大量研究资料反复证明

脑内5-羟色胺(5-HT)能神经元系统在针刺镇痛中有着重要作用。激活或加强这个系统的神经传递

针刺镇痛效应得到提高;相反

破坏或减弱这个系统的神经传递

则针刺镇痛效应明显降低。我们以往的动物实验结果表明

胰岛素和氨茶碱在提高脑内5-HT含量的同时

可明显提高大白鼠的针刺镇痛效应。为了验证上述动物实验结果

并探索提高临床针麻效果的可能途径

我们用双盲法观察了胰岛素和氨茶碱对临床针麻效Eor the purpose of verifying the experimental result that insulin and aminophylline could enhancethe analgesic effect of acupuncture in rats

326 cases of abdominal tuboligation under acupuncture anest-hesia were observed clinically. Preoperative forecast of the effect of acupuncture anesthesia was madein all cases. Operation began after 20-30 min. induction with electrical needling "Ciliao"

bilaterally.The efficiency of acupuncture anesthesta was scored according to the national unified 4-grade system aswell as to the multi-physiological parameters (mainly plethysmogram

combined with respiration

elect-romyogram

GSR and perspiration). Furthermore

the efficiency of acupuncture anesthesia was compa-red with the preoperative forecast

and the rate of transformation of the efficiency of acupuncture ane-sthesia was calculated. The observations were carried out by a double-blind method. The cases were divided into 5 groups(Insulin 8 units s. c.

Insulin 12 units s. c.

Aminophylline 0.2 gm p. o.

Aminophylline 0.3 gm p. o.and local anesthesia) with their respective controls. The control of insulin group received saline s. c. asplacebo

while in the case of aminophylline the placebo was vitamin B_1 p. o. The drugs and placeboswere administered 1 hour before the operation. The results indicate that administration of aminophylline 0.2 gm enhances signilicantly the efficie-ncy of acupuncture anesthesia. Thus

the rate of excellence (Grade I) (71.43%) was greater as compa-red with the control group (42.86%) in 4-grade system

while according to the multi-physiological para-mters the excellence-good rate (Grade I+II) (100%) was greater than that of the control group (86.67%).The rate of transformation of the efficiency of acupuncture anesthesia was also greater than its controlgroup. Similar results were obtained in the Aminophylline 0.3 gm group. On the contrary

in both thegroups of insulin 8 and 12 units the efficiency of acupuncture anesthesia was not greater significantlyas compared with the control groups.