the posterior ciliary artery; when to a depth of(41.4±1.3)mm, it reached the superior ophthalmic vein. When inserted to a depth of(40.4±1.5)mm, the needle tip may damage the ophthalmic artery and optic nerve. When the acupuncture needle was inserted inferiorly and closely along the orbital inferior wall to a depth of(13.2±1.4)mm, the infraorbital artery in the suborbital sulcus would be hurt. Conclusion It is recommended that when insert vertically into a depth of 12.0 mm in EX-HN7, the acupuncture needle tip should be slightly inclined inward and posterior-upward, and the depth should not exceed 26.0 mm.关键词：Qiuhou(EX-HN7);Acupuncture needle insertion;Needling depth;Needling direction204|249|5更新时间：2023-08-11
- 摘要：Objective To systematically evaluate the clinical effect and safety of acupuncture in the treatment of cardiac neurosis. Methods Chinese databases(including SinoMed, VIP, CNKI, and Wanfang Data) and English databases(including PubMed and The Cochrane Library) were searched for randomized controlled trials(RCTs) on acupuncture in the treatment of cardiac neurosis published up to March 2019. Two reviewers independently screened the literature, extracted data, and assessed the risk of bias of included studies, and then RevMan 5.3 was used to perform a meta-analysis. Results A total of 7 RCTs were included, with 491 patients with cardiac neurosis. The results of the meta-analysis showed that compared with the conventional western medicine group, the acupuncture group had a significantly higher total effective rate(risk ratio [RR]=1.16, 95% CI[1.05,1.28], P=0.005) and had significantly greater improvements in Hamilton Anxiety Scale score(mean difference [MD]=-3.22, 95% CI[-6.05,-0.39], P=0.03). There were no significant differences between the two groups in Hamilton Depression Scale score(MD=-1.92, 95% CI[-4.76,-0.91], P=0.18),traditional Chinese medicine symptom score(MD=-5.49, 95% CI[-11.55, 0.56], P=0.08), somatization symptom score(MD=-0.91, 95% CI[-3.28, 1.46], P=0.45), and adverse reactions(RR=0.67, 95% CI[0.26,1.78], P=0.42). Conclusion Acupuncture can alleviate the symptoms and is safe in the treatment of cardiac neurosis.关键词：Acupuncture;Cardiac neurosis;Meta-analysis;Systematic review;Randomized controlled trial289|1062|0更新时间：2023-08-11
- 摘要：Alzheimer's disease(AD), a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary degeneration, is the most common type of dementia and has no incurable therapies at the moment. Electroacupuncture(EA) therapy has been widely used in clinical treatment of AD, and has attained approving effects. This article reviews the development of researches on the mechanisms of EA underlying improving AD by diminishing β amyloid protein(Aβ) neurotoxicity, from 1) up-regulating hippocampal cellular autophagy, 2) improving cerebral energy metabolism by activating oxidation stress-related factors peroxisome proliferator-activated receptor γ coactivator 1 alpha and sirtuin 1 in the hippocampus and frontal cerebral cortex, 3) relieving inflammatory reaction by lowering expression of tumor necrosis factor-alpha and high-mobility group box 1 and increasing expression of Interleukin 10, and 4) promoting degradation of Aβ_(1-42) by down-regulating expression of insulin degeneration enzyme, lipoprotein, transthyretin, apolipoprotein and α2 mcroglobulin. Meanwhile, a comprehensive clinical therapy of AD is proposed.关键词：Electroacupuncture;Alzheimer's disease;β amyloid protein;Mechanism research248|713|2更新时间：2023-08-11
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