最新刊期
卷 46 ， 期 8 ， 2021
- 摘要：Objective To observe the effect of Sanjiao acupuncture(triple energizer acupuncture)on the small G protein guanosine triphosphate enzyme subfamily protein RhoA/Rho kinase(ROCK) pathway in Alzheimer's disease mice, and explore its effect on learning and memory function and neurosynaptic plasticity. Methods Forty SAMP8 senile dementia mice were randomly divided into model, Sanjiao acupuncture(acupuncture), non acupoint acupuncture(non-acupoint) and fasudil groups, with 10 mice in each group, another 10 SAMR normal aging mice were selected as normal aging group. Mice in the acupuncture group were treated with acupuncture intervention on “Danzhong”(CV18), “Zhongwan”(CV13), “Qihai”(BL24) and bilateral “Xuehai”(SP10) and “Zusanli”(ST36). Mice in the non-acupoint group were treated with acupuncture at each of the left and right non-acupoints under the ribs and mice in the fasudil group were intraperitoneally injected with fasudil(25 mg/kg). The mice in each group were given medicine or acupuncture on the second day after grouping for 28 continuously days, once a day. Morris water maze test was used to test the learning and memory ability of mice. HE staining was used to observe the pathological changes of neurons in hippocampus. The number of hippocampal neuron dendritic spine was detected by FD fast Golgi staining kit. The contents of β-amyloid 42(Aβ42) and phosphorylated tau protein(p-tau) in hippocampus were detected by ELISA. Western blot was used to detect the protein relative expression levels of RhoA, ROCK, F-actin and p-cofilin in hippocampus. Results Compared with those in the normal aging group, the hippocampal neurons of the model group were disorderly arranged, the number of neuron was reduced, the escape latency, hippocampal Aβ42 and p-tau contents, RhoA and ROCK protein expressions increased(P<0.05), the number of crossing the original platform, the number of neuronal dendritic spines, expressions of F-actin and p-cofilin decreased(P<0.05). After the interventions, there was no statistically significant difference in the above indicators in the non-acupoint group relevant to the model group(P>0.05). The acupuncture group and fasudil group improved the hippocampal pathological damage. The escape latency, hippocampal Aβ42 and p-tau contents, the expressions of RhoA and ROCK protein decreased(P<0.05), and the number of crossing the original platform, the number of hippocampal neuron dendritic spines, expressions of F-actin and p-cofilin increased(P<0.05) in both of the acupuncture and fasudil groups in contrast to the model and non-acupoint groups. Compared with the acupuncture group, there was no significant difference in the above indicators in the fasudil group(P>0.05). Conclusion Sanjiao acupuncture may inhibit the activation of the RhoA/ROCK pathway, so as to improve the learning and memory function of AD mice, increase the number of hippocampal neuron dendritic spines, and promote synaptic plasticity.关键词：Sanjiao acupuncture;Alzheimer's disease;Ras homolog gene subfamily member A/Rho associated protein kinase pathway;Learning and memory ability;Synaptic plasticity21|896|6更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) at “Zusanli”(ST36)-“Sanyinjiao”(SP6) on glucose and lipid metabolism and insulin resistance(IR) in obese diabetic rats, so as to explore its mechanism underlying improvement of obesity diabetes. Methods SPF male rats were randomly divided into normal control, model, meridian-acupoint EA(acupoint), non-meridian non-acupoint EA(non-acupoint), and medication(metformin) groups, with 10 rats in each group. The diabetes model was established by feeding the rats with high-fat diet for 8 weeks. EA(1.5 mA, 10 Hz/100 Hz) was applied to unilateral ST36 and SP6 for 20 min, once daily(except Sundays) for 4 weeks. Rats of the medication group were treated by gavage of metformin(300 mg/kg) once daily for 4 weeks(except Sundays). The body weight and length were measured and the Lee's index was calculated. The contents of total cholesterol(TC), triglyceride(TG), low density lipoprotein-cholesterol(LDL-C), high density lipoprotein-cholesterol(HDL-C) in the plasma were detected by using a full-automatic biochemical analyzer. The content of fasting serum insulin(FINS) was assayed by using radioimmunoassay, the fasting blood glucose(FBG) was measured, and serum superoxide dismutase(SOD) activity by using xanthine oxidase method, serum malondialdehyde(MDA) by color method, serum glutathione peroxidase(GSH-Px) activity by indirect method, reactive oxygen species(ROS) by Dithio-bis-nitrobenzoic acid(DTNB) direct method, and the homeostasis model assessment of IR(HOMA-IR) and insulin sensitive index(ISI) were calculated. The expression levels of pancreatic tissue P66 shc mRNA and PKCβ mRNA were detected by using RT-PCR, and the histopathological changes of the liver and adipose tissues were observed after H.E. staining.Results Compared with the normal control group, the Lee's index, levels of FBG, FINS, HOMA-IR, TC, TG, LDL-C, MDA, ROS, and P66 shc mRNA and PKCβ mRNA expressions were significantly increased(P<0.05,P<0.01), and ISI, HDL-C, SOD, GSH-Px significantly decreased(P<0.05, P<0.01) in the model group. After the interventions, the levels of Lee's index, levels of FBG, FINS, HOMA-IR, TC, TG, LDL-C, MDA, ROS, and expressions of P66 shc mRNA and PKCβ mRNA were remarkably down-regulated(P<0.05, P<0.01), and those of ISI, HDL-C, SOD, and GSH-Px up-regulated(P<0.05, P<0.01) in both EA and medication groups. H.E. staining showed many white adipocytes in the adipose tissue, radial and cord-like arrangement of liver cells, and many of them with vacuoles in the cytoplasm of small vesicular lipid droplets in the model group; and relative reduction of white adipocytes in number, smaller in cell body, and no obvious abnormal changes of structure and arrangement of liver cells in the EA and medication groups.Conclusion EA of ST36 and SP6 can improve glucose and lipid metabolism and IR in obese diabetic rats, which may be related to its function in suppressing PKCβ/P66 shc signaling and oxidative stress.关键词：Electroacupuncture;Obesity diabetes;PKCβ/P66shc signaling;Oxidative stress23|943|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) of “Zusanli”(ST36) and “Sanyinjiao”(SP6) on serum TNF-α, IL-1β, and IL-6 and expression of synovial matrimetalloproteinases(MMPs) and articular morphology in collagen-induced arthritis(CIA) rats, so as to explore its mechanisms underlying relief of arthritis. Methods Thirty male SD rats were randomly divided into normal control, CIA model and EA groups(n=10 rats per group). The arthritis model was induced by multi-point intradermal injection of bovine type Ⅱ collagen emulsion. EA(2 Hz/100 Hz, 1 mA) was applied to bilateral ST36 and SP6 for 30 min, once a day for 28 days. The hind-limb paw volume was measured and the arthritis index(AI) score given according to the swelling degree, rigidity and deformity of the ankle joint(0—4 points). After EA intervention, the morphological damage of the affected ankle joints was revealed by H.E. staining, safranin O-fast green staining, and tartrate-resistant acid phosphatase(TRAP) staining, separately. The levels of serum TNF-α, IL-1β, and IL-6 were measured by ELISA, and the expression levels of MMP-1, MMP-3, MMP-13, and receptor activator of nuclear factor Kappa B ligand(RANKL) in the synovial tissue were detected by Western blot.Results Compared with the normal control group, the paw volume, AI score, TRAP-revealed number of osteoclasts, contents of serum TNF-α, IL-1β and IL-6, and expression levels of MMP-1, MMP-3, MMP-13 and RANKL proteins were significantly increased in the model group(P<0.01, P<0.05). Following the intervention, the paw volume, AI score, number of osteoclasts, contents of serum TNF-α, IL-1β and IL-6, and expression levels of MMP-1, MMP-3, MMP-13 and RANKL proteins were significantly decreased in the EA group(P<0.05, P<0.01) in contrast to the model group. H.E. and safranin O-fast green staining showed rough articular cartilage surface with thinned cartilage layer, obvious hyperplasia of the synovial tissue with many inflammatory cells, and serious damage and degradation of the cartilage matrix in the model group, these situations were relatively milder in the EA group. Conclusion EA of ST36 and SP6 can reduce the articular damage in collagen-induced arthritis rats, which is associated with its function in reducing inflammatory response and down-regulating the expression of synovial MMP-1, MMP-3, MMP-13 and RANKL proteins.关键词：Electroacupuncture;Collagen-induced arthritis;Synovium;Bone and cartilage;Inflammatory factor28|305|3更新时间：2023-08-11
- 摘要：Objective To investigate the effect of internal heat-type acupuncture needle on the expression of osteoprotegerin(OPG), receptor activator of NF-κB ligand(RANKL), and receptor activator of NF-κB(RANK) in knee osteoarthritis(KOA) rabbits, so as to explore its mechanisms in relieving KOA. Methods Thirty New Zealand rabbits were randomly divided into control, model and treatment groups, with 10 rabbits in each group. The KOA model was established by using Hulth method. The rabbits of the treatment group received internal heat-type acupuncture needles(42 ℃) on the left hind limb 20 min, once a week for 4 weeks. The behavioral scores were assessed according to the pain severity, gait, joint motion range and articular swelling severity in reference to the modified Lequesne's methods. Toluidine Blue staining was performed to observe the structure of the subchondral bone and to analyze the difference of morphometric parameters. The protein and mRNA expressions of OPG, RANKL and RANK were detected by Western blot and real-time PCR, respectively. Results Compared with the control group, the Lequesne total score, the separation degree of trabecular bone, the protein and mRNA expressions of RANKL and RANK in subchondral bone tissues were significantly increased in the model group, while the percentage of trabecular bone area, number of trabecular bone, the expression of OPG protein and mRNA were decreased(P<0.05, P<0.01). The above indexes were all reversed in the treatment group relevant to those of the model group(P<0.05). Conclusion The internal heat-type acupuncture needle therapy can improve the motor function of rabbits with KOA, which may be related to its effects in up-regulating the expression of OPG and down-regulating the RANKL and RANK in subchondral bone tissue.关键词：Internal heat-type acupuncture needle;Knee osteoarthritis;Subchondral bone;Osteoprotegerin;Receptor activator of NF-κB ligand;Receptor activator of NF-κB22|538|2更新时间：2023-08-11
- 摘要：Objective To observe the effect of transcutaneous auricular vagus nerve stimulation(taVNS) on the autonomic nerve function in a rat model of functional dyspepsia(FD), so as to explore the mechanism of taVNS underlying regulation of FD. Methods SD rats were randomly divided into normal control group(n=8) and FD model group(n=26).The FD model was replicated with iodoacetamide gavage. The FD model rats were randomly divided into model, taVNS, sham-taVNS and Zusanli(ST36) groups, with 6 rats in each group. Rats in the taVNS group received electrical stimulation of auricular concha, while the sham-taVNS group received no electrical stimulation and rats in the ST36 group received stimulation at ST36 for 30 min once daily for 14 consecutive days. Cervical trapezius electromyography score and abdominal withdrawal reflex(AWR) score were used to evaluate gastric sensitivity. Histopathological changes of the gastric antrum tissue were observed under microscope after H.E. staining. Autonomic nerve function in rats was recorded and assessed by heart rate variability(HRV). The content of acetylcholine(Ach) and the expression of Ach receptor M3 R in gastric antrum was detect by ELISA and Western blot, separately. Results Compared with the normal control group, the cervical trapezius electromyography and AWR scores of the model group increased(P<0.01, P<0.001), and there was no erosion in the gastric antral mucosa and muscle layer. The high-frequency power(HF) in HRV decreased(P<0.05), the ratio of low-frequency power/high-frequency power(LF/HF) increased(P<0.001), and the Ach content and its receptor M3 R expression in gastric antrum tissue decreased(P<0.05). Following interventions, the cervical trapezius electromyography and AWR scores decreased(P<0.01,P<0.001, P<0.05), HF in HRV increased and LF/HF decreased(P<0.01,P<0.05,P<0.001), and the content of Ach in gastric antrum tissue and the expression of its receptor M3 R increased(P<0.01, P<0.05) in both taVNS and ST36 groups relevant to the model group. Conclusion taVNS can increase the activity of the vagus nerve and regulate the balance of the autonomic nerve function, which may be one of the mechanisms of taVNS in reducing the gastric sensitivity of rats with FD. In regulating the vagus nerve function, taVNS and acupuncture at ST36 acupoint have the similar effects.关键词：Transcutaneous auricular vagus nerve stimulation;Functional dyspepsia;Vagus nerve;Acetylcholine23|920|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) preconditioning of “Shenmen”(HT7)-“Tongli”(HT5) segment of the Heart Meridian on neuronal electrical activities of lateral hypothalamus area(LHA) in rats with myocardial ischemia reperfusion injury(MIRI), so as to investigate its possible mechanism underlying improvement of MIRI. Methods Twenty-four SD rats were randomly divided into sham, model, EA and damage + EA(D+EA) groups, with 6 rats in each group. The MIRI model was established by occlusion of the anterior descending branch(ADB) of the left coronary artery for 30 min, followed by reperfusion for 2 h. In the sham operation group, the ADB was only threaded beneath the artery without ligation. EA(2 Hz, 1 V) was applied to bilateral HT7-HT5 for 20 min, once daily for 7 days. In the D+EA group, FN was injected with 0.4 μL of 1 g/L kainic acid solution. Electrocardiogram(ECG) of the neck-thoracic lead was recorded by using PowerLab. The electrical activities of the LHA region were recorded by the implanted microelectrode array(2×4) and Plexon multi-channel acquisition system. Cluster analysis of neuronal signals was carried out by Offline Sorter software. The discharge waveforms, autocorrelation and cross-correlation of neuronal activities were analyzed by using Neuro Explorer software. Results Compared with the sham group, the ECG-ST height was significantly increased(P<0.05), the discharge frequency of pyramidal neurons was significantly reduced(P<0.01), while the discharge frequency of interneurons was increased(P<0.01) in the model group. After EA treatment, the ECG-ST height was significantly decreased(P<0.05), the discharge frequency of pyramidal neurons was significantly increased(P<0.01) relevant to the model group. In comparison with the EA group, the ECG-ST height in the D+EA group was significantly elevated(P<0.05), whereas the discharge frequency of pyramidal neurons was significantly decreased(P<0.01). The discharge frequency of interneurons was kept increasing after MIRI. Real-time spectrum analysis showed that the local field potential spectrum energy of the EA group was significantly lower than that of the model group and the D+EA group. Conclusion EA preconditioning of Heart Meridian can significantly increase the discharge frequency of LHA excitatory pyramidal neurons and reduce the energy of the local field potential spectrum, which maybe one of the important mechanisms of EA in anti-MIRI.关键词：Electroacupuncture;Heart meridian;Myocardial ischemia-reperfusion injury;Lateral hypothalamus area;Neuronal activity21|629|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) at “Zhiyang”(GV9) and “Jizhong”(GV6) of the Governor Vessel on the expression of calcitonin gene related peptide(CGRP)and NOD-like receptor pyrin containing 3(NLRP3) in the injured anterior horn(AH) of rats with spinal cord injury(SCI), so as to explore its mechanisms underlying improvement of SCI. Methods Thirty-six male SD rats were randomly divided into sham operation(sham) group, model group and EA group which were further randomly allocated to 7 day(d) and 14 d subgroups(n=6 per subgroup). The SCI model was established by clamping the exposed spinal cord with an aneurysm clip. Rats of the EA group received EA of GV6 and GV9 for 30 min, once daily for 7 and 14 days, respectively. The Basso, Beattie and Bresnahan(BBB) was used to assess changes of the locomotor function on the 1(st), 3(st), 3(rd), 7(rd), 7(th) and 14(th) and 14(th) day after SCI. The protein expression levels of CGRP, NLRP3, apoptosis-associated speck-like protein(ASC) and cysteinyl aspartate specific protease-1(caspase-1) in the anterior horn region of the spinal cord on the 7(th) day after SCI. The protein expression levels of CGRP, NLRP3, apoptosis-associated speck-like protein(ASC) and cysteinyl aspartate specific protease-1(caspase-1) in the anterior horn region of the spinal cord on the 7(th) and 14(th) and 14(th) after SCI were detected by Western blot. Results The BBB scores on the 1(th) after SCI were detected by Western blot. Results The BBB scores on the 1(st), 3(st), 3(rd), 7(rd), 7(th) and 14(th) and 14(th) d after SCI were significantly lower in the model group than in the sham group(P<0.05), whereas the expression levels of NLRP3, ASC and caspase-1 proteins on day 7 and 14 were markedly higher in the model group than in the sham group(P<0.05, P<0.01). Compared with the model group, the BBB score and CGRP expression on the 7(th) d after SCI were significantly lower in the model group than in the sham group(P<0.05), whereas the expression levels of NLRP3, ASC and caspase-1 proteins on day 7 and 14 were markedly higher in the model group than in the sham group(P<0.05, P<0.01). Compared with the model group, the BBB score and CGRP expression on the 7(th) and 14(th) and 14(th) d were significantly increased in the EA group(P<0.05,P<0.01), while the expression levels of NLRP3, ASC and caspase-1 were obviously decreased in the EA group(P<0.01). Conclusion EA of GV6 and GV9 can improve the locomotion of SCI rats, which may be associated with its function in up-regulating the expression of CGRP and down-regulating the expression of NLRP3, ASC and caspase-1 proteins in the spinal anterior horn tissue.关键词：Spinal cord injury;Electroacupuncture;NLRP3;CGRP;Neuroinflammation22|459|9更新时间：2023-08-11
- 摘要：Objective To observe the effect of transcutaneous electric acupoints stimulation(TEAS) on vascular endothelial function and inflammatory factors after percutaneous coronary intervention(PCI) in patients. Methods A total of 94 patients with coronary heart disease and undergoing PCI were randomized into a TEAS group and a sham-TEAS group, 47 cases in each one. In the TEAS group, TEAS started at unilateral Neiguan(PC6) and Ximen(PC4) 30 min before PCI till the end of PCI. In the sham-TEAS group, the procedure and persistent time were same as the TEAS group, but no electric stimulation was performed. Before treatment and at 8 h and 24 h after PCI, the levels of serum endothelin-1(ET-1), von Willebrand factor(vWF), nitric oxide(NO), blood flow dependent diastolic function(FMD), interleukin-6(IL-6), inteleukin-10(IL-10), matrix metalloproteinase-9(MMP-9) and high-sensitivity C-reactive protein(hs-CRP) were detected in the patients successively. Results Compared with the levels before PCI, the levels of ET-1 and vWF were all increased at 8 h and 24 h after PCI in the two groups(P<0.05) and the levels in the TEAS group were remarkably lower than those in the sham-TEAS group(P<0.05). Compared with the levels before PCI, the levels of NO and FMD at 8 h and 24 h after PCI were all reduced in the two groups(P<0.05) and the levels in the TEAS group were higher obviously than those in the sham-TEAS group(P<0.05). Compared with the levels before PCI, the levels of hs-CRP, MMP-9, IL-6 and IL-10 were all increased at 8 h and 24 h after PCI in the two groups(P<0.05); Compared with the sham-TEAS group, the levels of hs-CRP, MMP-9 and IL-6 were reduced and the level of IL-10 was increased at 8 h and 24 h after PCI in the TEAS group(P<0.05). Conclusion TEAS effectively improves the vascular endothelial function and reduces serum inflammatory factors after PCI.关键词：Coronary heart disease;Percutaneous coronary intervention;Transcutaneous acupoint electrical stimulation;Vascular endothelial function;Inflammatory factors27|273|0更新时间：2023-08-11
- 摘要：Objective To observe the clinical efficacy of Tiaoshen needling(dredging Governor Vessel and regulating mind)in the treatment of chronic insomnia(CI) and its effect on plasma melatonin(MT) and cortisol(CORT) levels, so as to explore its underlying mechanism. Methods Sixty patients with CI were randomly divided into the treatment group and the control group, with 30 cases in each group. Both groups were given sleep hygiene education before treatment. Patients in the treatment group received acupuncture or electroacupuncture at Baihui(GV20), Shenting(GV24), Yintang(GV29), bilateral Shenmen(HT7) and Sanyinjiao(SP6). Patients in the control group received acupuncture or electroacupuncture at bilateral Shousanli(LI10), Futu(ST32) and Feiyang(BL58). Both groups were treated every other day, 3 times a week, for a total of 4 weeks. Before and after treatment, Pittsburgh sleep quality index(PSQI) and fatigue severity scale(FSS) were used to evaluate sleep qua-lity and daytime fatigue, the plasma MT and CORT levels were measured by enzyme-linked immunosorbent assay. Results Compared with before treatment, the PSQI scores and total FSS score of the treatment group decreased significantly(P<0.01,P<0.05), and the plasma MT content increased and CORT decreased significantly in the treatment group(P<0.01),while the sleep-onset time score, sleep disturbance score and the PSQI total score of the control group decreased significantly(P<0.05). Compared with the control group, the PSQI sleep disorder score and total score, and the total FSS score as well as plasma CORT level were significantly down-regulated(P<0.01,P<0.05), while the plasma MT content was up-regulated(P<0.05) in the treatment group. Conclusion Tiaoshen acupuncture can significantly improve the sleep quality of patients with CI and relieve daytime fatigue, which may be related to the increase of plasma MT content in patients with CI, thereby inhibiting the excessive activation of the hypothalamic-pituitary-adrenal axis.关键词：Chronic insomnia;Acupuncture;Cortisol;Melatonin21|785|4更新时间：2023-08-11
- 摘要：Objective To explore the effect on the core symptoms in children with autism spectrum disorder(ASD) treated with acupuncture at “ghost points”, combined with the acupoints selected by syndrome differentiation. Methods A total of 124 ASD children were divided into a control group and a treatment group according to random number table, 62 cases in each group. In the control group, the routine rehabilitation treatment was provided in all of children, while in the treatment group, acupuncture was exerted at “ghost points”, combined with the acupoints selected by syndrome differentiation. Acupuncture treatment was conducted for 15 min each time, 5 days weekly, for 3 months totally. Before and after treatment, the children were assessed with autism spectrum rating scale(ASRS) in two groups. Results After treatment, the total score(T-score) of ASRS and the score of each sub-scale, e.g. peer socialization, adult socialization, social/emotional reciprocity, atypical language, stereotypy, repetitive behavior, sensory sensitivity, attention/self-regulation were all reduced remarkably as compared with those before treatment in intra-group comparison(P<0.05, P<0.01). Compared with the control group, the scores aforementioned were all significantly reduced in the treatment group(P<0.05). Conclusion Acupuncture at “ghost poitns” combined with the acupoints selected by syndrome differentiation effectively relieves the core symptoms of ASD in children and improves the holistic therapeutic effect.关键词：Acupuncture;Ghost points;Autism spectrum disorder;Syndrome differentiation;Core symptoms23|410|4更新时间：2023-08-11
- 摘要：Acupuncture treatment can regulate blood pressure(BP) through multiple levels and ways. In the present paper, we reviewed the progress of researches on the underlying mechanisms of acupuncture in lowering BP from 1) regulation of activities of the neuroendocrine, 2) improvement of metabolic abnormality, and 3) alternation of gene expression in the heart and BP-regulation-related centers of the brain. The neuroendocrine mechanism mainly involves the inhibition of neuroinflammatory reaction in some higher brain regions, reduction of neuronal apoptosis, and suppression of the sympathetic cardiovascular regulatory functional areas of the brain stem, regulation of neurotransmitters and autonomic balance, activation of brain areas related to BP regulation, and promotion of functional connection between brain networks. The improvement of metabolic abnormality mainly refers to amelioration of imbalance of intestinal flora and target metabolites related to hypertension. The alteration of gene expression mainly manifests as up-and down-regulation of expression of genes related to oxidative stress, inflammation and vascular endothelial function in the myocardium, hypothalamus, rostral ventrolateral medulla. We reviewed the new research progress on the mechanism of acupuncture for hypertension, in order to provide evidence and research ideas for the treatment of related cardiovascular diseases by using acupuncture therapy in the future.关键词：Acupuncture;Hypertension;Lowering blood pressure;Mechanism;Review25|1068|2更新时间：2023-08-11
- 摘要：Acupuncture therapy is widely used in the treatment of various clinical problems, but has some contraindications which should be highly noted. For example, patients with potential hemorrhagic tendency owing to administration of necessary anticoagulants and antiplatelets should be paid more attention when acupuncture therapy was performed. Usually, anticoagulants and antiplatelets combined with nonsteroidal anti-inflammatory hormones, antibiotic agents and vasodilators significantly increased the risk of bleeding. Chinese herbal medicines for activating blood circulation to arrest pain, and improper medication including the dosage and frequency should be avoided. Patients with chronic liver diseases, acute and severe liver and kidney function impairment due to inability to secrete coagulation factor in time to initiate coagulation mechanism are also unsuitable for acupuncture the-rapy. For this reason, we put forward some necessary countermeasures: a) collecting the patient's medical history in detail, b) paying attention to the coagulation related tests, c) taking the patient's blood volume and platelet related parameters seriously, and d) enacting reasonable diagnosis and treatment ideas.关键词：Acupuncture;Anticoagulant and antiplatelet drugs;Bleeding risks;Countermeasures17|171|0更新时间：2023-08-11
- 摘要：The schematic diagram is an indispensable part of research article in life science, which can effectively and intuitively show the specific content of the article with simple composition. As an intuitive expression of the interdisciplinary subject at the early stage, the schematic diagram in the literature has gained an all-round improvement in the quality along with the deve-lopment of computer technology and modern drawing tools. In contrast, the level of the schematic diagram appears to be lagged behind in the field of acupuncture research papers. In order to improve the drawing level of this field, we took the Five Shu-points of Hand and Foot Jueyin Meridian as an example, and drew some vector diagrams of their anatomical structures including the body surface, skeleton, nerves, arteries and veins by using the Adobe Illustrator image software, through which we sum up a simple and easy-to-learn process including application skills and key points needing attention. We hope these methods can play a role in the acupuncture research in the future.关键词：Image software;Adobe Illustrator;Five shu-points;Neuroanatomy;Schematic diagram23|406|0更新时间：2023-08-11
- 摘要：Moxibustion therapy has a good therapeutic effect in warming yang, strengthening body resistance to dispel pathogenic cold and qi, thus being able to prevent and treat infectious diseases. There are many records about clinical application of moxibustion to infectious diseases in ancient and modern literature. In the present paper, we expound the specific methods of moxibustion for strengthening the body resistance and preventing infectious diseases and its application in the treatment of miasma, bone steaming disease, cholera, pestis, epidemic hemorrhagic fever and so on, in the records of ancient and modern times, and expound its effectiveness. On this basis, we also proposed the feasibility of moxibustion in the prevention and treatment of COVID-19, a new type of infectious disease currently.关键词：Moxibustion;Infectious disease;COVID-1924|610|1更新时间：2023-08-11
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