大量临床和实验研究表明

神经系统多个水平共同参与丁针刺镇痛过程。过去我们的工作已证实大脑皮层参与针刺镇痛。Hecaen 等1949年首先报导了破坏中央中核能缓解丘脑痛

以后一些资料进一步表明破坏丘脑中央中核能缓解顽固性疼痛。毁损束旁核(pf)、中央中核(CM)或附近其他连接的丘脑核团能有效地取消猫In the present work

we recorded the evoked potentials of cerebralsomatosensory area

nucleus CM and the action potentials of nervi perona-eus communis simultaneously

while unilateral nervi peronaeus communiswas stimulated by noxious electric stimuli in rabbits.We observed and compared the responses of three levels before and after acupuncture.Besi-des

we also observed the change of the evoked responses of three levelswhen nucleus CM was damaged by the eletrolytic lesion.Furthermore

weanalysed the interaction of three levels and their roles in acupunctureanalgesia.The amplitude of multi-components of cerebral evoked potentials(after70ms.)and N21

p180 components of the evoked potentials of CM weredecreased while “Sanyinjiao” and “Yinlin quan” were stimulated by elec-tro-acupuncture for 5min.(13 rabbits

22 times).It showed that thedecrease of amplitude was with significant difference(p<0.05)

15-20miu.after ceasing acupuncture

the amplitude of p354 component of the evokedpotentials of CM was decreased and showed significant difference p<0.02.The amplitude of C wave of the action potentials of nervi peronaeus com-munis was decreased.This inhibitory mechanism might not be produced inperiphery;but it was realized through the descending inhibition of the centre.The amplitude of the evoked potentials of cortex and CM were decr-eased after electrolytic lesion of CM(5 rabbits);but the amplitude of Cwave of the action potentials of nervi peronaeus communis was increased.The results suggest that the high centre may exert a tonic inhibitorycontrol on the transmission of peripheral noxions afferent impulse throughthe descending pathway.