前列腺素(PGS)在哺乳动物各组织有广泛的分布

它是一个具有广谱的生物活性物质。一般认为

PGE 对中枢神经系统有抑制的功能。有人发现于猴、猫、大鼠腹腔内注入 PGE 能产生镇静、镇定效应

以及减少条件防御反射与对抗电或化学引起的惊厥作用。但最近有人报告脑室注入PGE_1有抗损伤效应

并可加强吗啡镇痛。我们在针麻手术病人身上曾观察到血浆PGE 水平与针麻效果有一定的关系

针麻效果好者(Ⅰ级)

血浆 PGE 含量诱导后比针前高

术中继续升高;针麻效果差者(Ⅲ级)

诱导后

术中血浆 PGE 含量不One-third of 40 rats under acupuncture showed analgesic effects.This individual variation of analgesic effects could be identified repeatedly.In part of the another two-thirds in which the analgesic effect had not been induced by acupuncture

intracerebroventricular administration of PGE_2 or PGE_1 potentiated the acupuncture analgesic effects.While in 10 rats the significant analgesic effect remarkably inhibited by intracerebroventricular administration of paracetamol.These findings indicate that endogenous PGS in brain might play some role in acupuncture analgesia.