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北京医学院生理教研室
纸质出版日期:1986
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李慧麟, 周燕春, 顾蕴辉. 电针加压效应及其与A_、A_5蓝斑核团的关系[J]. 针刺研究, 1986,(1):44-49.
RELATIONSHIP BETWEEN PRESSOR EFFECT OF ELECTROACUPUNCTURE AND FUNCTIONS OF A_1, A_5, AND LOCUS COERULEUS NUCLEI[J]. Acupuncture research, 1986, (1): 44-49.
文献报道调节疼痛和血压的核团在中枢内有重叠
本实验室也证明具有镇痛效应的电针刺激有升高动脉血压的作用。实验表明
电刺激A_1、A_5、A_6(蓝斑)核团都可引起升压效应
三者是延髓、桥脑加压区的一部分。因此
本工作目的是(1)进一步分析不同穴位、不同参数的电针刺激对血压的效应有否不同;(2)再次检验电刺激A_1、A_5蓝斑以及蓝斑内微量注射L-谷氨酸钠对血压的作用
并分析三核团在电针升压效应中的作用。
Our experiments showed that analgesic electroacupuncture (EA: 8c/s
3V) had a pressor effect in conscious paralysed male rats under artificial respiration. The pressor effects of "Zusanli--Sanyingiao" and "Quchi-Neigu- an" were statistically different
suggesting that the effects of different acu- points were relatively specific. There was no significant difference betwe- en effects of different EA parameters used. In further experiments
ele- ctrostimulation of A_1 (or A_5
locus coeruleus) or microinjection of sodium glutamate into locus coeruleus produced a marked rise in blood pressure
but the pressor effect of EA remained unchanged after bilateral lesions of A_1 or A_5 nuclei. Thus
it is liKely that A_1 and A_5 areas do not play an- important role in pressor effect of EA. On the contrary
the pressor effect of EA was abolished by bilateral lesions of locus coeruleus
indica- ting that locus coeruleus (A_6) plays a critical role in pressor effect of EA.
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