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Online ISSN: 2097-7042

Print ISSN: 1000-0607

CN: 11-2274/R

Governing Body: National Administration of Traditional Chinese Medicine

Sponsors: Institute of Acupuncture and Moxibustion, CACMS; China Association of Acupuncture-Moxibustion

Publishing Frequency: Monthly

Tel: +86-10-64089344

Email: zcyjbjb@vip.163.com

Address: 16 Nanxiaojie, Dongzhimennei, Beijing, China

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Volume 51 期 3，2026 2026年第51卷第3期
    “研究发现电针“内关”和“足三里”可调控心肌缺血大鼠心功能，其适宜刺激强度分别为1.5 mA和3 mA，且需自主神经系统参与。”

    LI Xiu-xuan, LI-Xia, RAO Xue-zhi, LÜ Tao, ZHANG Zi-yi, XI Han-qing, GAO Xin-yan

    DOI：10.13702/j.1000-0607.20250863
    摘要：ObjectiveTo screen the optimal stimulation intensity of electroacupuncture （EA） at “Neiguan” （PC6） and “Zusanli” （ST36） for regulating autonomic nerve activity and cardiac function in rats with myocardial ischemia （MI）， so as to explore the potential underlying mechanism.MethodsForty male Sprague-Dawley （SD） rats were randomly divided into a control group and a model group， with 20 rats in each group. The MI model was established by ligating the left anterior descending coronary artery （LAD）. Rats in the control group underwent thoracotomy without LAD ligation. Lead Ⅱ electrocardiogram （ECG） was used to monitor ST segment elevation； Masson staining was performed to measure the cardiac collagen volume fraction （CVF）； Doppler echocardiography was applied to assess ejection fraction （EF） and fractional shortening （FS）， respectively for model evaluation. At the 7th day after MI induction， EA with different intensities （0.5， 1.5， 3 mA） was administered at left PC6 and ST36 for 1 min in both the control and model groups. In vivo neuroelectrophysiological recording was used to detect the discharge frequency of the left cervical sympathetic nerve （SN） and cervical vagus nerve （VN）. ECG was employed to record heart rate （HR） and heart rate variability （HRV）， and the Millar pressure-volume conductance catheter system was used to measure stroke volume （SV）， stroke work （SW）， and cardiac output （CO）， so as to screen the optimal stimulation intensity for each acupoint. Autonomic denervation was performed in the model group （n=10）. Before and after denervation， EA with the optimal intensity was delivered at left PC6 and ST36， and the above indicators were measured repeatedly to verify whether the autonomic nervous system is involved in the regulatory effect of EA on cardiac function in MI rats.ResultsAfter LAD ligation， ECG showed a significant elevation of the ST segment （P<0.000 1）， accompanied by marked decreases in EF and FS （P<0.000 1） and an increase in CVF （P<0.01）， indicating successful establishment of the MI model. The basal discharge frequency of SN in the model group was significantly higher than that in the control group （P<0.05）. In the control group， 1.5 mA EA at PC6 resulted in an increased HR （P<0.01）. In the model group， 1.5 mA EA at PC6 led to increases in the discharge frequency of SN and VN， HRV， as well as SV， SW and CO （P<0.01， P<0.05， P<0.001）. 1.5 mA EA at ST36 increased the discharge frequency of VN in the model group （P<0.05）. In the control group，3 mA EA at ST36 induced an elevation of HR （P<0.05）； in the model group， the same intervention increased the discharge frequency of SN， along with SV， SW and CO （P<0.05，P<0.01）. After autonomic denervation， the regulatory effects of EA at the above acupoints with optimal intensities on cardiac function were abolished.ConclusionThe optimal intensity of EA at PC6 for improving cardiac function is 1.5 mA， while that at ST36 is 3 mA. The EA-induced regulatory effects depend on the integrity of the autonomic nervous system.  
    关键词：Electroacupuncture;Myocardial ischemia;Autonomic nerve;Cardiac function;Neiguan （PC6）;Zusanli （ST36）   
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    “专家研究麦粒灸对围绝经期失眠大鼠的影响，发现其可改善睡眠，机制与减轻SIRT1/Nrf2通路介导的下丘脑氧化应激和细胞焦亡有关。”

    LI Xin, SU Sheng-yong, ZHANG Xi, WANG Tian, YANG Pu, ZHENG Guang-mei, HUANG Wen-jing, HUANG Xin-yu, YIN Li-li, HUANG Ying, XU Zhi-yi, GUAN Yin-ling, LIN Li-xia, CAI Hui-qian

    DOI：10.13702/j.1000-0607.20250983
    摘要：ObjectiveTo observe the effect of wheat-grain moxibustion（WGM） at “Guanyuan”（CV4）， “Mingmen”（GV4）， and bilateral “Xuanzhong”（GB39） on the oxidative stress and pyroptosis， and the activity of the Sirtuin 1（SIRT1）/nuclear factor erythroid-2-related factor 2 （Nrf2） signaling pathway in the hypothalamus of perimenopausal insomnia （PI） rats， so as to explore its underlying mechanism in improving PI.MethodsThirty-two female SD rats were randomly divided into four groups： sham， model， WGM， and WGM+EX527 （n=8 per group）. The PI model was established by bilateral ovariectomy combined with an intraperitoneal injection of 4-Chloro-DL-phenylalanine suspension （350 mg/kg） for 2 consecutive days. Rats in the WGM and WGM+EX527 groups received WGM at CV4， GV4 and GB39， with 6 cones for each acupoint. The rats in the WGM+EX527 group received additional intraperitoneal injection of the SIRT1 inhibitor EX527 （10 mg/kg） 30 min before each moxibustion session. The interventions were conducted once daily for 14 consecutive days. The sleep latency and sleep duration were assessed using the pentobarbital sodium-induced sleep test （righting reflex）， and the spontaneous activities （total distance moved， center zone dwelling time， and rearing times in 5 min） were measured using the open field test （OFT）. The hematoxylin-eosin （H.E.） staining was used to observe morphological changes in the hypothalamic tissue. Western blot was used to detect protein expression levels of SIRT1， Nrf2， Kelch-like ECH-associated protein1 （Keap1）， heme oxygenase-1 （HO-1）， superoxide dismutase （SOD）， catalase （CAT）， NOD-like receptor thermal protein domain associated protein 3 （NLRP3）， cysteingl aspartate specific protease 1 （Caspase-1）， apoptosis-associated speck-like protein containing a CARD （ASC）， and gasdermin-D （GSDMD） in the hypothalamus. The qPCR was used to measure mRNA expression levels of SIRT1， Nrf2， Keap1， and HO-1 in the hypothalamus. The reactive oxygen species （ROS） assay kit was used to detect ROS level of hypothalamic tissue. The ELISA was used to measure the content of interleukin （IL）-1β and IL-18 in the hypothalamus.ResultsCompared to the sham group， the model group showed a striking decrease in the total distance traveled， central zone dwelling time and rearing times in the OFT （P<0.01）， and significantly shortened sleep duration and prolonged sleep latency （P<0.01）. In comparison with the model group and the WGM+EX527 group， the WGM group showed an obvious increase in the total distance traveled， central zone dwelling time and rearing times （P<0.01）， and shortened sleep latency， prolonged sleep duration （P<0.01）. Additionally， in comparison with the sham group， the model group had a significant down-regulation in the expression levels of hypothalamic SIRT1， Nrf2， Keap1， and HO-1 proteins and mRNAs， and SOD and CAT proteins （P<0.01）， and an obvious up-regulation in the expression levels of NLRP3， Caspase-1， ASC， GSDMD proteins， ROS level， and contents of IL-1β and IL-18 （P<0.01） in the hypothalamus. In comparison with the model group and the WGM+EX527 group， both the down-regulation and up-regulation of expression levels of the proteins and mRNAs mentioned above， and ROS level and the contents of IL-1β and IL-18 were reversed in the WGM group（P<0.01，P<0.05）. H.E. staining showed that in comparison with the sham group， more hypothalamic neurons were wrinkled with unclear cell structures， varying sizes and uneven distribution in the model and WGM+EX527 groups， which was alleviated in the degree of cell injury in the WGM group， for instance clearer cell structure and uniform distribution.ConclusionWGM can improve the sleep and spontaneous activity of PI rats， which may be related to its functions in alleviation of hypothalamic oxidative stress and pyroptosis by regulating the SIRT1/Nrf2 signaling pathway.  
    关键词：Perimenopause;Insomnia;Wheat-grain moxibustion;SIRT1;Nrf2;Hypothalamus   
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    更新时间：2026-03-16
    ““电针可改善PD小鼠运动功能障碍，减少中脑黑质多巴胺能神经元的丢失，提高TH表达水平，其作用机制可能与调控SIRT3/NF-κB/MAPK信号通路抑制神经炎性反应有关。””

    QI Ling, ZHANG Xiao-lei, LI Ya-nan, WANG Yao, LI Han-zhang, XIAO Die, TAO Xiao-yi, MA Jun

    DOI：10.13702/j.1000-0607.20250234
    摘要：ObjectiveTo investigate the effects of electroacupuncture （EA） at “Fengfu” （GV16） and “Taichong” （LR3） on tyrosine hydroxylase （TH）， microglia （MG）， and the silent information regulator 3（SIRT3）/nuclear factor-kappa B （NF-κB）/mitogen-activated protein kinase （MAPK） signaling pathway-related proteins in the substantia nigra of Parkinson’s disease （PD） mice， and to explore the potential mechanisms underlying the therapeutic effects of EA on PD.MethodsC57BL/6J mice were randomly divided into 4 groups： control group， model group， non-acupoint group， and EA group， with 12 mice in each group. A PD model was established by intraperitoneal injections of MPTP for 7 consecutive days. The EA group received EA at GV16 and LR3. The non-acupoint group underwent needle insertion 3 mm lateral to GV16 and LR3 without electrical stimulation. Treatments were administered for 15 min per session， once daily for 14 days. Motor function was assessed using the pole test and suspension test. Immunohistochemistry was used to detect TH-positive expression in the substantia nigra. Immunofluorescence was employed to quantify activated MG. Western blot was used to measure the protein expression levels of SIRT3， NF-κB p65， and p38 MAPK. ELISA was used to determine the serum levels of tumor necrosis factor-α （TNF-α） and interleukin-1β （IL-1β）.ResultsCompared with the control group， the model group exhibited a longer total time in the pole test （P<0.01）， a lower score in the suspension test （P<0.01）， a reduce in mean TH optical density in the substantia nigra （P<0.01）， an increase in the number of MG-positive cells （P<0.01）， a decrease in SIRT3 protein expression （P<0.01）. The protein expression levels of NF-κB p65 and p38 MAPK proteins in the substantia nigra， and the serum levels of TNF-α， and IL-1β were all elevated （P<0.01）. Compared with model group and the non-acupoint group， the EA group showed a shortened total time in the pole test （P<0.01）， a higher score in the suspension test （P<0.01）， an increase in mean TH optical density in the substantia nigra （P<0.01）， a decrease in the number of MG-positive cells （P<0.01）， an increase in SIRT3 protein expression （P<0.05）. The expression levels of NF-κB p65 and p38 MAPK proteins in the substantia nigra， and the serum contents of TNF-α and IL-1β were all decreased （P<0.01）.ConclusionEA can improve motor dysfunction in PD mice， reduce the loss of dopaminergic neurons， and increase TH expression in the substantia nigra. The underlying mechanism may involve the modulation of the SIRT3/NF-κB/MAPK signaling pathway to suppress neuroinflammation.  
    关键词：Parkinson’s disease;Electroacupuncture;Microglia;Silent information regulator 3;Nuclear factor-kappa B;Mitogen-activated protein kinase   
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    “研究发现益元灸通过NRF2/GPX4通路减轻脊髓神经元铁死亡，改善脊髓损伤大鼠尿潴留，为相关治疗提供新思路。”

    WANG Hui-xin, DUAN Shu-ting, BAI Cheng-jie, GAO Jing, LIU Cheng-mei

    DOI：10.13702/j.1000-0607.20250170
    摘要：ObjectiveTo investigate the mechanism of Yiyuan moxibustion in improving lipid peroxidation and urine retention in spinal cord injury （SCI） rats by regulating ferroptosis via the nuclear factor erythroid 2-related factor 2 （NRF2）/glutathione peroxidase 4 （GPX4） pathway.MethodsForty-eight female Wistar rats were randomly divided into sham operation， model， moxibustion and moxibustion + inhibitor （combination） groups， with 12 rats in each group. SCI induced urinary retention model was established by using Allen’s method. Moxibustion was applied to “Shenque” （CV8）， “Guanyuan”（CV4） and “Zhongji” （CV3） for 15 min， once daily for 14 d. Rats in the combination group received moxibustion combined with intraperitoneal injection of the NRF2 inhibitor ML385 （30 mg/kg） once daily for 14 consecutive days. Urodynamic analysis was used to record bladder leak point pressure， maximum bladder volume， and bladder compliance to evaluate bladder function. H.E. staining was used to observe morphological changes in spinal cord tissue. Prussian blue staining was used to observe iron deposition in spinal cord tissue. Transmission electron microscopy （TEM） was used to observe mitochondrial morphological changes in spinal cord tissue. Colorimetric assays were used to measure serum Fe2+， malondialdehyde （MDA）， and reduced glutathione （GSH） levels. Western blot was used to detect the protein expressions of NRF2， GPX4， and solute carrier family 7 member 11 （SLC7A11） in spinal cord tissue.ResultsRats in the model group had disrupted spinal architecture， vacuolated neurons， swollen mitochondria with lost cristae， and brownish iron deposits， which were relatively milder in the moxibustion group. Compared with the sham operation group， the bladder leak point pressure， serum GSH content， and expression levels of NRF2， SLC7A11， and GPX4 proteins in spinal cord tissue were all significantly reduced （P<0.01）， while the maximum bladder volume and bladder compliance， as well as the serum contents of Fe2+ and MDA， were significantly increased （P<0.01） in the model group. When compared to the model group and the combination group， the moxibustion group exhibited a decrease in maximum bladder volume， bladder compliance， serum Fe2+ and MDA content （P<0.01）， but an increase in bladder leak point pressure， GSH content， and the expression of NRF2， SLC7A11， and GPX4 proteins （P<0.01，P<0.05）.ConclusionYiyuan moxibustion may alleviate lipid peroxidation caused by ferroptosis in spinal neurons by up-regulating the NRF2/GPX4 pathway， thereby promoting the recovery of neural regulation of bladder function and improving urine retention in SCI rats.  
    关键词：Spinal cord injury;Yiyuan Moxibustion;Ferroptosis;Lipid peroxidation   
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Column of Encephalopathy

Column of Encephalopathy

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