最新刊期
卷 46 ， 期 5 ， 2021
- 摘要：Objective To explore the effect of electroacupuncture(EA) on the ability of spatial learning-memory and the expression of IL-1β, IL-6 and TNF-α in the hippocampus and spleen tissues and the number of hippocampal neurons and spleen lymphocytes in Alzheimer's disease(AD) mice, so as to study its mechanisms underlying improvement of AD. Methods Twenty-four SAMP8 mice were randomly and equally divided into AD model, EA and medication groups, and 8 SAMR1 mice were used as the control group. EA(2 Hz, 0.1 mA) was applied to "Baihui"(GV20) and "Yintang"(EX-HN3) for 20 min in the EA group, and intragastric administration of donepezil hydrochloride(0.92 mg/kg) was applied in the medication group, once daily for 15 d. The learning-memory ability was determined by Morris water maze task, and the histopathological changes of hippocampus were observed after H.E. staining, followed by determining neurons and the number of splenic lymphocytes. The expression levels of IL-1β, IL-6 and TNF-α in the hippocampus and spleen were detected by immunohistochemistry and Western blot, respectively. Results After mode-ling, the escape latency of place navigation test in the Morris water maze, the spleen index, immunoactivity and expression levels of IL-1β, IL-6 and TNF-α proteins in the hippocampus and spleen tissues were significantly increased(P<0.05, P<0.01). Compared with the model group, the escape latency, spleen index, immunoactivity and expression levels of IL-1β, IL-6 and TNF-α proteins in both hippocampus and spleen were significantly down-regulated in the medication(except the escape latency) and EA groups(P<0.01, P<0.05). The effect of EA was evidently superior to that of medication in shortening the escape latency, lowering the spleen index, and immunoactivity of hippocampal IL-6 and splenic TNF-α immunoactivity(P<0.01, P<0.05). Outcomes of H.E. staining showed disordered arrangement of neurons with nuclear pyknosis or apoptosis in partial neurons in the hippocampus, and thickened and swollen spleen capsule tissue with loose structure and an increased number of lymphocytes in the model group, which was relatively milder in the EA and medication groups. Conclusion EA can improve the learning-memory ability of AD mice, which may be associated with its effect in relieving the inflammation reaction in the hippocampus and spleen tissues.关键词：Electroacupuncture;Alzheimer's disease;Learning-memory ability;Central inflammation;Peripheral immunity;Hippocampus39|591|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) intervention on the behavior, colon and midbrain substantia nigra α-synuclein(α-syn) expression in Parkinson's disease(PD) mice, so as to explore the mechanism of early EA on prevention of PD. Methods C57 BL/6 J mice were randomly divided into blank, model and EA groups, with 8 mice in each group. The PD mouse model was established by subcutaneous injection of rotenone. Mice in the EA group received EA(2 Hz, 1 mA) at "Quchi"(LI11), "Shangjuxu"(ST37) and acupuncture at "Shenting"(GV24)and "Tianshu"(ST25) for 10 min once daily, with 7 d for a course, a total of 8 courses. Behavioral tests of hanging and climbing poles were carried out before, during and after modeling. The expressions of a-syn in substantia nigra and colon were detected by Western blot and immunohistochemistry or immunofluorescence. Results After 8 weeks of modeling, the mice in the model group showed symptoms such as listlessness, dim hair color, coldness and curling up. Compared with the blank group, the hanging score of the model group was significantly lower(P<0.01), the pole climbing time and the expressions of α-syn protein in colon and substantia nigra were significantly increased(P<0.01). Following intervention, mice in the EA group were always in good mental state, with shiny fur and stable body weight. The hanging scores was significantly higher and the pole climbing time and the expressions of α-syn protein in colon and substantia nigra were significantly down-regulated(P<0.05, P<0.01) in the EA group relevant to the model group. Conclusion Early EA intervention can delay the onset of PD induced by rotenone, which may be related to its effect in reducing the expression of α-syn in midbrain substantia nigra and colon.关键词：Parkinson's disease;α-synuclein;Electroacupuncture;Substantia nigra;Colon33|621|6更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) preconditioning on left-cardiac function, contents of serum TNF-α and IL-6 and expression of myocardial farnesoid X receptor(FXR), small heterodimer partner(SHP), apoptosis inducing factor(AIF) and heat shock proteins 70(HSP70) genes in myocardial ischemia-reperfusion injury(MIRI) rats, so as to explore its mechanisms underlying improvement of ischemic myocardial injury. Methods Forty male Wistar rats were randomly divided into normal control, sham operation, MIRI model and EA pretreatment groups, with 10 rats in each group. Rats of the sham operation group received exposure of the thorax and heart. The MIRI model was established by occlusion of the anterior descending branch of the left coronary artery(LAD). EA(2 Hz/100 Hz and 1 mA) was applied to bilateral "Neiguan"(PC6), "Zusanli"(ST36) and "Guanyuan"(CV4) for 20 min, once a day for 7 days. The left ventricular end-diastolic pressure(LVEDP), left ventricular systolic pressure(LVSP)and maximal rates of rise and fall of left ventricular pressure(±dp/dt_(max)) were detected, the contents of serum TNF-α and IL-6 were detected by using enzyme-linked immunosorbent assay(ELISA), and the expression of FXR, SHP, AIF and HSP70 apoptotic genes in the myocardial tissue were measured by fluorescent quantitative RT-PCR. Results Compared with the normal control group, the LVEDP, contents of serum TNF-α and IL-6, and the expression levels of myocardial FXR, SHP, AIF and HSP70 mRNAs were significantly increased(P<0.05), while LVSP and ±dp/dt_(max) levels were obviously decreased in the model group(P<0.05). In comparison with the model group, MIRI-induced increases of LVEDP, TNF-α and IL-6 contents, and FXR, SHP and AIF mRNA expression and decreases of ±dp/dt_(max) and LVSP levels were reversed(P<0.05), except HSP70 mRNA expression with significantly increased(P<0.05) in the EA pretreatment group. Conclusion EA pretreatment can protect the left ventricular function of the ischemic heart in MIRI rats, which may be related to its effects in reliving peripheral inflammation and regulating the expression levels of apoptosis-related factors FXR, SHP, AIF and HSP70 in the myocardium.关键词：Myocardial ischemia;Reperfusion injury;Electroacupuncture pretreatment;Apoptosis38|534|2更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) at "Ciliao"(BL32) and "Huiyang"(BL35) on the expression of extracellular signal-regulated kinase 1/2(p-ERK1/2) and cellular oncogene fos(c-fos) phosphorylated of spinal dorsal horn in rats with interstitial cystitis(IC). Methods Eighteen female Wistar rats were randomly divided into control, model and EA groups, with 6 rats in each group. The IC model was established by intraperitoneal injection of cyclophosphamide(150 mg/kg). EA(30 Hz, 1 mA) was applied to bilateral BL32 and BL35 for 20 min, once daily for 3 consecutive days. The bladder pain was measured by using a Von Frey at 48 h after modeling and 24 h after EA. The expression levels of p-ERK1/2 and c-fos protein in L6-S1 segment of spinal cord were detected by Western blot, and the expression of p-ERK1/2 and c-fos in the right spinal dorsal horn were displayed by immunofluorescence staining. Results After modeling, the bladder mechanical pain threshold(PT) was significantly decreased(P<0.05), the protein expression of p-ERK1/2 and c-fos in the spinal cord was increased(P<0.05) and the immunofluorescence surface density of p-ERK1/2 and c-fos in the right dorsal horn of spinal cord was increased(P<0.05) in the model group relevant to the control group. After EA intervention, IC-induced reduction of PT, and increases of the expression of p-ERK1/2 and c-fos as well as immunofluorescence surface density of p-ERK1/2 and c-fos were reversed in the EA group relevant to the model group(P<0.05). Conclusion EA at BL 32 and BL 35 has an analgesic effect in IC rats, which may be related to its effect in down-regulating the expression of p-ERK1/2 and c-fos in spinal dorsal horn.关键词：Electroacupuncture;Interstitial cystitis;Pain;p-ERK1/2;c-fos37|524|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupoint catgut embedding(ACE) combined with moxibustion on the expressions of Notch receptor 1 and target genes Hes 1 and Math 1 in colonic mucosa of ulcerative colitis(UC) rats, so as to reveal its mechanism of treating UC from the perspective of Notch signaling pathway. Methods Thirty SD rats were randomized into normal, model, ACE combined with moxibustion(combination), ACE, and moxibustion groups(n=6 in each group). The UC model was established by intrarectal administration of 5% trinitro-benzene-sulfonic acid and 50% ethyl alcohol. Moxibustion was applied to bilateral "Shangjuxu"(ST37), "Tianshu"(ST25) and "Dachangshu"(BL25) for 10 min, once daily for 14 days, and ACE applied to the same 3 acupoints, once a week for two weeks. After the treatment, colonic mucosal pathological changes were observed after hematoxylin eosin(HE) stain. Protein and mRNA expressions of Notch 1,Hes 1 and Math 1 were detected by RT-PCR and Western blot, respectively. Results H.E. staining showed severe defect of the colonic mucosal epithelium with infiltration of a large number of inflammatory cells in the model group, which was milder in moxibustion, ACE and moxibustion + ACE groups. After modeling, the protein and mRNA expressions of Notch 1 and Hes 1 in the colonic mucosa were obviously increased(P<0.01), while the protein and mRNA expressions of Math 1 were significantly decreased(P<0.01) in the model group relevant to the normal group. Following the intervention, the protein and mRNA expression levels of Notch 1 and Hes 1 in the colonic mucosa were significantly lower(P<0.05,P<0.01) in moxibustion, ACE and combination groups, the mRNA expression level of Math 1 was significantly increased in both ACE and combination groups(P<0.01), and the protein expression of Math 1 was significantly higher in the three treatment groups relevant to the model group(P<0.01). The above indexes of moxibustion + ACE were considerably superior to those of simple ACE and simple moxibustion(P<0.05, P<0.01). Conclusion Acupoint catgut embedding combined with moxibustion can repair the injured colonic mucosa of UC rats, which may be related with its effects in suppressing the expression of Notch 1 and Hes 1, up-regulating the expression of Math 1 in the colonic mucosa, thereby regulating the balance of differentiation between colonic epithelial secretory and absorption cell lines.关键词：Ulcerative colitis;Acupoint catgut embedding;Moxibustion;Notch signaling pathway43|527|4更新时间：2023-08-11
- 摘要：Objective To investigate the effect of joint administration of electroacupuncture(EA) and bone marrow mesenchymal stem cells(BMMSC) on the expression of estrogen receptor(ER) and progesterone receptor(PR) in thin endometrium rats, so as to explore its mechanisms underlying improvement of conception rate. Methods Forty female SD rats were divided into control, model, BMMSC and EA+BMMSC groups. The thin endometrium model was established by intrauterine infusion of 95% ethanol and saline. EA(1 mA,2 Hz/15 Hz) was applied to "Guanyuan"(CV4), unilateral "Zigong"(EX-CA1) and unila-teral "Sanyinjiao"(SP6) for 15 min, once daily for 10 d. Rats of the BMMSC and EA+BMMSC groups received injection of BMMSC suspension through caudal vein on the day of modeling, the 3(rd) day after surgery, and the 2(rd) day after surgery, and the 2(nd) and the 3(nd) and the 3(rd) estrus phases, respectively. Changes of body weight and estrus phase were continuously recorded. After three estrus cycles, uterine specimens were taken and the uterine coefficient was calculated. The immunoactivity of KI67(an antigen for cell proliferation) was detected by immunohistochemistry, and the expression of ER and PR was detected by Western blot. Results Compared with the control group, the uterine coefficient, and expression of endometrium ER and PR proteins were significantly decreased in the model group(P<0.001,P<0.01). In Comparison with the model group, the uterine coefficient, immunoactivity of KI67, and expression of ER and PR proteins were significantly increased in both BMMSC and EA+BMMSC groups(P<0.000 1,P<0.001, P<0.01). The expression level of PR in the EA+BMMSC group was notably higher than that in the BMMSC group(P<0.05), but no significant difference was found between the BMMSC and EA+BMMSC groups in the levels of uterine coefficient and ER expression(P>0.05). Conclusion EA combined with BMMSC injection has a positive effect in promoting the proliferation of endometrium cells in rats with thin endometrium, which may be related to its effect in up-regulating the expression of ER and PR proteins.关键词：Electroacupuncture;Thin endometrium;Bone marrow mesenchymal stem cells;Endometrium cell proliferation;KI67;Estrogen receptor;Progesterone receptor31|453|4更新时间：2023-08-11
- 摘要：Objective To observe the effects of electroacupuncture(EA) on the body weight, disease progression and the expression of heat shock protein 70(HSP70) in lumbar spinal cord of amyotrophic lateral sclerosis(ALS) mice, so as to explore the mechanism of EA on treating ALS. Methods Eighteen ALS transgenic SOD1(G93 A) mice were randomly divided into model, EA and medication groups, with 6 mice in each group, and six C57 BL/6 J mice were used as the normal group. Mice in the EA group received EA at "Quchi"(LI11)-"Hegu"(LI4), "Zusanli"(ST36)-"Sanyinjiao"(SP6), 30 min/time, 5 times/week, for 8 weeks.Mice in the medication group were given riluzole solution(7.6 mg·kg(G93 A) mice were randomly divided into model, EA and medication groups, with 6 mice in each group, and six C57 BL/6 J mice were used as the normal group. Mice in the EA group received EA at "Quchi"(LI11)-"Hegu"(LI4), "Zusanli"(ST36)-"Sanyinjiao"(SP6), 30 min/time, 5 times/week, for 8 weeks.Mice in the medication group were given riluzole solution(7.6 mg·kg(-1)·d(-1)·d(-1)) by gavage for 8 weeks. The body weight of the mice was recorded and the motor function of the hind limbs was evaluated by the neurological function scoring stan-dard of the ALS Therapeutic Development Institute. The expression of HSP70 in lumbar spinal cord was detected by Western blot and immunohistochemistry, respectively. Results Compared with the normal group, the body weight and the expression of HSP70 in the model group decreased significantly(P<0.05), while no significant difference in the body weight was found among other groups(P>0.05). After intervention and in comparison with the model group, the disease onset time and paralysis time of the EA group and the medication group were significantly delayed(P<0.05,P<0.01), the expression of HSP70 in the EA group and the medicine group was significantly increased(P<0.05,P<0.01).But there was no significant difference in the survival time among all groups(P>0.05). The disease onset time of the EA group was shorter than that in the medication group(P<0.05).Conclusion EA can increase the expression of HSP70 in lumbar spinal cord, thereby delaying the progression of ALS.关键词：Electroacupuncture;Amyotrophic lateral sclerosis;Transgenic mouse;Heat shock protein 70;Energy metabolism32|248|0更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) of "Weizhong"(BL40) on the expression of platelet-derived growth factor(PDGF)-CC, PDGF receptor(PDGFR)α and matrix metalloproteinase-1(MMP-1) in rats with lumbar multifidus muscle injury(LMMI) so as to study its mechanisms underlying improvement of skeletal muscle injury. Methods Fifty-four male SD rats were randomly divided into normal group(n=6), model group(n=24) and EA group(n=24), and the latter two groups were further divided into four subgroups(1, 3, 5 and 7 days), with 6 rats in each group. The LMMI model was established by injection of 0.5% bupivacaine(BPVC, 100 μL×4) into the multifidus along the L4 and L5 spinous process. EA(2 Hz/50 Hz, 1 mA) was applied to bilateral "Weizhong"(BL40) for 20 min, once daily for 1, 3, 5 and 7 days respectively, from the first day on after modeling. Histopathological changes of the left multifidus muscle were observed after H.E. staining, and the expression of PDGF-CC, PDGFR-α and MMP-1 proteins in the right multifidus was observed by Western blot. Results Compared with the normal group, the expression levels of PDGF-CC protein in the model subgroup 1 d, 3 d and 7 d were significantly decreased(P<0.05), and those of PDGFR-α and MMP-1 proteins in the model subgroup 5 d and 7 d, and PDGF-CC protein in the model subgroup 5 d significantly increased(P<0.05). In comparison with the model subgroups, the expression levels of PDGF-CC in the EA subgroup 3 d, 5 d and 7 d, PDGFR-α in the EA subgroup 5 d, and MMP-1 in the EA group 3 d and 5 d were significantly increased or significantly further increased(P<0.05). H.E. staining showed different shapes and uneven sizes, with large area of damage, enlarged muscle space and inflammatory cell infiltration in the model group, which was relatively milder in the EA subgroups particularly in subgroup 5 d and 7 d. Conclusion EA stimulation of BL40 for about 5 days has a positive effect in promoting the repair of the injured multifidus muscle in LMMI rats, which may be related to its function in up-regulating the expression of muscular PDGF-CC, PDGFR-α and MMP-1 proteins.关键词：Electroacupuncture;Lumbar multifidus muscle injury;Platelet-derived growth factor(PDGF)-CC;PDGFR-α;MMP-130|371|3更新时间：2023-08-11
- 摘要：Objective To compare the effect of electroacupuncture(EA) and transcutaneous electrical acupoint stimulation(TEAS) of skin and muscle layers of "Liangqiu"(ST34) area on inflammatory muscular pain in rats, so as to study the role of different-layer afferent nerve fibers in acupuncture analgesia. Methods A total of 120 male SD rats were used in the present study, including 8 rats used for determining the excitatory threshold of Aδ(Ta) and C(Tc) afferent nerve fibers, 48 employed for comparing the analgesic effect of EA and TEAS at intensities of Ta and Tc, and 64 for observing the effect of EA and TAES stimulation of ipsilateral(Ipsi),contralateral(Contra) ST34 and ipsilateral LI4 at Ta and Tc intensities. Inflammatory muscle pain was induced by injection of complete Freund's adjuvant(CFA) into the right biceps femoris muscle. In the second part of the present study, 48 rats were randomly and equally divided into control, model, TEAS-Ta, TEAS-Tc, EA-Ta and EA-Tc groups, while in the 3 rd part, 64 rats were randomly and equally divided into control, model, Ipsi-ST34-TEAS, Contra-ST34-TEAS, Ipsi-ST34-EA, Contra-ST34-EA, Ipsi-LI4-TEAS and Ipsi-LI4-EA groups. TEAS or EA was applied to the skin and muscle layers, respectively. Before and after modeling, the animal was forced to stand on a bipedal equilibrator, the difference in body mass distribution of both feet(bearing difference) was used to assess the pain severity. The frequency of myoelectrical discharges of the right bicep femoris muscle in responding to electrical stimulation of the spot between the 4(th) and 5(th) and 5(th) toes of the ipsilateral hindlimb at an intensity of two-folds of C-fiber excitatory threshold was recorded. Results 1) The bearing difference between the bilateral hindlimbs was markedly higher in the model group than in the control group(P<0.01), and significantly lower at the 2(th) toes of the ipsilateral hindlimb at an intensity of two-folds of C-fiber excitatory threshold was recorded. Results 1) The bearing difference between the bilateral hindlimbs was markedly higher in the model group than in the control group(P<0.01), and significantly lower at the 2(nd) and 3(nd) and 3(rd) day in the EA-Ta and EA-Tc, and TEAS-Tc groups relevant to the model group(P<0.05, P<0.01). 2) The frequency of C-fiber reflex induced electromyogram(EMG) activities were significantly decreased at 0 and 1 min after TEAS of both ipsilateral ST34 at Tc, and 0 min after TEAS of the contralateral ST34 at Tc(rather than at Ta and not LI4 even at Tc) in comparison with pre-TEAS, and 0, 1 and 2 min after TEAS of ipsilateral ST34 at Tc, and 0 min after TEAS of contra-ST34 at Tc compared with the model group, respectively(P<0.01, P<0.05). In comparison with pre-EA, the frequency of C-fiber reflex induced EMG activities were significantly decreased at 0 and 1 min after EA of the ipsilateral ST34 at Ta, and 0 min after EA of the contra-ST34 at Ta. In addition, the frequency of C-fiber reflex induced EMG activities were decreased at 0, 1 and 2 min after EA of the ipsilateral ST34 at Tc, and 0 and 1 min after EA of the contra-ST34 at Tc, as well as 0 min after EA of LI4 at Tc(P<0.01, P<0.05).In comparison with the model group, the frequency of C-fiber reflex induced EMG activities are significantly decreased at 0, and 1 min after EA of the ipsilateral ST34 at Ta, and 0 min after EA of the contra-ST34 at Ta. In addition, the frequency of C-fiber reflex induced EMG activities were decreased at 0, 1,2,and 3 min after EA of the ipsilateral ST34 at Tc, and 0 and 1 min after EA of the contra-ST34 at Tc, as well as 0 min after EA of LI4 at Tc, respectively(P<0.01, P<0.05). Conclusion TEAS-ST34 at Tc and EA-ST34 at both Ta and Tc can alleviate pain behavior in inflammatory pain rats, which may be related to its effect in activating the afferent nerve fiber in different layers of ST34 area.关键词：Inflammatory muscle pain;Electroacupuncture;Transcutaneous electrical acupoint stimulation;C-fiber reflex38|796|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of application at Back-Shu with Front-Mu acupoints on serum uric acid(SUA) and kidney uric acid transport related proteins in hyperuricemia rats, so as to explore the mechanism of Shu-Mu acupoint application on treatment of hyperuricemia. Methods SD rats were randomly divided into blank control, model, vaseline application and medication application groups, with 8 rats in each group. The hyperuricemia rat model was established by gavage of potassium oxonate. Rats in the vaseline application group received application of vaseline at bilateral "Ganshu"(BL18) and "Qimen"(LI14),"Pishu"(BL20) and "Zhangmen"(LR13),"Shenshu"(BL23) and "Jingmen"(GB25). Rats in the medication application group received application of traditional Chinese medicine at the same acupoints. The contents of SUA and creatinine(SCr) were detected by automatic biochemical analyzer. H.E. staining was used to observe the pathological changes of kidney. And the protein expression levels of organic anion transporter 1(OAT1) and adenosine triphosphate binding cassette transporter G2(ABCG2) were detected by immunohistochemistry. Results Rats in the model group showed symptoms such as polydipsia, polyuria, loose stools, fatigue, weakness, etc. The renal tubules atrophied, and urate crystals can be seen in the lumen. Compared with the control group. the SUA content in the model group increased(P<0.01)and the expressions of OAT1 and ABCG2 protein in kidney decreased(P<0.01). After intervention and in comparison with the model group showed that, the diet, excretion function, and mental state of the rats in the medication application group returned to normal, and the pathological changes of the kidney tissue were alleviated, the SUA content was down-regulated(P<0.01)and the expression levels of OAT1 and ABCG2 in the kidney up-regulated(P<0.01). There was no statistically significant difference in the SCr content among the 4 groups(P>0.05). Conclusion Medication application at Shu-Mu points can effectively reduce the SUA level of hyperuricemia rats, which may be related to its effects in up-regulating the protein expressions of OAT1 and ABCG2 in the kidney and reducing the damage to the kidneys.关键词：Shu-Mu acupoint;Application;Hyperuricemia;Serum uric acid;Uric acid transport related protein35|283|0更新时间：2023-08-11
- 摘要：Objective To observe the curative effect of joint administration of acupuncture, western and herbal medicines and bamboo-jar-cupping in the treatment of locomotor dysfunction in patients with apoplexy(acute phase) of wind-phlegm blocking meridian-collateral type in acute stroke patients, and its influence on some relevant laboratory indexes.Methods A total of 100 cases of acute stroke patients of wind-phlegm blocking meridian-collateral type were recruited, and equally and randomly divided into control group and treatment group according to the random number table. The patients of both groups received treatment of conventional western medicines(for anti-platelet aggregation, blood-lipid regulation, arterial plaque-stabilization, cerebral cell protection and blood pressure-lowering), Chinese herbal medicines(for promoting blood circulation to dredge the meridian-collaterals), and acupuncture of Neiguan(PC6), Chize(LU5), Zusanli(ST36), Binao(LI14) and Sanyinjiao(SP6); and in addition, the patients of the treatment group also treated by cupping with bamboo-jar(kept for 10 min). The treatment was conducted once a day for 2 weeks. After the treatment, the National Institute of Health Stroke Scale(NIHSS), Fugl-Meyer assessment(FMA), Barthel Index(BI), and traditional Chinese medicine(TCM) syndrome score were used to assess the state of neurofunction, locomotor function, daily living ability, and TCM symptoms. The contents of serum C-reactive protein, D-dimer and blood homocysteine were detected using radical immunodiffusion, immunoturbidimetry, and enzymic methods, respectively.Results After the treatment, of the 50 and 50 cases in the control and treatment groups, 5 and 6 were cured, 7 and 18 experienced marked improvement, 23 and 20 were effective, and 15 and 6 ineffective, with the effective rate being significantly higher in the treatment group(88.0%) than in the control group(70.0%, P<0.05). Self-comparison showed that the FMA and BI scores were significantly increased(P<0.01), and the NIHSS score and TCM syndrome score notably decreased in both groups( P<0.01) in comparison with their own pre-treatment. Comparison between the two groups showed that the FMA and BI scores were obviously higher in the treatment group than in the control group(P<0.05), whereas the NIHSS score and TCM syndrome score as well as the C-reaction protein content evidently lower in the treatment group than in the control group(P<0.05, P<0.01). Conclusion Joint administration of acupuncture, western and Chinese herbal medicines and cupping can promote the recovery of nerve function, improve locomotor function, activities of daily living and quality of life, and reduce inflammatory state in acute stroke patients with wind-phlegm blocking collaterals.关键词：Acupuncture;Cupping with water-jar;Acute ischemic stroke;Syndrome of wind-phlegm blocking collaterals;Neurological function28|347|1更新时间：2023-08-11
- 摘要：Objective To evaluate the effect of electroacupuncture(EA) combined with acupoint catgut embedding the-rapy for postoperative pain after fistulotomy. Methods A total of 138 patients were randomly assigned into EA, acupoint catgut embedding and combination groups, with 46 patients in each group. The interventions were performed 30 min before surgery in all the three groups. The acupoints were Changqiang(GV1) and Chengshan(BL57). The visual analogue scale(VAS) score and limb activity score of the three groups at 6, 12, 24, 48 and 72 h after surgery, as well as maximum VAS score within 24 h(T24 max VAS) of 1—3 d and total amounts of oral analgesic within 72 h after surgery were observed and recorded. Results The VAS score and limb activity score from the 6, 12 and 24 h after surgery, and T24 max VAS score on the 1(st) day of the EA group were lower than those of the acupoint embedding group(P<0.05). While the VAS pain score and limb activity score at the 48 h and 72 h after surgery, and T24 max VAS score at the 2(st) day of the EA group were lower than those of the acupoint embedding group(P<0.05). While the VAS pain score and limb activity score at the 48 h and 72 h after surgery, and T24 max VAS score at the 2(nd) to 3(nd) to 3(rd) day, and total dose of oral analgesic within 72 h in the acupoint embedding group were lower than those of the EA group(P<0.05). The combination group was superior to the EA and acupoint embedding groups in terms of VAS score and limb activity score at different postoperative time, T24 max VAS score at 1-3 d after surgery, and the total amounts of analgesic used within 72 h(P<0.05). Conclusion EA combined with acupoint catgut embedding is more effective than simple EA or acupoint catgut embedding for postoperative pain after fistulotomy, with significant curative effect and no adverse reactions.关键词：Fistulotomy;Pain;Electroacupuncture;Acupoint catgut embedding29|362|0更新时间：2023-08-11
- 关键词：DOU Han-qing;Acupuncture;Academic achievements;Literature research30|415|2更新时间：2023-08-11
- 摘要：Objective To systematically evaluate the efficacy and safety of thrombolysis combined with acupuncture therapy in the treatment of acute cerebral infarction(ACI) in the light of evidence-based medicine. Methods Randomized controlled trials(RCT) for acupuncture and thrombolysis treatment of acute cerebral infarction published from the inception of databa-ses to March 2020 were searched from PubMed, Cochrane Library, Embase, Web of science, CNKI, Wanfang, VIP, and CBM Database. According to the inclusion and exclusion criteria, two reviewers independently screened the RCTs and extracted the data. The quality of the included literature was evaluated, and the Meta-analysis was performed by using Revman 5.3 software. Results A total of 330 studies were identified, and 14 RCTs(including 604 cases of the treatment group, 598 cases of the control group) met the inclusion criteria. The Meta-analysis showed that the thrombolysis combined with acupuncture therapy was better than acupuncture therapy alone in the clinical effective rate(risk ratio [RR]=1.19,95% confidence interval [CI] [1.13,1.25]), NIHSS score(mean difference [MD]=-3.51,95% CI [-4.54,-2.48]), BI index(MD=12.26,95% CI [8.07,16.46]), and in lowering C-reaction protein levels(MD=-3.99, 95% CI [-4.35,-3.63]). The rate of complete recanalization(RR = 1.20, 95% CI [1.00, 1.44]), adverse reaction(RR = 0.76, 95% CI [0.41, 1.41]) and hemorrhagic conversion(RR = 0.72, 95% CI [0.14, 3.62]) was not statistically significant.Conclusion The current effective evidence shows that acupuncture has certain advantages in improving the therapeutic effect and safety of thrombolysis in the treatment of ACI patients.关键词：Acute cerebral infarction;Thrombolysis;Acupuncture;Meta-analysis31|910|1更新时间：2023-08-11
- 摘要：Post-traumatic stress disorder(PTSD) is a kind of chronic mental disorder after severe traumatic events. In this paper, the author reviewed the development of clinical and mechanism research of acupuncture and moxibustion for treating PTSD in the past 5 years. Clinical studies have shown that acupuncture could alleviate the symptoms of PTSD, and is an effective therapy for PTSD. The underlying mechanisms may include regulating neural circuit, neurotransmitters and receptors expression, signal pathway, apoptosis, immune cytokines and endocannabinoid system, et al. It could provide scientific basis of acupuncture and moxibustion for treating PTSD, and provide references for further study.关键词：Post-traumatic stress disorder;Acupuncture and moxibustion;Review33|1189|4更新时间：2023-08-11
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