近年来

许多作者报告内源性鸦片样物质(Endogenons Opiate Like Substan-ces

OLS)可以抑制腺苷酸环化酸

使脑内环化-磷酸腺苷(cAMP)含量降低。设法提高脑内cAMP的水平

则可对抗吗啡的镇痛作用。现已证明

内源性鸦片样物质在针刺镇痛过程中具有重要作用。在针刺过程中

脑内鸦片样物质亦明显升高。我们实验室还发现

给大鼠脑室注射cAMP

Rats were given electroacupuncture for 30 minutes and decapitated for determination of cerebralcAMP. There was a significant reduction of cerebtal cAMP with the elevation of pain threshold afteracupuncture. The content of cerebral cAMP was also recovered when analgesia had been disappeared afterstopping acupuncture. Intraventricular injection of Naloxon

an opiate receptor antagonist

may comple-tely reversed the lowering of cerebral cAMP

but it failed to block acupuncture analgesia. It can be suggested from the above results that there was a complex mechanism in acupuncture anal-gesia besides its effect on the endogenous opiate like substances and cAMP.