最新刊期
卷 46 ， 期 11 ， 2021
- 摘要：Objective To observe the effect of electroacupuncture(EA) at “Zusanli”(ST36) on the phosphorylated tau levels in pancreas and hippocampus of type 2 diabetes mellitus(T2 DM) rats, so as to explore the underlying mechanism of EA in diabetic demention rats. Methods Forty-eight male Sprague-Dawley rats were randomly divided into control, model and EA groups, with 16 rats in each group. The T2 DM model was established by 6 weeks of high-fat, high-sugar diet as well as intrape-ritoneal injection of streptozocin(STZ) solution(35 mg/kg). After that, EA(2 Hz, 0.1 mA) was applied to unilateral “Zusanli”(ST36) for 30 min, once a day, 6 times a week for 4 weeks. The survival rate was recorded every week, and the fasting blood glucose(FBG) was detected on the 1(st), 6(st), 6(th) and 11(th) and 11(th) week. The level of serum insulin(INS) was measured by using ELISA. The morphological structure of pancreas islet was observed by H.E. staining. The expressions of phosphorylated tau at the sites of Ser 396(pS396) and Thr 231(pT231), total tau(Tau5), phosphorylated glycogen synthase kinase-3β(pGSK-3β) and total glycogen synthase kinase-3β(GSK-3β) in pancreas and hippocampus were detected by Western blot. The expression and distribution of pS396 and pT231 in pancreas and hippocampus were assayed with immunohistochemistry.Results Compared with the control group, the survival rate presented a significant decline, the contents of FBG and INS were obviously higher(P<0.01), and the structure of the pancreas islet appeared shrunken, obscure and disordered in the model group. Furthermore, the levels of pS396, pT231 in pancreas and hippocampus were obviously higher in the model group(P<0.01),while the level of pGSK-3β in pancreas and hippocampus was significantly lower in the model group(P<0.01). In comparison with the model group, the survival rate of EA group was higher. Following 4 weeks' interventions, the enhanced levels of tau phosphorylation and GSK-3β activity in pancreas and hippocampus were partly reversed in the EA group compared to the model group(P<0.05,P<0.01). Conclusion EA at ST36 can reduce the level of tau phosphorylation via regulating the activity of GSK-3β in the pancreas and hippocampus of T2 DM rats, which may be related with the effect of EA on the brain function in T2 DM rats.关键词：Electroacupuncture;Diabetes;Pancreas;Hippocampus;Tau phosphorylation26|446|3更新时间：2023-08-10
- 摘要：Objective To observe the effect of electroacupuncture(EA) on skeletal muscle adiponectin receptor(Adipor1)/adenylate activated protein kinase(AMPK)/peroxisome proliferator-activated receptor α(PPARα) signaling pathway and skeletal muscle morphology by the secretion of serum adiponectin in Zucker diabetic obese(ZDF) rats, so as to explore its mechanism underlying regulating glucose and lipid metabolism of type 2 diabetes mellitus(T2 DM) and improving skeletal muscle insulin resistance(IR). Methods Twelve male ZDF rats and six Zucker thin(ZL) rats were selected. The rats were fed with Purina#5008 high-fat diet for four weeks to induce T2 DM model after adaptive feeding with normal diet for one week. The ZDF rats were randomly divided into model group and EA group according to blood glucose level after modeling and 6 ZL rats were used as the blank control group. Rats in the EA group were treated with “Pishu”(BL20), EA stimulation of “Yishu”(EX-B3), “Zusanli”(ST36) and “Sanyinjiao”(SP6), once a day and 6 times a week for 4 weeks. Rats of the model and blank control groups were grabbed and fixed in the same way as EA group. Fasting blood glucose(FBG) was measured before and after EA intervention. Serum levels of insulin(INS), C-peptide(C-P), adiponectin(APN) were measured by radioimmunoassay, and those of free fatty acid(FFA), low-density lipoprotein(LDL), cholesterol(TC), triglyceride(TG) content determined by enzyme colorimetry and insulin resistance index(HOMA-IR) was calculated. The protein expression levels of AdipoR1, AMPK and PPARα proteins in the quadriceps femoris tissues were detected by Western blot and histopathological changes of quadriceps femoris muscle were observed by H.E. staining. Results Compared with the blank control group, the levels of FBG, serum INS, C-P, FFA, LDL, TC, TG and HOMA-IR in the model group were significantly increased(P<0.01, P<0.05), while the levels of serum APN and the expressions of AdipoR1, AMPK and PPARα proteins in the skeletal muscle were significantly decreased(P<0.01, P<0.05). Compared with the model group, the levels of FBG, serum INS, C-P, FFA, LDL, TC and HOMA-IR in the EA group were significantly decreased(P<0.01), and those of serum APN and expression levels of AdipoR1, AMPK and PPARα proteins in the skeletal muscle significantly increased(P<0.01), but the serum TG level had no remarkable change in the EA group(P>0.05). In addition, H.E. staining showed disordered arrangement of skeletal muscle cells, rupture and fuzziness of muscle fibers, enlargement of the space between muscular fibers and infiltration of small number of adipose cells which were relatively milder in the EA group. Conclusion EA can reduce blood glucose and lipid levels, and improve IR in ZDF rats, which may be related to its functions in up-regulating AdipoR1/AMPK/PPARα signaling and in promoting APN secretion.关键词：Electroacupuncture;Type 2 diabetes;Disorder of glucose and lipid metabolism;Adiponectin signaling pathway;Insulin resistance24|1093|5更新时间：2023-08-10
- 摘要：Objective To observe the effect of electroacupuncture(EA) of “Shuigou”(GV26) on the activities of sonic hedgehog(Shh) signaling molecules(Shh, Ptch, Smo, Gli and Gli2) in ischemic brain tissues in rats with cerebral ischemia(CI), so as to explore its mechanisms underlying improvement of CI.Methods Male Wistar rats were randomly divided into blank control group(n=10), sham operation group(n=90), model group(n=90) and EA group(n=90). The CI model was established by occlusion of the right middle cerebral artery(MCAO). According to the postoperative time points of MCAO, the later three groups were further divided into 1, 3, 6, 9, 12 and 24 h, and 3, 7 and 12 d subgroups, with 10 rats in each subgroup. EA(15 Hz, 2 mA) was applied to GV26 for 20 min. The 1 h to 24 h subgroups were treated immediately after modeling, the 3-12 d subgroups treated one time a day. The neurological severity score(NSS, 0 to 18 points) was used to evaluate the rats' neurological function, and TTC staining was employed to assess the cerebral ischemic volume(percentage of cerebral infarct volume, CIV). Western blot was employed to detect the expression of Shh, Ptch, Smo, Gli1 and Gli2 proteins in the ischemic cerebral tissue. Results Compared with the sham operation group, the NSS scores of the model group increased at all time points(P<0.01). The percentages of CIV of the model group from 3 h to 12 d were obviously higher than those of the sham operation group(P<0.01). The NSS scores at 3, 7 and 12 d and the percentages of CIV at 1, 3, 7 and 12 d after MCAO were significant lower in the EA group than in the model group(P<0.05). The protein expression levels of Shh from 12 h to 12 d(i.e. 12 h, 24 h, 3, 7 and 12 d), Ptch from 6 h to 12 d, Smo from 9 h to 12 d, Gli1 at 9 h, 12 h, and from 3 d to 12 d, Gli2 at 6, 9 and 12 h, and 3 d were significantly higher in the model group than in the sham operation group(P<0.05, P<0.01), while those of Shh at 3, 7 and 12 d, Ptch from 24 h to 7 d, Smo from 12 h to 7 d, Gli1 from 24 h to 7 d, Gli2 at 12 h, 3 and 7 d were significantly higher in the EA group than in the model group(P<0.05, P<0.01). No statistical significances were found between the sham operation and the blank control groups in all the indexes mentioned above(P>0.05).Conclusion EA of GV26 can improve neurological function and reduce infarct volume in MCAO rats, which may be related to its function in up-regulating the activities of Shh signaling pathway in the ischemic cerebral tissues.关键词：Electroacupuncture;Shuigou(GV26);Cerebral infarction;Sonic Hedgehog signaling pathway23|420|4更新时间：2023-08-10
- 摘要：Objective To observe the protective effect of electroacupuncture(EA) on neurovascular unit, neurological function in rats with cerebral ischemia(CI), so as to explore its mechanisms underlying improvement of ischemic cerebral tissue. Methods Male SD rats, SPF grade, were randomly and equally divided into sham operation group, model group, EA group Ⅰ and EA group Ⅱ,27 rats in each group. The CI model was established by occlusion of the middle cerebral artery(MCAO). EA(2 Hz/20 Hz, 0.5 mA) was applied to “Quchi”(LI11), “Hegu”(LI4), “Zusanli”(ST36) and “Shuigou”(GV26) for rats of the EA group Ⅰ, and to “Baihui”(GV26), “Fengfu”(GV16), “Neiguan”(PC26) and “Xinshu”(BL15) for rats of the EA group Ⅱ for 20 min, once a day for 14 days. The modified neurologic severity score(mNSS) was calculated according to the state of locomotor, sensory, and reflex parameters. Transmission electron microscope(TEM) was used to observe the neuronal structure of the ischemic cerebral area. The CD34 positive cells(for microvessels) of the ischemic brain tissue were detected by using immunohistochemistry, and the expression levels of cerebral phosphatidylinositol-3 kinase(PI3 K) and protein kinase B(Akt) mRNAs were detected by quantitative real-time-PCR, respectively. Results Along with the extension of time, the mNSS at 4 h, and 3, 7 and 14 d after CI were apparently decreased, and the number of CD34 positive cells from 3 d to 14 d after CI, and the expression of PI3 K mRNA and Akt mRNA from 3 d to 7 d were significantly increased in the model, EAⅠand EA Ⅱ group(P<0.01, P<0.05). Compared with the sham operation group, the mNSS at 4 h, and 3, 7 and 14 d, and CD34-positive number and PI3 K mRNA and Akt mRNA expression levels at 3, 7 and 14 d were significantly increased in the model group(P<0.01, P<0.05). In comparison with the model group, the mNSS at 3, 7 and 14 d were obviously decreased(P<0.01), and the CD34-positive number and PI3 K and Akt mRNA expression levels at 3, 7 and 14 d considerably increased in both EA group Ⅰ and Ⅱ(P<0.01, P<0.05). The therapeutic effect of EA group Ⅱ was significantly superior to that of EA group Ⅰ in lowering mNSS at 14 d, up-regulating the CD34-positive number at 7 and 14 d, and PI3 K mRNA at 3, 7 and 14 d and Akt mRNA at 3 and 7 d(P<0.05, P<0.01). Results of TEM showed an irregular shape of neurons with nuclear pyknosis, non-uniform chromatin, more organelle loss, swollen mitochondrial Golgi complex and expansion of rough endoplasmic reticulum, being relatively milder in the EA group Ⅰ, particularly in the EA group Ⅱ. Conclusion EA therapy can improve the neurological function in cerebral ischemia rats, which may be related to its effects in protecting the neurovascular unit and up-regulating PI3 K/Akt signal pathway. The effects of EA at GV26, GV16, PC26 and BL15 are better than those of EA at LI11, LI4, ST36 and GV26.关键词：Cerebral ischemia;Electroacupuncture;Neurological function;Neurovascular unit;PI3K/Akt signaling pathway;Acupoint combination26|724|11更新时间：2023-08-10
- 摘要：Objective To observe the effect of electroacupuncture(EA) at “Fengfu”(GV16) and “Taichong”(LR3) on the expression of tyrosine hydroxylase(TH), α-synuclein(α-syn) and microglial-related microglial(MG), Toll-like receptor 4(TLR4)/nuclear factor kappa B(NF-κB) signaling pathway in the substantia nigra(SN) of midbrain in Rotenone-induced Parkinson's disease(PD) rats, so as to explore its mechanisms underlying improvement of PD. Methods SD male rats were randomly divided into normal control, PD model and EA groups(n=12 in each group). The PD model was established by subcutaneous injection of rotenone(1 mg/kg) at the back of neck. EA(2 Hz, 1 mA) was applied to bilateral GV16 and LR3, once daily for 2 weeks. The rats' behavior(hair color, reaction capacity, locomotion and gait state)scores(0-10 points) were given and the autonomic movement state(trajectory of autonomous motion, total distance, average speed and duration of motion in 8 min) was detected by using open field tests. The immunoactivity of TH and α-syn in the SN tissue were determined by using immunohistochemistry staining, and the number of Iba-1-labelled microglia(MG) was detected by using immunofluorescence staining. The expression levels of TLR4 and NF-κB P65 proteins in the SN were detected by Western blot, and the contents of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in the SN were determined by using enzyme-linked immunosorbent assay. Results In comparison with the normal group, the behavioral score, α-syn immunoactivity, number of Iba-1 labelled microglia, expression of TLR4 and NF-κB P65 proteins and the contents of TNF-α and IL-6 in the SN were significantly increased(P<0.01), whereas the total distance, average speed, duration of motion of the autonomic movement in 8 min, and the TH immunoactivity were remarkably decreased in the model group(P<0.01). After EA intervention, compared with the model group, the increase of the behavioral score, α-syn immunoactivity, number of Iba-1-labelled microglia, expression of TLR4 and NF-κB P65 proteins, the contents of TNF-α and IL-6 in the SN, and the decrease of the total distance, average speed, duration of motion of the autonomic movement in 8 min, and the TH immunoactivity were reversed(P<0.05, P<0.01). Conclusion EA can improve the behavioral manifestations of PD rats, which may be associated with its functions in down-regulating the abnormal accumulation of pathological α-syn, TLR4/NF-κB signaling, inhibiting activities of microglia and in up-regulating the expression of TH in the SN of midbrain.关键词：Parkinson's disease;Electroacupuncture;Toll-like receptor 4;Nuclear factor kappa B;Microglia;Inflammatory factor23|844|13更新时间：2023-08-10
- 摘要：Objective To observe the effect of moxibustion combined with benazepril on cardiac function and expression levels of myocardial interleukin-18(IL-18), phosphorylated protein kinase B(p-Akt) in rats with chronic heart failure(CHF), so as to explore its underlying mechanisms in improvement of CHF. Methods Fifty male rats were randomly divided into normal, model, moxibustion, benazepril and moxibustion+benazepril groups(n=10 rats per group). The CHF model was established by intraperitoneal injection of doxorubicin hydrochloride solution(DOX, 2.5 mg/kg) twice a week for 4 weeks. After successful modeling, the rats in the normal and model groups were fed with normal diet, and fixed on a rat plate for 20 min each time without any treatment. Mild moxibustion was applied to bilateral “Feishu”(BL13) and “Xinshu”(BL15) for 20 min each time, for 3 weeks in the moxibustion and moxibustion+benazepril groups. Rats of the benazepril and moxibustion+benazepril groups received gavage of benazepril(2 mg/kg) once daily for 3 weeks. The general behaviors of rats were observed. The ejection fraction(EF), left ventricular diameter shortening(FS), left ventricular end-diastolic diameter(LVIDd), left ventricular end-systolic diameter(LVIDs), heart rate(HR) and ventricular septal thickness(IVS) were examined by echocardiography. The content of serum N-terminal pro-brain natriuretic peptide(NT-proBNP) was detected by enzyme-linked immunosorbent assay, and expression levels of myocardial IL-18, p-Akt were detected by Western blot. Results Compared with the normal group, the EF, FS, IVS, and myocardial p-Akt expression level were significantly reduced(P<0.01), and the LVIDd, LVIDs, HR, and serum NT-proBNP content and myocardial IL-18 expression level were significantly increased in the model group(P<0.01). In comparison with the model group, the EF, FS, IVS, and myocardial p-Akt were remarkably up-regulated(P<0.05, P<0.01), and the LVIDd, LVIDs, HR, serum NT-proBNP content, and myocardial IL-18 expression level were significantly down-regulated(P<0.05, P<0.01) in the moxibustion, benazepril, and moxibustion+benazepril groups. Compared with the moxibustion+benazepr group, the levels of LVIDs, HR, serum NT-proBNP and myocardial IL-18 expression were obviously higher(P<0.05, P<0.01), while the levels of EF, FS, IVS and p-Akt were significantly lower in the moxibustion and benazepril groups(P<0.01). Conclusion Moxibustion combined with benazepril improves cardiac function in CHF rats, and is superior to simple moxibustion and simple benazepril in reducing IL-18 expression and increasing p-Akt expression in myocardial tissue.关键词：Moxibustion;Chronic heart failure;Cardiac function;Interleukin-18;Protein kinase B22|398|4更新时间：2023-08-10
- 摘要：Objective To observe the effect of electroacupuncture(EA) at “Ciliao”(BL32) on the survival rate and serum inflammatory cytokine levels in rats with lethal endotoxemia, and to explore its parasympathetic mechanism in suppressing severe systemic inflammation. Methods A total of 82 male SD rats were used in the present study. In the first part of this study, 40 rats were randomized into model and EA-BL32 groups(n=20/group). The endotoxemia model was established by intraperitoneal injection of lethal amount of lipopolysaccharide(LPS, 10 mg/kg). EA(30 Hz, 6 mA) was applied to bilateral BL32 for 30 min before and after LPS injection. The survival rate in 7 days was then recorded. In the second part of this study, 42 rats were randomized into normal control, model, EA-BL32, EA-BL32+cervical vagotomy, EA-BL32+truncal(subdiagrammatical) vagotomy and EA-BL32+pelvic neurectomy groups(n=7/group). The endotoxemia model was established by intraperitoneal injection of LPS(6 mg/kg) 30 min after the neurectomy. Rats of the control group received intraperitoneal injection of 6 mg/kg saline. EA with the same parameters mentioned above was applied to bilateral BL32 for 30 min before and after LPS injection. Blood sample was collected from the abdominal aorta 3 h after LPS injection for detecting the levels of TNF-α, IL-1β and IL-6 by ELISA. Results(1) The EA survival rate was 25% in the model group and 60% in the EA-BL32 group, being significantly improved after EA(P<0.05).(2) The contents of serum TNF-α, IL-1β and IL-6 were significantly higher in the model group than those in the control group(P<0.000 1). After EA intervention, and compared with the model group, the levels of TNF-α, IL-1β and IL-6 were significantly decreased in the EA-BL32, EA-BL32+cervical vagotomy, EA-BL32+truncal vagotomy and EA-BL32+pelvic neurectomy groups(P<0.000 1,P<0.01). After neurectomy and compared to the EA-BL32 group, the contents of TNF-α and IL-6 in the EA+cervical vagotomy and EA+pelvic neurectomy groups, IL-1β in the EA+pelvic neurotomy group were significantly higher(P<0.0000 1, P<0.05), suggesting an elimination of EA effects after neurectomy. No significant differences were found among the 3 neurectomy groups in the levels of TNF-α, IL-1β and IL-6(P>0.05). Conclusion EA of BL32 can improve the survival rate and attenuate the level of inflammatory cytokines in rats with lethal endotoxemia, which is closely related to the intact of parasympathetic pathway including the vagus nerve and pelvic nerve.关键词：Electroacupuncture;Endotoxemia;Anti-inflammatory pathway;Parasympathetic nerve25|398|4更新时间：2023-08-10
- 摘要：Objective To observe the effects of penetrating technique of scalp acupuncture on emotion, sleep and function development in children of autism spectrum disorder(ASD). Methods A total of 60 SAD children aged 3 to 6 years were randomized in a control group(music education rehabilitation, n=30) and an observation group(penetrating technique of scalp acupuncture + music education rehabilitation, n=30). In the two groups, the treatment for 3 months was as 1 course, and 2 courses of treatment were required. Before and after treatment, the changes were observed in childhood autism rating scale(CARS), emotion regulation subscale(ER), children's sleep habits questionnaire(CSHQ) and children autism and psycho-educational profile for autistic and developmentally disabled children(C-PEP-3), separately.Results Compared with the scores before treatment, CARS score, the score of each subscale of CSHQ, e.g. bedtime resistance, sleep onset delay, irregular sleep duration, sleep anxiety, parasomnias and daytime sleepiness as well as the total score of CSHQ were all reduced in children of two groups(P<0.05); and the score of ER and C-PEP-3 were all increased(P<0.05) after 6 months' treatment. Compared with the control group, ER score was increased in 3 and 6 months after treatment(P<0.05), CARS score was reduced(P<0.05) and C-PEP-3 score was increased obviously(P<0.05) 6 months after treatment in the observation group; but the scores of the subscale for night waking and sleep disordered breathing did not changed noticeably(P > 0.05). Conclusion Penetrating technique of scalp acupuncture improves the emotion and sleep disorder and promotes the function development in ASD children.关键词：Penetrating technique of scalp acupuncture;Autism spectrum disorder;Emotion;Sleep23|619|0更新时间：2023-08-10
- 摘要：Objective To compare the therapeutic results and the occurrence of adverse reactions of medicine between the combined therapy of warm acupuncture at back-shu points of five zang organs and the western medicine and the simple wes-tern medication, and observe the therapeutic effect and attenuating effect of this combined therapy in treatment on depression of yang deficiency pattern. Methods A total of 80 patients with depression of yang deficiency pattern were randomly divided into an observation group and a control group(39 cases/group). In the control group, escitalopram oxalate tablets were administered orally every day. In the observation group, on the base of the medication as the control group, warm acupuncture therapy was exerted at back-shu points of five zang organs, for 30 min each time, 5 times a week. The duration of treatment was 6 weeks in two groups. Before and after treatment, the scores of Hamilton depression scale(HAMD) and the antidepressant side effect scale(SERS) were evaluated and electroencephalogram(EEG) was detected; and the curative effect was assessed according to HAMD reduction rate in patients of the two groups. Results After treatment, the HAMD and SERS scores were lower than those before treatment in both groups. Compared with the control group, the HAMD and SERS scores were lower(P<0.05, P<0.01), and the EEG result was improved(P<0.01) in the observation group. The clinical total effective rate of the observation group was 97.43%(38/39), higher than 92.30%(36/39) of the control group(P<0.05). Conclusion The combined therapy of warm acupuncture at back-shu points of five zang organs and western medicine effectively relieves depression of yang deficiency pattern in the patients and its overall therapeutic effect is better than simple western medication, besides, the combined therapy alleviates the adverse reactions induced by simple western medication.关键词：Depression;Yang deficiency pattern;Warming acupuncture;Back-shu points of five zang organs;Escitalopram oxalate;Attenuating effect21|735|4更新时间：2023-08-10
- 摘要：Objective To investigate the effect of electroacupuncture combined with thunder-fire moxibustion on urodynamics in patients with neurogenic bladder(NB) after spinal cord injury(SCI). Methods A total of 60 patients with NB after SCI were divided into control group and observation group using a random number table, with 30 patients in each group. Bladder management protocol was performed for both groups. The patients in the control group were given electroacupuncture at Shangliao(BL31), Zhongliao(BL33), Xialiao(BL34), and Ciliao(BL32) at both sides, and those in the observation group were given thunder-fire moxibustion as mild-warm moxibustion at Yaoyangguan(GV3), Mingmen(CV4), Qihai(CV6), Guanyuan(CV4), and Zhongji(CV3) in addition to the treatment in the control group; electroacupuncture or moxibustion was performed for 20 min each time, once a day, with 10 times as one course of treatment, and both groups were treated for 3 courses. Number of times of voluntary urination, maximum single urine volume, and number of times of urethral catheterization were recorded at 3 d before and after treatment; maximum urinary flow rate during urination, maximum bladder capacity during urination, bladder pressure during the bladder filling period, and residual urine volume were recorded before and after treatment, and bladder compliance was calculated; clinical outcome was evaluated for both groups. Results After treatment, both groups had significant reductions in the numbers of times of urination and urethral catheterization(P<0.05) and a significant increase in maximum single urine volume(P<0.05), and the observation group had significantly better results than the control group(P<0.05). After treatment, both groups had significant reductions in residual urine volume and bladder pressure during the bladder filling period, and the observation group had significantly greater reductions than the control group(P<0.05); both groups had significant increases in bladder compliance, maximum bladder capacity during urination, and maximum urinary flow rate during urination, and the observation group had significantly higher values than the control group(P<0.05). The observation group had a significantly higher response rate than the control group [90.00%(27/30) vs 63.33%(19/30), P<0.05]. Conclusion Thunder-fire moxibustion combined with electroacupuncture can effectively improve bladder urodynamics and has a marked clinical effect in patients with NB after SCI.关键词：Spinal cord injury;Neurogenic bladder;Electroacupuncture;Thunder-fire moxibustion;Urodynamics21|557|6更新时间：2023-08-10
- 摘要：Objective To observe the effect of transcutaneous electrical acupoint stimulation(TEAS) on the recovery of patients undergoing gastrointestinal surgery under general anesthesia. Methods Sixty patients(ASA Ⅱ-Ⅲ) selected for scheduled gastrointestinal surgery were randomly divided into control group and TEAS group(n=30 cases per group). Patients in the two groups received general anesthesia, and those of the TEAS group also received TEAS for 30 min(8-12 mA) immediately after surgery. The changes of systolic blood pressure(SBP), diastolic blood pressure(DBP), heart rate(HR) before anesthesia, before acupoint stimulation, before extubation, immediately after extubation, 10 and 30 min after extubation were recorded. The recovery time of spontaneous breathing, extubation time, VAS scores and Bruggman comfort scale(BCS) scores at the time of discharging from postanesthesia care unit(PACU) were recorded. Results Compared with the control group, the recovery time of spontaneous breathing and extubation time were significantly shorter(P<0.05), the VAS score was significantly lower(P<0.05), and the BCS score significantly increased in the TEAS group(P<0.05). There were no significant differences between two groups in the levels of SBP, DBP and HR at each time point(P>0.05). Conclusion TEAS can accelerate the gastrointestinal surgery patients' recovery from general anesthesia, enhance the postoperative analgesic effect, improve patients' discomfort, has less adverse reactions, and is thus conducive to promote the postoperative rehabilitation.关键词：Gastrointestinal surgery;Transcutaneous electrical acupoint stimulation;General anesthesia;Postoperative rehabilitation21|337|2更新时间：2023-08-10
- 摘要：The theory of acupoints has gone through a long process from its embryonic form to its maturity, including its gradual improvement in later generations. Starting from the acupuncture literature in different historical periods, we, in the present paper, gave some examples and analyzed the connotation of important concepts in the development of acupoint theory. It is believed that the signs of the establishment of acupoint theory mainly include the standardization of acupoints' names, the specific description of acupoint positioning, the enrichment and explicitation of the content of acupoints' indications, the highlights of the meridian theory via classification of acupoints, and the interpretation of connotations of acupoints from a clinical perspective.关键词：Acupoints;Acupoint theory;Theory development;Theory characteristics;Acupuncturology26|774|5更新时间：2023-08-10
- 摘要：Parkinson's disease(PD) is a common neurodegenerative disease, and acupuncture has shown potential advantages in the treatment. By analyzing the experimental researches on acupuncture therapy of PD over the past 10 years, the authors find that acupuncture can play a therapeutic role by regulating multiple targets such as basal ganglia neurotransmitter disorder, oxidative stress, abnormal protein folding, immune inflammatory response, apoptosis, neural stem cells and calcium homeostasis. Although the mechanism of acupuncture in the treatment of PD is widely studied, there is still a lack of systematic, in-depth and high-quality research, and the mechanism of acupuncture therapy has not reached a consensus. In the future, the potential mechanisms including mitochondrial dysfunction and intestinal flora should be further studied.关键词：Acupuncture;Parkinson's disease;Mechanism;Review54|1919|4更新时间：2023-08-10
- 摘要：Acupuncture therapy is effective in the treatment of chronic fatigue syndrome(CFS) and has its own unique advantages. In the present paper, we reviewed the progress of experimental researches on the underlying mechanisms of acupuncture treatment of CFS in recent 10 years from: 1) regulating the immune system including the peripheral immune organ, immune cells and immune cytokines, proinflammatory and anti-inflammatory cytokines, and lowering the increase of positive rate of multiple mycoplasma infection; 2) regulating the neuroendocrine system including the hypothalamus-pituitary-adrenal axis and stress hormones, monoamine neurotransmitters, and opioid peptides; 3)raising the anti-oxidative stress ability by reducing malondiadehyde, and upregulating activities of antioxidant enzymes superoxide dismutase and glutathione peroxidase; and 4) regulating multiple cellular molecule signaling pathways revealed by genomic and proteomic technologies. In conclusion, acupuncture can relieve CFS through multiple ways and systems, which may provide some ideas for further studies on the biological mechanisms.关键词：Chronic fatigue syndrome(CFS);Acupuncture therapy;Experimental researches;Review25|1353|3更新时间：2023-08-10
- Postal code：100700
- Tel：010-64089344,84014607 Email：zcyjbjb@vip.163.com
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05017590号-8
京公网安备11010802020460号 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
0