最新刊期
卷 49 ， 期 8 ， 2024
- “最新研究揭示，电针治疗能显著改善缺血性脑卒中大鼠的神经功能，减少脑梗死体积，促进血管新生，其机制可能通过miR-142-5p及ADAMTS1/PI3K/AKT通路调控实现。”摘要：ObjectiveTo observe the effect of electroacupuncture on miR-142-5p and ADAMTS1/PI3K/AKT pathway in rats with ischemic stroke， so as to explore the regulatory mechanism of electroacupuncture on angiogenesis after ischemic stroke.MethodsThis study was divided into two parts. The first part of the experiment： SD rats were randomly divided into sham operation group， model group and electroacupuncture group. There were 20 rats in each group. The middle cerebral artery occlusion （MCAO） rat model was prepared using a modified Longa’s method. In the electroacupuncture group， “Shuigou” （GV26） was selected for electroacupuncture intervention （4 Hz/20 Hz） for 30 min each time. The rats in the electroacupuncture group were given electroacupuncture immediately after successful modeling， once a day for 4 times. Hunter score and TTC staining were used to observe the neurological deficits and infarct volumes respectively； HE staining was used to observe the cortical pathological changes； immunohistochemistry was used to determine the changes of cerebral microvascular density. Real-time quantitative PCR and Western blot were used to observe the miR-142-5p expression， mRNA and protein expression levels of ADAMTS1， VEGF， PI3K， AKT， eNOS in ischemic cortex. The second part of the experiment： The rats were randomly divided into electroacupuncture+control group and electroacupuncture+miR-142-5p Antagomir group with 8 rats in each group. MCAO model was established after injection. Electroacupuncture+control group was given 0.9% sodium chloride solution injected into the right ventricle.The rats in the electroacupuncture+miR-142-5p Antagomir group were injected with miR-142-5p inhibitor into the right ventricle 30 min before modeling. Rats in electroacupuncture+control group and electroacupuncture+miR-142-5p Antagomir group were all given the same electroacupuncture treatment. Real-time fluorescence quantitative PCR was used to observe the effect of miR-142-5p Antagomir on the expression of miR-142-5p and ADAMTS1 mRNA. The effect of miR-142-5p Antagomir on ADAMTS1 protein was observed by Western blot.ResultsIn the first part of the experiment， compared with the sham operation group， the Hunter score in the model group was significantly increased （P<0.01）； the volume of cerebral infarction in the model group was significantly increased （P<0.01）； the degree of brain edema and neuronal necrosis and the density of cerebral microvessels was increased； the cerebral microvascular density was significantly increased （P<0.01）； the expression levels of miR-142-5p and the mRNA expression levels of VEGF， AKT and eNOS were significantly decreased （P<0.01，P<0.05）， and the protein expression levels of VEGF， p-AKT and eNOS were significantly down-regulated （P<0.01）， while the mRNA expression levels of ADAMTS1 and PI3K， and the protein expression levels of ADAMTS1 and p-PI3K were all up-regulated （P<0.01， P<0.05） in the model group. Compared with the model group， after intervention， the Hunter score in the electroacupuncture group was decreased （P<0.01）， the volume of cerebral infarction was significantly decreased （P<0.01）； the degree of brain edema and neuronal necrosis were alleviated； the cerebral microvascular density was significantly increased （P<0.01）； the expression of miR-142-5p and the mRNA expression of VEGF， PI3K， AKT and eNOS were increased （P<0.01）， the protein expressions of VEGF， p-PI3K， p-AKT and eNOS were increased （P<0.01， P<0.05）， while the mRNA and protein expression of ADAMTS1 were decreased （P<0.05， P<0.01）. After injection of miR-142-5p inhibitor， compared with electroacupuncture+control group， the expression of miR-142-5p in electroacupuncture+miR-142-5p Antagomir group was decreased（P<0.05）， while the mRNA and protein expression of ADAMTS1 were increased （P<0.01， P<0.05）.ConclusionElectroacupuncture at GV26 can improve the neurological damage of ischemic stroke rats， reduce the volume of cerebral infarction and promote angiogenesis. The mechanism may be associated with the function of electroacupuncture in promoting the expression of miR-142-5p， so as to inhibit the expression of its target gene ADAMTS1， mediate the up-regulation of VEGF expression， activate PI3K/AKT pathway， promote the release of eNOS， and participate in promoting angiogenesis in ischemic stroke rats.关键词：Ischemic stroke;Electroacupuncture;Middle cerebral artery occlusion;miR-142-5p;ADAMTS1/ PI3K/AKT pathway163|14|0更新时间：2024-08-29
- “最新研究发现，艾灸“足三里”能有效缓解膝关节骨关节炎大鼠的疼痛和炎症，通过调节血浆氨基酸代谢物水平，发挥抗炎镇痛和软骨保护作用。”摘要：ObjectiveTo observe the effect of moxibustion at “Zusanli ”（ST36） on the plasma amino acid metabolism in rats with knee osteoarthritis （KOA）， and to explore the amino acid metabolism mechanism of moxibustion in repairing cartilage injury in KOA.MethodsA total of 30 SD rats were randomly divided into normal， model and moxibustion groups， with 10 rats in each group. Rats in the model and moxibustion groups were injected with the mixture of L-cysteine and papain into bilateral knee joint cavity to make the KOA model. The moxibustion group received moxibustion at bilateral ST36 for 30 min， once daily for 30 days. At the end of the experiment， the swelling degree of knee joint was calculated， the mechanical pain threshold was measured by the Von Frey filament， the cartilage tissue injury was observed by HE staining， the matrix metalloproteinase-13 （MMP-13） content in the synovial tissue was detected by enzyme-linked immunosorbent assay （ELISA）， and the differential amino acid metabolites in plasma were detected and screened by liquid chromatography-mass spectrometry （LC-MS）.ResultsCompared with the normal group， the model group showed irregular cartilage surface， decreased number of chondrocytes， uneven distribution， and local clusters of chondrocytes； the contour of the tide line was blurred. The degree of joint swelling in the model group was higher than that in the normal group （P<0.01）， the mechanical pain threshold was lower （P<0.01）， and the content of MMP-13 in synovial tissue was higher （P<0.01）. The contents of proline and tryptophan in the model group were down-regulated （P<0.01，P<0.05）. Compared with the model group， the cartilage tissue damage and knee joint swelling were decreased（P<0.05）， mechanical pain threshold was increased（P<0.05）， MMP-13 content in synovial tissue and levels of glutamate and histidine expression were decreased （P<0.01，P<0.05）.ConclusionMoxibustion at ST36 significantly alleviated arthritis-related swelling and pain in KOA model rats， attenuated cartilage damage， and regulated levels of certain plasma amino acid metabolites. Moxibustion may regulate KOA cartilage synthesis and degradation through amino acid metabolic pathways such as proline， tryptophan， glutamate and histidine， exerting anti-inflammatory， analgesic， and protection of cartilage injury effects.关键词：Moxibustion;Knee osteoarthritis;Amino acid metabolism;Cartilage injury102|9|1更新时间：2024-08-29
- “最新研究发现，电针治疗能通过调节肠道菌群和短链脂肪酸代谢，有效改善肥胖症大鼠的脂质代谢紊乱，为肥胖治疗提供了新思路。”摘要：ObjectiveTo observe the effect of electroacupuncture （EA） on the intestinal flora-short chain fatty acids （SCFAs） metabolism axis in rats with simple obesity， so as to explore the underlying mechanism of EA in reducing obesity.MethodsMale SD rats were randomly divided into control group， model group and EA group， with 6 rats in each group. The obesity model was established by feeding the rats with high-fat diet. Rats in the EA group were treated with EA at “Quchi” （LI11） and “Zusanli” （ST36） for 15 min， once daily for 21 consecutive days. The changes of body weight were observed every other day. H.E. staining was used to observe the pathological changes of adipose tissue and liver. The blood lipid content was detected by automatic biochemical analyzer. The diversity of intestinal flora in rat feces was analyzed by 16S rRNA high-throughput sequencing. The content of SCFAs in rat feces was detected by ultra-high performance liquid chromatography-electrospray ionization-mass spectrometry （UPLC-ESI-MS/MS）. The correlation between the relative abundance of fecal intestinal flora and the content of SCFAs in rats was analyzed by Pearson method.ResultsCompared with the control group， the body weight of rats， the serum total cholesterol （TC） and triglyceride （TG） were significantly increased （P<0.01） in the model group. The results of 16S rRNA sequencing showed that， at the genus level the relative abundance of Bacteroides， Butyrivibrio and Roseburia in were decreased significantly（P<0.05）， while that of the Lachnospiraceae_NK4A136_group increased（P<0.05）. After the intervention， compared with the model group， the body weight， serum TC and TG contents of rats in the EA group were significantly decreased （P<0.05，P<0.01）； the results of 16S rRNA sequencing showed that， the relative abundance of the Bacteroidota phylum significantly increased （P<0.01） and Firmicutes decreased （P<0.01） at the phylum level， and at the genus level the relative abundances of Bacteroides， Butyrivibrio and Roseburia significantly increased （P<0.01，P<0.05）； the contents of acetic acid and propionic acid in SCFAs significantly increased （P<0.01）. H.E. staining showed an increase of the diameter of adipocytes， with obvious lipid droplets and inflammatory infiltration in the model group， which was relatively milder in the EA group. PCoA analysis showed that there were significant differences in the structure of intestinal flora between the control group and the model group， as well as the model group and the EA group. At the phylum level， the relative abundance of Bacteroidota was positively correlated with acetic acid and propionic acid contents， with that of Firmicutes negatively correlated with acetic acid and propionic acid contents （P<0.001）. At the genus level， the relative abundances of Bacteroides， Streptococcus and Butyricimonas were positively correlated with acetic acid content （P<0.01，P<0.05）， and the relative abundances of Bacteroides， Streptococcus and Roseburia were positively correlated with propionic acid content （P<0.001，（P<0.05）.ConclusionEA can improve the disorder of lipid metabolism in obese rats by improving the disorder of intestinal flora-SCFAs metabolic axis， thus playing a role in inhibiting obesity.关键词：Obesity;Electroacupuncture;Adipocyte;Intestinal flora;Short chain fatty acids114|13|0更新时间：2024-08-29
- “最新研究发现，隔姜隔盐灸“神阙”能有效改善逼尿肌过度活动大鼠的膀胱功能，其机制可能与上调膀胱组织中ATP敏感性钾离子通道蛋白及mRNA表达水平有关。”摘要：ObjectiveTo observe the effect of ginger-salt-partitioned moxibustion on ATP-sensitive potassium （KATP） channel of bladder in detrusor overactivity （DO） rats.MethodsFemale SD rats were randomly divided into sham operation， model， moxibustion and antagonist groups （n=9 in each group）. Thorax （T） 10 spinal cord transection was performed by surgery. Ginger-salt partitioned moxibustion was applied to “Shenque” （CV8） for 3 cones， once daily for 14 consecutive days. Rats of the antagonist group were intraperitoneally injected with KATP channel specific antagonist glibenclamide （10 μg·kg-1·d-1） once daily for 14 consecutive days. Urodynamic tests were performed after treatment. The distribution and expression of KATP channel tetrameric subunit （SUR2B） in the bladder of rats was observed by immunofluorescence. The protein and mRNA expression levels of SUR2B in bladder tissue were detected by Western blot and qPCR respectively.ResultsCompared with the sham operation group， rats of the model group showed intensive and large phasic contractions of the detrusor during bladder filling， the frequency and amplitude of phasic contractions of the detrusor 5 min before leakage were significantly increased （P<0.001）； the voiding threshold pressure was significantly decreased （P<0.001）； the bladder perfusion volume was increased （P<0.001）； the SUR2B protein and mRNA expression in bladder tissue were significantly reduced （P<0.001）. Compared with the model group and the antagonist group， the above-mentioned indicators in the moxibustion group were all reversed （P<0.01， P<0.001， P<0.05）.ConclusionGinger-salt partitioned moxibustion can reduce the frequency and amplitude of detrusor phase contraction during bladder filling and prolong the time of first phase contraction in DO rats， which may be associated with up-regulating the expression level of KATP channel protein and mRNA， promoting the outflow of potassium ions， and inhibiting the inflow of calcium ions， thus improve the stability of detrusor during storage.关键词：Moxibustion;Detrusor overactivity;KATP channel75|5|0更新时间：2024-08-29
- “最新研究发现，电针治疗可促进颈椎病模型家兔椎间盘组织自噬相关蛋白表达，减少髓核细胞凋亡，改善椎间盘退变，为颈椎病治疗提供新思路。”摘要：ObjectiveTo observe the effects of electroacupuncture （EA） on the morphological changes of intervertebral disc tissues， apoptosis of nucleus pulposus cells， and the protein expression of Unc-51 like autophagy-activated kinase 1 （ULK1）， homologous series of yeast Atg6 （Beclin1）， and light chain protease complication 3 type （LC3） in nucleus pulposus tissue of cervical spondylosis rabbits， so as to explore the role of cellular autophagy in EA treatment of cervical spondylosis.MethodsA total of 24 New Zealand white rabbits were randomly divided into blank， model and EA groups， with 8 rabbits in each group. In the EA group， both sides of the cervical （C）3—C6 “Jiaji” （EX-B2） were stimulated by EA （2 Hz/100 Hz， 1 mA） for 25 min， once daily for 5 days in a course， with a 2-day interval between courses， totaling 4 treatment courses. X-ray was used to assess cervical spine radiographic changes and evaluate radiographic scores； transmission electron microscopy was used to observe ultrastructural changes in nucleus pulposus cells； HE staining was used to observe morphological changes of intervertebral disc tissues and conduct pathological scoring； TUNEL staining was used to observe apoptosis rate of nucleus pulposus cells； Western blot was performed to detect protein expression levels of ULK1， Beclin1， and LC3 in nucleus pulposus tissue.ResultsCompared with the blank group， rabbits in the model group showed significantly higher cervical spine radiographic scores （P<0.01）， higher pathological scores of intervertebral disc tissues （P<0.05）， increased apoptosis rate of nucleus pulposus cells （P<0.01）， and decreased expression levels of ULK1， Beclin1， and LC3Ⅱ proteins in nucleus pulposus tissue （P<0.05）. Compared with the model group， the EA group showed significantly lower pathological scores of intervertebral discs （P<0.05）， lower apoptosis rate of nucleus pulposus cells （P<0.01）， and higher protein expression levels of ULK1， Beclin1， and LC3Ⅱ in nucleus pulposus tissue （P<0.01）. Rabbits in the blank control group exhibited generally normal organelle structures in nucleus pulposus tissues with few autophagic vacuoles， indicative of early stages of autophagy； while those in the model group showed disrupted organelle structures with cytoplasmic condensation and those in the EA group exhibited autophagosomes with double-membrane structures in nucleus pulposus tissues.ConclusionEA promotes the expression of ULK1， Beclin1， and LC3Ⅱ proteins in nucleus pulposus tissues， reduces apoptosis of nucleus pulposus cells， and improves intervertebral disc degeneration.关键词：Electroacupuncture;Cervical spondylosis;Intervertebral disc degeneration;Nucleus pulposus;Autophagy77|8|0更新时间：2024-08-29
- “最新研究发现，电针治疗能有效改善坐骨神经慢性缩窄大鼠的疼痛和焦虑行为，可能通过调节海马P物质/神经激肽1受体/β-抑制蛋白1通路发挥作用。”摘要：ObjectiveTo observe the effect of electroacupuncture （EA） on pain， anxiety like behavior， and substance P（SP） /neurokinin-1 receptor （NK1R） /β -arrestin 1（ARRB1） pathway related protein expression in hippocampus of chronic constriction injury （CCI） rats， so as to explore its mechanisms underlying improvement of neuropathic pain.MethodsTwenty-seven male SD rats were randomly divided into sham operation， model and EA groups， with 9 rats in each group. The CCI model was established by ligature of the left sciatic nerve. On the 8th day following modeling， EA （2 Hz， 0.5—1.5 mA） was applied to the left “Huantiao” （GB34） and “Yanglingquan” （GB34） for 30 min， once every other day for 13 times. Mechanical paw withdrawal threshold （MWT）， thermal paw withdrawal threshold （TWL） and difference of the weight distribution of the hind limbs were detected before operation and at the 5th， 9th， 17th， 25th and 33rd days after operation. Open field test was used to evaluate the anxiety-like behavior of rats. The content of SP in hippocampus was determined by ELISA. The protein expression of NK1R and ARRB1 in hippocampus was detected by Western blot.ResultsCompared with the sham operation group， the MWT and TWL of the left hind limb at the 5th， 9th， 17th， 25th and 33rd days after operation， the time of entering the central area and the total distance of movement， and the content of SP in the hippocampus were significantly decreased （P<0.001， P<0.01）， while the difference of the weight distribution of the hind limbs at the 5th， 9th， 17th， 25th and 33rd days after operation and the protein expression of NK1R and ARRB1 were significantly increased （P<0.001， P<0.05） in the model group. After EA intervention， the MWT and TWL of the left hind limb， the time of entering the central area and the total moving distance， and the expression of SP in the hippocampus were significantly increased （P<0.01， P<0.001， P<0.05）， while the difference in the weight distribution of the hind limbs was significantly reduced， and the expression of NK1R and ARRB1 protein in the hippocampus were significantly decreased （P<0.001， P<0.05） in the EA group.ConclusionEA can effectively improve the pain and anxiety behaviors in CCI rats， and reverse the abnormal expression of SP， NK1R and ARRB1 proteins in the hippocampus， which may be related to its effects in regulating the SP/NK1R/ARRB1 pathway in the hippocampus.关键词：Electroacupuncture;Neuropathic pain;Hippocampus;Substance P;Neurokinin-1 receptor103|10|0更新时间：2024-08-29
- “最新研究发现，麦粒灸通过调节TLR4/MyD88/NF-κB信号通路，降低炎性因子释放，有效改善溃疡性结肠炎小鼠结肠损伤。”摘要：ObjectiveTo observe the effect of moxibustion with seed-size moxa cones on the Toll-like receptor 4（TLR4）/myeloid differentiation factor 88（MyD88）/nuclear transcription factor-κB（NF-κB） signaling pathway in mice with ulcerative colitis（UC）， so as to explore the therapeutic mechanism of moxibustion with seed-size moxa cones on colonic injury in UC.MethodsForty male C57BL/6 mice were randomly divided into blank group， model group， moxibustion group， and western medicine group， with 10 mice in each group. The UC mouse model was established by 3% DSS solution by free drinking for 7 consecutive days. Mice in the moxibustion group were treated with seed-size moxa cones at “Zhongwan”（CV12）， “Tianshu”（ST25） and “Shangjuxu”（ST37）， 3 moxa cones per point， with each cone applied for approximately 30 s， while mice in the western medicine group were orally administered with 300 mg/kg mesalazine solution， which were both conducted once a day for 7 consecutive days. The general condition of mice was observed every 2 days， and the disease activity index （DAI） score was calculated. HE staining was used to observe the morphology of colonic tissue in mice. ELISA was used to detect the serum interleukin（IL）-1β， tumor necrosis factor（TNF）-α， IL-6， and IL-8 contents. Immunohistochemistry was used to detect the positive expression of TLR4 and MyD88 in colonic tissue of mice. Real-time fluorescence quantitative PCR was used to detect the expression levels of TLR4， MyD88， and NF-κB p65 mRNAs in colonic tissue.ResultsCompared with the blank group， varying degrees of soft or watery stools were observed， colon length and body weight were decreased（P<0.01） in mice of the model group， while DAI score， colon weight index， mucosal damage score， colonic pathological score， serum IL-1β， TNF-α， IL-6， and IL-8 contents， positive expressions of TLR4 and MyD88， and TLR4， MyD88， and NF-κB p65 mRNA expressions in colonic tissue were increased（P<0.01）. Compared with the model group，improved fecal characteristics were observed， colon length and body weight were increased（P<0.01） in mice of the moxibustion group and western medicine group， while DAI scores， colon weight indexes， mucosal damage scores， colonic pathological score， serum contents of IL-1β， TNF-α， IL-6， and IL-8， positive expressions of TLR4 and MyD88， and TLR4， MyD88， and NF-κB p65 mRNA expressions in colonic tissue were decreased（P<0.01， P<0.05）. There was no significant difference in the above indicators between the moxibustion group and the western medicine group.ConclusionMoxibustion with seed-size moxa cones may alleviate colonic injury in UC mice by regulating the TLR4/MyD88/NF-κB signaling pathway and reducing the release of inflammatory factors.关键词：Moxibustion with seed-size moxa cones;Ulcerative colitis;Colonic injury;Inflammatory response;TLR4/MyD88/NF-κB signaling pathway121|7|0更新时间：2024-08-29
- “最新研究显示，针刺联合刺血及中药清瘟泄热汤治疗轻中型COVID-19感染，可显著改善患者临床症状，缓解肺部炎性损伤，降低炎性因子含量，减轻焦虑和抑郁情绪，且无不良反应发生。”摘要：ObjectiveTo evaluate the clinical efficacy and safety of acupuncture combined with bloodletting therapy and Qingwen Xiere decoction in mild to moderate COVID-19 patients.MethodsA total of 100 mild to moderate COVID-19 patients collected from December 2022 to February 2023 were randomly divided into control and observation groups， with 50 patients in each group. Patients in the control group received oral Qingwen Xiere decoction for 6 days. The observation group received acupuncture combined with bloodletting therapy in addition to oral Qingwen Xiere decoction， with the acupuncture （at Kongzui ［LU6］， Hegu ［LI4］， Quchi ［LI11］， Feishu ［BL13］， Zhongwan ［CV12］， Qihai ［CV6］， Yinlingquan ［SP9］） administered 30 min each day for 6 days， and bloodletting （at Shaoshang ［LU11］， Shangyang ［LI1］， Dazhui ［GV14］） administered every other day for 3 times. Traditional Chinese medicine syndrome scores and pulmonary CT scores were recorded before and after treatment. Serum contents of C-reactive protein （CRP）， interleukin-6 （IL-6）， and tumor necrosis factor-alpha （TNF-α） were measured using ELISA. Anxiety and depression degree were assessed using the Hamilton Depression Scale （HAMD） and Hamilton Anxiety Scale （HAMA）. Safety of the treatments was evaluated in both groups.ResultsCompared with before treatment， after treatment， the control group showed improvement in fever， dry cough， sore throat， and total traditional Chinese medicine syndrome scores （P<0.01）， but no significant improvement in muscle pain or fatigue； the observation group showed significant improvement in total traditional Chinese medicine syndrome and individual symptoms scores （P<0.01）； both groups demonstrated reductions in pulmonary CT scores， HAMA score， HAMD score and serum contents of CRP and IL-6 （P<0.01）； serum TNF-α content significantly decreased in the observation group （P<0.01）. All outcome measures were superior in the observation group to the control group （P<0.01， P<0.05）. No adverse reactions were reported in either group.ConclusionAcupuncture combined with bloodletting therapy and oral Qingwen Xiere decoction effectively improves clinical symptoms， alleviates pulmonary inflammatory injury， reduces inflammatory cytokine contents， and mitigates anxiety and depression in mild to moderate COVID-19 patients， and without adverse effects.关键词：COVID-19 infection;Acupuncture;Bloodletting;Qingwen Xiere decoction110|12|0更新时间：2024-08-29
- “针刺治疗缺血性脑卒中研究取得新进展，通过调控微小RNA改善神经功能，为治疗提供新思路。”摘要：MicroRNAs play an important role in the occurrence and development of ischemic stroke （IS）. A lot of researches have shown that acupuncture intervention can improve IS-induced neural dysfunction by regulating miRNA. In the present paper， we summarized the current progress of researches on the mechanisms of acupuncture underlying improvement of IS via regulation of miRNA from 1） promoting angiogenesis and increasing cerebral blood flow， 2） inhibiting inflammatory response， 3） maintaining blood-brain barrier homeostasis and relieving brain edema， 4） regulating programmed cell death， 5） promoting neuron regeneration， and 6） improving synaptic plasticity. These miRNA -related mechanisms may provide a reference for the follow-up research .关键词：Acupuncture;microRNA;Ischemic stroke;Mechanism;Review111|18|0更新时间：2024-08-29
- “最新研究揭示针灸治疗阿尔茨海默病的多途径作用机制，为临床治疗提供新思路。”摘要：Alzheimer’s disease （AD） is a neurodegenerative disease with high incidence in the elderly population， and the synaptic changes in central neurons are the key pathological feature. The clinical effect of acupuncture and moxibustion in the treatment of AD is positive， and the research on the mechanism of acupuncture intervention of AD from the perspective of central synaptic plasticity regulation has been conducted uninterruptedly. In the present paper， we made a summation about the relevant experimental studies in recent years， and analyzed its mechanisms underlying improvement of AD by regulating synaptic plasticity from 1） repairing synaptic structure （synaptic contact area ［total number of synapses， synaptic surface density， synaptic number density］， postsynaptic dense zone thickness， synaptic gap width， and interface curvature）， 2） improving synaptic transmission efficiency （regulating long-term potentiation and long-term depression）， 3） promoting the expression of synapse related proteins （synaptophysin， postsynaptic density protein 95， growth associated protein 43）， 4） regulating the expression of neurotransmitters （acetylcholine， monoamines， amino acids， etc.） and receptors （α7 nicotinic acetylcholine receptor， glutaminergic receptor， etc.）， and 5） improving the level of neurotrophic factors （brain derived neurotrophic factor， BDNF） and BDNF/SYN/microtubule-associated protein 2 signaling， etc.， hoping to provide a reference for future studies.关键词：Acupuncture;Alzheimer’s disease;Synaptic plasticity;Review144|13|0更新时间：2024-08-29
- “针灸调神法在精神心理、神经系统和消化系统疾病治疗中取得显著进展，为中医疗法的临床应用提供了理论依据和发展方向。”摘要：The active role of “Shen” （mind） in the process of disease treatment has always been valued by scholars of traditional Chinese medicine （TCM）. “Tiaoshen” （mind-regulating） is regarded as the fundamental component of TCM therapy. “Mind-regulating” acupuncture and moxibustion therapy， as a treatment method for both body and mind， is consistent with the present bio-psycho-social medical model. In recent years， a large number of clinical studies have confirmed the exact efficacy of “mind-regulating” acupuncture and moxibustion therapy. This article reviewed the clinical applications of that in psychosomatic diseases， neurological diseases， and digestive diseases over the last decade. This article also summarized the research progress of various “mind-regulating” acupuncture and moxibustion methods， investigated the theoretical connotations of “Tongdu Tiaoshen” （dredging Governor Vessel and regulating mind） acupuncture， “Shugan Tiaoshen” （soothing liver and regulating mind） acupuncture， and the “Tiaoshen needling technique” （mind-regulating needling technique）， and generalized the main acupoint selection rules. Lastly，future development directions were provided for the theoretical basis of clinical application of “mind-regulating” acupuncture and moxibustion therapy for further improvement.关键词：Acupuncture;Mind-regulating;Clinical application68|8|0更新时间：2024-08-29
- “在中医针刺领域，专家深入探讨了“安慰针刺”与“假针刺”的区别，阐明了针刺“安慰剂效应”与“内在效力”的关系，为优化针刺临床试验提供了新思路。”摘要：Acupuncture is a comprehensive therapy which takes the theory of traditional Chinese medicine as the core. Currently， there is much controversy surrounding the “placebo effect” of acupuncture： some people argue that acupuncture is a “super placebo”， while others believe that the so-called placebo effect is just part of the therapeutic effect of acupuncture. To solve the controversy， this article clarified the definition， composition， and research purposes of “placebo acupuncture”， pointed out its differences from “sham acupuncture”， elucidated the relationship between the placebo effect and the intrinsic efficacy of acupuncture， distinguished the differences between the “observed placebo effect” and the “real placebo effect” in acupuncture clinical trials， and proposed the dilemmas and prospects of implementing “placebo acupuncture” and “sham acupuncture” contrasts at the current stage， in order to provide clues for optimizing randomized controlled trials of acupuncture.关键词：Sham acupuncture;Placebo acupuncture;Randomized controlled trial;Placebo effect220|16|0更新时间：2024-08-29
- “在针刺研究领域，专家提出了针刺动物实验中动物伦理的实施方法，为保障动物权利和实验科学性提供参考性建议，推动动物福利伦理规范化和科学化进程。”摘要：The animal experiment is an important form of acupuncture research， which is of great significance for revealing the regularities and mechanisms of acupuncture effects. The ethical principle of animal welfare is the important guarantee of animal rights and experimental scientificity in the process of research. Starting from the “3R principle” and “five welfare” rules， and the specific operation process of acupuncture animal experiments， we， in this paper， proposed the implementation methods of animal ethics in acupuncture experiments， including ethical execution before acupuncture experiments， and ethical requirements during the experimental stage （such as animal fixation method that meets the needling needs， selection of acupuncture apparatus， acupuncture manipulations， acupuncture stimulation intensity， and sampling of animal tissues）. These proposed methods may provide some appropriate references for the guarantee of animal ethics in acupuncture research， and provide ideas for establishing a new paradigm of animal welfare ethics in acupuncture animal experiments， and finally promote the standardization and scientificity process of the implementation of animal welfare ethics in acupuncture animal experiments.关键词：Acupuncture;Animal experiments;Animal ethics;Animal welfare70|5|0更新时间：2024-08-29
- “在医学领域，针灸学与工程学结合创新，推动了转化医学发展，为现代针灸学提供了新思路和挑战。”摘要：With the increasing value of translational medicine and medical engineering in the medical field， the collaborative innovation of acupuncture and engineering has become a trend. The mode and concept of the discipline of medicine-engineering junction can promote the development of translational research with acupuncture characteristics， including the rule of syndrome evolution， the application of meridians and acupoints， the exploration of treatment methods， the research of effect mechanism and the innovation of diagnosis and treatment. This paper put forward the future underlying research ideas， the existing questions and challenges for medicine-engineering junction， so as to provide the evidences for the clinical promotion of “combination of medicine and engineering” in the application of modern acupuncture and moxibustion.关键词：Acupuncture-moxibustion;Medicine-engineering translation;New ideas54|3|0更新时间：2024-08-29
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