最新刊期
卷 49 ， 期 6 ， 2024
- “最新研究发现，艾灸“心俞”“肺俞”能改善慢性心力衰竭大鼠心肌损伤，可能通过调控TRPV1通路，促进抗炎因子IL-10上调，减轻心肌纤维化。”摘要：ObjectiveTo observe the effect of moxibustion at “Xinshu” （BL15） and “Feishu” （BL13） on transient receptor potential vanilloid type 1（TRPV1）， calcitonin gene-related peptide （CGRP）， and serum interleukin-10 （IL-10） in the myocardial tissue of rats with chronic heart failure （CHF）， so as to explore its underlying mechanisms in improvement of CHF.MethodsMale SD rats were randomly divided into the normal， model， moxibustion， capsaicin， moxibustion + capsaicin， and moxibustion + solvent groups， with 10 rats in each group. The CHF model was established by permanent ligation of the anterior descending branch of the left coronary artery. Mild moxibustion was applied to bilateral BL13 and BL15 for 30 min once daily for 4 weeks. Rats in the capsaicin group were smeared with capsaicin in the acupoint area once a day for 4 weeks. For rats of the moxibustion + capsaicin and moxibustion + solvent groups， capsaicin and solvent were applied to the acupoint area before moxibustion for 4 weeks， respectively. The ejection fraction （EF） and left ventricular fractional shortening rate （FS） were examined by echocardiography. HE staining was used to observe the myecardial morphological structure. The mRNA and protein expression levels of TRPV1， CGRP and galectin-3 （Gal-3） in myocardial tissue were detected by real-time quantitative PCR and Western blot， respectively. The content of IL-10 in serum was detected by ELISA.ResultsAfter modeling， the pathological changes of myocardium （as cardiac muscle fiber disorder， inflammatory cell infiltration， etc.） were obvious， and the EF， FS， serum IL-10， protein and mRNA exspression of TRPV1 and CGRP were significantly decreased （P<0.01） in the model group compared with the normal group， while the protein and mRNA exspression of Gal-3 were significantly up-regulated （P<0.01）. Following the interventions， the above-mentioned indexes were all reversed in moxibustion， capsaicin， and moxibustion + capsaicin groups （P<0.01）， and the effect of moxibustion + capsaicin was the best （P<0.05，P<0.01）.ConclusionMoxibustion can reduce myocardial injury and improve cardiac function in CHF rats， which may be related to its effects in up-regulating the expression of TRPV1 and CGRP， and down-regulating the expression of Gal-3 to alleviate myocardial fibrosis.关键词：Chronic heart failure;Myocardial fibrosis;Moxibustion;Transient receptor potential channel vanilloid;Calcitonin gene-related peptide91|8|0更新时间：2024-07-04
- “最新研究发现，电针“内关”能有效改善心肌肥厚小鼠的心脏形态和功能，其作用机制可能与降低心肌组织中瞬时受体电位通道（TRPCs）蛋白表达有关。”摘要：ObjectiveTo observe the effect of electroacupuncture （EA） at “Neiguan”（PC6） on cardiac function， cardiac morphology and transient receptor potential channel （TRPC） protein expressions in myocardial tissue of mice with myocardial hypertrophy， so as to explore its mechanisms underlying improvement of myocardial hypertrophy.MethodsForty-five male C57BL/6 mice were randomly divided into control， model and EA groups （15 mice/group）. The myocardial hypertrophy model was established by subcutaneous injection of isoproterenol hydrochloride （15 mg·kg-1·d-1） for 14 days. The mice of the control group received subcutaneous injection of same amount of normal saline. The mice of the EA group received EA stimulation （frequency of 2 Hz， intensity of 1 mA） of bilateral PC6 for 20 min each time， once a day for 14 consecutive days. After the intervention， the body weight， tibia length and heart weight were measured. The left ventricular ejection fraction （EF）， fractional shortening index （FS）， left ventricular end-systolic volume （LVEV）， left ventricular end-systolic internal diameter （LVID） and left ventricular posterior wall thickness （LVPW） were measured by using echocardiography for evaluating the cardiac function. The mean number and surface area of myocardial cells was detected by wheat germ agglutinin （WGA） staining， and changes of the cardiac morphology were observed under light microscopy after HE staining. The expression levels of TRPC1， TRPC3， TRPC4 and TRPC6 （TRPC1/3/4/6） in the myocardial tissue were detected by real-time quantitative PCR （qPCR） and Western blot， separately.ResultsCompared with the control group， the heart-body weight ratio（P<0.05） and heart-weight-to-tibia-length ratio （P<0.01）， LVEV and LVID levels， the relative surface area， left ventricular area ratio， and the expression levels of cardiac TRPC1/3/4/6 were significantly increased （P<0.01， P<0.05）， while the EF，FS，LVPW，number of cardiomyocytes， and the left ventricular posterior wall ratio were obviously decreased （P<0.01，P<0.05） in the model group. In comparison with the model group， the heart/body weight ratio， heart-weight-to-tibia-length ratio， LVEV and LVID levels， relative surface area， left ventricular area ratio， and the expression levels of cardiac TRPC1/3/4/6 were significantly decreased （P<0.01，P<0.05）， while the EF， FS， LVPW， number of cardiomyocytes and left ventricular posterior wall ratio were significantly increased （P<0.01，P<0.05） in the EA group. H.E. staining showed disordered arrangement of cardiomyocytes and obvious myocardial interstitial inflammatory cell infiltration in the model group， and evident reduction of degree of cardiac fibrosis and interstitial edema in the EA group.ConclusionEA of PC6 can improve the cardiac function and cardiac morphology in mice with myocardial hypertrophy， which may be related to its functions in down-regulating the expression of transient receptor potential channels.关键词：Myocardial hypertrophy;Electroacupuncture;Transient receptor potential channel;Cardiac function63|6|0更新时间：2024-07-04
- “最新研究发现，电针治疗可能通过抑制Wnt/β-catenin信号通路，逆转上皮间质转化进程，降低宫腔粘连大鼠子宫内膜组织纤维化程度，促进子宫内膜修复，为治疗宫腔粘连提供新方案。”摘要：ObjectiveTo observe the effect of electroacupuncture （EA） on the Wnt/β-catenin signaling pathway and epithelial-mesenchymal transition （EMT）-related proteins in rats with intrauterine adhesions （IUA）， so as to explore the possible mechanisms of EA in repairing endometrial damage in IUA.MethodsFemale SD rats were randomly divided into blank， model， EA， and ICG-001 groups， with 10 rats in each group. The IUA model was established by using mechanical scraping combined with lipopolysaccharide infection for double injury. In the EA group， “Guanyuan” （CV4） was needled and EA （2 Hz/15 Hz， 1—2 mA） was applied to “Zusanli” （ST36） and “Sanyinjiao”（SP6） on both sides. In the ICG-001 group， ICG-001 （5 mg/kg）， the inhibitor of β-catenin was intraperitoneally injected. After intervention， samples were taken from 5 rats in each group， and uterine endometrium morphology， endometrial thickness， and gland counts were observed using HE staining. Masson staining was used to assess the degree of fibrosis in the endometrial tissue. Immunohistochemistry was used to detect the positive expression of transforming growth factor β1 （TGF-β1）， α-smooth muscle actin （α-SMA）， fibronectin （FN）， connective tissue growth factor （CTGF）， type I collagen （Col- Ⅰ）， glycogen synthase kinase-3β （GSK-3β）， β-catenin， E-cadherin， N-cadherin， and Vimentin in the endometrial tissue. Western blot was used to detect the relative expression of GSK-3β， β-catenin， E-cadherin， N-cadherin， and Vimentin proteins in the endometrial tissue. Another 5 rats from each group were placed in cages with male rats after intervention to record the number of embryo implantations.ResultsNecrosis and loss of endometrial tissue in the model group observed after HE staining were alleviated in the EA group， better than those in the ICG-001 group. Compared with the blank group， the numbers of glands and endometrial thickness in the uterine endometrial tissue， relative expression and positive expression of E-cadherin and GSK-3β proteins in the uterine endometrial tissue， and embryo implantation numbers were reduced（P<0.000 1， P<0.001， P<0.01） in the model group， while fibrosis area ratio in the uterine endometrial tissue， TGF- β 1， α -SMA， FN， CTGF， Col- Ⅰ positive expressions， N-cadherin， Vimentin， and β-catenin proteins expression and positive expression were increased（P<0.000 1， P<0.001， P<0.01）. Compared with the model group， the number of glands and endometrial thickness， E-cadherin and GSK-3β proteins expression and positive expression， and embryo implantation numbers were increased （P<0.001， P<0.05， P<0.01） in the EA and ICG-001 groups， while the fibrosis area ratio in the uterine endometrial tissue， TGF-β1， α-SMA， FN， CTGF， Col- Ⅰ positive expression， and N-cadherin， Vimentin， and β-catenin proteins expression and positive expression were decreased（P<0.001， P<0.01， P<0.05）. Compared with the EA group， the differences of the above-mentioned indicators in the ICG-001 group were not statistically significant.ConclusionEA may reverse the EMT process and reduce the degree of fibrosis in endometrial tissue by inhibiting the Wnt/β-catenin signaling pathway， thereby promoting the repair of endometrial damage in IUA.关键词：Intrauterine adhesions;Electroacupuncture;Endometrial fibrosis;Wnt/β -catenin pathway;Epithelial-mesenchymal transition115|9|0更新时间：2024-07-04
- “最新研究发现，电针“足三里”“血海”能有效改善咪喹莫特诱导的小鼠银屑病样皮损，其机制可能通过调控MAPK信号通路抑制血管生成相关因子CD31和VEGF的表达，为银屑病治疗提供新思路。”摘要：ObjectiveTo observe the effect of electroacupuncture （EA） stimulation of “Zusanli”（ST36） and“Xuehai”（SP10） on the angiogenesis of the local injured skin tissue in mice with psoriasis， so as to explore its mechanisms underlying improvement of psoriasis-induced skin lesions.MethodsA total of 24 female BALB/c mice aged 6—8 weeks were randomly divided into control， model and EA groups， with 8 mice in each group. The psoriasis-like skin lesion model was established by application of 5% imiquimod （IMQ） cream to the mice’s back skin， 62.5 mg/d， for 7 days after local depilation， and the mice of the control group received local application of an equal amount of petroleum jelly once a day for 7 days. EA stimulation （2 Hz/100 Hz） was applied to ST36 and SP10 for 30 min， once daily for 7 consecutive days. Photos of the topical injured skin at the back were taken every day， and the severity of psoriasis lesions （psoriasis area and severity index ［PASI］） was scaled. Following H.E. staining， the morphological changes in the injured skin tissue were observed with epidermal thickness analyzed， and the Masson staining was used to observe the proportion of collagen fibers in the injured skin tissues. Immunohistochemical method was used to detect the expression of microvascular markers CD31 and vascular endothelial growth factor （VEGF） and the microvascular density （MVD） was calculated. Western blot was used to detect the expression levels of CD31， VEGF proteins and mitogen activated protein kinases （MAPK） signaling pathway related proteins p38， phosphorylated p38 （p-p38）， extracellular regulated protein kinases （ERK）， p-ERK， c-Jun N-terminal kinase （JNK） and p-JNK in the injured skin tissue.ResultsCompared with the control group， the mice in the model group showed an evident increase in the erythema score， scales score， skin thickening score and PASI score， epidermal thickness， proportion of the collagen fibers， MVD value of CD31 and VEGF， and expression levels of CD31 and VEGF proteins， and p-p38/p38， p-ERK/ERK and p-JNK/JNK ratios in the injured skin tissue （P<0.001， P<0.01）. In contrast to the model group， the EA group had a significant decrease in the levels of all the indexes mentioned above （P<0.05， P<0.01， P<0.001）.ConclusionEA intervention can improve the psoriasis-like skin lesions induced by IMQ in mice， which may be related with its functions in down-regulating the expression of angiogenic related factors CD31 and VEGF proteins and MAPK signaling pathway related proteins in the topical injured skin tissue.关键词：Psoriasis;Electroacupuncture;Angiogenesis;Mitogen activated protein kinases signal pathway51|8|0更新时间：2024-07-04
- “最新研究揭示，热补针法能有效改善类风湿关节炎家兔的痛阈和膝关节周径，抑制炎性反应，其作用机制与降低缺氧诱导因子1α及糖酵解活性密切相关。”摘要：ObjectiveTo observe the effect of heat-reinforcing needling （HRN） on synovial inflammation， hypoxia-inducible factor-1α （HIF-1α） and glycolytic activity in serum and synovial tissue in rabbits with cold syndrome of rheumatoid arthritis （RA）， so as to explore its mechanisms underlying improvement of RA.MethodsA total of 32 rabbits were randomly divided into normal， model， inhibitor and HRN groups， with 8 rabbits in each group. The RA with cold syndrome model was induced by injecting ovalbumin dry powder and Freund’s complete adjuvant combined with cold freezing. Rabbits in the inhibitor group were intraperitoneally injected with 2-methoxyestradiol （2.5 mg/kg）， rabbits in the HRN group were received HRN at bilateral “Zusanli” （ST36） for 30 min. The treatments were conducted once daily for 14 consecutive days. After the interventions， the knee circumference and pain threshold were measured. The contents of nicotinamide adenine dinucleotide phosphoric （NADPH）， Hexokinase II （HK2） and 6-phosphofructo-2-kinase/fructose-2，6-biphosphatase 3 （PFKFB3） in serum of rabbits were detected by ELISA. The pathological morphology of synovial tissue of the knee joints were observed by HE staining. The positive expressions of tumor necrosis factor （TNF-α）， interleukin （IL）-1β， IL-6 and IL-17 in synovial tissue of knee joint were detected by immunohistochemistry. The content of lactic acid in synovial tissue of rabbit knee joint was detected by spectrophotometry. The expression levels of HIF-1α， pyruvate kinase 2 （PKM2） and lactate dehydrogenase （LDHA） in synovial tissue of knee joint were detected by Western blot.ResultsAfter intervention， compared with the normal group， the knee circumference was significantly enlarged （P<0.05）， the pain threshold was significantly decreased （P<0.05）； the synovial tissue of knee joints showed significant cell proliferation and inflammatory infiltration， the pathological score was significantly increased （P<0.05）； positive expressions of TNF-α， IL-1β， IL-6 and IL-17， the content of lactic acid in synovial tissue， the contents of NADPH， HK2 and PFKFB3 in serum， and the protein expression levels of HIF-1α， PKM2 and LDHA in synovial tissue were increased （all P<0.05） in the model group. Compared with model group， the circumference of knee joint was significantly decreased （P<0.05）， the pain threshold was significantly increased （P<0.05）； in synovial tissue， the pathological score was decreased （P<0.05）； the positive expressions of TNF-α， IL-1β， IL-6 and IL-17 in synovial tissue were decreased （P<0.05）， the lactic acid content in synovial tissue was decreased （P<0.05）； the contents of NADPH， HK2 and PFKFB3 in serum and the protein expression levels of HIF-1α， PKM2 and LDHA in synovial tissue were decreased （P<0.05） in inhibitor group and HRN group. Compared with the inhibitor group， the synovial pathological score was significantly increased （P<0.05）， positive expressions of TNF-α， IL-1β， IL-6 and IL-17， the content of lactic acid in synovial tissue， the contents of NADPH， HK2 and PFKFB3 in serum， and the protein expression levels of HIF-1α， PKM2 and LDHA in synovial tissue were increased （all P<0.05） in HRN group.ConclusionHRN can increase the pain threshold， reduce the knee circumference and inhibit the inflammatory response in rabbits with cold syndrome of RA. The possible mechanism is related to the down-regulation of HIF-1α and glycolysis activity.关键词：Rheumatoid arthritis;heat-reinforcing needling;Glycolysis;Hypoxia-inducible factor-1α;Inflammatory response79|10|0更新时间：2024-07-04
- “电针治疗慢性疲劳综合征大鼠研究取得新进展，揭示了电针改善疲劳状态、缓解焦虑情绪、提高学习记忆能力的机制，为电针治疗CFS提供了科学依据。”摘要：ObjectiveTo observe the effect of electroacupuncture （EA） on behavior and hippocampal protein phosphorylation in rats with chronic fatigue syndrome （CFS）， so as to explore its mechanisms underlying improvement of CFS.MethodsMale SD rats were randomly divided into control， model and EA groups （n=12 rats in each group）. The CFS model was established by chronic multifactor combined with stress stimulation （treadmill training + restraint stress + sleep disturbance + crowded environment）. For rats of the EA group， EA （1 mA，frequency of 10 Hz） was applied to “Shenting” （GV24） （with an acupuncture needle penetrated from GV24 to “Baihui” ［GV20］） and “Dazhui” （GV14） for 15 min， once daily for 28 days. After treatment， the body weight，food intake and water intake of rats in each group were observed. The fatigue degree of rats was evaluated by Semi-quantitative score observation table of the general condition of experimental rats.The open field test （OFT） was used to assess the rats’anxiety severity by detecting the total number of grid-crossing and the times of the central area entered in 5 min， and Morris water maze test was employed to assess the rats’ learning-memory ability by detecting the escape latency in 1 min， and the times of the original platform quadrant crossing in 1 min. The hippocampaus was taken for phosphorylated Label-free quantitative proteomics analysis by using Maxquant technology based on full scan mode to calculate the integral of each peptide signal of liquid chromatography-mass spectrometry（LC-MS）. The differentially-expressed proteins （>1.5 folds for up-regulation or <0.67 folds for down-regulation） were evaluated by gene ontology （GO） and Kyoto Encyclopedia of Genes and Genomes （KEGG） enrichment analysis.ResultsCompared with the control group， the body weight， food intake， and the times of original-platform quadrant crossing of spatial exploring of Morris water maze test were significantly decreased （P<0.01，P<0.05） ， and the score of general conditions， times of grid-crossing and center area-entering of OFT， and the escape latency of navigation task were apparently increased （P<0.01） in rats of the model group. After EA intervention， the decreased original-platform quadrant crossing， and the increased score of general conditions， times of grid-crossing and the escape latency of navigation task were all reversed （P<0.01，P<0.05）. Outcomes of proteomics analysis indicated that compared with the model group， there were 297 differentially expressed peptide （48 up-regulated and 249 down-regulated） segments in the control group， and there were 245 differentially expressed peptide （185 up-regulated and 60 down-regulated） segments in the EA group， in which， 25 overlapping peptide segments were reversed after EA treatment， corresponding to 24 proteins， mainly involving cytoskeletal structure. GO function annotation analysis showed that the top three differentially expressed phosphorylated proteins involved in the effect of EA intervention were the actin filament polymerization，protein depolymerization and cytoskeletal tissue in the biological process， the actin binding， structural molecular activity and cytoskeletal protein binding in the molecular function， and the cytoskeleton， dendrites and dendritic trees in the cellular component， respectively. The KEGG pathway annotation analysis for differentially expressed phosphorylated proteins showed that theinsulin secretion， axon guidance， phosphatidylinositol signaling system and lysine biosynthesis， etc. were involved in the effect of EA intervention.ConclusionEA of GV24-GV20 and GV14 can improve the general state， anxiety and learning-memory ability of CFS model rats， which may be related to its functions in regulating the hippocampal protein phosphorylation level， and repairing the structure and function of synapses in hippocampus.关键词：Electroacupuncture;Chronic fatigue syndrome;Phosphorylated proteomics;Liquid chromatography mass spectrometry;Hippocampus71|11|1更新时间：2024-07-04
- “最新研究显示，超声引导下针刀疗法在神经根型颈椎病治疗中，显著改善患者术后残留症状，疗效优于传统手术，且安全可靠。”摘要：ObjectiveTo observe the clinical efficacy and safety of ultrasound-guided acupotomy in adjuvant treatment of residual symptoms after percutaneous cervical disc nucleoplasty （PCDN） for cervical spondylotic radiculopathy （CSR）.MethodsA total of 70 CSR patients were divided into treatment group and control group according to random number table， with 35 cases in each group. Patients in the control group received PCDN， while patients in the treatment group further received ultrasound-guided acupotomy， which was performed once every 5 to 7 days for a total of 4 to 6 times （adjusted according to the condition of patients）. The visual analog score （VAS）， neck dysfunction index （NDI）， Japanese Orthopaedic Association cervical spondylosis scale （JOA score）， and Tanaka Yasuhisa 20-point scale were adopted in the assessment before PCDN and 1 day， 1 month， 3 months， 6 months after PCDN. The clinical efficacy， postoperative adverse reactions and complications of the 2 groups were evaluated.ResultsCompared with those before PCDN， the VAS score and NDI score of the 2 groups were decreased （P<0.05）， JOA score and Tanaka Yasuhisa 20-point score were increased （P<0.05） at 1 day and 1， 3 and 6 months after surgery. Compared with same group 1 day after surgery， the VAS score and NDI score of the treatment group were decreased （P<0.05）， while JOA score and Tanaka Yasuhisa 20-point score were increased （P<0.05） at 1， 3 and 6 months after surgery. Compared with the control group at the same time points， the VAS score and NDI score of the treatment group were decreased （P<0.05）， while JOA score and Tanaka Yasuhisa 20-point score were increased （P<0.05） at 1， 3 and 6 months after operation. The effective rate and excellent rate of the treatment group 1， 3 and 6 months after PCDN were higher than those of the control group （P<0.05）. Follow-up to 1 year after surgery， no significant postoperative adverse reactions and complications were found in both groups.ConclusionUltrasound-guided acupotomy can significantly improve the residual symptoms after PCDN for CSR patients， and the clinical efficacy is significantly better than that of PCDN alone， and this therapy is safe and reliable.关键词：Cervical spondylotic radiculopathy;Acupotomy;Ultrasound-guided;Percutaneous cervical disc nucleoplasty96|15|0更新时间：2024-07-04
- “最新研究显示，针灸能有效改善颈动脉粥样硬化早期患者的动脉弹性，且治疗安全无严重不良事件。”摘要：ObjectiveTo observe the effect of acupuncture and moxibustion on arterial elasticity in patients with early carotid atherosclerosis.MethodsA total of 62 patients with early carotid atherosclerosis were randomly divided into a blank group （12 cases， 1 cases dropped-off）， a sham-acupuncture group （25 cases， 5 cases dropped-off） and an acupuncture group （25 cases， 3 cases dropped-off）. Patients in the acupuncture group received acupuncture treatment， including ①acupuncture： Baihui （GV20）， Yintang （GV24+）， Renying （ST9）， Neiguan （PC6）， Yanglingquan （GB34）； ②moxibustion： Yinqiguiyuan （Zhongwan ［CV12］， Xiawan ［CV10］， Qihai ［CV6］， Guanyuan ［CV4］）， Sihua （Geshu ［BL17］， Danshu ［BL19］）； ③Intradermal needle： Xinshu （BL15）， Danshu （BL19）. Patients in the sham acupuncture group received placebo acupuncture， moxibustion， an intradermal needle， and the acupoints were the same as the acupuncture group. The above treatments were performed twice a week for 12 weeks. No intervention was given to the patients in the blank group. Diet and lifestyle education was given to the three groups. The ultrafast pulse wave velocity， including beginning-systolic pulse wave velocity （BS） and end-systolic pulse wave velocity （ES）， was observed before treatment and 1， 2， 3 months after treatment in the three groups. The blood lipid level and platelet count （PLT） at each time point were observed. The safety of the treatments was also evaluated.ResultsCompared with those before treatment， the BS and ES values of both sides in the acupuncture group decreased at 2 and 3 months after treatment （P<0.05）. Compared with the blank group， the bilateral ES of the acupuncture group were decreased at 2 months after treatment （P<0.05）， and the bilateral BS and ES were decreased at 3 months （P<0.05）. Compared with the sham-acupuncture group， the acupuncture group showed a decrease in left BS and left ES after 3 months of treatment （P<0.05）， and the overall decrease on the left side of the acupuncture group was better than that on the right side. There were no significant differences between three groups in the levels of blood lipid and PLT at each time point. No serious adverse safety events occurred in the three groups during the treatment.ConclusionAcupuncture and moxibustion therapy can improve arterial elasticity in patients with early carotid atherosclerosis， and it is safe and effective.关键词：Carotid atherosclerosis;Vascular elasticity;Acupuncture and moxibustion;Ultrafast pulse wave velocity108|17|0更新时间：2024-07-04
- “最新研究显示，针刺治疗突发性聋的时机对疗效有显著影响。早期介入针刺治疗的患者，其听力恢复和耳鸣残疾程度改善更为显著。这一发现为突发性聋的临床治疗提供了重要指导。”摘要：ObjectiveTo observe the clinical efficacy of acupuncture intervention at different time for patients with sudden hearing loss.MethodsAccording to the timing of acupuncture intervention， 86 patients were divided into early exposure group （n=43） and late exposure group （n=43） . The early exposure group was given acupuncture treatment within 14 days of onset， and the late exposure group was given acupuncture treatment after 14 days of onset. After propensity score matching （PSM， a statistical matching technique for observational data） processing by using SPSS26.0 software， outcomes of 30 cases in the early exposure group and 30 cases in the late exposure group were analyzed. In addition to receiving basic treatment with drugs for vascular dilatation， thrombolysis， nourishing nerve， etc.， all patients of the two groups were treated with neck acupuncture （“Neck Seven Meridian Lines” acupuncture）， once every other day except Sundays， for a total of 12 time. Before， after the treatment and 3 months after the treatment， the total score of the Tinnitus Handicap Inventory （THI， 0， 2 and 4 points for each of the 25 items， total scores = 100 points） scale was used to evaluate the improvement of tinnitus symptoms caused by hearing loss. The clinical therapeutic effect was evaluated according to the efficacy grading criteria in the Guidelines for Diagnosis and Treatment of Sudden Deafness （2015） and the changes of pure tone audiometry curve. Multivariate Logistic regression was used to analyze the effect of factors that might influence efficacy before propensity score matching.ResultsThe THI scores of patients in both groups decreased strikingly after the treatment and 3 months’ follow-up （P<0.05）. Compared with the same time-points of the late exposure group， the total THI scores of post-treatment and 3 months’ follow-up were evidently lower in the early exposure group （P<0.05）. The effective rate of the early exposure group （22/30， 80.00%） was significantly higher （P<0.05） than that of the late exposure group （16/30， 53.33%）. The classification of sudden deafness and the application of traditional Chinese medicine in this study were not independent factors affecting the total effective rate.ConclusionThe time point of acupuncture intervention is an important factor affecting the effect on hearing and tinnitus disability of patients with sudden deafness. The earlier acupuncture treatment is accepted， the better the therapeutic effect is.关键词：Sudden hearing loss;Acupuncture;Intervention time;“Neck Seven Meridian Lines” acupuncture;Tinnitus handicap inventory scale103|9|0更新时间：2024-07-04
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Progress of researches on mechanisms of acupuncture for secondary prevention of ischemic stroke AI导读
“针刺疗法在缺血性脑卒中二级预防领域取得显著进展，通过调节神经-内分泌系统，有效控制高血压、高胆固醇血症、糖尿病等危险因素，为预防脑卒中复发提供新策略。”摘要：Ischemic stroke （IS） is one of the main causes inducing death and disability in adults. Because of the high recurrence rate of IS， prevention of recurrence is of great significance to this population， for which the evidence-based and effective secondary prevention strategy is an important means， and acupuncture intervention has a positive effect on its risk factors. In the present article， we reviewed the progress of researches on the mechanisms of acupuncture underlying prevention of IS relapse from the perspective of its main risk factors， namely 1） hypertension （preventing and controlling the adverse effects caused by the imbalance of blood pressure level， vascular and other tissue structures， endocrine factors and central nervous system activities in patients with hypertension after IS）， 2） hypercholesterolemia （lowering serum total cholesterol， triglyceride， low-density lipoprotein-cholesterol （LDL-C） and raising high-density lipoprotein cholesterol）， 3） diabetes （regulating the secretion function of adipose tissue， activating the insulin signal transduction pathway， protecting the function of pancreatic β cells， and regulating the central nervous system functions to participate in the secondary prevention of IS）， 4） smoking （relieving the symptoms of smoking cessation and reducing the smoker’s dependence on smoking by changing the internal environment， lowering the level of blood endorphin and regulating the excitability of central nervous system）， 5） sleep apnea syndrome （regulating local muscle function and the excitability of the nervous system， but also affecting some organic changes as reducing tonsil swelling） and 6） obesity （lowering blood glucose and lipid， increasing the ratio of brown/white fat， reducing leptin resistance， and suppressing appetite to induce body weight loss， or directly regulate the changes of fat tissue， etc）. Results shows that the acupuncture’s regulatory mechanism for IS risk factors is closely related to the neuroendocrine system， and simultaneously involves multiple targets of multiple risk factors. Due to its good efficacy and safety， acupuncture therapy is of great value for clinical promotion as an important intervention for secondary prevention.关键词：Acupuncture;Ischemic stroke;Secondary prevention;Risk factors89|8|0更新时间：2024-07-04 - “最新研究显示，针灸可协同化疗抑制肿瘤生长，改善患者生存质量，为提高化疗疗效提供新思路。”摘要：The application of acupuncture and moxibustion in alleviating the adverse effects of chemotherapy drugs has been widely recognized at home and abroad， but the studies have been rarely summarized for the enhanced anti-tumor effect and its mechanism of acupuncture and moxibustion to synergize the chemotherapy drugs. This paper reviewed the clinical and basic studies on the synergism of chemotherapy with acupuncture and moxibustion in recent years. It was found that chemotherapy synergized with acupuncture and moxibustion can suppress cancer to a certain extent and improve the quality of life in patients. The effect mechanism of acupuncture and moxibustion combined with chemotherapy drugs is related to promoting tumor cell apoptosis， improving the immune and vascular microenvironment， and advancing chemotherapy drug enrichment on the affected area. It provides the evidences and ideas for enhancing the effect of chemotherapy by delivering acupuncture and moxibustion as an adjuvant therapy.关键词：Acupuncture and moxibustion;Tumor;Chemotherapy;Synergism94|11|1更新时间：2024-07-04
- “最新研究发现，针刺治疗二型糖尿病（T2DM）与改善胰岛素抵抗、调节炎性反应等多种机制密切相关，为进一步探索针刺降糖作用机制提供新思路。”摘要：Acupuncture is an effective measure for treating type 2 diabetes mellitus （T2DM）. Many studies have shown that acupuncture can reduce blood glucose in patients with T2DM， but its mechanism is still unclear. This review summarized the mechanism of acupuncture on T2DM， the mechanisms of acupuncture in treating T2DM is related to improving insulin resistance， regulating inflammation， promoting insulin secretion， improving lipid metabolism disorders， resisting oxidative stress， improving obesity， controlling intestinal flora， and regulating the nervous system. At the same time， this review also points out the lack of current relevant research and the future research directions to provide a reference for further exploring the mechanism of acupuncture hypoglycemic action.关键词：Type 2 diabetes mellitus;Acupuncture;Electroacupuncture;Mechanism;Review184|13|0更新时间：2024-07-04
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Scalp acupuncture targets for neurological disorders：evidence from neuroimaging studies （part 1） AI导读
“最新研究揭示了现代脑科学在神经系统疾病头针刺激靶点的突破性成果。通过Neurosynth平台的Meta分析，识别并定位了帕金森病、慢性疼痛、失语症和失读症的潜在头针靶点，为头针临床应用和神经刺激治疗提供了现代影像学证据。”摘要：ObjectiveScalp acupuncture is a unique acupuncture method developed based on brain functional and pathophysiological knowledge. In past decades， there has been significant development in the understanding of the brain pathology of many neurological disorders through cutting-edge brain imaging techniques. Yet， these findings have not been incorporated into scalp acupuncture. In the present paper， we aimed to initiate an attempt to develop/identify scalp acupuncture targets based on neuroimaging findings.MethodsBased on the meta-analysis of neuroimaging studies in the Neurosynth database platform （http：//neurosynth.org/）， the brain clusters related to neurological disorders were automatically identified according to the search terms “Parkinson’s disease”（PD）， “chronic pain”（CP）， “aphasia”（APH）， “dyslexia”（DYS）， “mild cognitive impairment”， “Alzheimer’s disease” and “dementia”. Subsequently， the discovered brain region clusters projected onto the brain surface and scalp surface were listed， and the peak points of the clusters projected to the scalp surface were proposed as the potential stimulation targets for the corresponding diseases. Further， by combining the traditional scalp acupoints （including the scalp acupuncture lines） with 10-20 EEG system sites， we made localization suggestions for scalp stimulation targets and made acupuncture operation suggestions by combining with the shape of the brain region clusters. The literature search was conducted on July 30， 2022.ResultsThe localization and manipulation suggestions of neuroimage-based scalp acupuncture targets were introduced in two parts. This part （part 1） includes PD， CP， APH， and DYS. Here are 3 target examples of each of these 4 diseases simply introduced due to word limitation. 1） PD. Based on the 175 articles retrieved from Neurosynth， we identified 7 potential scalp acupuncture targets for PD， the locations of the acupuncture stimulation and the recommended acupuncture needle operation （RANO） as well as the corresponding brain regions （CBRs） respectively are as below. PD1： about 0.5 cun （1 cun≈33.3 mm） superior-posterior to the left Xuanlu （GB5）； puncturing subcutaneously and forward-upward； the left premotor area， subfrontal cortex of the island， inferior frontal gyrus and middle frontal gyrus. PD2： about 1 cun lateral-inferior to the left Chengling （GB18）； puncturing subcutaneously and backward-upward； the inferior parietal lobule and postcentral gyrus. PD3： about 0.5 cun lateral-anterior to the left GB18； puncturing subcutaneously and inward-backward； left anterior central gyrus and posterior central gyrus. 2） CP. Based on the retrieved 92 articles， we identified 8 potential scalp acupuncture targets， the location of the acupuncture stimulation and the RANO， and CBRs respectively are as below. CP1： about 1 cun anterior-inferior to the left Xuanli （GB8）； puncturing subcutaneously and backward-inwards； the left inferior frontal gyrus orbitalis and pars triangularis. CP2： about 0.5 cun posterior-superior to the left GB5； puncturing subcutaneously and forward-upward； the left anterior central gyrus and premotor area. CP3： about 0.5 cun posterior-superior to the left GB8； puncturing subcutaneously and forward； left inferior central area/central sulci operculum （second somatosensory area）. 3） APH. Based on the retrieved 82 papers， we identified 7 potential scalp acupuncture targets for APH， their locations， RANO， and CBRs respectively are as below. APH1： close to the left GB5； puncturing subcutaneously and forward-downward； left subfrontal gyrus operculi/triangularis. APH2： about 0.5 cun posterior to the left Hanyan （GB4）； puncturing subcutaneously and backward-upward； the left anterior central gyrus and posterior central gyrus. APH3： about 0.5 cun anterior-inferior to the left Qubin （GB7）； puncturing subcutaneously and backward-downward； left medial/superior temporal gyrus. 4） DYS. Based on the retrieved 76 researches， we identified 8 potential scalp acupuncture targets for DYS， their locations， RANO and CBRs respectively are as below. DYS1： about 1 cun anterior-inferior to the left GB5； puncturing subcutaneously and forward-upward； the pars triangularis of the left inferior frontal gyrus. DYS2： about 0.5 cun posterior-superior to the left GB5； puncturing subcutaneously and forward-downward； the left subfrontal gyrus operculum， pars triangularis and anterior central gyrus. DYS3： the midpoint between the left GB5 and GB18； puncturing subcutaneously and forward； the left anterior central gyrus and posterior central gyrus.ConclusionWe identified scalp acupuncture targets for several common neurological disorders based on neuroimaging evidence for clinical application and research. The proposed targets may also be used for treating these disorders using brain stimulation methods.关键词：Scalp acupuncture;Scalp acupuncture stimulation targets;Neuroimaging;Neurological disorders;Brain stimulation135|13|1更新时间：2024-07-04 - “最新报道：STRICTA清单作为针刺临床试验干预报告的指南，其发展与更新过程被系统梳理。专家分析了其效用特点及改进空间，为临床研究报告质量提升提供新思路。”摘要：The STRICTA checklist is the guideline for reporting clinical trials undertaken using acupuncture intervention. As an extension of the CONSORT checklist， the STRICTA checklist facilitates the reporting quality of acupuncture clinical trials. The clinical research paradigm changes along with the development of science and technology. It is crucial to ensure whether or not the existing STRICTA checklist guides the reporting clinical trials of acupuncture now and in the future as well. This paper introduces the development and the updating procedure of the STRICTA checklist， analyzes the characteristics of utility and the limitation， and proposes several suggestions on the difficulties and challenges encountered in the implementation of the STRICTA checklist of current version so as to advance the further update and improvement.关键词：STRICTA checklist;Acupuncture clinical trials;Reporting standard;Guideline52|3|0更新时间：2024-07-04
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