在我们已往的工作中

曾观察到针麻胃大部切除手术病人及狗实验模型上

血中反映交感神经机能状态的多巴胺β-羟化酶活性降低

手术器官组织肾上腺素能神经纤维去甲肾上腺素释放减少。血中游离5-羟色胺含量减少。在中枢神经系统、中脑、桥脑、延脑等脑区内

5-羟色胺的含量有所升高

去甲肾上腺素有所降低。近几年来

随着国外关于内源性吗啡样物质的发现

在针刺镇痛原理的研究中

也报导脑脊液中内源性吗啡样物质的含量有所增加。由于这些物质都是通过细胞表面的特殊受体而影响细胞内 cAMP 的含量

也This communication reports the content of adenosine 3′

5′-cyclic mon- ophosphate

guanosine 3′

5′-cyclic monophosphate and methionine enkepha- lin in nine areas of the rat brain under basal conditions.The 9 areas are the hypothalamus

the corpus striatum

the medulla

the pons

the hippo- campus

the cerebral cortex

the thalamus

the middle brain and the cere- bellum.The rat brain was fixed with microwave radiation;adenosine 3′

5′-cyclic monophosphate

guanosine 3′

5′-cyclic monophosphate and me- thionine enkephalin in each brain area were determined with either protein binding assay or radioimmunoassay.A tritiated tracer was used for the calculation of the total recoveries of the studied compounds.On a wet tissus weight basis

among the nine areas examined

the thalamus

the middle brain and the cerebellum have higher contents of adenosine 3′

5′- cyclic monophosphate

while the cerebellum

the medulla

the pons and the middle brain have higher contents of guanosine 3′

5′-cyclic monopho- sphate.The content of methionine enkephalin is higher in the corpus striatum

the thalamus and the hypothalamus.The difference of contents of each compound among the area of brain has been statistically analyz- ed.