最新刊期
卷 49 ， 期 11 ， 2024
- “最新研究发现，电针耳甲区耳穴能减轻创伤后应激障碍小鼠焦虑行为，可能通过提高ACC谷氨酸能神经元兴奋性实现。”摘要：ObjectiveTo elucidate the relationship between the auricular point stimulation and the activity of glutamatergic neurons in the anterior cingulate cortex （ACC） from the perspective of intrinsic excitability plasticity of neurons in mice with posttraumatic stress disorder （PTSD）， so as to explore the underlying mechanisms of acupuncture at auricular points in improving emotional diseases induced by PTSD.MethodsC57BL/6J male mice were randomly divided into control， PTSD model， sham electroacupuncture （EA）， and EA groups， with 5 mice in each group. The glutamatergic neurons were labelled by injection of AAV2/9-CaMKⅡα-EGFP viral fluid into the bilateral ACC. Fourteen days after the injection， the PTSD model was established by single prolonged stress （restraint stress， forced swimming， ether exposure） and plantar electrical shock. EA （2 Hz/15 Hz， 1 mA） was applied to bilateral “Xin” points and the center of auriculae of auricular concha area for 30 min， once daily for 7 days. Mice of the sham EA group were anesthetized for 30 min per day for 7 days， but no EA treatments were given. The anxiety-like behavior of mice was evaluated by open field （OF） and elevated plus maze （EPM） tests after 2 weeks of modeling. The whole-cell patch-clamp method was used to record the intrinsic excitability level of ACC glutamatergic neurons.ResultsCompared with the control group， the dwell time and locomotor distance in the central area of the OF， the dwell time and entry times percentage in the open arms of the EPM in the model group were significantly reduced （P<0.001， P<0.01）. At the same time， the intrinsic excitability of ACC glutamatergic neurons in model mice was suppressed， presenting as enhanced rheobase currents （P<0.01） and decreased spike number （P<0.05， P<0.01， P<0.001）. Compared with the model group， the dwell time and locomotor distance in the central area of the OF， the dwell time and entry times percentage in the open arms of the elevated plus maze were significantly increased （P<0.001， P<0.01）， and the intrinsic excitability of ACC glutamatergic neurons was significantly improved， presenting as reduced rheobase currents （P<0.05） and an increased spike number （P<0.05） in the EA group. Compared with the sham EA group， the dwell time and locomotor distance in the central area of the OF， the dwell time and entry times percentage in the open arms of the EPM were significantly increased （P<0.001， P<0.01） in the EA group， and the intrinsic excitability of ACC glutamatergic neurons was significantly improved， presenting as reduced rheobase currents （P<0.01） and an increased spike number （P<0.05）.ConclusionEA of auricular points can effectively alleviate the anxiety-like behavior of PTSD mice and increase the intrinsic excitability level of glutamatergic neurons in ACC， which may be one of the neural mechanisms of auricular point stimulation in the treatment of emotional diseases.关键词：Electroacupuncture;Auricular points;Posttraumatic stress disorder;Anterior cingulate cortex;Neural intrinsic excitability95|5|1更新时间：2024-12-04
- “最新研究发现，“夹脊”电针能通过调节HMGB1/TLR4/NF-κB信号通路，抑制脊髓损伤后神经炎性反应，促进神经功能恢复。”摘要：ObjectiveTo observe the effect of electroacupuncture （EA） of “Jiaji” （EX-B2） on expression of high mobility group box 1 （HMGB1）/Toll-like receptor 4 （TLR4）/nuclear factor-κB （NF-κB） related proteins and inflammation-related factors in spinal cord injury （SCI） rats， so as to explore the dynamic process of inhibiting inflammatory response in rats with SCI， and to provide a new idea and theoretical basis of molecular biology for the treatment of SCI.MethodsFifty-four SD rats were randomly divided into sham operation， model， and EA groups （n=18 in each group）， which were further divided into 3 d， 7 d and 14 d subgroups， with 6 rats at each time point. The SCI model was established according to the Allen’s method. Rats in EA group received EA （1 mA， 100 Hz） intervention at EX-B2 of T9 and T11 24 hours after modeling for 30 min， once a day for 3 d， 7 d， or 14 d， respectively. The motor function of rats’ hind limbs was evaluated using BBB scale， the morphological structure of rats’ spinal cord tissue was observed by H.E. staining. The contents of inducible nitric oxide synthase （iNOS） and cyclooxygenase-2 （COX-2） in spinal cord tissue were detected by ELISA. Western blot and immunofluorescence staining were used to detect the relative protein expression and fluorescence positive expression of HMGB1， TLR4 and NF-κB p65 in spinal cord tissue， respectively.ResultsCompared with the sham operation group， the BBB scores after modeling and on day 3， 7 and 14 were all decreased （P<0.05）， while the contents of iNOS and COX-2 in spinal cord tissue， the protein expression and fluorescence positive expression of HMGB1， TLR4， and NF-κB p65 were increased （P<0.05） in the model group. In comparison with the model group， the BBB scores on day 3， 7 and 14 were obviously increased （P<0.05）， while the contents of iNOS and COX-2， the protein expression and fluorescence positive expression of HMGB1， TLR4， and NF-κB p65 were significantly down-regulated in the EA group （P<0.05）.ConclusionEA of “Jiaji” can promote the recovery of SCI neurological function， which may be related to its function in regulating the HMGB1/TLR4/NF-κB signaling pathway， down-regulating the expression of iNOS and COX-2， and inhibiting the neuroinflammatory response after SCI.关键词：Electroacupuncture;“Jiaji”（EX-B2）;Spinal cord injury;High mobility group box 1;Toll like receptor 4;Nuclear factor-κB106|5|0更新时间：2024-12-04
- “最新研究发现，电针能减轻局灶性脑缺血大鼠的脑组织炎性损伤，改善神经功能缺损，可能通过激活miR-218抑制HMGB1/TLR4通路及其下游促炎细胞因子水平。”摘要：ObjectiveTo observe the effect of electroacupuncture （EA） on high mobility group box 1 （HMGB1） / toll-like receptor 4 （TLR4） signaling pathway and inflammatory injury in rats with focal cerebral ischemia （FCI）， so as to explore its mechanisms underlying amelioration of ischemic stroke.MethodsMale SD rats were randomly divided into sham operation （n=18）， model （n=18） and EA （n=18） groups. The FCI model was established according to Longa’s method. In the EA group， 24 h after modeling， EA stimulation was applied to “Baihui”（GV20）， “Fengfu”（GV16）， and “Neiguan” （PC6） and “Xinshu” （BL15） on the left side for 20 min， once a day for 1 week. The neurological deficit severity was evaluated by the modified neurological severity score （mNSS）， and the morphological changes of neurons were observed after H.E. staining. The expression of HMGB1 and TLR4 proteins were detected by immunofluorescence staining. The contents of tumor necrosis factor（TNF）-α and interleukin（IL）-6 in the ischemic area tissue of the brain were detected using ELISA. The mRNA expressions of HMGB1 and TLR4 as well as the expression of miR-218 in the ischemic cortex were detected by PCR.ResultsCompared with the sham operation group， the mNSS at 2 h， 48 h and 7 day （d），IL-6 and TNF-α contents， HMGB1 and TLR4 immunoactivity and mRNA expression at 48 h and 7 d were significantly increased （P<0.01）， while miR-218 expression at 48 h and 7 d was obviously down-regulated （P<0.01） in the model group. In comparison with the model group， the mNSS at 7 d，IL-6 and TNF-α contents， HMGB1 and TLR4 immunoactivity and mRNA expression at 7 d not at 48 h were significantly decreased （P<0.01， P<0.05）， while the expression of miR-218 at 7 d was apparently up-regulated （P<0.05） in the EA group. H.E. staining showed that there were signs of neuronal necrosis including blurred outline of the cells， disordered internal structure， dense cytoplasm， shrunk nuclei， etc. in the ischemic area of the brain at 48 h and 7 d in the model group， which was evidently milder on day 7 in the EA group.ConclusionEA can reduce the inflammatory injury of brain tissue and improve the neurological impairment in rats with FCI， which may be associated with its effects in inhibiting HMGB1/TLR4 signaling and down-regulating the level of pro-inflammatory cytokines.关键词：Focal cerebral ischemia;Electroacupuncture;Inflammatory injury;microRNA;HMGB1/TLR4 signaling pathway74|8|0更新时间：2024-12-04
- “最新研究发现，督脉电针能改善脊髓损伤大鼠神经功能，减少神经元凋亡，可能通过调控GSK-3β蛋白及其磷酸化水平实现。”摘要：ObjectiveTo observe the effect of electroacupuncture （EA） stimulation of “Dazhui”（GV14） and “Mingmen” （GV4） of the Governor Vessel （GV） on the apoptosis of neurons in rats with spinal cord injury （SCI） by regulating the expression of glycogen synthase kinase-3β （GSK-3β） protein and its phosphorylation level， so as to reveal partial mechanism for the treatment of SCI with EA of GV.MethodsA total of 45 male SD rats were randomly divided into sham-operation， model and EA groups， 15 rats in each group. The SCI model was established by using the modified Allen’s percussion device. EA stimulation （2 Hz， 1 mA） was applied to GV14 and GV4 for 20 min， once daily for 28 days. Basso-Beattie-Bresnahan （BBB） locomotor rating scale was used to assess the rat’s hind limb motor function at the 1st， 7th， 14th， 21th and 28th day after modeling. H.E. staining was used to observe the histopathological changes of the injured spinal cord tissue. The expressions of GSK-3β and its phosphorylation at Ser9 site in the spinal cord were detected by immunohistochemistry and Western blot， respectively. The TUNEL staining was used to observe the apoptosis of neuron in the spinal cord.ResultsIn comparison with the control group， the BBB scores from day 1 to day 28， and the expression and immunoactivity of p-GSK-3β were significantly decreased （P<0.01）， while the expression and immunoactivity of GSK-3β and the apoptosis index were significantly increased （P<0.01） in the model group. In contrast to the model group， the EA group had a remarkable increase in the BBB score from day 7 to day 28， and the expression and immunoactivity of p-GSK-3β （P<0.05， P<0.01）， and an obvious decrease （P<0.05， P<0.01） in the expression and immunoactivity of GSK-3β and the apoptosis index. H.E. staining showed that in the model group， the spinal cord structure of the SCI region was disorganized， with tissue cavity， blurred gray matter boundary， severe inflammatory infiltration， reduction of normal neurons， loss of cytoplasm， and nuclear contraction， which was relatively milder in the EA group.ConclusionEA at GV14 and GV4 can improve the symptoms of neurological function injury and reduce the apoptosis of neurons in rats with SCI， which may be achieved by regulating GSK-3β protein and its phosphorylation level.关键词：Spinal cord injury;Electroacupuncture;Governor Vessel;GSK-3β;Cell apoptosis66|4|0更新时间：2024-12-04
- “最新研究发现，瘤周围刺联合阿霉素能有效控制三阴性乳腺癌肿瘤生长，可能通过影响铜死亡增强化疗疗效。”摘要：ObjectiveTo explore the enhanced sensitization effect of peritumoral electroacupuncture （PEA） on doxorubicin （DOX） chemotherapy in mice with triple-negative breast cancer （TNBC）.MethodsEighteen female Balb/c mice were randomly divided into the model， DOX， and EA+DOX groups， with 6 mice in each group. TNBC cells were injected into the mammary fat pad of mice to establish the breast cancer-bearing mice model. Mice of the DOX and EA+DOX groups were injected intraperitoneally with DOX solution at 4 mg/kg once a week for 4 weeks. For mice of the EA+DOX group， 4 filiform needles were inserted surrounding tumor tissues， followed by giving the mice with EA （1 mA， 2 Hz/100 Hz） stimulation for 3 min， once a week for 4 weeks. During the intervention， the tumor volume was measured every two days， and at the end of intervention， the weight of the tumor tissue was measured. The expression of Ki67 and proliferating cell nuclear antigen （PCNA） in tumor tissues was detected by immunohistochemistry. The protein expression levels of iron redox protein 1 （FDX1）， lipoic acid synthase （LIAS）， aconitase 2 （ACO2） and NADH：ubiquinone oxidoreductase core subunit V1 （NDUFV1）， dihydrolipoamide S-acetyltransferase（DLAT），dihydrolipoyl succinyltransferase（DLST） in tumor tissues were detected by Western blot. The content of copper ions， pyruvic acid and α-ketoglutaric acid， succinic acid in tumor tissues was detected by copper ion kit， and the content of reactive oxygen species （ROS） in tumor tissues of mice was detected by fluorescence method.ResultsCompared with the model group， the tumor volume and weight， the expression levels of Ki67 and PCNA in tumor tissues were decreased （P<0.05， P<0.01） in the DOX and EA+DOX groups. The improvement of the above indicators was more significant in the EA+DOX group than that in the DOX group （P<0.05， P<0.01）. Compared with the model and DOX groups， the contents of ROS， copper ions， pyruvic acid and α-ketoglutaric acid were increased （P<0.05， P<0.01）， while the contents of succinic acid， and the expressions of FDX1， LIAS， ACO2 and NDUFV1， DLAT， DLST proteins were decreased （P<0.01） in the EA+DOX group.ConclusionThe combination of PEA and DOX can effectively control the growth rate of tumors in mice with TNBC， which may contribute to its function in enhancing the chemotherapy efficacy of DOX on TNBC by promoting cuproptosis.关键词：Electroacupuncture;Triple-negative breast cancer;Doxorubin;Cuproptosis93|5|0更新时间：2024-12-04
- “最新研究发现，穴位注射能有效改善变应性鼻炎大鼠鼻黏膜炎性反应，减少过敏症状和MUC5AC分泌，其机制可能与抑制p38 MAPK磷酸化有关。”摘要：ObjectiveTo observe the effects of acupoint injection on the expression of p38 mitogen-activated protein kinase （MAPK）， phosphorylated （p）-p38 MAPK， mucin 5 subtype AC （MUC5AC） in the nasal mucosa， and serum inflammatory factors of rats with allergic rhinitis， so as to explore the mechanism of acupoint injection in improving inflammatory reactions in the nasal mucosa of rats with allergic rhinitis.MethodsSD rats were randomly divided into the normal group， model group， acupoint injection group， and non-acupoint group， with 7 rats in each group. The allergic rhinitis rat model was established using ovalbumin sensitization. Intervention was performed by injecting dexamethasone and 1% lidocaine mixture （0.05 mL） into the bilateral “Yingxiang”（LI20） and “Yintang”（GV24+） acupoints， with injection at non-acupoints for non-acupoint group as the control， once every 3 days for a total of 4 times. Allergic symptoms in the rat nose were evaluated using a cumulative scoring method； histopathological changes in the nasal mucosa were observed after HE staining； serum histamine （HA）， interleukin （IL）-6， IL-8， and tumor necrosis factor-alpha （TNF-α） contents were detected using ELISA； real-time fluorescent quantitative PCR was used to detect the expression of MUC5AC mRNA in the nasal mucosa； Western blot was used to detect the expression of p38 MAPK， p-p38 MAPK， and MUC5AC protein in the nasal mucosa.ResultsCompared with the normal group， nasal allergic symptom score， serum HA， IL-6， IL-8， and TNF-α contents， nasal mucosal p38 MAPK， p-p38 MAPK proteins expression， MUC5AC mRNA and protein expression were significantly increased（P<0.01） in the model group. Compared with the model group and non-acupoint group， nasal allergic symptom score， serum HA， IL-6， IL-8， and TNF-α contents， nasal mucosal p38 MAPK and p-p38 MAPK proteins expression， MUC5AC mRNA and protein expression were significantly reduced （P<0.01， P<0.05） in the acupoint injection group.ConclusionAcupoint injection can reduce nasal allergic symptom， and MUC5AC secretion in rats with allergic rhinitis， alleviate nasal mucosal inflammatory reactions， and its mechanism of action may be related to the inhibition of p38 MAPK phosphorylation， thereby reducing the release of inflammatory factors.关键词：Allergic rhinitis;Acupoint injection;p38 mitogen-activated protein kinase;Inflammatory reaction;Cytokines;Mucin 5 subtype AC85|4|0更新时间：2024-12-04
- “最新研究发现，电针能改善睡眠剥夺大鼠学习记忆能力，可能通过调控突触蛋白PSD95、MeCP2和改善突触结构发挥作用。”摘要：ObjectiveTo observe the effect of electroacupuncture （EA） on the expression of synaptic function related proteins PSD95 and MeCP2 and synaptic ultrastructure in sleep deprived rats， so as to explore its mechanism underlying improvement of learning and memory ability caused by sleep deprivation.MethodsSD rats were randomly divided into normal， model， EA and sham EA groups （n=10）. The sleep deprivation model was prepared by modified multi-platform water environment. Rats of the EA group received EA stimulation at “Baihui” （GV20） and “Dazhui” （GV14）， while the sham EA group received shallow needling 4 mm away from the above acupoints without electrical stimulation. The learning and memory ability was evaluated with Morris water maze test. The density of dendritic spines in hippocampal CA1 region was detected by Golgi staining. The synaptic ultrastructure of hippocampus was observed by electron microscope. The protein expression levels of PSD95 and MeCP2 in hippocampus was detected by Western blot.ResultsCompared with the normal group， the escaping latency of the positioning navigation experiment in the model group was prolonged （P<0.05）， the number of crossing the platform and the residence time in the target quadrant were decreased（P<0.05）， the density of dendritic spines in the hippocampal CA1 area was decreased （P<0.05）， the number of synapses was reduced， with swollen synaptosomes， blurred synaptic structure， disappeared and narrowed synaptic clefts， the protein expression levels of PSD95 and MeCP2 were significantly decreased （P<0.05） in the model group. Compared with the model group， the escape latency of the positioning navigation experiment was shortened （P<0.05）， the number of crossing platforms and the time spent in the target quadrant were increased （P<0.05）， the density of dendritic spines in the hippocampal CA1 region was increased （P<0.05）， the morphology of synaptic improved， the protein expression levels of PSD95 and MeCP2 were increased （P<0.01） in the EA and sham EA groups. The improvement of the above indexes in EA group was more obvious than those in sham EA group.ConclusionEA can improve the learning and memory of sleep deprivation rats， which may be related to its function in regulating the expressions of synaptic related proteins PSD95 and MeCP2， and improving the synaptic structure.关键词：Sleep deprivation;Electroacupuncture;Synaptic;PSD95;MeCP278|3|0更新时间：2024-12-04
- “最新研究发现，电针对慢性失眠症患者睡眠质量有显著改善，并通过调节脑电特征信号发挥作用。”摘要：ObjectiveTo observe the effect of electroacupuncture （EA） on sleep quality and electroencephalogram （EEG） signal in the patients with chronic insomnia and to explore its mechanism.MethodsSixty patients with chronic insomnia were randomized into an EA group （30 cases， 3 cases dropped out） and a health learning group （30 cases， 3 cases dropped out）. In the health learning group， the sleep health education was provided. In the EA group， besides the health education as the health learning group， EA was delivered at Baihui （GV20）， Yintang （GV24+）， bilateral Shenmen （HT7）， bilateral Sanyinjiao （SP6）， with continuous wave， 2 Hz in frequency， once every other day， and 3 interventions a week. EA was given for 4 weeks successi-vely， composed of 12 treatments. The score of Pittsburgh sleep quality index （PSQI）， Hamilton anxiety scale （HAMA）， and patient health questionnaire-9 （PHQ-9） before and after treatment were compared between the two groups. The EEG signals were collected and the relative power and entropy of EEG before and after treatment were compared between the two groups.ResultsAfter treatment， the scores of PSQI， HAMA and PHQ-9， the relevant power of β wave in F8 and T3 channels， and that of α wave in T4 channel， and the entropy in T3 channel under the eyes-open （EO） resting state， as well as the relevant power and the entropy of γ wave in F8 channel under the eyes-closed （EC） resting state in the EA group were lower （P<0.05） than those before the treatment. All of the above results were lower than those of the health learning group at the same time points （P<0.05）. Under the EO resting state， the relevant power of the θ and δ waves of T3 channel and θ wave of T4， O2 and Pz channels of patients in the EA group after the treatment were increased （P<0.05） than those before the treatment， and higher （P<0.05） than those of the health learning group at the same time points.ConclusionAcupuncture is effective on chronic insomnia， which may be related to the regulation EEG signals.关键词：Chronic insomnia;Electroacupuncture;Sleep quality;Electroencephalogram;Randomized controlled trial127|8|0更新时间：2024-12-04
- “最新研究显示，“醒神解郁”法电针能改善抑郁症患者症状，通过调节谷氨酸与GABA发挥作用。”摘要：ObjectiveTo explore the effect of “Xingshen-Jieyu” （inducing resuscitation and dispel ling melancholy） electroacupuncture （EA） on serum metabolites in patients with depression and its underlying mechanisms through serum non-targeted metabolomics.MethodsFifteen depression patients were subjected into the EA group， and 15 healthy volunteers were matched into the healthy group. EA （2 Hz/15 Hz， a tolerable strength） was applied to Baihui （GV20）， Shenting （GV24）， Toulinqi （GB15）， Benshen （GB13）， Touwei （ST8）， Xuanli （GB6） and Qubin （GB7） for 30 min， 3 times a week for 6 weeks. The severity of depression was assessed using Hamilton Depression Scale-17 （HAMD-17） and Hamilton Anxiety Scale （HAMA）， the degree of fatigue was evaluated using Fatigue Scale-14 （FS-14）. The subjects sleep quality was assessed using Pittsburgh sleep quality index （PSQI）. Blood samples were collected before and after the treatment for processing serum to perform non-targeted metabolomics profile detection using ultra-high-performance liquid chromatography coupled with mass spectrometry （UPLC-MS）， and Partial Least Squares Discriminant Analysis （PLS-DA， a statistical approach）. Differential metabolites were screened and pathway enrichment analysis was performed.ResultsAfter the treatment， the scores of HAMD-17， HAMA， PSQI and FS-14 of depression patients were significantly lowered in the EA group （P<0.05）. Compared with the healthy subjects， 46 differential metabolites （21 up-regulated， 25 down-regulated） were screened in patients with depression. Compared with pre-treatment in the EA group， 19 differential （17 up-regulated， and 2 down-regulated） metabolites were screened. Four down-regulated metabolites of the 46 differential metabolites in depression patients were recovered after EA treatment. Kyoto Encyclopedia of Genes and Genomes （KEGG） analysis of differential metabolites before and after EA showed that 19 metabolic pathways were enriched， mainly involving glutaminergic synapses， GABAergic synapses and several amino acid metabolism related pathways.Conclusion“Xingshen-Jieyu” EA mainly regulates the metabolism of amino acids， and activities of neurotransmitter glutamate and GABA， and restores the excitatory/inhibitory balance， thus playing a role in improving depression.关键词：Depression;Electroacupuncture;“Xingshen-Jieyu”;Metabolomics;Serum69|4|0更新时间：2024-12-04
- “在恶性胸腔积液治疗领域，研究显示热敏灸联合胸腔灌注顺铂疗效优于单纯顺铂治疗，能改善患者胸腔积液量、日常生活能力及中医证候，同时降低化疗药物毒性和不良反应。”摘要：ObjectiveTo investigate the clinical efficacy of heat-sensitive moxibustion combined with intrapleural perfusion of cisplatin in comparison with simple intrapleural perfusion of cisplatin on malignant pleural effusion （MPE）.MethodsForty patients with MPE， in compliance with the inclusion criteria， were randomly divided into an observation group （20 cases） and a control group （20 cases）. In the control group， cisplatin solution （60 mg/m2） was injected into the thoracic cavity after pleural drainage under B-ultrasound positioning， once a week for 4 weeks. In the observation group， based on the intervention as the control group， the heat-sensitive moxibustion was delivered at the back and lumbar region （where Feishu ［BL13］， Pishu ［BL20］ and Shenshu ［BL23］ are located） and the chest-abdomen region （where Danzhong ［CV17］， Guanyuan ［CV4］ and Shuidao ［ST28］ are located）， for 30 min to 90 min， once daily （the treatment was discontinued on Saturday and Sunday） and for 4 weeks. Before and after treatment， in the two groups， the pleural effusion volume was detected using B ultrasound， the activity of daily living was evaluated with Karnofsky performance statue （KPS） scale and TCM symptoms with TCM syndrome grading scale. The clinical therapeutic effect was evaluated in the two groups. According to the classification criteria table for acute and subacute toxicity of anticancer drugs made by WHO， the toxic and side reaction was judged.ResultsAfter treatment， the pleural effusion volume was reduced in comparison with that before treatment in the two groups （P<0.01， P<0.001）， and the volume in the observation group was lower than that of the control group （P<0.05）. KPS score was increased in the two groups after treatment compared with that before treatment （P<0.001）， and the score in the observation group was higher than that of the control group （P<0.05）. After treatment， the total score of TCM syndromes and the scores for dyspnea， cough and chest pain were lower than those before treatment in the two groups （P<0.001）， and the scores in the observation group were lower than those of the control group （P<0.001， P<0.05）. The scores for anorexia and lassitude were reduced in comparison with those before treatment in the observation group （P<0.001）； and the scores in the observation group were lower than those in the control group after treatment （P<0.001， P<0.01）. After treatment， the effective rate of the observation group was 65.0%（13/20）， which was higher than that of the control group （30.0%， 6/20， P<0.05）. The incidence of bone marrow suppression in the observation group was 15.0%（3/20）， lower than that in the control group （55.0%， 11/20， P<0.05）. The incidence of gastrointestinal reactions in the observation group was 30.0%， lower than that in the control group （65.0%， 13/20， P<0.05）.ConclusionHeat-sensitive moxibustion combined with intrapleural infusion of cisplatin is superior to intrapleural infusion of cisplatin in the aspects of the amelioration of pleural effusion， daily-living activity and TCM syndromes in patients with MPE. This combined therapy presents the synergism by cooperating with chemotherapeutics and reduces the incidence of toxic and side effects implicated in chemotherapy so as to attenuate the toxicity of chemotherapeutics.关键词：Malignant pleural effusion;Heat-sensitive moxibustion;Intrapleural infusion of cisplatin;Randomized controlled trial85|4|0更新时间：2024-12-04
- “最新研究发现，贺氏强通法能显著促进急性缺血性脑卒中患者神经功能恢复，改善运动功能和日常生活能力，为治疗提供新思路。”摘要：ObjectiveTo investigate the repair effects of He’s qiangtong method of acupuncture （involved bloodletting technique with strong action of unblocking） on the neurovascular unit of the patients with acute ischemic stroke （AIS） in terms of serological indicators so as to provide new ideas for the treatment of AIS.MethodsSeventy subjects with AIS were randomly divided into an observation group （35 cases，1 case dropped out） and a control group （35 cases ，4 cases dropped out）. Patients in the control group were treated with conventional regimen. In the observation group， the bloodletting was operated， combined with the conventional treatment. Bloodletting was performed at Baihui （GV20）， Sishencong （EX-HN1） and bilateral Erjian （EX-HN6）， using He’s qiangtong method of acupuncture， 3 times a week and for 2 weeks. Before and after treatment， the scores of the national institute of health stroke scale （NIHSS）， the modified Rankin scale （MRS）， and the Barthel index were evaluated； and the serological levels of the serum brain-derived neurotrophic factor （BDNF）， vascular endothelial growth factor （VEGF）， glial fibrillary acidic protein （GFAP）， neuron-specific enolase （NSE） and blood-brain barrier permeability-associated protein （S100β protein） were detected in the two groups.ResultsAfter treatment， NIHSS score and MRS score were decreased （P<0.01）， and Barthel score was increased （P<0.01） in both groups. NIHSS score of the observation group was lower than that of the control group （P<0.01）. Compared with those before treatment， the content of BDNF in both groups increased （P<0.05）， and VEGF content was elevated in the observation group （P<0.05） after treatment. The total effective rate was 100% （34/34） in the observation group， higher than that （67.74%， 21/31） in the control group （P<0.01）.ConclusionHe’s qiangtong method of acupuncture can promote the recovery of neurological deficits in AIS patients and effectively improve their motor function and the activity of daily living， which may be related to the reconstruction of neurovascular unit in the brain of AIS patients by increasing the levels of serological repair factors.关键词：He’s qiangtong method of acupuncture;Bloodletting;Acute ischemic stroke;Cytokine67|6|0更新时间：2024-12-04
- “最新研究发现，针灸通过调节阿尔茨海默病神经元细胞周期蛋白等多靶点，可能防治阿尔茨海默病。”摘要：Alzheimer’s disease （AD） is the most common type of dementia. Studies have shown that neuronal cell cycle re-entry is an abnormal change in the early stage of AD， and it is also one of the key reasons for mediating neuronal death. The mechanism of acupuncture and moxibustion in treating AD may be related to the regulation of abnormal cell cycle. In this article， we reviewed the occurrence of AD neuronal cell cycle re-entry and its mediated cell death mechanism， listed the factors affecting neuronal cell cycle re-entry， explored the possible mechanism of acupuncture and moxibustion in preventing and treating AD by regulating AD cell cycle protein， AD neuronal cell cycle re-entry influencing factors （β-amyloid protein and Tau protein phosphorylation level， oxidative stress， brain-derived neurotrophic factor）， the multi-target regulation of neuronal cell cycle re-entry， so as to provide reference for the application and research of acupuncture and moxibustion in preventing and treating AD.关键词：Alzheimer’s disease;Acupuncture;Moxibustion;Neuron;Cell cycle66|5|0更新时间：2024-12-04
- “针刺治疗慢性阻塞性肺疾病临床疗效确切，研究显示其作用机制包括抑制炎性反应、氧化应激和调节蛋白酶/抗蛋白酶失衡，为临床应用提供理论依据和新思路。”摘要：Chronic obstructive pulmonary disease （COPD） is a common disease that seriously jeopardizes human health and affects patients’ quality of life. The clinical efficacy of acupuncture in treating COPD is definite， and it can exert positive effects such as improving skeletal muscle degradation， airway mucus hypersecretion and pulmonary vascular remodeling in COPD rats. In recent years， the research on the underlying mechanisms of acupuncture in improving COPD has become more and more in-depth. In this review， we searched and organized the domestic and international literatures on the basic experimental aspects of acupuncture in COPD treatment， and found that the underlying mechanisms of acupuncture mainly include （1） reducing the number of inflammatory cells in the lung tissue， regulating inflammasome， epigenetic modification and inflammation-related signaling pathways to inhibit the synthesis and release of cytokines， inhibiting the level of autophagy and inhibiting the release and expression of neurotransmitters； （2） improving antioxidant capacity and reducing oxidative damage， suppressing oxidative stress in the lung tissue； （3） regulating protease/antiprotease imbalance to maintain pulmonary homeostasis. These results provide a theoretical basis and a new way of thinking for the clinical application of acupuncture in the treatment of COPD.关键词：Chronic obstructive pulmonary disease;Acupuncture;Mechanism;Review104|8|0更新时间：2024-12-04
- “最新研究揭示针刺治疗癌性疼痛机制，为临床镇痛提供新思路。”摘要：Cancer pain is one of the common complications in patients with intermediate or advanced cancer， which brings severe sufferings to patients and their families， and also seriously interferes with the anti-tumor process. Acupuncture is an effective method for the treatment of cancer pain， which has the advantages of simple operation， quick effect and fewer side effects， and is widely used in clinic. In this paper， we reviewed the relevant literature on the mechanisms of acupuncture in the treatment of cancer pain both at home and abroad in recent years， and summarized the analgesic mechanisms of acupuncture for cancer pain from the peripheral level and the central level. It is found that acupuncture can relieve cancer pain by regulating immune inflammatory response， expression of ion channels and pain-related receptors， remising central sensitization， activating endogenous pain modulating system and suppressing pain transmission pathways. In addition， we also think that the use of high-throughput multi-omics techniques and neuroimaging methods to detect and analyze the brain areas or body fluids before and after acupuncture should be the focus of acupuncture analgesia research in the future.关键词：Acupuncture;Cancer pain;Research progress;Mechanism95|8|0更新时间：2024-12-04
- “针刺疗法中操作者差异影响疗效，专家提出理论分析并给出解决方案，为临床研究和实践提供指导。”摘要：As the principal part of acupuncture therapy， acupuncture operators play the key role in clinical effect. There are the inevitably differences in the characteristics among different operators when delivering acupuncture， which may bring a potential impact on the therapeutic effect of acupuncture. However， this impact has not been drawn enough attention in acupuncture research， and the relevant evidences are still contradictory and partially viewed. If ignored， the quality of the relevant outcomes in research is reduced undoubtedly. In order to ensure these problems being realized by more investigators， perfect the clinical design of acupuncture research and improve the quality of acupuncture operation and research， we put forward the theory of the effects of acupuncture operator， analyzed the limitations of current researches in the aspect of the consideration by acupuncture operators and holistic cognition， and provided the corresponding solutions. It is significant in guiding clinical research and practice of acupuncture in future.关键词：Acupuncture;Acupuncturist;Effects of acupuncture operator58|10|0更新时间：2024-12-04
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