最新刊期
卷 37 ， 期 4 ， 2012
- 摘要：Objective To observe the effect of mild moxibustion on the number of macrophages and contents of collagen Ⅰ and Ⅲ in the raw surface tissue in chronic skin ulcer rats so as to study its mechanism underlying promoting scar formation.Methods Eighty male SD rats were randomly divided into normal(n=8),model(n=24),TDP(n=24) and moxibustion(n=24) groups.Chronic refractory skin ulcer was established by making an open wound at the back and local intramuscular injection of hydrocortisone sodium succinate.For rats of the TDP and moxibustion groups,TDP irradiation or mild moxibustion was applied to the raw surface,bilateral "Shenshu"(BL 23) and "Zusanli"(ST 36) for 15 min,once daily for 7,10 and 14 days,respectively.The number of macrophages in the raw surface tissue was counted under light microscope after H.E.staining and collagen Ⅰ and Ⅲ expressions of the raw surface tissue were detected by immunohistochemistry.Results In comparison with the normal group,the numbers of macrophages in the raw surface tissue were increased significantly in the model group on day 7,10 and 14(P<0.05);while compared with the model group,the numbers of macrophages were increased further obviously in the moxibustion group on day 7 and 10 and in the TDP group on day 10 after the treatment(P<0.05).Compared with the model group,the numbers of macrophages in both TDP and moxibustion groups were down-regulated obviously(P<0.05).In regard to collagen Ⅰ and Ⅲ expression of the raw surface tissue,compared with the normal group,the collagen Ⅲ protein expression level was down-regulated markedly in the model group on the 7th day(P<0.01);whereas in comparison with the model group,the expression levels of collagen Ⅰ and Ⅲ were increased considerably in the TDP and moxibustion groups on day 7 and 14 after the treatment(P<0.05,P<0.01).The ratios of collagen Ⅰ/ Ⅲ expression were remarkably higher in the model group than in the normal group on day 7 and 14(P<0.05),and significantly lower in the TDP group on day 7 and 14 and in the moxibustion group on day 14 than in the model group(P<0.05,P<0.01).The effects of moxibustion were obviously superior to those of TDP in up-regulating macrophage number on day 10,up-regulating collagen Ⅰ and Ⅲ expressions on day 14,and down-regulating macrophage number on day 14 after the treatment(P<0.05,P<0.01).No significant differences were found between the TDP and moxibustion groups in up-regulating macrophage number,and collagen Ⅰ and Ⅲ protein expressions,and in down-regulating the ratios of collagen Ⅰ/Ⅲ expression on day 7 after the treatment(P>0.05).Conclusion Mild moxibustion can regulate the number of macrophages and strengthen the expression of collagen proteins in the raw surface tissue in the chronic skin ulcer rats,which may contribute to its effect in promoting wound healing and reducing scar formation.关键词：Mild moxibustion;Chronic skin ulcers;Macrophages;Collagen Ⅰand Ⅲ1375|367|7更新时间：2023-08-11
- 摘要：Objective To observe effects of electroacupuncture(EA) of "Guanyuan"(GV 4)-"Housanli"(ST 36)-"Baihui"(GV 20,"Shuanggu Yitong" acupoint prescription) on the expression of splenic lymphocyte apoptosis-related genes Fas,Bax,and Bcl-2 in aging rats with yang deficiency.Methods Thirty Sprague-Dawley aged female rats were randomly and equally divided into normal control,yang deficiency model(model) and EA groups.The yang deficiency model was established by subcutaneous injection of D-galactose(125 mg/kg) and hydrocortisone(1.5 mg/100 g).EA(2 Hz,1 mA) was applied to "Guanyuan"(GV 4),"Housanli"(ST 36) and "Baihui"(GV 20) for 15 min,once daily,6 times per week for 4 weeks.The expression of pro-apoptotic genes Fas,Bax and anti-apoptosis gene Bcl-2 in the spleen tissues were detected by real-time quantitative RT-PCR.Results In comparison with the normal control group,splenic Fas mRNA and Bax mRNA expression levels were up-regulated significantly,and Bcl-2 mRNA expression level was down-regulated considerably in the model group(P<0.01).After EA intervention,splenic Fas mRNA and Bax mRNA expression levels were down-regulated markedly,while Bcl-2 mRNA expression up-regulated remarkably in the EA group(P<0.05,P<0.01).Conclusion EA of acupoint prescription ["Guanyuan"(GV 4),"Housanli"(ST 36) and "Baihui"(GV 20)] can down-regulate spleen Fas mRNA and Bax mRNA expression,and up-regulate Bcl-2 mRNA expression in aging rats with yang deficiency,which may contribute to its effect in improving yang deficiency in clinic.关键词：Yang deficiency;Electroacupuncture;Spleen;Fas,Bax and Bcl-2 genes;Immuno-regulation1129|218|3更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) or manual acupuncture of unilateral or bilateral "Zusanli"(ST 36) on the contents of serum inflammatory factors interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α),and anti-inflammatory factors interleukin 2(IL-2),interleukin 4(IL-4) and interleukin 10(IL-10),so as to reveal their mechanism underlying improvement of chronic arthritis.Methods Sixty SD rats were randomly divided into normal control,model,electroacupuncture(EA)-left(L) Zusanli(ST 36),EA-bilateral(Bi)-ST 36,and manual acupuncture(MA)-L-ST 36 groups(12 rats/group).Arthritis model was established by subcutaneous injection of complete Freund's adjuvant(0.1 mL)into the hindpaw.EA(2 Hz/100 Hz,1-3 mA,pulse duration: 0.6 ms/0.2 ms) or manual needle stimulation was applied to the left or bilateral "Zusanli"(ST 36) for 30 min,twice every week for 4 weeks.Enzyme linked immunosorbent assay(ELISA) was used to detect the contents of serum IL-1β,TNF-α,IL-2,IL-4 and IL-10,respectively.Results Compared with the normal control group,the contents of serum inflammatory factors IL-1β and TNF-α,anti-inflammatory factors IL-4 and IL-10 were increased significantly in the model group(P<0.001).In comparison with the model group,serum IL-1β,TNF-α,IL-4 and IL-10 contents were down-regulated considerably in the EA-L-ST 36,EA-Bi-ST 36 and MA-L-ST 36 groups(P<0.001,P<0.005).Serum IL-2 content had no apparent changes after modeling in comparison with the normal group(P>0.05).While serum IL-2 contents were markedly higher in the EA-L-ST 36,EA-Bi-ST 36 and MA-L-ST 36 groups than in the model group(P<0.05).No significant differences were found among the EA-L-ST 36,EA-Bi-ST 36 and MA-L-ST 36 groups in serum IL-1β,TNF-α,IL-2,IL-4 and IL-10 contents(P>0.05).Conclusion EA or manual acupuncture stimulation of single or bilateral ST 36 can effectively down-regulate serum inflammatory factors IL-1β and TNF-α levels,and upregulate anti-inflammatory factor IL-2 level in chronic arthritis rats,which may contribute to their effects in relieving chronic arthritis.关键词：Chronic adjuvant arthritis;Electroacupuncture;Manual acupuncture;Zusanli(ST 36);Inflammatory cytokines;Anti-inflammatory cytokines1053|599|10更新时间：2023-08-11
- 摘要：Objective To observe the effect of traditional manipulations of "Shaoshanhuo"(heat-producing needling) and "Toutianliang"(cool-producing needling) on body temperature and serum endotoxin level in heat syndrome rabbits.Methods Twenty-four Japanese rabbits were randomly divided into control,model,Shaoshanhuo and Toutianliang groups.Heat-syndrome model was established by subcutaneous injection of bacterium coli endotoxin solution(40 μg/mL,2 mL/kg).Heat-producing and cool-producing needling was applied to bilateral "Quchi"(LI 11) for 5 min,respectively.Rectal temperature was detected by using a thermometer,and serum endotoxin content assayed by using Limulus Ameboyte Lysate kit(luminescence measuring).Results In comparison with the control group,both rectal temperature and serum endotoxin levels were increased significantly in the model group(P<0.01).While compared to the model group,the rectal temperature and serum endotoxin levels were down-regulated considerably in both Shaoshanhuo and Toutianliang groups(P<0.05,P<0.01).The effect of the Toutianliang group was obviously superior to that of the Shaoshanhuo group in reducing serum endotoxin content(P<0.01).Conclusion Both heat-producing needling and cool-producing needling can lower rectal temperature and serum endotoxin levels in heat-syndrome rabbits,and the effect of cool-producing needling is relatively better in reducing endotoxin content.关键词："Shaoshanhuo"(heat-producing needling);"Toutianliang"(cool-producing needling);Heat-syndrome;Rectal temperature;Serum endotoxin1422|398|1更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) at different frequencies on serum estradiol(E2),progesterone(P),thromboxance B2(TXB2),6-Keton-prostaglandin F 1 alpha(6-keto-PGF1α)contents in late pregnancy rats so as to study its mechanisms underlying labor promotion.Methods A total of 66 late-stage pregnant Wistar rats were randomly divided into 6 groups: normal control,late-pregnancy model(model),2 Hz-EA,20 Hz-EA,50 Hz-EA and 100 Hz-EA groups,with 11 rats in each group.On the 19th day after pregnancy,EA(2 Hz,20 Hz,50 Hz,100 Hz,0.1 mA) was applied to bilateral "Hegu"(LI 4) for 20 min first and to bilateral "Sanyinjiao"(SP 6) for 5 min afterwards.Serum E2,P,TXB2 and 6-keto-PGF1α contents were assayed by radioimmunoassay,and the ratios of E2/P and TXB2/6-keto-PGF1αwere calculated.Results Compared to the normal control group,serum E2 contents in 2 Hz-EA,20 Hz-EA,50 Hz-EA and 100 Hz-EA groups were increased significantly(P<0.001,P<0.01,P<0.05).Compared to the model group,serum E2 levels in the 2 Hz-EA and 20 Hz-EA groups were up-regulated further significantly(P<0.05).Comparison among the four EA groups showed that serum P level in the 100 Hz-EA group was significantly higher than those in the 20 Hz-EA and 50 Hz-EA groups(P<0.05).Compared to the normal control group,the contents of serum TXB2 and the ratios of E2/P in both 2 Hz-EA and 50 Hz-EA groups were significantly higher(P<0.05,P<0.001,P<0.01).Conclusion Both 2 Hz and 20 Hz EA can effectively increase serum E2.content,and 2 Hz and 50 Hz EA can raise serum TXB2 and E2/P levels in late pregnancy rats,which may contribute to their effects in strengthening the uterine contractility to promote labor by regulating hormone secretion.关键词：Late pregnancy;Electroacupuncture;Stimulating frequency;Endocrine;Hegu(LI 4);Sanyinjiao(SP 6)1288|171|1更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) on the expression of proliferating cell nuclear antigen(PCNA) and glial fibrillary acidic protein(GFAP) in the subventricular zone(SVZ) of Parkinson's disease(PD) rats,so as to explore its mechanisms underlying improvement of PD.Methods Eighteen SD rats were randomized into normal control,model and EA groups(6 rats/group).PD model was duplicated by microinjection of 6-hydroxydopamine(2.5 μg/μL,6 μL) containing 0.02% antiscorbic acid into the right medial forebrain bundle region(P:-4.0,L: 0.8,H: 8.0).On the 7th day after mo-deling,EA(100 Hz) was applied to bilateral "Hegu"(LI 4) and "Taichong"(LR 3) for 30 min,once a day for 21 days.The expression levels of tyrosine hydroxylase(TH),GFAP and PCNA in the right SVZ tissue were detected by immunohistochemistry.Results TH expression was strong in the normal control group,but no TH expression was found in the model and EA groups.In comparison with the normal control group,the expression levels of PCNA and GFAP proteins and the number of PCNA-IR-positive cells in the right SVZ were decreased significantly in the model group(P<0.01);while compared with the model group,the expression levels of PCNA and GFAP proteins and the number of PCNA-IR-positive cells in the right SVZ were up-regulated consi-derably in the EA group(P<0.01,P<0.05).Conclusion EA can up-regulate the expression of PCNA and GFAP proteins in the SVZ in PD rats without changes of TH expression,which may contribute to its effect in improving clinical symptoms of PD.关键词：Parkinson's disease;Electroacupuncture;Subventricular zone;Proliferating cell nuclear antigen;Glial fibrillary acidic protein1151|202|3更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) of "Weizhong"(BL 40),"Sanyinjiao"(SP 6) and "Yinlingquan"(SP 9) on changes of intravesical pressure and contents of adenosine triphosphate(ATP) in the urinary bladder tissue in rabbits with acute urine retention,so as to explore the relatively specificity of acupoints for urinary bladder problems.Methods Forty-eight male adult rabbits were randomly divided into normal control,model,Weizhong(BL 40,EA-BL 40),San-yinjiao(SP 6,EA-SP 6),Yinlingquan(SP 9,EA-SP 9) and non-acupoint(EA-NA) groups.Acute urinary retention model was established by filling the rabbits' bladder with normal saline at a volume of 2 times above their normal capacity for 2 hours.EA(2 Hz/15 Hz,0.6 mA) was applied to bilateral "Weizhong"(BL 40),"Sanyinjiao"(SP 6) and "Yinlingquan"(SP 9) for 20 min,respectively.Intravesical pressure was detected by using a pressure transducer and an amplifier.Bladder ATP content was detected by using enzyme linked immunosorbent assay(ELISA).Results In comparison with pre-modeling,the intravesical pressure levels were decreased significantly after modeling in the model,EA-BL 40,EA-SP 6,EA-SP 9 and EA-NA groups(P<0.05).Compared with pre-EA,intravesical pressure values were increased remarkably in the EA-BL 40,EA-SP 6,EA-SP 9 and EA-NA groups(P<0.05).The percentages of the increased vesical pressure after EA were considerably higher in the EA-BL 40,EA-SP 6,EA-SP 9 and EA-NA groups than in the model group(P<0.05).Compared with the normal group,bladder ATP content in the model group was reduced significantly(P<0.05);while in comparison with the model group,ATP contents in the EA-BL 40,EA-SP 6 and EA-SP 9 groups were up-regulated apparently(P<0.05).The bladder ATP level of the EA-BL 40 group was significantly higher than those of EA-SP 6 and EA-SP 9 groups(P<0.05).No significant differences were found between the model and EA-NA groups,and between the EA-SP 6 and EA-SP 9 groups in bladder ATP contents(P>0.05),and among the EA-BL 40,EA-SP 6 and EA-SP 9 groups in the percentages of the increased intravesical pressure(P>0.05).Conclusion EA of BL 40,SP 6 and SP 9 can significantly raise intravesical pressure and bladder ATP content in urine retention rabbits,which may contribute to its effect in improving urinary retention.关键词：Acute urinary retention;Electroacupuncture;Intravesical pressure;Adenosine triphosphate;Weizhong(BL 40);Sanyinjiao(SP 6);Yinlingquan(SP 9)1303|425|4更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) on ultrastructure of facial nerve and Schwann cells in facial nerve injury rabbits so as to explore its mechanism underlying improving facial palsy.Methods A total of 60 Japanese white rabbits were randomly assigned to normal control(normal,n=6),sham-operation(sham,n=18),model(n=18) and EA(n=18) groups.The facial nerve injury model was established by clamping the right facial nerve for 5 min by using a pair of forceps.EA(1.5 V,3 Hz/60 Hz) was applied to "Yifeng"(TE 17)-"Hegu"(LI 4),and "Dicang"(ST 4)-"Jiache"(ST 6) on the affected side for 30 min,respectively,once daily for 3 weeks.Morphologic changes of the myelin sheath and Schwann cells of the facial nerve were observed by using electron microscope after 1,2 and 3 weeks' treatment.Results Compared with the normal control group,the number of the myelin sheaths and the thickness values of the facial nerve after treatment of 1,2 and 3 weeks in the model group were decreased significantly(P<0.01,P<0.05).While in comparison with the model group,the thickness value of the facial nerve 2 weeks after modeling in EA group was increased considerably(P<0.01).In the model group,there were many vacuoles in the cytoplasm of Schwann cells instead of organells in the facial nerve.In the sham group,the demyelination was milder than that of the model group,and majority of myelin sheaths showed integral structure after 2 and 3 weeks,being similar to the normal group.Compared with the model group,the extent of demyelination was less distinct,with rela-tively more abundant organells in the facial nerve of the EA group,especially after 1 week of treatment.Among the three time points in the EA group,demyelination was milder in the 1st week not in the other time points.In contrast,along with the continuous EA treatment,the situation became worse after 3 weeks of treatment in the EA group.Conclusion In the acute stage of facial nerve injury,EA intervention can play a positive effect on the repair of the nerve and Schwann cells.However,continuous 3-weeks' EA intervention may worsen the facial nerve injury.关键词：Facial nerve injury;Electroacupuncture;Schwann cells;Myelin sheath;Intervention duration1204|448|7更新时间：2023-08-11
- 摘要：Objective To observe the effect of acupuncture of "Shenmai"(BL 62) and "Zhaohai"(KI 6),"Shenmen"(HT 7),etc.on the expression of hypothalamic γ-aminobutyric acid(GABA) and GABAA receptor(GABAAR) proteins in experimental insomnia rats so as to explore its mechanism underlying improving sleeping.Methods Seventy Wistar rats were randomly divided into normal control,model,"Sanyinjiao"(SP 6),"Neiguan"(PC 6),"Zusanli"(ST 36),"Shenmen"(HT 7),and "Shenmai"(BL 62)-Zhaohai(KI 6,BL 62-KI 6) groups,with 10 rats in each group.Insomnia model was established by intrape-ritoneal injection of chlorophenylalanine solution(PCPA,1 mL/100 g).An acupuncture needle was inserted into each of the bila-teral HT 7,PC 6,SP 6,ST 36 and BL 62-KI 6 respectively and manipulated for about 1 min,once daily for 7 days.Hypothamic GABA and GABAAR protein expressions were detected by immunohistochemistry.The animals' physical ability was evaluated by using pole-climbing test in a water tank.Results In comparison with the normal control group,the numbers of hypothalamic GABA immunoreaction(IR)-and GABAAR IR-positive neurons and the pole-climbing time were reduced significantly in the model group(P<0.05).While in comparison with the model group,the numbers of hypothalamic GABA IR-positive neurons and those of hypothalamic GABAAR IR-positive neurons in the HT 7,PC 6,SP 6,ST 36 and BL 62-KI 6 groups,as well as the pole-climbing duration in the SP 6,ST 36 and BL 62-KI 6 groups were increased considerably(P<0.05,P<0.01).The effects of HT 7 and BL 62-KI 6 groups were significantly superior to those of PC 6,ST 36 and SP 6 groups in up-regulating GABA and GABAAR expression,and the effect of BL 62-KI 6 group was remarkably better than those of HT 7,PC 6,SP 6 and ST 36 groups in lengthening the pole-climbing time(P<0.05).Conclusion Acupuncture can effectively suppress insomnia induced down-regulation of hypothalamic GABA and GABAAR in rats and lengthen pole-climbing time,which may contribute to its effect in relieving insomnia.关键词：Acupuncture;Insomnia;Hypothalamus;γ-aminobutyric acid;GABAA receptor2413|1641|16更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) of "Zusanli"(ST 36)-"Quchi"(LI 11) on behavior changes and spinal inflammatory reactions in spinal ischemia-reperfusion injury(SI/RI) rabbits,so as to assess its protective effect on SI/RI.Methods Thirty New Zealand rabbits were randomly divided into sham-operation(sham),SI/RI model(model) and EA groups.SI/RI model was established by occlusion of the abdominal aorta for 45 min.EA(2 Hz,1 mA) was applied to bilateral "Zusanli"(ST 36)-"Quchi"(LI 11) for 30 min after modeling,4 times(0 h,12 h,24 h and 36 h after modeling) altogether.The animals' motor function score of the hindlimb was assessed according to Tarlov's method.The contents of tumor necrosis factor-α(TNF-α) and Interleukin-6(IL-6) of the lumbar spinal cord tissue were assayed by ELISA 48 h after modeling.Results Compared with the sham group,the animals' motor scores at 24 h and 48 h after modeling were decreased,and spinal TNF-α and IL-6 contents were increased significantly(all P<0.05) in the model group.In comparison with the model group,the animals' motor scores at both 24 h and 48 h were up-regulated considerably in the EA group(P<0.05),suggesting an improvement of the neuronal function after EA intervention.The spinal TNF-α and IL-6 contents were obviously lower in the EA group than in the model group(P<0.05).Conclusion Electroacupuncture has a protective effect on the spinal cord ischemia-reperfusion injury of rabbits probably by reducing the local inflammatory reactions.关键词：Electroacupuncture;Spinal ischemia-reperfusion injury;Motor function;Spinal tumor necrosis factor-α;Interleukin-61178|203|5更新时间：2023-08-11
- 摘要：Objective To observe the effect of electroacupuncture(EA) of "Dingzhongxian"(MS 5) and "Dingpang-xian"(MS 8) on the expression of cerebral protein kinase C(PKC) isozymes in local cerebral ischemia reperfusion injury(CI/RI) rats so as to explore its underlying mechanism in protecting ischemic brain tissue.Methods Seventy-two Wistar rats were randomized into normal control(n=8),CI/RI model(model,n=32),and EA(n=32) groups.The later two groups were further divided into 4,12,24 and 72 h subgroups,respectively,with 8 rats in each.CI/RI model was established by occlusion of the middle cerebral artery under anesthesia and reperfusion for 4,12,24 and 72 h,respectively.EA(1 mA,2 Hz/15 Hz) was applied to "Dingzhongxian"(MS 5) and "Dingpangxian"(MS 8) for 10 min every time,and once again every 12 h after modeling.The expression of PKCγ and PKCδ in the ischemic cortex tissue was detected using immunohistochemistry.TdT-mediated dUTP Nick-End Labeling was used to detect neuronal apoptosis of the local ischemic cerebral cortex.Results In comparison with the normal group,the expression levels of cerebral PKCγ and PKCδ proteins as well as the number of the apoptotic neurons at time-points of 4,12,24 and 72 h after modeling were increased apparently in the model group(P<0.01);while compared with the model group,cerebral PKCγ and PKCδ protein expressions and the apoptotic neuronal number were decreased considerably in the EA group(P<0.01,P<0.05).No significant differences were found among the 4 time-points in the expression levels of PKCγ and PKCδ and apoptotic neuronal number in the model group and EA group(P>0.05).Conclusion EA intervention can effectively down-regulate expressions of cerebral PKCγ,PKCδ proteins and apoptotic neuronal number in cerebral ischemia rats,which may contribute to its effect in protecting the ischemic cerebral tissue.关键词：Cerebral ischemia;Electroacupuncture;Cerebral cortex;Apoptosis;Protein kinase C isozymes1099|312|5更新时间：2023-08-11
- 摘要：Objective To observe the curative effect of different duration of mild moxibustion in superficial gastritis patients with deficiency cold pattern of spleen and stomach.Methods A total of 84 superficial gastritis patients were randomly divided into moxibustion-20 min group,moxibustion-40 min group and medication(Ranitidine) group,with 28 cases in each group.Mild moxibustion was applied to bilateral Zusanli(ST 36) and Zhongwan(CV 12,odd days),Pishu(BL 20) and Weishu(BL 21,even-numbered days) for 20 min and 40 min respectively,once daily for 20 days.The symptom integrative score of superficial gastritis patients and the therapeutic effects were assessed according to "The Scoring Table for Symptoms and Signs of Gastrointestinal Disorders of Chinese Medicine",etc.Results Following 20 days' treatment,of the three 28 gastrititis patients in the medication,moxibustion-20 min and moxibustion-40 min groups,0,1,and 0 cases were cured,5,7 and 12 experienced marked improvement in their symptoms,15,16 and 12 had an improvement,and 8,4 and 4 were invalid,with the effective rates being 71.4%,85.7% and 85.7%,respectively.After one month's follow up,of the three 28 cases in the medication,moxibustion-20 min and moxibustion-40 min groups,0,4 and 0 cases were cured,4,8,and 13 experienced marked improvement,15,16 and 13 had an improvement,9,0 and 2 were ineffective,with the effective rates being 67.9%,100% and 92.9%,respectively.Self-comparison of each group showed that the integrative scores of symptoms were all decreased significantly after the treatment and one-month's follow up in the three groups(P<0.01).The effective rates of both moxibustion-20 min and-40 min were significantly higher than that of the medication group after one month's follow up(P<0.01,P<0.05).The therapeutic effect of moxibustion-20 min group was significantly superior to that of the medication group in lowering the integrative score of symptoms after one month's follow up(P<0.01).No significant differences were found among the three groups in the therapeutic effects and in reducing integrative scores of symptoms after 20 days' treatment(P>0.05).Conclusion Mild moxibustion is significantly superior to medication in long-term therapeutic effects in the treatment of superficial gastritis patients with spleen-stomach deficiency-cold pattern.关键词：Superficial gastritis;Spleen-stomach deficiency-cold pattern;Mild moxibustion;Clinical therapeutic effect;Symptom integrative score1186|467|1更新时间：2023-08-11
- 摘要：Objective To observe the instant effect of "Balance Acupuncture" in relieving sore throat in patients with acute pharyngitis.Methods A total of 74 acute pharyngitis patients with sore throat were randomly assigned to treatment group(Balance Acupuncture,n=36) and placebo acupuncture group(sham acupoint,n=38).Patients of the Balance Acupuncture group were treated by acupuncture stimulation of bilateral "Yantong"(sore throat) point(the mid-point of the second metacarpal bone on the radial side) and those of the sham acupoint group were treated by acupuncture stimulation of the sham point(the site 1 cm lateral to the mid-point between the ulnar endpoint of the cubic transverse striation and that of the wrist-palm transverse striation).After insertion,the acupuncture needle was manipulated repeatedly till "Deqi" for patients of the treatment group but not manipulated for patients of the placebo acupuncture group,then removed immediately.The VAS(Visual Analogue Scores) were assessed 1 min after the treatment in addition to safety index records.Results Before the treatment,the VAS values of the treatment group and sham acupoint group were(5.25±1.51) points and(4.83±1.59) points,respectively,which had no signi-ficant differences between the two groups(P>0.05).One minute after the treatment,VAS values of the treatment and sham acupoint groups were(2.11±1.88) points and(3.39±1.94) points,respectively,both decreasing significantly(P<0.01).The effect of the former group was significantly superior to that of the sham acupoint group(P<0.05).Conclusion Both Balance Acupuncture and sham-acupoint acupuncture treatments can relieve sore throat in acute pharyngitis patients,and the therapeutic effect of Balance Acupuncture treatment is obviously better.关键词：Balance acupuncture;Sore throat of pharyngitis;Acupuncture analgesia;Visual analogue scores977|555|0更新时间：2023-08-11
- 摘要：In the present paper,the authors introduce the approved and finished research projects for acupuncture and moxibustion therapies supported by the National Natural Science Foundation of China(NSFC) during the 11th 5-year-plan.A total of 194 research projects were subsidized by NSFC from 2006 to 2010.These projects include 6 aspects: meridian-collaterals,acupoint theory,acupuncture analgesia,mechanisms underlying improvement of different clinical problems,clinical trials,and moxibustion therapy.The research on acupoints has been becoming a new hotspot in recent years.Majority of the research projects focus on the mechanism of acu-moxibustion underlying improvement of different clinical problems,while fewer projects on clinical trials.During the 11th 5-year-plan,119 projects were completed;most of them involved meridian-collateral theory,acupoint theory,mechanism of acu-moxibustion underlying improvement of clinical problems and acupuncture manipulations.Following analysis of the finished research projects,we find that 1) many neurobiological methods and techniques are commonly used in the research on meridian-collateral theory;2) the research on acupoint theory is changing from observing the local morphological structure to identifying characteristics of the regional activated receptors,particularly under the circumstances of visceral pathological conditions and efficacies of acupoints;3) researches on the underlying mechanism of acu-moxibusiton for improving clinical disorders mainly focused on its cerebral protective effects against cerebral ischemia,in addition,researches about other diseases on clinical conditions have been also carried out,but the related mechanisms are far from understanding;4) In many research projects,various new methods and techniques,such as fMRI,position emission tomography,genomics,proteomics,molecular biology,nerve stem cell,etc.were widely used;5) Randomized controlled multi-center clinical trials are definitely insufficient.Only two clinical projects were finished during the 11th 5-year-plan.Moreover,it should be noted that in the subject of acu-moxibustion,independent innovation researches are fewer;the foundation of competitive ability is relatively weaker;the supporting conditions for finishing the research projects are poorer in some institutes or districts;and the interrelations among the theoretical,experimental and clinical researches are not intimately close,leading to relative lag in the subject development.关键词：Acu-moxibustion;Research projects;The 11th 5-year-plan;Current status;Weaker points1046|758|3更新时间：2023-08-11
- 摘要：The so-called ultrasound acupuncture is a therapeutic approach for clinical problems and health care by app-lying the ultrasound energy to the acupoints of the human body directly or indirectly.It has been applied in clinic for about 30 years since 1980 s.In the present paper,the authors review the development of both experimental and clinical researches in the past 30 years.Its clinical application includes allergic rhinitis,local pain,mastitis,angina pectoris of coronary heart disease,stroke,etc.Regarding the researches on the underlying mechanism of ultrasound and ultrasound acupuncture,the authors make a summary from 1) bioeffects(thermal and nonthermal effects) of ultrasound intervention;2) cell lysis and nonlysis effects of ultrasound intervention;and 3) effects of ultrasound acupuncture on the degranulation of mast cells.Based on the idea that "inflammatory reaction caused by mast cell degranulation is one of the initial factors of acupuncture for inducing therapeutic effects",bioeffects including cellular changes,especially mast cell degranulation caused by ultrasound stimulation,are thought to be the main possible mechanisms underlying the favorable efficacy of ultrasound acupuncture intervention.However,the ultrasound metrology and the specific superiority of ultrasound acupuncture remain unknown up to now.1661|752|4更新时间：2023-08-11
- 摘要：It has been documented that adenosine triphosphate(ATP) is a multifunctional nucleoside triphosphate used in cells,including chemical energy transportation,extra-and intracellular signaling,cell structure maintaining,DNA and RNA synthesis,etc.In the present paper,the authors reviewed studies on the involvement of ATP in different efficacies of acupuncture intervention from the following four aspects.1) ATP release in the stimulated acupoint area is one of the key factors for producing acupuncture analgesia;2) Acupuncture induced suppression of ATP activity in the central nervous system results in pain relief;3) ATP application on the human body surface may strengthen the sensation propagation along the meridian;4) Favorable regulation of acupuncture intervention on the abnormal functional activities of some viscera often accompanies with an increase of ATP content and ATPase activity in the related internal organs.It has been proposed that ATP,Ca2+ and reactive oxygen species(ROS) are closely related each other in the life activities of the organism.Hence,a reasonable regulation on ATP levels in the related organs of the body may be a new approach for raising clinical therapeutic effects of acupuncture therapy.关键词：Adenosine triphosphate;Acupuncture therapy;Clinical efficacy;Acupuncture analgesia;Sensation propagation along the meridian;Visceral functional regulation1500|846|6更新时间：2023-08-11
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