近十余年来

对于环-磷酸鸟苷(cGMP)在中枢神经系统中的机能作用引起了人们的注意.有报导 cGMP 具有镇痛性质

并假设 cGMP 或许是一种或一种以上的神经递质的调节者。本工作是观察脑室注射cGMP 对针刺镇痛的影响

并探索它与乙酰胆碱及阿片样物质之间可能存在的关系.The purpose of this study is to observe the effects of intraventricular injection(IVT)of cGMP on acupuncture analgesia(AA)and its relationship with acetylcholine and endogenous opiate like substances.The following results have been obtained. 1.After the intraventricular injection of cGMP(400μg)pain thresho- lds of rats were markedly elevated (47%～63%).During continuous electro- acupuncture for thirty minutes

the average pain threshold increased by 47%.Intraventicular injection of cGMP associated with additional electro- acupuncture elevated markedly Pain thresholds(130%).The effect was more that of arithmetic sum of cGMP plus electro-acupuncture.These results indicated that cGMP enhanced the effects of AA. 2.The effects of AA decreased by 18% at 3 hours after IVT of hemi- cholinium-3(50μg).On the basis of that

cGMP raised the effects of AA by 42%

but the effect failed to reach the original level.The result suggested that the enhancement of cGMP on AA could be partially antagonized by hemicholinium-3. 3.The effect of AA of rats could not be blocked by the IVT of naloxone(30μg).When cGMP was used in combination with naloxone

the reenforce effect of cGMP on AA was not shown.The results suggested that the enhancement action of cGMP on AA could be antagonized by bloc- king the opiate receptor with naloxone.