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1. 江西中医学院附属医院
2. 江西中医学院生化教研组
纸质出版日期:1982
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金之刚, 伍嘉宁. 针刺镇痛与脑组织碳酸酐酶活性的关系[J]. 针刺研究, 1982,(1):47-49.
Jin Zhigang, Wu Jianing. THE RELATION BETWEEN ACUPUNCTURE ANALGESIA AND THE ACTIVITY OF CARBONIC ANHYDRASE IN RAT BRAIN[J]. Acupuncture research, 1982, (1): 47-49.
关于针麻原理
国内学者已提出不少论点。按祖国医学经络脏腑学说认为
针刺是通过经络系统的传导
影响气血而起镇痛作用;神经观点则认为
针刺是通过神经系统而发挥作用的
根据近代对神经系统活动
神经兴奋抑制传导
与神经介质的产生和22 rats were used as the experimental model test. 12 of them were used as the control group
and 10 were used as the experimental group. Electric-acupuncture at the acupuncture point
Tsusanli (足三里) on both legs of the rats was used to investigate the effect of anesthesia. After thirty minutes of simple electric-acupuncture five rats with elevation of threshold of pain>30% were thought to be the group of effective analgesia; however
the other five that the threshold of pain was elevated<2% were thought to be the negative group. Then we respectively determined the units of the carbonic anhydrase of the brain regions. The experimental results showed that the activity of carbonic anhydrase in several parts of brain of effective group was inhibited apparently. In comparing the result with the control group
the difference was very significant (cerebrum p<0.05
cerebellum p = 0.01 brain stem p<0.01). However
there was no apparent difference in negative group (cerebrum p>0.05
cerebellum p>0.05
brain stem p>0.05). The results of the animal experiments indicate that the carbonic anhydrase of brain may have the effect on the action of acupuncture analgesia. According to Ashby
carbonic anhydrase exists in cerebral cortex and greywhite substance of the brain. It can accelerate the speed of extension of the stimulation in the central nervous system. By inhibition
the excited cerebrum will be inhibited. In EEG
the exciting type wave was changed into the resting type wave. How did the inhibition of carbonic anhydrase of the brain change the excited brain into inhibited? Ashby suggested that activity of carbonic anhydrase was related with carbohydratic metabolism and energy metabolism and change the pH of brain. Achav has pointed out that the activity of carbonic anhydrase may lead to change the ion permeability of cellular membrane. These factors shall influence the metabolism of some neurotransmitters.Moreover they shall influence the nerve cells to change the transmission mechanism of some neurotransmitters.
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