最新刊期
卷 51 ， 期 2 ， 2026
- “研究发现电针“足三里”对慢性炎性痛-焦虑共病小鼠的镇痛和情绪缓解效果优于其他穴位，其机制可能与抑制特定脑区兴奋性有关。”摘要：ObjectiveTo observe the effect of electro-acupuncture （EA） at different acupoints on chronic inflammatory pain-anxiety comorbidity in mice， and to investigate the effect of naloxone on EA induced activation of neurons of the anterior cingulate cortex （ACC）， medial prefrontal cortex （mPFC）， paraventricular nucleus of the thalamus （PVT）， and mediodorsal thalamus nucleus （MD）， so as to explore whether the anti-anxiety effect of EA depends on its analgesic mechanism.MethodsIn the first part of the experiment， the efficacy of EA at different acupoints was compared. Sixty male C57BL/6 mice were randomly divided into control， model， EA Zusanli （ST36）， EA Baihui （GV20）， and EA Shengmen （HT7） groups （12 mice/group）. In the second part， the impact of naloxone on the analgesic and anxiety effects of EA at ST36 was investigated. Forty male C57BL/6 mice were randomly divided into control， model， EA ST36， and EA ST36 + naloxone groups （10 mice/group）. Except for those in the control group， all the mice were subjected to a chronic inflammatory pain-anxiety comorbidity by subcutaneous injection of 20 μL emulsified complete Freund’s adjuvant （CFA） into the hind paw. Mice in the control group received an equivalent volume of PBS. EA （2 Hz/100 Hz， 0.2—0.4 mA） intervention was initiated on the 12th day after modeling， and applied to “Zusanli” （ST36， bilateral） or “Baihui”（GV20）， or “Shengmen” （HT7， bilateral）. The EA intervention was conducted for 30 min， once daily for 6 d. Naloxone was intraperitoneally injected 30 min before EA intervention. Paw withdrawal thresholds （PWTs） were measured using von Frey filaments. The anxiety-like behaviors were assessed using the open field （OF） test and elevated plus maze （EPM） test， separately. The expression of c-Fos in the ACC， mPFC， PVT， and MD was detected by immunofluorescence staining.ResultsCompared with the control group， the model group exhibited a significant decrease in the PWTs， number of entries into the open arms and time spent in the open arms in the EPM test， and in the number of entries into the central area， time spent in the central area， and distance traveled in the central area in the OF test （P<0.01）， and a significant increase in the number of c-Fos positive neurons in the bilateral ACC， mPFC and MD （P<0.05）. The total distance traveled of OF test remained unchanged. Compared with the model group， 1） EA at ST36， GV20， and HT7 significantly increased the PWTs （P<0.01， P<0.05）， 2） EA at ST36 significantly increased the number of entries into the open arms， time spent in the open arms in the EPM test， and increased the number of entries， time spent， and distance traveled in the central area in the OF test （P<0.01 P<0.05）， 3） EA at GV20 significantly increased the time spent in the open arms in the EPM test （P<0.01）， 4） EA at HT7 obviously increased the time spent in the open arms of the EPM test and increased the time spent in the central area of the OF test （P<0.01）， and 5） EA at ST36 significantly decreased the expression of c-Fos in the bilateral ACC， contralateral mPFC， bilateral PVT， and bilateral MD （P<0.05）. Compared with the EA ST36 group， the EA ST36 + naloxone group showed a significant decrease in the PWTs （P<0.01）， number of entries into the open arms， total distance traveled and time spent in the open arms in the EPM test （P<0.05）， and in the number of entries into the central area and time spent in the central area in the OF test （P<0.01）. The expression levels of c-Fos in the bilateral ACC and ipsilateral MD were strikingly higher in the EA ST36 + naloxone group than those in the EA ST36 group （P<0.05）， suggesting a disappearance of the suppressive effect of EA after administration of naloxone.ConclusionEA at ST36 has a better analgesic and emotional relief effects on mice with comorbid pain and emotion compared to EA at GV20 and HT7. The underlying mechanism may involve the inhibition of neuronal excitability in the ACC， mPFC， MD and PVT. Additionally， the emotional relief effect of EA at ST36 is dependent on its analgesic efficacy， which may be related to the inhibition of neuronal excitability in the ACC and MD.关键词：Chronic inflammatory pain-anxiety comorbidity;Acupuncture analgesia;anti-anxiety;Anterior cingulate cortex;Medial prefrontal cortex;Paraventricular nucleus of the thalamus;Mediodorsal thalamus nucleus105|95|0更新时间：2026-02-24
- “最新研究聚焦于电针治疗早发性卵巢功能不全（POI）的机制。专家通过构建POI大鼠模型，发现电针可调节激素水平，改善卵巢功能，其机制可能与调节ACSL4/LPCAT3/ALOX15通路，抑制铁死亡有关。”摘要：ObjectiveTo observe the effect of electroacupuncture （EA） on long-chain acyl-CoA synthetase 4 （ACSL4）/ phosphatidylcholine acyltransferase 3 （LPCAT3）/ arachidonic acid lipoxygenase 15 （ALOX15） signaling pathway in the ovarian tissue in rats with premature ovarian insufficiency （POI）， so as to explore its mechanisms underlying improvement of POI from the perspective of ferroptosis.MethodsForty-eight female SD rats were randomly divided into control， POI model， EA and hormone replacement treatment （medication） groups， with 12 rats in each group. The POI model was established by intraperitoneal injection of cyclophosphamide （50 mg/kg on the 1st day， then 8 mg·d-1·kg-1 for 14 d）. EA （2 Hz） was applied to “Guanyuan”（CV4）， bilateral “uterus”（EX-CA1） and “Sanyinjiao”（SP6） for 20 min each time. Rats of the medication group were treated by gavage of estradiol valerate for 4 consecutive days， with medroxyprogesterone acetate additionally administered on the 4th day. The treatment of both EA and medication was conducted once daily， with 4 d + one day’s rest being a cycle， lasting for 4 cycles （20 d）. After the intervention， the serum follicle-stimulating hormone （FSH）， luteinizing hormone （LH）， estradiol （E2） and anti-mullerian hormone （AMH） contents were detected by ELISA. The H.E. staining was used to observe the morphological changes of the ovarian tissue. The contents of serum iron （Fe）， glutathione （GSH）， malondialdehyde （MDA） and activity of superoxide dismutase （SOD） were detected by colorimetry. The level of reactive oxygen species （ROS） in the ovarian tissue was detected by flow cytometry. The ultrastructure of mitochondria in the ovarian tissue was observed by transmission electron microscope. The mRNA and protein expression levels of ACSL4， LPCAT3， and ALOX15 in the ovarian tissue were detected separately by real-time fluorescence quantitative PCR and Western blot.ResultsCompared with the control group， the model group had a significant increase in the serum FSH， LH， Fe， MDA contents， and ovarian ROS mean fluorescence intensity， and the mRNA and protein expression levels of ACSL4， LPCAT3 and ALOX15 （P<0.01）， and a striking decrease in the contents of serum E2， AMH， GSH， and SOD activity （P<0.01） in the model group. After the treatment， both the increased contents of serum FSH， LH， Fe， MDA contents， and ovarian ROS mean fluorescence intensity， and ACSL4， LPCAT3 and ALOX15 mRNA and protein expressions and the decreased contents of serum E2， AMH， GSH and SOD activity were completely reversed in the EA and medication groups （P<0.01）. No significant differences were found between the EA and medication groups in up-regulating and down-regulating all the related indexes mentioned above. Morphological observation showed decreased number of growing follicles at all levels， increased number of atretic follicles， abnormal structure of follicles， disordered arrangement of the granulosa cell layer， increase of damage of the mitochondria and decrease or even disappearance of the mitochondrial cristae in the ovarian tissues in the model group， which was apparently milder in the injury state in both EA and medication groups.ConclusionEA can regulate hormone levels and improve ovarian function in POI rats， which may be related to its function in regulating ACSL4/LPCAT3/ALOX15 signaling pathway， reducing lipid peroxide accumulation and inhibiting ferroptosis.关键词：Electroacupuncture;Premature ovarian insufficiency;Ferroptosis;Lipid peroxidation;ACSL4/LPCAT3/ALOX15 signaling pathway73|57|0更新时间：2026-02-24
- “研究发现电针“关元”“三阴交”可缓解原发性痛经大鼠症状，其抗炎机制可能与调控A20/NF-κB/NLRP3/GSDMD信号通路有关。”摘要：ObjectiveTo observe the effect of electroacupuncture （EA） at “Guanyuan” （CV4） and “Sanyinjiao” （SP6） on the ubiquitin-editing enzyme A20 （A20）/nuclear factor-κB （NF-κB）/NOD-like receptor protein 3 （NLRP3）/Gasdermin D （GSDMD） signaling pathway in rats with primary dysmenorrhea （PDM）.MethodsFemale naive SD rats were randomly divided into blank， model， EA and medication groups （n=6 per group）. PDM rat model was established by subcutaneous injection of estradiol benzoate combined with intraperitoneal injection of oxytocin. EA （50 Hz） was applied to CV4 and bilateral SP6 of rats in the EA group， with needles retained for 20 min， once daily for 10 consecutive days. Rats in the medication group received ibuprofen（125 mg/100 mL， 0.8 mL） by gavage for 10 consecutive days. At the 11th day， writhing behavior of rats was assessed. Uterine pathology was assessed by HE staining. Serum contents of prostaglandin F2α （PGF2α） and tumor necrosis factor-α （TNF-α） were measured by ELISA. Protein expression of A20， phosphorylated NF-κB p65 （p-NF-κB p65）， NF-κB p65， NLRP3， Caspase-1， Interleukin （IL）-1β， GSDMD， and GSDMD N-terminal domain （GSDMD-N） in uterine tissue were detected by Western blot.ResultsCompared with the blank group， the writhing times， scores， and latency period， the contents of PGF2α and TNF-α in serum， and the protein expression levels of p-NF-κB p65， NF-κB p65， NLRP3， Caspase-1， IL-1β， GSDMD， and GSDMD-N in the uterine tissues of rats in the model group were all significantly increased （P<0.05， P<0.01）. In contrast， the expression level of A20 was decreased （P<0.01）. Compared with the model group， the writhing times and scores， the contents of PGF2α and TNF-α in serum， and the protein expression levels of p-NF-κB p65， NF-κB p65， NLRP3， GSDMD， and GSDMD-N in rats of the EA and medication groups were all significantly decreased （P<0.05， P<0.01）. Conversely， the writhing latency period and the expression level of A20 were significantly increased （P<0.01）. After modeling， the endometrial epithelial cells were dead， accompanied by endometrial edema and neutrophil infiltration， which was milder in the EA and the medication groups.ConclusionEA intervention can effectively relieve inflammatory response in PDM rats， which may be associated with its effect in activating the A20-mediated NF-κB negative feedback pathway and inhibiting the NF-κB/NLRP3/GSDMD signaling pathway.关键词：Primary dysmenorrhea;Electroacupuncture;Ubiquitin-editing enzyme;Nuclear factor-κB;Inflammatory reaction67|119|0更新时间：2026-02-24
- “研究发现电针“神门”可调节丙酮酸 - 乳酸代谢轴，改善急性心肌缺血大鼠心肌损伤，为心肌缺血治疗提供新思路。”摘要：ObjectiveTo explore the underlying mechanism of electroacupuncture （EA） of “Shenmen” （HT7） in amelioration of myocardial injury by regulating pyruvate-lactate metabolic axis in rats with acute myocardial ischemia （AMI）.MethodsSD rats were randomly divided into sham operation （sham）， AMI model （model）， EA， monocarboxylic acid transporter 4 （MCT4） inhibitor group and EA+mitochondrial pyruvate vector （MPC） inhibitor groups， with 6 rats in each group. The AMI model was made by ligating the left anterior descending coronary artery. EA （2 Hz， 1 mA） was applied to bilateral HT7 for 30 min， once a day for 3 days. Both MCT4 and MPC inhibitors were separately given to rats of the MCT4 inhibitor and EA+MPC inhibitor groups by intraperitoneal injection， once a day for 3 d. The HE staining was used to observe the histopathological changes of the myocardium tissue. The Sirius red staining was used to observe the myocardial fibrosis. The left ventricular ejection fraction（EF） and fractional shortening （FS） were detected by echocardiography. The contents of serum brain natriuretic peptide （BNP）， lactic acid， lactate dehydrogenase （LDH）， and myocardial lactic acid and LDH were detected by ELISA. The ultrastructure of mitochondria in the myocardial cells was observed by transmission electron microscopy. The protein expressions of MCT4， MPC and pan-lysine lactylation （Pan-Kla） in the myocardium were detected by Western blot.ResultsCompared with the sham group， the model group had a striking decrease in the levels of EF and FS and MPC protein expression （P<0.05）， and a significant increase in the proportion of myocardial collagen deposition area， contents of serum BNP， lactic acid， LDH and myocardial lactic acid and LDH， and expression levels of myocardial MCT4 and Pan-Kla protein expressions （P<0.05）. In contrast to the model group， the levels of EF and FS in both EA and MCT4 inhibitor groups and myocardial MPC expression in the EA group were significantly increased （P<0.05）， the proportion of collagen deposition area， contents of serum BNP， lactic acid， LDH and myocardial lactic acid and LDH in both EA and MCT4 inhibitor groups and the expression levels of MCT4 and Pan-Kla proteins in the EA group were considerably decreased （P<0.05）. In comparison with the EA group， the EA+MPC inhibitor group showed an obvious increase in the proportion of myocardial collagen deposition area， serum BNP， lactic acid， LDH and myocardial lactic acid and LDH （P<0.05）， and a notable decrease in the levels of EF and FS （P<0.05）. There was a positive correlation between the MCT4 and BNP levels， and between the MPC and EF levels， and a negative correlation between the MCT4 and EF and between the MPC and BNP levels. The myocardial morphological structure observation displayed disordered arrangement and rupture of the myocardial fibers， infiltration of inflammatory cells， damaged and swollen mitochondria， broken cristae， etc. in the model group. While in comparison with the model group， the myocardial cellular injury and the structure of mitochondria in the EA group and MCT4 inhibitor group （not in the EA+MPC inhibitor group） were improved， with fewer broken cristae and milder disorder of myofilaments.ConclusionEA of HT7 can improve myocardial energy metabolism and cardiac functional injury in rats with AMI， which may be related with its functions in inhibiting myocardial lactate excretion， mitigating lactate accumulation and lactylation by down-regulating MCT4， up-regulating MPC to promote pyruvate mitochondrial oxidation and energy supply， and modulating the pyruvate-lactic acid metabolic axis.关键词：Acute myocardial ischemia;Electroacupuncture;Mitochondrial pyruvate carrier;Monocarboxylic acid transporter 4;Lactic acid32|72|0更新时间：2026-02-24
- “壮医药线点灸阳明经穴可调节血糖，促进胃排空，改善糖尿病胃轻瘫症状，抑制相关蛋白表达，减轻胃平滑肌细胞凋亡，为糖尿病胃轻瘫治疗提供新思路。”摘要：ObjectiveTo observe the effect of Zhuang-medicine medicated thread moxibustion on endoplasmic reticulum stress-associated apoptotic proteins in rats with diabetic gastroparesis （DGP）， so as to explore its underlying therapeutic mechanisms.MethodsMale SD rats were randomly divided into five groups： blank control， DGP model， medication， non-meridian non-acupoint （non-acupoint） moxibustion， and Yangming meridian acupoint moxibustion groups， with 12 rats in each group. The DGP model was established by intraperitoneal injection of 2% streptozotocin （STZ， 55 mg/kg）. Rats of the medication group received gavage of mosapride citrate suspension （0.15 mg/mL）. For rats in the Yangming meridian acupoint moxibustion group， the medicated thread moxibustion was applied to bilateral “Liangmen” （ST21）， “Qichong” （ST30）， “Zusanli” （ST36） and “Fenglong” （ST40）， with three moxa cones for each acupoint. For rats of the non-acupoint group， the same medicated thread moxibustion was applied to the sites 2.5 mm or 5 mm away from the abovementioned Yangming meridian acupoints. The 3 intervention groups were conducted once daily for 3 weeks. The symptom scores were assessed. The blood glucose levels were measured using a blood glucose meter， and the gastric emptying rate was assessed by using phenol red gavage method. The apoptosis index of gastric smooth muscle cells was detected using TUNEL staining. The expression levels of glucose-regulated protein 78 （GRP78）， activating transcription factor 6 （ATF6）， and CCAAT/enhancer-binding protein homologous protein （CHOP） in the gastric antral smooth muscle were detected using Western blot， and the immunoactivities of B-cell lymphoma-2 （Bcl-2）， Bcl-2-associated X protein （Bax）， and Caspase-12 in the gastric smooth muscle tissues were detected using immunohistochemistry method.ResultsCompared to the control group， rats in the model group exhibited a significant increase in the symptom score， blood glucose level， smooth muscle cell apoptosis index， and the expression levels of GRP78， ATF6， CHOP， Bax and Caspase-12 proteins （P<0.01）， and an obvious decrease in the gastric emptying rate and expression of Bcl-2 protein （P<0.01）. In contrast to the model group， both the significant increase and decrease of the indexes mentioned above were all reversed by Yangming acupoint moxibustion and medication （P<0.01，P<0.05）， but not by non-acupoint moxibustion， except blood glucose level which was only decreased in the Yangming acupoint moxibustion group （P<0.01）. Comparison between the Yangming meridian acupoint group and non-acupoint group displayed that the symptom score， blood glucose， apoptosis index， and expression of GRP78， ATF6， CHOP， Bax and Caspase-12 proteins were significantly higher in the latter group than in the former group （P<0.01，P<0.05）， while the gastric emptying rate and expression of Bcl-2 were significantly lower in the latter group than in the former group （P<0.01）.ConclusionZhuang-medicine medicated thread moxibustion can ameliorate symptoms， promote gastric emptying and lower blood glucose in DPG rats， which may be related to its functions in regulating the expression of endoplasmic reticulum stress-associated apoptotic proteins， suppressing the expression of GRP78， ATF6， CHOP， Caspase-12， and Bax proteins （ATF6/CHOP signaling pathway） and upregulating the expression of Bcl-2 protein in the gastric antral smooth muscle.关键词：Zhuang-medicine medicated thread moxibustion;Diabetic gastroparesis;Endoplasmic reticulum stress;ATF6/CHOP signaling pathway;Apoptosis;Gastric emptying81|54|0更新时间：2026-02-24
- “研究发现温针灸可激活慢性疲劳综合征大鼠骨骼肌AMPK/ULK1信号通路，促进线粒体自噬，改善线粒体形态，为治疗慢性疲劳综合征提供新思路。”摘要：ObjectiveTo observe the effect of warming needle moxibustion （WNM） on the expression of AMP-activated protein kinase （AMPK）/Unc-51 like autophagy activating kinase 1 （ULK1） signaling pathway in chronic fatigue syndrome （CFS） rats， so as to explore its mechanism underlying improvement of CFS.MethodsMale SD rats were randomly divided into control， model， WNM and coenzyme groups， with 10 rats in each group. The CFS model was established by multi-factor compound stress stimulation method （exhaustive swimming + chronic restraint + alternate-day fasting）. The rats of the WNM group received warming needle moxibustion stimulation at bilateral “Zusanli” （ST36）， “Guanyuan” （CV4） and “Zhongwan” （CV12）for 15 min， once daily for 14 days. The rats of the coenzyme group were administered coenzyme Q10 （1 mg/kg） by gavage once daily for 14 days. Body weight and swimming time of the rats were recorded before and after modeling and after intervention. Behavioral changes were assessed using the open-field test. Histological changes in skeletal muscle were observed via HE staining. The structure of mitochondria and autophagosomes in skeletal muscle were observed using transmission electron microscopy. The protein expression levels of AMPK， phosphorylated （p）-AMPK， ULK1， p-ULK1， microtubule-associated protein 1 light chain 3 （LC3）-Ⅰ and LC3-Ⅱ in skeletal muscle were detected by Western blot， and the ratios of p-AMPK/AMPK， p-ULK1/ULK1 and LC3-Ⅱ/LC3-Ⅰ were calculated. The mRNA expression levels of AMPK， ULK1 and LC3 in skeletal muscle were detected by real-time PCR.ResultsCompared with the control group， the body weight， swimming time， and the duration of standing and the number of grid crossing were significantly reduced （P<0.05）， while the mRNA expression levels of ULK1 and LC3， and the ratio of p-ULK1/ULK1 were significantly increased in the model group （P<0.05）. Compared with the model group， the body weight， swimming time， and the duration of standing and the number of grid crossing were significantly increased （P<0.05）， and the mRNA expression levels of AMPK， ULK1 and LC3， as well as the ratios of p-ULK1/ULK1 and LC3-Ⅱ/LC3-Ⅰ， were significantly up-regulated in both the WNM and coenzyme groups （P<0.05）.ConclusionWarming needle moxibustion can alleviate chronic fatigue syndrome by activating the AMPK/ULK1 pathway， upregulating the expression of AMPK/ULK1/LC3， and promoting mitochondrial autophagy， thereby enhancing mitochondrial morphology.关键词：Chronic fatigue syndrome;AMPK/ULK1 signaling pathway;Warming needle moxibustion;Mitochondrial autophagy;Skeletal muscle59|122|0更新时间：2026-02-24
- “研究发现针刺“跷脉”可改善失眠大鼠睡眠质量，增强其免疫功能，为失眠治疗提供新思路。”摘要：ObjectiveTo observe the effect of acupuncture at the “Qiaomai” points on the immune function activity of central and peripheral macrophages in insomnia rats， so as to explore its underlying therapeutic mechanisms.MethodsSD rats were randomly divided into 4 groups （blank group， model group， Western medicine group， and acupuncture group）， with 10 rats in each group. An insomnia rat model was established by intraperitoneal injection of para-chlorophenylalanine suspension for 2 d. After successful modeling， the Western medicine group was given diazepam at a dose of 1 mg/kg by gavage， while the acupuncture group was treated with the “Zhaohai” （KI6） and “Shenmai” （BL62） acupuncture technique for 15 min per session. All interventions were administered once daily for a total of 7 d. The general condition of the rats was observed， and their body weight was recorded before modeling， before intervention， and after intervention. The threshold dose of pentobarbital sodium in sleep experiment before and after treatment were also recorded. The thymus index and spleen index were calculated. Flow cytometry was used to determine the CD68+， CD86+， and CD163+ positive cells in peripheral blood. Immunohistochemistry was used to detect the expression levels of ionized calcium-binding adapter molecule 1 （Iba-1）， inducible nitric oxide synthase （iNOS）， and arginase-1 （Arg-1） in hippocampal tissue. The BioLegend LEGENDplex™ multiplex assay was used to measure the levels of 6 inflammatory factors in the plasma of peripheral blood， including tumor necrosis factor-α （TNF-α）， granulocyte-macrophage colony-stimulating factor （GM-CSF）， interleukin（IL）-12， IL-1β，IL-1α and IL-6.ResultsCompared to the blank group， the model group rats exhibited lethargy， rough fur， reduced food intake， decreased daytime sleep， increased daytime activity， and weight loss （P<0.01）. Sleep latency was prolonged （P<0.01） and sleep duration was shortened （P<0.01）. Spleen index and thymus index were reduced （P<0.01）. The proportions of CD68+ and CD68++CD86+ cells in peripheral blood were decreased （P<0.01）. The positive expressions of Iba-1 and iNOS in hippocampal tissue were decreased （P<0.01）. The plasma levels of GM-CSF， IL-1α， IL-1β， IL-6， IL-12， and TNF-α in peripheral blood were lower （P<0.01）. Compared to the model group， the Western medicine group and the acupuncture group rats showed improved general condition， increased food intake， increased daytime sleep， reduced daytime activity， and increased body weight （P<0.01， P<0.05）. Sleep latency was shortened （P<0.01） and sleep duration was extended （P<0.01）. The proportion of CD68++CD86+ cells in peripheral blood was increased（P<0.05， P<0.01）. Additionally， compared to the model group， the acupuncture group showed higher spleen index and thymus index （P<0.01， P<0.05）； the proportion of CD68+ cells in peripheral blood was increased （P<0.01）； the positive expressions of Iba-1 and iNOS in hippocampal tissue were elevated （P<0.05）； and the plasma levels of IL-1α， IL-1β， IL-6， IL-12， TNF-α， and GM-CSF were higher （P<0.01， P<0.05）. Compared with the Western medicine group， the acupuncture group showed higher spleen index and thymus index （P<0.05）. The proportions of CD68+ and CD68++CD86+ cells in peripheral blood were increased （P<0.05， P<0.01）. The plasma levels of IL-1α， IL-1β， IL-6， IL-12， TNF-α， and GM-CSF were increased （P<0.05， P<0.01）.ConclusionAcupuncture at the “Qiaomai” points can improve the sleep quality of insomnia rats， potentially by promoting macrophage proliferation and their transformation into M1-type macrophages， thereby increasing the levels of inflammatory factors related to sleep regulation and enhancing the immune function activity of central and peripheral macrophages.关键词：Insomnia;Acupuncture;Qiaomai;Immunity;Macrophage80|124|0更新时间：2026-02-24
- ““”这段话，介绍了其在肌筋膜疼痛综合征治疗领域的研究进展，专家验证了捻转法与提插法在治疗肌筋膜疼痛综合征中的疗效，为临床治疗提供了新的解决方案。”摘要：ObjectiveTo observe the efficacy of different needle manipulation techniques at myofascial trigger points （MTrPs） in treating myofascial pain syndrome （MPS） and to determine which technique is more advantageous.MethodsA total of 108 MPS patients were randomly divided into a twisting group （36 cases， with 5 dropouts）， a lifting-thrusting group （36 cases， with 3 dropouts）， and a non-manipulation group （36 cases， with 6 dropouts）. The twisting group and lifting-thrusting group received twisting or lifting-thrusting techniques for 1 min at MTrPs， respectively， while the non-manipulation group retained the needles without manipulation for 1 min. Treatments were administered every other day， totaling 3 sessions. Before and after the first treatment and after the final treatment， patients completed the short-form McGill pain questionnaire （SF-MPQ）， including the pain rating index （PRI）， visual analog scale （VAS）， and present pain intensity （PPI） scores. Young’s modulus values at MTrPs were measured using ultrasound elastography before and after treatment. The Massachusetts acupuncture sensation scale （MASS） was used during each treatment to record the types and intensity of needling sensations. Clinical efficacy was evaluated after the final treatment.ResultsAfter the final treatment， SF-MPQ， PRI， VAS， PPI scores， and Young’s modulus values decreased （P<0.05） in all the 3 groups compared to pretreatment. After treatment， the twisting and lifting-thrusting groups showed greater reductions in SF-MPQ， PRI， PPI scores， and Young’s modulus values （P<0.05） compared to the non-manipulation group， while the lifting-thrusting group had lower VAS scores （P<0.05） than the non-manipulation group. The lifting-thrusting group exhibited higher frequencies of twitching sensations and greater distension intensity （P<0.05） than the non-manipulation group. Both the twisting and lifting-thrusting groups had higher mean needling sensation intensity of twitching sensations， needle grasp （practitioner’s sense of tightness）， and MASS values （P<0.05） than the non-manipulation group. The total effective rates were 80.65% （25/31） in the twisting group， 84.85% （28/33） in the lifting-thrusting group， and 66.67% （20/30） in the non-manipulation group， with the lifting-thrusting group showing higher efficacy than the non-manipulation group （P<0.05）. Pain relief was positively correlated with the occurrence of twitching sensations and needle grasp （P<0.01）， as well as with the intensity of distension， twitching sensations， MASS values， and needle grasp （P<0.01）.ConclusionBoth twisting and lifting-thrusting techniques at MTrPs yield better clinical outcomes for MPS than non-manipulation， with the lifting-thrusting technique demonstrating superior overall efficacy. The lifting-thrusting technique is more advantageous than twisting in eliciting twitching sensations during MTrP acupuncture.关键词：Myofascial pain syndrome;Myofascial trigger point;Needling manipulation;Lifting-thrusting technique;Twirling-rotating technique83|86|0更新时间：2026-02-24
- ““”这段话，专家研究了针刺夹脊对中风偏瘫患者上肢痉挛的影响，发现其能显著降低肌张力，缓解痉挛，促进运动功能恢复，提高生活质量。”摘要：ObjectiveTo observe the effect and clinical efficacy of acupuncture at Jiaji （EX-B2） on F-wave latency and amplitude in stroke patients with hemiplegic upper limb spasticity.MethodsA total of seventy-six patients with hemiplegia after stroke were randomly and equally divided into an observation group （38 cases，3 cases dropped off） and a control group （38 cases， 2 cases dropped off）. The both groups received basic medical treatment， acupuncture at Jianyu（LI15）， Quchi （LI11）， Huantiao （GB30）， Yanglingquan （GB34） and rehabilitation training. The observation group received acupuncture at Jiaji point （C4 to T5） on the hemiplegic side. The treatment lasted 30 min per session， once daily， 5 times a week for 4 weeks. The F-wave latency and amplitude of the median nerve on the affected side were measured， and scores of the modified Ashworth scale （MAS） and the Fugl–Meyer assessment–upper extremity （FMA-UE） were evaluated before treatment and after 4 weeks of treatment.ResultsAfter 4 weeks of treatment， F-wave latency in the hemiplegic limb was significantly shorter （P<0.01） and F-wave amplitude was markedly lower （P<0.01） in both groups compared with baseline， with the observation group showing a significant change compared with the control group （P<0.01）. Additionally， the scores of FMA-UE and MAS in both groups were improved compared with those before treatment （P<0.01）， and the scores of the observation group were significantly better than those of the control group （P<0.01）.ConclusionAcupuncture at Jiaji can inhibit the excitability of motor nerves， reduce muscle tension， alleviate spasticity， and enhance motor function recovery in patients with upper limb spasticity after stroke hemiplegia， thereby improving their quality of life.关键词：Stroke;Upper limb spasticity;Acupuncture;Jiaji;F-wave30|70|0更新时间：2026-02-24
- “佛山市第五人民医院专家研究乂针治疗带状疱疹后神经痛，发现其联合普瑞巴林疗效显著，可调节血清疼痛介质及炎性因子，改善患者情绪与睡眠。”摘要：ObjectiveTo observe the clinical effect of yizhen therapy on post-herpetic neuralgia （PHN） and explore its mechanism.MethodsNinety two patients with PHN， visited Foshan Fifth People’s Hospital （Foshan Rehabilitation Hospital Co.， Ltd.） from January 2023 to April 2024， were selected as the subjects. These patients were divided into three groups， a sham-acupuncture group （31 cases， one dropped out）， an acupuncture group （31 cases， one excluded） and a yizhen therapy group （30 cases）， based on a randomized， single-blind method. Pregabalin was administered in each group. Additionally， the sham-acupuncture was delivered in the sham-acupuncture group at same acupoints as in the yizhen group， during which， the needles were not invaded， and the therapy was operated for about 20 min each time. In the acupuncture group， acupuncture was exerted at conventional acupoints， about 20 min each time. In the yizhen therapy group， yizhen therapy was delivered at Jiaji （EX-B2） and Ashi points， 15 to 20 min. The treatment was administered consecutively for 5 days in each group， and 2 weeks of treatment were required， at the interval of 2 days. Before and after treatment， and 1 month after treatment completion， the scores of the short-form McGill pain questionnaire （SF-MPQ）， Hamilton anxiety scale （HAMA）， Pittsburgh sleep quality index （PSQI）， and Hamilton depression scale （HAMD） were evaluated， as well as the safety. The contents of substance P （SP）， interleukin-6 （IL-6）， and tumor necrosis factor alpha （TNF-α） in the serum were detected in each group. The clinical effect was evaluated.ResultsThe total effective rates in the yizhen therapy group and the acupuncture group were 93.33% （28/30） and 80.00% （24/30）， respectively， higher than 53.33% （16/30） in the sham-acupuncture group （P<0.05）. The clinical curative rate in either the yizhen therapy group or the acupuncture group increased in comparison with the sham-acupuncture group （P<0.05）； and when compared with the acupuncture group， the curative rate of yizhen therapy group was higher （P<0.05）. Compared with those before treatment， the scores of HAMD， HAMA， PSQI and SF-MPQ were reduced after treatment and in 1 month of treatment completion in the yizhen therapy group and acupuncture group （P<0.05）； and every indicator in the yizhen therapy group was lower when compared with the acupuncture group and sham-acupuncture group （P<0.05）. After treatment and in 1 month of treatment completion， in the yizhen therapy group and the acupuncture group， the contents of SP， TNF-α and IL-6 were reduced in comparison with those before treatment， and these indicators in the yizhen therapy group were lower when compared with the acupuncture group and sham-acupuncture group （P<0.05）. There was no significant difference in the incidence of adverse reactions among the three groups.ConclusionThe combination of yizhen acupuncture therapy and pregabalin is effective and safe in treatment of PHN. It can regulate the levels of pain and inflammatory factors in the serum， alleviate pain， thereby improving patients’ emotional state and sleep quality.关键词：Post-herpetic neuralgia;Yizhen;Pain degree;Inflammatory factors;Emotional state41|94|0更新时间：2026-02-24
- ““针刺力敏腧穴治疗IBS - D具有确切疗效，安全性高且远期疗效佳；在改善IBS - D患者的症状严重程度、提升生活质量方面，针刺高敏感力敏腧穴较低敏感力敏腧穴疗效更显著。””摘要：ObjectiveTo evaluate the clinical efficacy of acupuncture on force-sensitive acupoints with different sensitization degrees in treatment of diarrhea-predominant irritable bowel syndrome （IBS-D）.MethodsA total of 108 patients with IBS-D were randomly divided into a high-sensitivity group （36 cases， 2 cases dropped out）， a low-sensitivity group （36 cases， 1 case dropped out） and a waiting group （36 cases， 2 cases dropped out）. In the high-sensitivity group， 5 high-sensitivity （the lowest pain threshold） acupoints were selected in acupuncture treatment， and in the low-sensitivity group， 5 low-sensitivity （the highest pain threshold） acupoints were selected. The patients in both groups received 3 times of acupuncture treatment per week， lasting 6 consecutive weeks. The patients in the waiting group did not receive any treatment during the research and the non-investigational standard acupuncture therapy would be provided after follow-up， 3 times a week， for 6 consecutive weeks. The scores of IBS severity scale （IBS-SSS） and IBS quality of life scale （IBS-QOL）， and fecal traits of Bristol fecal form scale （BSFS） were evaluated before and after treatment， as well as in follow-up. The occurrence of adverse reactions was recorded.ResultsCompared with those before treatment， the scores of IBS-SSS and IBS-QOL in the waiting group were not significantly different after treatment or in follow-up； the scores of IBS-SSS and IBS-QOL in the high-sensitivity group and the low-sensitivity group were decreased at each time point （P<0.05）. When compared with the waiting group， the score of IBS-SSS in either the high-sensitivity group or the low-sensitivity group were reduced， starting from 2 weeks after treatment and till the follow-up （P<0.05）. In 4 and 6 weeks of treatment and during follow-up， the score of IBS-SSS in the high-sensitivity group was lower than that in the low-sensitivity group （P<0.05）. In comparison with the score in the waiting group， the scores of IBS-QOL were reduced in both the high-sensitivity group and the low-sensitivity group after treatment and in follow-up （P<0.05）； and the score in the high-sensitivity group was lower than that of the low-sensitivity group （P<0.05）. In the waiting group， there was no statistically significant difference in fecal traits of BSFS after treatment and in follow-up， but the improvements in BSFS were obtained in the high-sensitivity group and the low-sensitivity group （P<0.01）. When compared with the waiting group， the improvements in BSFS were presented in the high-sensitivity group and low-sensitivity group after treatment and in follow-up （P<0.01）. No significant adverse reactions were observed in all groups.ConclusionAcupuncture at force-sensitive acupoints has a definite curative effect on IBS-D. This therapy is high in safety and satisfactory in long-term effect. In the aspects of the alleviation of the severity of symptoms and the improvement of the quality of life in the patients with IBS-D， acupuncture at force-sensitive acupoints with high sensitivity is more effective than that with low sensitivity.关键词：Diarrhea-predominant irritable bowel syndrome;Acupuncture;Force-sensitive acupoints;Sensitization;Randomized controlled trials48|115|0更新时间：2026-02-24
- “阿尔茨海默病（AD）是一种常见的神经退行性疾病，线粒体功能障碍与AD发病密切相关。针刺是治疗AD的有效方法之一，可显著改善AD症状，延缓病情发展，其作用机制研究也不断深入。针刺主要从保护线粒体形态结构、改善线粒体动力学、调控线粒体能量代谢、调节线粒体自噬、维持线粒体钙稳态、减轻氧化应激损伤、抑制细胞凋亡等方面恢复和维持线粒体功能，发挥治疗AD的作用。现有研究存在多集中于线粒体功能障碍单一因素、较少考虑除神经元以外其他细胞的参与机制、实验设计方案欠完整、未考虑疾病分期分段与线粒体功能障碍间的联系等不足。未来研究有必要探讨AD发病过程中不同阶段线粒体的功能状态及针刺的具体调节作用。”摘要：Alzheimer’s disease （AD） is a common neurodegenerative disease， and mitochondrial dysfunction is closely related to the pathogenesis of AD. Acupuncture is one of the effective methods for treating AD， which can significantly improve AD symptoms and delay disease progression， and research on its mechanism of action has been continuously deepened. This article combs and summarizes the relevant studies on acupuncture regulating mitochondrial function to improve AD. The results show that acupuncture restores and maintains mitochondrial function mainly by protecting mitochondrial morphology and structure， improving mitochondrial dynamics， regulating mitochondrial energy metabolism， modulating mitophagy， maintaining mitochondrial calcium homeostasis， reducing oxidative stress damage， and inhibiting cell apoptosis， thereby exerting a therapeutic effect on AD. Existing studies have limitations， such as focusing more on single factor of mitochondrial dysfunction， rarely considering the involvement mechanism of other cells besides neurons， incomplete experimental design schemes， and failing to consider the connection between disease stages and mitochondrial dysfunction. Future studies need to explore the functional status of mitochondria at different stages of AD pathogenesis and the specific regulatory effect of acupuncture.关键词：Acupuncture;Alzheimer’s disease;Mitochondrial function;Review61|167|0更新时间：2026-02-24
- “冠心病是常见病，针刺可改善其症状，减少心绞痛发作，提高生活质量。专家总结针刺改善冠心病心肌缺血的研究进展，发现针刺通过多途径改善血流灌注，缓解心肌损伤，为冠心病治疗提供新思路。”摘要：Coronary heart disease （CHD） is a common and frequently occurring disease in clinical practice. As an adjunctive therapy， acupuncture can effectively improve the clinical symptoms of CHD， reduce the frequency and duration of angina attacks， decrease adverse cardiovascular events， and improve patients’ quality of life. Myocardial ischemia is the core pathological mechanism of CHD. In this paper， we summarized the basic research on acupuncture for myocardial ischemia in CHD both domestically and internationally in recent years. The findings showed that acupuncture can improve blood perfusion， alleviate post-ischemic myocardial tissue damage and post-ischemic reperfusion injury through multiple pathways， including inhibiting myocardial inflammatory response， beneficially regulating cardiac autonomic nerves， suppressing hyperactivity of hypothalamic-pituitary-adrenal axis， modulating cardiomyocyte apoptosis and autophagy， regulating myocardial energy metabolism， and promoting angiogenesis. Additionally， acupuncture exhibits protective effects against ischemia-reperfusion injury， characterized by its multi-target， multi-pathway， and comprehensive therapeutic features.关键词：Coronary heart disease;Myocardial ischemia;Acupuncture;Mechanism;Ischemia-reperfusion injury;Review69|124|0更新时间：2026-02-24
- “介绍了其在针刺领域的研究进展，专家探讨了Meta分析设计、实施和报告的关键问题，为提高针刺Meta分析质量提供方法学支持。”摘要：As an important approach to secondary research， Meta-analysis provides researchers with a means to supplement evidence. However， though being considered the highest level of evidence， the application of Meta-analysis in acupuncture faces challenges. Despite a substantial number of acupuncture Meta-analyses exists， the varied quality creates the confusion in evidence body. To improve methodological quality， the key issues have been explored in the design， implementation， and reporting of acupuncture Meta-analyses. Before setting up the design， the emphasis should be laid on the prioritization of scientific questions and the feasibility of Meta-analysis methods. During the design， special attention should be given to the development of detailed and transparent methods. In the implementation phase， the importance of researchers’ knowledge base and the standardized use of relevant tools should be highlighted. In reporting， the completeness of results should be emphasized， particularly in conclusion formation， with full consideration of evidence quality and clinical significance. The above recommendations of this review aim to provide methodological support for improving the quality of acupuncture Meta-analyses.关键词：Acupuncture;Meta-analysis;Methodology;Quality assessment89|406|0更新时间：2026-02-24
- “专家分析针刺治疗卒中后疲劳选穴规律，建立数据库，为临床治疗提供依据及思路。”摘要：ObjectiveTo analyze the acupoint selection rules of acupuncture for treating post-stroke fatigue （PSF） and provide evidence and insights for clinical acupoint selection in PSF treatment.MethodsDatabases including China Biomedical Literature Database （CBM）， China National Knowledge Infrastructure （CNKI）， China Science Periodical Database （CSPD）， Chinese Core Journal Database （CCD）， PubMed， Embase， Web of Science， and Cochrane Library were searched for literature on acupuncture treatment of PSF from their inception to November 1， 2024. Eligible literature was screened strictly in accordance with the inclusion and exclusion criteria， and a database for acupuncture treatment of PSF was established. Excel 2021 was used to analyze the acupoints， meridian attribution， specific acupoints， and acupoint locations in the acupuncture prescriptions. IBM SPSS Modeler 18.0 was employed for association rule analysis， and IBM SPSS Statistics 26.0 for cluster analysis.ResultsA total of 22 articles were included， involving 58 acupoints with a total usage frequency of 231 times. The top 5 acupoints by frequency were Sanyinjiao （SP6）， Baihui （GV20）， Zusanli （ST36）， Neiguan （PC6）， and Guanyuan （CV4） & Hegu （LI4， tied for the 5th place）. The top 4 meridians by usage frequency were the Bladder Meridian of Foot-Taiyang， Stomach Meridian of Foot-Yangming， Gallbladder Meridian of Foot-Shaoyang， and Governor Vessel. The commonly used specific acupoints included HE-sea points （of the five SHU points）， lower HE-sea points， YUAN-source points， and LUO-connecting points. In terms of location， most acupoints were distributed in the lower limbs， head and face， upper limbs， and chest and abdomen. The core prescription consisted of SP6-ST36-GV20-PC6-LI4， and acupoints could be supplemented based on syndrome differentiation according to individual differences of patients. Intervention methods mainly included filiform needle acupuncture， electroacupuncture， and press tack needle.ConclusionThe acupoint selection rules for acupuncture in treating PSF are consistent with the therapeutic principles of replenishing qi and blood and dredging meridians. However， the parameters of acupuncture for PSF are not unified at present； therefore， the scientificity and rigor of clinical design schemes related to acupuncture treatment of PSF still need to be improved.关键词：Acupuncture;Post-stroke fatigue;Acupoint selection rules;Data mining36|128|0更新时间：2026-02-24
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