多巴胺(DA)是重要的单胺类神经递质

脑内DA能神经系统与许多方面的脑机能状态密切相关

如情绪、精神病及锥体外运动等等。已有的实验资料证明针刺可激发脑内DA能系统

使DA及其代谢产物高香草酸在脑内含量明显升高。但脑内DA能系统机能对针刺镇痛的影响如何

有着不同的看法。无关、对抗和协同三种意见都有。本实验利用DA受体激动剂阿扑吗啡(Apomorphine)和DA受体拮抗剂The present paper deals with the effects which were induced by injection into lateral ventricle with apomorphine

agonist of DA-receptor or haloperidol

antagonist of DA-receptor during electrical acupuncture analgesia in mice. The results show that the effects of electrical acupuncture analgesia will increase approximately twice after apomorphine is injected. The effects of electrical acupuncture analgesia were almost abolished by haloperidol. It suggests that the dopaminergic system participated in and enhanced the effects of electrical acupuncture analgesia. Based on the previous experiments and the present one

we think that there is a synergic effect between the brain dopaminergic system and the electrical acupuncture analgesia. In addition

we assume that DA path of mesencephalonlimbic system might play an important role in the electrical acupuncture analgesia.