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Online ISSN: 2097-7042

Print ISSN: 1000-0607

CN: 11-2274/R

Governing Body: National Administration of Traditional Chinese Medicine

Sponsors: Institute of Acupuncture and Moxibustion, CACMS; China Association of Acupuncture-Moxibustion

Publishing Frequency: Monthly

Tel: +86-10-64089344

Email: zcyjbjb@vip.163.com

Address: 16 Nanxiaojie, Dongzhimennei, Beijing, China

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Volume 51 期 7，2026 2026年第51卷第7期

    HUANG Liu-yang, YANG Shu-rui, TANG Qian, LU Da-min, XUE Ting-zheng, YANG Wen-zhuo, HE Qian-li, LIANG Feng-xia, CHEN Rui

    DOI：10.13702/j.1000-0607.20250715
    摘要：ObjectiveTo observe the effect of electroacupuncture （EA） at “Hegu” （LI4） and “Quchi” （LI11） on skin inflammatory injury， itching， and poly（ADP-ribose） polymerase 1 （PARP1）-dependent cell death （Parthanatos） in mice with atopic dermatitis （AD） based on the protease-activated receptor 2 （PAR2）/transient receptor potential vanilloid 3 （TRPV3） pathway， and to explore the possible mechanism of EA in the treatment of AD.MethodsThirty-six male BALB/c mice were randomly divided into a normal group， a model group， and an EA group， with 12 mice in each group. The AD model was established by topical application of calcipotriol （MC903） solution. After successful modeling， the EA group received EA at bilateral LI4 and LI11 once daily， 30 min per session， for 7 consecutive days. The scoring atopic dermatitis （SCORAD） index and scratching frequency were recorded before and after intervention in each group. Histopathological morphology of skin tissue was observed by HE staining. Cell apoptosis in skin tissue was detected by TUNEL assay. The protein expressions of PAR2，TRPV3， interleukin （IL）-33， IL-31， IL-13， PARP1， mitochondrial apoptosis-inducing factor 1 （AIFM1）， and macrophage migration inhibitory factor （MIF） in skin tissue were measured by Western blot. The mRNA expression levels of PAR2，TRPV3， inflammatory factors （IL-33， IL-31， IL-13）， and Parthanatos-related genes （PAR2， TRPV3， PARP1， AIFM1， MIF） in skin tissue were detected by real-time quantitative PCR. The expression of PARP1 in skin tissue was determined by immunofluorescence.ResultsCompared with the normal group， the model group showed significantly increased SCORAD score （P<0.01）， elevated scratching frequency （P<0.01）， higher skin cell apoptosis rate （P<0.01）， up-regulated protein and mRNA expressions of PAR2， TRPV3， inflammatory factors （IL-33， IL-31， IL-13）， and Parthanatos-related factors PARP1， AIFM1， MIF （P<0.01， P<0.05）， as well as enhanced PARP1 fluorescence intensity （P<0.01）. Compared with the model group， the EA group exhibited decreased SCORAD score （P<0.01）， reduced scratching frequency （P<0.01）， lower skin cell apoptosis rate （P<0.01）， down-regulated protein and mRNA expressions of PAR2， TRPV3， inflammatory factors （IL-33， IL-31， IL-13）， and Parthanatos-related factors PARP1， AIFM1， MIF （P<0.05， P<0.01）， and weakened PARP1 fluorescence intensity （P<0.01）. HE staining showed severe skin lesions， marked epidermal hyperplasia and massive inflammatory cell infiltration in the model group， whereas the EA group displayed relatively intact epidermal structure， significantly alleviated structural damage， and less inflammatory cell infiltration.ConclusionEA at LI4 and LI11 can alleviate skin inflammatory injury and itching in AD mice， and its mechanism may be related to down-regulating the PAR2/TRPV3 pathway and inhibiting Parthanatos in skin cells.  
    关键词：Electroacupuncture;Atopic dermatitis;Protease-activated receptor 2/transient receptor potential vanilloid 3 pathway;Parthanatos   
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    更新时间：2026-07-17

    XU Ya-shuang, ZHONG Li-yan, DU Jun-ying, ZHOU Jie, LIANG Yi, FANG Jian-qiao, FANG Jun-fan

    DOI：10.13702/j.1000-0607.20250697
    摘要：ObjectiveTo explore the mechanism of hyperalgesia priming （HP） and evaluate the intervention effect of electroacupuncture （EA） on pain transition.MethodsFifty-nine male C57 mice were used for 4 separate experiments. In the first experiment， the mice were divided into a control group， a sham sensitization group， and a sensitization group， with 5 mice per group. In the second experiment， the mice were divided into a sham sensitization group， a sensitization group， and a sensitization + EA group， with 5 mice per group. The third experiment consisted of a sensitization group and a sensitization + minocycline group， with 7 mice per group. In the fourth experiment， the mice were divided into a sensitization group， a sensitization + EA + PBS group， and a sensitization + EA + colony-stimulating factor （CSF） group， with 5 mice per group. A HP mouse model was established via consecutive intraplantar injections of carrageenan and prostaglandin E2. EA was applied to bilateral “Zusanli” （ST36） and “Kunlun” （BL60） for 30 min， once daily for 8 d. Mechanical paw withdrawal thresholds （PWTs） were measured at different time points to assess pain transition and the effect of EA. Immunofluorescence was used to detect the activation of microglia marker （Iba1） and astrocyte marker （GFAP） in the spinal cord dorsal horn. Intrathecal injection of minocycline was also administered， and its impacts on Iba1 activation and PWTs were tested. After the experiment， skeleton and Sholl analyses were performed to analyze the morphology of microglia. To further examine the role of CSF-1， the factor was administered intrathecally to assess its influence on the effects of EA.ResultsIn the pain transition mouse model， the PWTs at various time points decreased significantly （P<0.01）. After modeling， the microglia was activated （P<0.01）， but the astrocyte was not. EA increased the PWTs in pain transition mice （P<0.01） and suppressed microglia activation （P<0.01）. Intrathecal minocycline administration inhibited microglia activation， reduced Iba1 expression in the spinal cord dorsal horn （P<0.01）， and effectively reversed the PWTs reduction （P<0.01）. Subsequent intrathecal CSF-1 injection promoted microglia activation and blocked the analgesic effect of EA in the model mice （P<0.01）.ConclusionMicroglia activation is critical in pain transition. EA can alleviate hyperalgesia in HP mice by inhibiting microglia activation.  
    关键词：Hyperalgesia priming;Pain transition;Spinal cord dorsal horn;Microglia;Minocycline;Colony-stimulating factor 1;Electroacupuncture   
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    更新时间：2026-07-17

    HU Zhi-xiang, WU Han, LÜ Heng, ZHANG Hao, ZHAI Chun-tao, LI Sheng-yun, WANG Zheng-hao, LÜ Yu-e

    DOI：10.13702/j.1000-0607.20251108
    摘要：ObjectiveTo observe the effect of acupuncture at the acupoint pair “Houxi”（SI3） and “Huantiao”（GB30） on the phosphatidylinositol-3 kinase （PI3K）/protein kinase B （AKT）/mammalian target of rapamycin （mTOR） signaling pathway and autophagy of nucleus pulposus cells in a rat model of intervertebral disc degeneration （IDD）， so as to explore its underlying mechanism in delaying IDD.MethodsA total of 36 male SD rats were randomly assigned to sham operation， model and acupoint pair groups， with 12 rats in each group. The IDD model was established by annulus fibrosus puncture. After modeling， rats of the acupoint pair group received acupuncture stimulation of bilateral SI3 and GB30， with the acupuncture needles retained for 20 min， once daily for 14 consecutive days. Before and after modeling and after the intervention， the mechanical withdrawal reflex threshold （mechanic pain threshold） of the right foot was measured using VonFrey filaments， and the thermal pain threshold measured by using a thermal pain tester. The morphological characteristics of the intervertebral disc tissue were observed by H.E. staining. The contents of type Ⅱ collagen （Collagen Ⅱ）， Aggrecan， matrix metalloproteinase 3 （MMP3）， matrix metalloproteinase 13 （MMP13）， and transcription factor sex-determining region Y-box protein 9 （SOX9） in the nucleus pulposus tissue were detected by ELISA. The mRNA relative expression levels of SOX9 and MMP13 in the nucleus pulposus tissue were detected by real-time fluorescence quantitative PCR. The positive expression of microtubule-associated protein 1 light chain 3 （LC3） in the nucleus pulposus tissue was detected by immunofluorescence staining. The expression levels of PI3K/AKT/mTOR signaling pathway-related proteins and LC3- Ⅱ， Beclin1， and chaperone 1 （p62） in the nucleus pulposus tissue were detected by Western blot.ResultsAfter modeling， in contrast to the sham operation group， the model group showed a striking decrease in the mechanical and thermal pain thresholds on day 7 and 14， contents of Aggrecan， collagen Ⅱ and SOX9， and the expression levels of SOX9 mRNA and p62 protein， ratios of p-PI3K/PI3K， p-AKT/AKT， and p-mTOR/mTOR in the nucleus pulposus tissue （P<0.001， P<0.01）， and a notable increase in the contents of MMP3 and MMP13， and MMP13 mRNA expression level， LC3 immunofluorescence intensity， and protein expressions of LC3-Ⅱ and Beclin 1 （P<0.001）. Under light microscope， the nucleus pulposus cells in the model group was relatively small in the number and discorded in the distribution， with a large number of vacuoles and chaotic matrix arrangement， and the lumbar intervertebral discs showed obvious degeneration， and decrease in the height. In comparison with the model group， both the decrease and increase of the indexes mentioned above were all reversed in the acupoint pair group （P<0.001， P<0.01， P<0.05）. The results of H.E. stain displayed that in the acupoint pair group， the arrangement of the nucleus pulposus cells was more regular， and the number of vacuoles was reduced.ConclusionAcupuncture of acupoint pair SI3 and GB30 can mitigate pain and regulate the autophagy process of lumbar intervertebral disc nucleus cells， reduce the degree of degradation of cytoplasmic matrix， and thereby delay the progression of IDD， which may be associated with its function in activating PI3K/AKT/mTOR signaling pathway in IDD rats.  
    关键词：Acupuncture;Houxi（SI3）;Huantiao（GB30）;intervertebral disc degeneration;PI3K/Akt/mTOR signaling pathway;Autophagy   
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    更新时间：2026-07-17

    KAN Yu-hong, CAO Xiao-min, SA Zhe-yan, SHANG Xin-yu, GAO Hui-min, XU Jin-sen, DONG Ya-qin

    DOI：10.13702/j.1000-0607.20250470
    摘要：ObjectiveTo observe the effect of electroacupuncture （EA） on the homeostasis of Th17/Treg cells and the expressions of key proteins of the janus kinase 1/signal transducer and activator of transcription 3 signaling pathway in myocardial tissue of rats with myocardial ischemia（MI）， so as to explore its mechanisms underlying amelioration of inflammatory injury following MI.MethodsSD rats were randomly divided into control， model， and EA groups， with 6 rats in each group. The MI model was established by subcutaneous injection of isoproterenol hydrochloride（5 mg∙kg-1∙d-1）， once daily for 7 consecutive days. After successful modeling， the rats of EA group received EA stimulation （2 Hz/10 Hz， 2 to 3 mA） of unilateral “Neiguan” （PC6） and “Zusanli” （ST36） for 20 min， once daily for 21 d. The standard limb lead II electrocardiogram （ECG） was recorded to analyze the height of ST and amplitude of T wave for assessing the degree of ischemic myocardial injury. The hematoxylin-eosin （H.E.） staining was used to observe histopathological changes in the myocardial tissue， and the Masson staining performed to examine the collagen deposition of the myocardial cells. The concentrations of tumor necrosis factor-alpha （TNF-α）， interleukin （IL）-17， and IL-10 in the serum and myocardial tissue were detected using enzyme-linked immunosorbent assays （ELISA）， and the proportions of Th17 cells and Treg cells in the myocardial tissue analyzed using flow cytometry. The expression levels of signal transducers and activators of transcription 3 （STAT3）， phosphorylated （p）- STAT3， forkhead box protein 3 （Foxp3）， Janus kinase 1 （JAK1）， retinoic acid-related orphan nuclear receptor-α（RORα）， suppressor of cytokine signaling 3 （SOCS3） proteins in the myocardial tissue were detected using Western blot.ResultsCompared with the control group， the model group had a significant increase in the ST height and T-wave amplitude， myocardial collagen volume fraction （CVF）， TNF-α and IL-17 contents in the serum and myocardial tissue， myocardial Th17/Treg ratio， and expression levels of myocardial JAK1， STAT3， p-STAT3， and RORα proteins （P<0.01， P<0.05）， and a striking decrease in the proportion of Treg cells， contents of myocardial and serum IL-10， and expression levels of myocardial FOXP3 and SOCS3 （P<0.01， P<0.05）. In contrast to the model group， both the increase and the decrease of the indexes mentioned above were reversed in the EA group （P<0.05， P<0.01）. H.E. staining showed necrosis and dissolution of a large number of myocardial cells， with increased cell spacing and blurred boundaries， inflammatory infiltration and fibrous tissue hyperplasia in the model group， which was relatively and significantly milder in the degree of myocardial injury in the EA group.ConclusionEA at PC6 and ST36 can improve myocardial inflammation injury in rats with MI， which may be related to its function in regulating the homeostasis of Th17/Treg cells in myocardial tissue through JAK1/STAT3 signaling， balancing the secretion of pro-inflammatory factors TNF-α， IL-17 and anti-inflammatory factor IL-10.  
    关键词：Electroacupuncture;Myocardial ischemia;Inflammatory injury;Th17/Treg cells;JAK1/STAT3 signaling pathway   
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  • Special Issues
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Special Issue on Innovative Exploration and Interpretation of Acupuncture Neural Circuits

Special Issue on Innovative Exploration and Interpretation of Acupuncture Neural Circuits

key scientific questions in acupuncture and moxibustion support the development of modern acupuncture medicine

key scientific questions in acupuncture and moxibustion support the development of modern acupuncture medicine

Special lssue on Acupuncture-moxibustion and Tumor

Special lssue on Acupuncture-moxibustion and Tumor

Special lssue on Acupuncture-moxibustion and Translational Medicine

Special lssue on Acupuncture-moxibustion and Translational Medicine

Special lssue on Acupuncture-moxibustion and Chronic Inflammatory Diseases

Special lssue on Acupuncture-moxibustion and Chronic Inflammatory Diseases

Special Issue on Interdisciplinary and Acupuncture Development

Special Issue on Interdisciplinary and Acupuncture Development

Column of the Institution 70th Anniversary

Column of the Institution 70th Anniversary

Column on Acupuncture Analgesia

Column on Acupuncture Analgesia

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