最新刊期
卷 45 ， 期 7 ， 2020
- 摘要：Objective To observe the effect of electroacupuncture(EA) on the expression of cAMP-response element binding protein(CREB, a key protein for BDNF-TrkB signaling) and it's blinding ability to synaptic key protein in the amygdala and hippocampus of rats with post-traumatic stress disorder(PTSD), so as to lay a foundation for further study of the interaction mechanism between BDNF-TrkB signaling and synaptic plasticity. Methods Twenty-four male SD rats were randomly divided into blank, model and electroacupuncture(EA) groups, with 8 rats in each group. The PTSD model was established by psychological stress(bondage) and physiological stress(forced swimming and anesthesia). After modeling, EA(2 Hz/100 Hz, 1 mA) was applied to "Baihui"(GV20) "Shenting"(GB24) and bilateral "Shenshu"(BL23) for 20 min, once daily for 21 days. The behavioral changes(spontaneous locomotor within 30 min and contextual fear conditioning tests in 7 days) were detected by using a spontaneous locomotor detection box, and a conditioned fear response test chamber, respectively. The expression of CREB was detected by immunohistochemistry and Western blot, separately. The binding abilities of CREB to synaptic proteins(post synaptic density 95 [PSD95], synaptophysin [SYN] and growth-associated protein 43 [GAP43]) were verified by chromatin-immunoprecipitation(CHIP) technique. Results After modeling, the spontaneous locomotor distance, the expression levels of CREB and the binding ability of CREB to PSD95 protein in the amygdala and hippocampus were significantly decreased(P<0.01), and the percentage of freezing time significantly increased in the model group relevant to the blank group(P<0.01). Following the intervention, the spontaneous locomotor distance, and the expression levels of CREB and the binding ability of CREB to PSD95 protein were considerably increased in the EA group relevant to the model group(P<0.05,P<0.01). No significant changes were found in the binding abilities of CREB to SYN and GAP43 after modeling and after EA intervention(P>0.05). Conclusion EA can improve the motor activity in PTSD rats, which may be associated with its effect in increasing the binding ability of CREB to the synaptic key protein PSD95 to regulate the interaction between the synaptic plasticity and BDNF-TrkB signaling pathway of the amygdala and hippocampus.关键词：Electroacupuncture;Post-traumatic stress disorder;Amygdala;Hippocampus;cAMP-response element binding protein(CREB);Binding ability257|570|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture on the expression of phosphorylated adenosine 5'-monophosphate-activated protein kinase(p-AMPK), phosphorylated mammalian target of rapamycin(p-mTOR) and phosphorylated Ulk1(p-Ulk1) proteins in the cortex of traumatic brain injury(TBI) rats, so as to explore its mechanisms underlying treatment of TBI. Methods Male SD rats were randomly divided into sham operation(sham), model, electroacupuncture Ⅰ(EA Ⅰ), electroacupuncture Ⅱ(EA Ⅱ) groups(n=10 in each group). TBI model was established by using a free fall brain injury striking device after exposing the local cranial bone(to induce the left parietal cerebral contusion). Rats in EA Ⅰ group were treated by electroacupuncture at "Neiguan"(SP6) and "Zusanli"(ST36) combined with acupuncture at "Shuigou"(GV26) and "Baihui"(GV20) on the 7(th)day after modeling, once a day for 7 consecutive days. Rats in EA Ⅱ group received the treatments as those in EA Ⅰ group on 24 h after modeling, once a day for 14 d. After the treatment, histopathological changes of the injured cerebral cortex were observed by HE staining and Nissl staining. Western blot was used to detect the expression of AMPK, p-AMPK, mTOR, p-mTOR, Ulk1, p-Ulk1 proteins in the injured cerebral cortex tissue. Results After modeling and compared with the sham group, a large number of tissue necrosis, scattered arrangement of nerve fibers, vacuolar changes of cells, nuclear fragmentation, consolidation and hyperplastic scar tissue were found in the brain trauma area of rats in the model group. Nissl corpuscles were obviously absent. The ratio of p-AMPK/AMPK was up-regulated in the cortex of the wound region(P<0.01), and the ratio of p-mTOR/mTOR, p-Ulk1/Ulk1 were down-regulated(P<0.01). Compared with the model group, the pathological changes in brain injury area of rats in both EA groups were alleviated, the number of Nissl corpuscles increased, the ratio of p-AMPK/AMPK was down-regulated in cortex of the injury area(P<0.01), and the ratios of p-mTOR/mTOR and p-Ulk1/Ulk1 were up-regulated(P<0.01). Compared with EA Ⅰ group, the pathological changes in the brain injury area in EA Ⅱ group showed obvious improvement, with down-regulation of p-AMPK/AMPK(P<0.05), and up-regulation of p-mTOR/mTOR and p-Ulk1/Ulk1(P<0.05). Conclusion Electroacupuncture may inhibit the over-activation of autophagy of cranial neurons by regulating the activation of AMPK, mTOR and Ulk1, thus exerting brain protection effect on TBI rats, and early electroacupuncture intervention is more effective in acute phase of TBI.关键词：Traumatic brain injury;Electroacupuncture;Autophagy;Adenosine 5'-monophosphate-activated protein kinase;Mammalian target of rapamycin;Ulk1252|395|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) and manual acupuncture(MA) on learning-memory ability, changes of ultrastructure of neurons and expression of CDK5 and Tau proteins in hippocampus of SAMP8 mice,so as to explore its mechanisms underlying improvement of Alzheimer's disease(AD).Methods A total of 45 male SAMP8 mice were randomly divided into model, EA and MA groups, with 15 mice in each group. The other 15 SAMR1 mice were used as the normal group. In the EA group, EA(2 Hz, 1 mA) was applied to bilateral "Shenshu"(BL23) and manual acupuncture was applied to "Baihui"(GV20) for 20 min. In the MA group, MA was applied to GV20 and bilateral BL23 for 20 min. Both group were treated once a day for 31 days, and with an interval of one day between every two 7 days. Morris water maze was performed to assess the animals' learning-memory ability. The morphological changes of hippocampal neurons were observed under transmission electron microscopy. The expression levels of CDK5, p25 and Tau-5 proteins in the hippocampus were detected by immunohistochemistry and Western blot, separately.Results ①Compared with the normal group, the average escape latency of Morris water maze test was prolonged in the model group(P<0.05, P<0.01), duration of swimming in the original platform quadrant and the number of original platform crossing were significantly shorter and less respectively(P<0.01). Compared with the model group, the average escape latency in the EA group was shortened(P<0.05, P <0.01), the duration of swimming in the original platform quadrant and the number of original platform crossing were significantly prolonged and increased(P<0.01); The average escape latency in the MA group was shortened(P<0.05, P <0.01),and the duration of swimming in the original platform quadrant was prolonged(P<0.05). Compared with the EA group, the average escape latency of the MA group was prolonged(P<0.05), the duration of swimming in the original platform quadrant was shortened(P<0.05). ②Transmission electron microscopy revealed that the neurons in the hippocampal CA1 area had irregular shape and vague structure, reduction in size and number of mitochondria accompanied with swelling, and malformed changes of mitochondrial crest in the model group, which was relatively milder in both EA and MA groups. ③The expression levels of hippocampal Tau-5, p25 and CDK5 proteins were significantly up-regulated in the model group in contrast to the normal group(P<0.01, P<0.05), and obviously down-regulated in both EA and MA groups relevant to the model group(P<0.05, P<0.01). Compared with the EA group, the expression levels of p25 and CDK5 proteins were significantly increased in the MA group(P<0.05). Conclusion EA of BL23 can improve the learning-memory ability in SAMP8 mice, which is associated with its effect in down-regulating the expression of hippocampal CDK5, p25 and Tau-5 proteins.关键词：Alzheimer's disease;Electroacupuncture;Learning-memory ability;Cyclin dependent kinase 5;Tau protein;Hippocampus300|433|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of moxibustion on visceral pain, diarrhea, colonic 5-hydroxytryptamine(5-HT) content, and expression of tryptophan hydroxylase 1(TPH1), serotonin reup take transporter(SERT) and 5-hydroxytryptamine receptor 3(5-HT3 R) in colon tissue of rats with diarrhea irritable bowel syndrome(IBS-D), so as to reveal its underlying mechanisms in treating IBS-D. Methods Thirty male SD rats were randomly divided into blank control, model and moxibustion groups(n=10 rats in each group). The IBS-D model was established by chronic restraint combined with gavage of Senna leaf solution. Moxibustion was applied to bilateral "Tianshu"(ST25) and "Shangjuxu"(ST37) for 30 min, once a day for 7 days. After the treatment, the loose stool rate(number of loose stool/total number of feces granules X100%) and the minimum volume threshold of abdominal reflex(abdominal pain threshold) induced by rectal dilatation were observed. The content of colonic 5-HT was detected by using ELISA, and the expression of TPH1, SERT and 5-HT3 R mRNAs and proteins were detected by using quantitative real time-PCR and Western blot, respectively. Results Compared with the blank control group, the minimum volume threshold of abdominal retraction reflex and the relative expression of SERT protein and mRNA were significantly decreased(P<0.01), and the loose stool rate, colonic 5-HT content, and relative expression of TPH1 and 5-HT3 R proteins and mRNAs were notably increased in the model group(P<0.01). After moxibustion, both the decrease of minimum volume threshold and SERT protein and mRNA expressions and the increase of loose stool rate, colonic 5-HT content and TPH1 and 5-HT3 R protein and mRNA expressions were reversed(P<0.01). Conclusion Moxibustion of ST25 and ST37 can relieve abdominal hypersensitivity and diarrhea in IBS-D model rats, which is related to its effects in down-regulating colonic 5-HT content and expression of TPH1 and 5-HT3 R proteins and mRNAs and in up-regulating expression of SERT protein and mRNA(regulating 5-HT/5-HT3 R signaling).关键词：Moxibustion;Diarrhea-type irritable bowel syndrome;Visceral hypersensitivity;Diarrhea;Colonic tissue;5-hydroxytryptamine signaling pathway295|908|6更新时间：2023-08-11
- 摘要：Objective To investigate the effect of electroacupuncture(EA) on intestinal Toll-like receptor 4(TLR4) and nuclear factor-kappa B(NF-κB) in obese rats, so as to explore the mechanism of action of acupuncture in losing weight. Me-thods A total of 50 male Wistar rats were randomly divided into control and model groups. High-fat feed was used to establish a rat model of obesity, and after modeling, the 24 rats were randomly divided into model group, TLR4 inhibitor group, and EA group, with 8 rats in each group. The rats in the EA group were given EA at "Guanyuan"(CV4), "Zhongwan "(CV12), "Zusanli"(ST36), and" Fenglong"(ST40), 10 minutes each time, 3 times a week, and those in the TLR4 inhibitor group were given intraperitoneal injection of TAK-242 three times a week; the course of treatment was 8 weeks for both groups. Body weight and blood glucose were measured every two weeks. Co-immunoprecipitation was used to observe the interaction between TLR4 and NF-κB p65 in the intestinal tissue; electrophoretic mobility shift assay was used to measure the activity of NF-κB p65; Western blot was used to measure the protein expression of TLR4, phosphorylated nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha(p-IκBα), and NF-κB p65; quantitative real-time PCR was used to measure the mRNA expression of TLR4, NF-κB p65, and IκBα. Results Compared with the control group, the model group had significant increases in body weight, blood glucose, and protein and mRNA expression of TLR4 and NF-κB p65(P<0.01, P<0.05), as well as significant enhancement in the interaction between TLR4 and NF-κB p65 and activity of NF-κB p65(P<0.05,P<0.01). Compared with the model group, the EA group had a significant reduction in body weight(P<0.05), both of the EA group and the TLR4 inhibitor group had significant reductions in blood glucose, and protein and mRNA expression of TLR4, p-IκBα, and NF-κB p65(P<0.05,P<0.01), as well as significant reductions in the activity of NF-κB p65(P<0.01). Conclusion EA can effectively regulate intestinal TLR4, inhibit the interaction between TLR4 and NF-κB p65, and reduce the activity of NF-κB p65, which may be a potential mechanism of EA in reducing body weight and blood glucose in obese rats.关键词：Obesity;Electroacupuncture;Toll-like receptor 4;Nuclear factor-kappa B;Intestinal tract275|464|2更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupoint catgut embedding on levels of prostaglandin F_(2α)(PGF_(2α)), cyclooxygenase-2(COX-2) and nuclear factor kappa B(NF-κB) in the uteruses of rats with primary dysmenorrhea(PD), so as to explore its mechanisms underlying improvement of PD. Methods Forty female SD rats were randomly divided into normal, model, acupoint catgut embedment and medication groups, with 10 rats in each group. The PD model was established by subcutaneous injection of estradiol benzoate(0.5 mg on the 1(st) day, and 0.2 mg thereafter) once daily for 10 days, followed by i.p. of oxytocin 2 U(0.5 mg·5 U(st) day, and 0.2 mg thereafter) once daily for 10 days, followed by i.p. of oxytocin 2 U(0.5 mg·5 U(-1)·mL(-1)·mL(-1)) on the 11(-1)) on the 11(th) day. Catgut embedment was applied to "Guanyuan"(CV4) and "Sanyinjiao"(SP6) on day 1 and 5 while modeling, and rats of the medication group received gavage of ibuprofen(1.25 mg/mL, 0.8 mL/rat) once daily for 10 d. The level of PGF_(2α)in the uterus tissuewas assayed by ELISA, and the expression levels of uterine COX-2, phospho(p)-NF-κB p65, NF-κB p65 proteins were detected by Western blot. Results Compared with the normal group, the levels of PGF_(2α), COX-2, p-NF-κB p65 and NF-κB p65 in the uterine tissues were significantly increased in the model group(P<0.05). Compared with the model group, the levels of PGF_(2α) and COX-2 in both catgut embedment and medication groups as well as p-NF-κB p65 in the catgut embedment group were significantly decreased(P<0.05). Compared with the medication group, the level of p-NF-κB 65 in the catgut embedment group was significantly decreased(P<0.05). Conclusion The analgesic effect of acupoint catgut embedding may be related to its effects in down-regulating the expression of p-NF-κB and the levels of COX-2 and PGF_(2α)in uteruses of PD rats.关键词：Acupoint catgut embedding;Primary dysmenorrhea;Uterine;Prostaglandin F_(2α);Cyclooxygenase-2;Nuclear factor kappa B295|589|3更新时间：2023-08-11
- 摘要：Objective To investigate the clinical effect of Tongdu Tiaoshen needling in the treatment of chronic insomnia and its mechanism based on the hypothalamic-pituitary-adrenal(HPA) axis. Methods A total of 60 patients with chronic insomnia were randomly divided into treatment group and control group, with 30 patients in each group. In addition to the health education on sleep, the patients in the treatment group were given Tongdu Tiaoshen needling, i.e., electroacupuncture at Baihui(GV20), Shenting(GV24), Yintang(EX-HN3), bilateral Shenmen(HT7), and bilateral Sanyinjiao(SP6), and those in the control group were given superficial acupuncture at Shousanli(LI10), Futu(ST32), and Feiyang(BL58) at both sides, once every other day and three times a week for 4 consecutive weeks. Before and after treatment, the Pittsburgh Sleep Quality Index(PSQI) was used to assess the quality and efficiency of sleep, and ELISA was used to measure the serum levels of corticotropin-releasing hormone(CRH), adrenocorticotropic hormone(ACTH), and corticosterone(CORT). Results After treatment, the treatment group had significant reductions in the total PSQI score and the score of each component of PSQI(P<0.01), and the control group had significant reductions in the total PSQI score(P<0.01) and the scores of all components except sleep duration(P<0.05); compared with the control group, the treatment group had significantly lower total PSQI score and the score of each component(P<0.01). After treatment, the treatment group had significant reductions in the serum levels of CRH, ACTH and CORT(P<0.05,P <0.01), and compared with the control group, the treatment group had significant reductions in the serum levels of CRH, ACTH and CORT(P<0.01,P<0.05). Conclusion Tongdu Tiaoshen needling has a good clinical effect in the treatment of chronic insomnia and can significantly improve the sleep condition of patients with chronic insomnia, possibly by reducing the hormones associated with the HPA axis.关键词：Chronic insomnia;Acupuncture;Hypothalamic-pituitary-adrenal axis;Randomized controlled trial307|1316|9更新时间：2023-08-11
- 摘要：Objective To study the position and hierarchical structure of Five-shu points, i.e., "Guanchong"(TE1), "Yemen"(TE2), "Zhongzhu"(TE3), "Yangchi"(TE4) and "Zhigou"(TE6), and the Source-point "Tianjing"(TE10) of the Triple Energizer(TE) Meridian in the rabbit. Methods Based on WHO Standard Acupuncture Point Locations in the Western Pacific Region(WHO Standard) and National Standard(GB/T 22103-2008) for Acupuncture Point Locations in human body, and combined with X-ray images, the hierarchical structure of Five-shu points and Source-point of the TE Meridian were observed in ten New Zealand rabbits. The acupoint locations were determined by comparing the same name tissues of the rabbits and human body after dissecting the above-mentioned acupoints. After inserting acupuncture needles into the aforementioned acupoints, the relationship between the acupuncture needle and adjacent structure were dissected and measured. Results "Guanchong"(TE1) was located on the lateral side of the 4(th) terminal phalanx, and behind the corner of the onyx root. When needled, the penetrated tissues of the acupuncture needle are skin, superficial fascia, deep fascia, and the root region of the 4(th) terminal phalanx, and behind the corner of the onyx root. When needled, the penetrated tissues of the acupuncture needle are skin, superficial fascia, deep fascia, and the root region of the 4(th) phalanx, respectively. "Yemen"(TE2) was located between the 4(th) phalanx, respectively. "Yemen"(TE2) was located between the 4(th) and 5(th) and 5(th) onyxes, at the depression of intersection of coat hair superior to the fingerweb edge. When needled, the penetrated tissues of the acupuncture needle are the superficial fascia, deep fascia and lumbrical muscles of the forepaw, respectively. "Zhongzhu"(TE3) was located between the 4(th) onyxes, at the depression of intersection of coat hair superior to the fingerweb edge. When needled, the penetrated tissues of the acupuncture needle are the superficial fascia, deep fascia and lumbrical muscles of the forepaw, respectively. "Zhongzhu"(TE3) was located between the 4(th) and 5(th) and 5(th) metacarpal bones, at the depression proximal to the 4(th) metacarpal bones, at the depression proximal to the 4(th) metacarpophalangeal joint. When needled, the penetrated tissues are skin, superficial fascia, deep fascia, and lumbrical muscle, respectively. "Yangchi"(TE4) was positioned at the dorsal side of the forepaw, and the surface connection line between the accessory and radial bones intersected with the depression of the extensor digitorum communis on the ulnar side. When needled, the penetrated tissues are skin, superficial fascia, deep fascia, and the ulnar side of the common extensor tendon, respectively. "Zhigou"(TE6) was positioned between the radius and ulna, on the posterior aspect of the forelimb and 3 Bone-cun proximal to the distal dorsal forepaw crease. When needled, the penetrated tissues are skin, superficial fascia, deep fascia, and the extensor digitorum, respectively. "Tianjing"(TE10) was located at the junction of the body of humerus and the lateral condyle of humerus, on the posterior aspect of the elbow and proximal to the prominence of the olecranon. When needled, the penetrated tissues are skin, superficial fascia, deep fascia, and triceps brachii muscle, respectively. Conclusion The Five-shu points and Source-point of the TE Meridian on the forelimb in rabbits are innervated by the cutaneous branches of the ulnar radial nerve and the medial brachial cutaneous nerve at the superficial layer, and by the branches of the ulnar nerve and radial nerve in the deep layer, accompanied with cephalic vein and forearm blood vessels and their branches.关键词：Comparative anatomical study;Five-shu acupoint;Source-acupoint;Triple Energizer(TE) Meridian;X-ray image;Rabbit242|312|2更新时间：2023-08-11
- 摘要：Objective To observe the difference of therapeutic effect between hysteretic acupuncture and Celecoxib capsules for knee osteoarthritis(KOA), and to investigate their effects on levels of interleukin 6(IL-6) and tumor necrosis factor α(TNF-α) in articular fluid. Methods Seventy-two patients with KOA were randomly divided into hysteretic acupuncture and me-dication groups, with 36 cases in each group. The patients of the hysteretic acupuncture group received hysteretic acupuncture stimulation at Dubi(ST35), Neixiyan(EX-LE4), Zusanli(ST36), Yanglingquan(GB34), Yinlingquan(SP9), Xuehai(SP10), Liangqiu(ST34) and Heding(EX-LE2) as the main acupoints for 30 min once daily. The patients of the medication group received oral administration of Celecoxib capsules(200 mg) once daily. Both of the two groups were treated with 14 days as a course of treatment, with a 2-day rest between each course of treatment, and the treatments were conducted for 2 courses. The visual analogue scale(VAS) score of pain, Lequesne index score, IL-6 and TNF-α level in joint fluid and the change of traditional Chinese medicine(TCM) syndrome score were observed before and after treatment. Results Compared with pre-treatment, the VAS score, Lequesne index score, IL-6 and TNF-α level, and total TCM syndrome score decreased significantly after treatment in both of the two groups(P<0.05). Hysteretic acupuncture was more effective in reducing VAS score, Lequesne index score, IL-6 and TNF-α level than Celecoxib capsules(P<0.05), and there was no significant difference in total TCM syndrome score and total effective rate between the two groups(P>0.05). No adverse events occurred in both groups during the treatment. Conclusion Hysteretic acupuncture can effectively relieve pain symptoms and improve joint function in KOA patients. Its effect is comparable to that of oral administration of Celecoxib capsules.关键词：Knee osteoarthritis;Hysteretic acupuncture;Pain;Joint function;Randomized controlled trial254|482|1更新时间：2023-08-11
- 摘要：Objective To compare the clinical efficacy of acupuncture, electroacupuncture(EA) and moxibustion in the treatment of knee osteoarthritis(KOA). Methods A total of eight-four patients with KOA were randomly and equally divided into acupuncture group, EA group and moxibustion group. Neixiyan(EX-LE40), Dubi(ST35), Heding(EX-LE2), Liangqiu(ST34), Xuehai(SP10), Zusanli(ST36) and Ashi-point on the affected side of the body were punctured with filiform needles or EA(2 Hz/100 Hz) for 30 min. In the moxibustion group, moxibustion was applied to the surrounding area of the affected joint for 60 min. The treatment was conducted once every other day for 4 weeks. The pain degree was assessed by using numerical rating scale(NRS) and the Western Ontario McMaster Universities Osteoarthritis Index(WOMAC) scale(0-240 points) was used to evaluate the severity of KOA. The "Minimal Clinically Important Improvement(MCII)" was used to assess the therapeutic effect after the treatment. Results After the treatment, the scores of NRS, and the pain, stiffness, motor function and total scores of WOMAC were significantly decreased in the three groups compared with their own pre-treatment(P<0.05), and were obviously lower in the EA and moxibustion groups than in the acupuncture group(P<0.05), and those of the moxibustion group was notably lower than those of the acupuncture group(P<0.05). Of the 28 cases in the acupuncture, EA and moxibustion groups, 11, 17 and 22 were effective, with the effective rate being 39.29%, 60.71% and 78.57%, respectively. The comprehensive therapeutic effect of the moxibustion group was significantly superior to that of the acupuncture and EA groups(P<0.05). Conclusion All the three different kinds of acupuncture and moxibustion methods have positively regulatory effect on KOA, and moxibustion is the best for reducing the joint pain and stiffness, and improving the motor function.关键词：Knee osteoarthritis;Acupuncture;Electroacupuncture;Moxibustion298|974|12更新时间：2023-08-11
- 摘要：Objective To observe the effect of ginger-partitioned moxibustion intervention on gastrointestinal reaction, the quality of life, the counts of blood platelet(PLT) and white blood cells(WBC) after chemotherapy in lung cancer patients. Methods The lung cancer patients treated with chemotherapy were randomized into observation group(30 cases) and control group(30 cases). In the control group, the intravenous injection with Tropisetron(5 mg) was given 1 h before chemotherapy. In the observation group, in addition to the same treatment as the control group, 2 hours after chemotherapy, ginger-partitioned moxibustion was applied to bilateral Zusanli(ST36), bilateral Neiguan(PC6) and bilateral Tianshu(ST25) for 20 min each time. The treatments were conducted once daily for 3 days. Separately, 2 days before chemotherapy, 24 h and 7 days after chemotherapy, the gastrointestinal reaction score and the score of the quality of life, the PLT and WBC counts were observed in the two groups. Results The effective rate of the gastrointestinal reaction degree in the observation group were higher than those in the control group 24 h and 7 days after chemotherapy(P<0.05). Twenty-four hours after chemotherapy, the score of the quality of life, the PLT and WBC counts were lower as compared with those before the treatment in both groups respectively(P<0.05). Seven days after chemotherapy, the score of the quality of life, the PLT and WBC counts in the observation group were higher than those in the control group(P<0.05). Conclusion The ginger-partitioned moxibustion achieves the definite clinical effect of the prevention of nausea and vomiting induced by chemotherapy in lung cancer. This therapy is simple in operation, high in safety, absent in obvious adverse reactions and high in patient's compliance.关键词：Ginger-partitioned moxibustion;Lung cancer;Chemotherapy;Nausea;Vomiting275|638|2更新时间：2023-08-11
- 摘要：Objective To observe the clinical effect of electroacupuncture combined with moxibustion in the treatment of urinary incontinence after stroke due to deficiency of kidney-yang. Methods Sixty patients with urinary incontinence after stroke due to kidney-yang deficiency were randomly divided into a control group and an observation group,with 30 cases in each group. The patients in the control group were given oral administration of Jingui Shenqi pills and Suoquan capsules. On the basis of the treatment in the control group, the patients in the observation group were given electroacupuncture treatment at the Foot Motor sensory Area on the head, Shenshu(BL23) and Huiyang(BL35), together with moxibustion at Guanyuan(CV4) and Qihai(CV6) once daily. The treatment was conducted 6 times per week and for 2 successive weeks. The average number of daily urinary incontinence and night urinary incontinence, maximum bladder volume, residual bladder urine volume, degree of urinary incontinence and clinical symptoms score of the two groups before and after treatment were observed. And the clinical efficacy of the two groups were compared. Results After the treatment, compared with those before the treatment, the average numbers of daily and night urinary incontinence of the two groups were significantly reduced(P<0.01), the maximum bladder volume was significantly increased(P<0.05), and the residual urine volume of the bladder was significantly reduced(P<0.05). The number of cases with urinary incontinence degree Ⅰ and Ⅱ increased(P<0.05), and the score of clinical symptoms of urinary incontinence was significantly reduced(P<0.05). After the treatment, compared with the control group, the number of daily and night urinary incontinence in the observation group decreased(P<0.05), the maximum bladder volume increased(P<0.05), the residual bladder urine volume decreased(P<0.05), and the number of cases with urinary incontinence degree Ⅰ and Ⅱ increased(P<0.05), the clinical symptom score of urinary incontinence was significantly reduced(P<0.05). The total effective rates of the control group and the observation group were 73.3%(22/30) and 93.3%(28/30) respectively, and the effective rate of the observation group was higher than that of the control group(P<0.05). Conclusion The combination of electroacupuncture, moxibustion and traditional Chinese medicine is effective in treating urinary incontinence after stroke due to deficiency of kidney-yang.关键词：Urinary incontinence after stroke;Deficiency of kidney-yang;Electroacupuncture;Moxibustion244|570|2更新时间：2023-08-11
- 摘要：Objective To observe the clinical effect of elongated needle by Hui-puncture method in the treatment of piriformis syndrome. Methods A total of 100 piriformis syndrome patients were randomly divided into routine acupuncture group(n=50) and elongated needle by Hui-puncture method(Hui-puncture) group(n=50). For patients of the routine acupuncture group, Huantiao(GB30), Juliao(GB29), Zhibian(BL54), Weizhong(BL40), Yanglingquan(GB34), Juegu(GB39) and Ashi-point on the affected side of the body were punctured with filiform needles for 30 min. And for those of the Hui-puncture group, elongated needles were respectively inserted into GB30 and Ashi-point. The treatment was conducted once every other day for 10 times. The visual analog scale(VAS) pain score and the severity scores of symptoms(hip pain, lower limb pain, walking ability, straight leg elevation test, piriformis muscle tension test, piriformis muscle tenderness, 0—15 points) were measured before and after the treatment. The therapeutic effect was assessed by Criteria for Diagnosis and Assessment of Therapeutic Effect of Syndromes or Illnesses of Traditional Chinese Medicine(1994). Results After the treatment, the scores of symptoms and VAS scores of both routine acupuncture and Hui-puncture groups were significantly decreased in comparison with their own pre-treatment(P<0.05), and the scores of the two indexes of the Hui-puncture group were evidently lower than those of the routine acupuncture group(P<0.05). Of the two 50 cases in the routine acupuncture and Hui-puncture groups, 39 and 47 were effective, with the effective rate being 78.00% and 94.00%, respectively. The comprehensive therapeutic effect of the Hui-puncture group was significantly superior to that of the routine acupuncture group(P<0.05). Conclusion Elongated-needle by Hui-puncture method has significant effect in treating piriformis syndrome patients and is worthy of promotion.关键词：Elongated-needle;Hui-puncture;Piriformis Syndrome;Acupuncture236|483|1更新时间：2023-08-11
- 摘要：Acupuncture therapy has been shown to have a positive effect in treating symptoms of patients with traumatic brain injury(TBI) in China. The present paper summarizes findings of recent researches on the underlying mechanisms of acupuncture intervention for improving TBI from 1) inhibiting inflammatory response, 2) regulating neurotransmitters, 3) promoting nerve repair and regeneration, 4) antioxidation, 5) inhibiting intracellular calcium overload, 6) regulating aquaporin content, 7) regulating cellular energy metabolism, 8) improving brain circulation, and 9) inhibiting cell apoptosis.关键词：Acupuncture;Traumatic brain injury;Mechanism;Review230|689|3更新时间：2023-08-11
- 摘要：Objective To compare the therapeutic effect and safety in treatment of functional constipation between electroacupuncture(EA) and gastro-kinetic drugs. Methods Using "functional constipation", "prucalopride", "mosapridecitrate", "electro-acupuncture" and "randomized controlled trial", both in Chinese and English, as search terms, the articles of randomized controlled trial(RCT) regarding to the comparison of therapeutic effect on functional constipation in the patients between EA and gastro-kinetic drugs were retrieved from CMB, Wanfang, VIP, CNKI, OpenGrey, CINAHL, Cochrane Library, JBI, PubMed, WOS and Ovid databases. The retrieval time was from the establishment date to June 2018. The two researchers screened articles, extracted data and assessed literature quality in reference to Cochrane Handbook. Using RevMan 5.3 software, the meta-analysis was conducted. Results A total of 11 articles were included finally, with 744 patients involved. It was found after meta-analysis that in EA group, the weekly spontaneous defecation frequency, constipation related quality of life in patients, depression relief and incidence of adverse reaction were all better than those in gastro-kinetic medication group. The therapeutic effect of the improvements in stool character and defecation difficulty in EA group were better or similar to that in gastro-kinetic medication group. Conclusion Regarding the therapeutic effect and safety in treatment of functional constipation, the results of electroacupuncture are superior or similar to gastro-kinetic medication, presenting a satisfactory therapeutic prospect.关键词：Functional Constipation;Prucalopride;Mosapridecitrate;Electroacupuncture;Systematic review;Meta analysis292|711|4更新时间：2023-08-11
- 摘要：Objective To analyze the rules of acupoints selection for phlegm disorder in treatment with acupuncture and moxibustion in ancient literature so as to provide guidance to clinical treatment of phlegm disorder. Methods The word "phlegm" was taken as the search term and the relevant articles were retrieved from Zhonghuayidian(Dictionary of Chinese Medicine). According to the inclusion and exclusion criteria, the articles were screened and the database was set up. The analysis was conducted on acupoint selection, the correlation with meridians involved and distribution location, as well as the use frequency of specific points and acupoint combination. Results It was found that in treatment of phlegm disorder, the highest frequently used acupoints were Zusanli(ST36) and Zhongwan(CV12). The use frequency of three yang meridians was higher than that of three yin meridians. The commonly involved meridians were the Conception Vessel, Bladder Meridian of Foot-taiyang and the Governor Vessel. The acupoints located in the chest and abdomen were highly used. The use frequency of specific points was higher than that of non-specific ones. The sequence of the use frequency of specific points, from high to low, is the crossing point, the front-mu point and luo-connecting point. The combination of Danzhong(CV17) and Zusanli(ST36) is of the high frequency. Conclusion Ancient medical scholars focus on regulating spleen and stomach functions, as well as qi activity in treatment of phlegm disorder with acupuncture and moxibustion, which is coincident with the treatment principle of phlegm disorder in traditional Chinese medicine. In treatment, acupuncture-moxibusiton is characterized as laying the emphasis on the specific points, the local acupoints and the holistic idea as " regulation of yang for yin disorder ".关键词：Phlegm disorder;Rules of acupoints selection;Frequency217|513|1更新时间：2023-08-11
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